Jon Miller is having trouble believing that baseball legend Frank Robinson is gone. Robinson, 83, passed away Thursday morning.

Renza Scibilia
Jul 1, 2019; 37:302-303
Book Reviews

A Florida sheriff's office said a driver reversing out of a bank parking lot accidentally ended up backing up onto two other cars.

Prediabetic state -- Prevention.

The scene at Marjory Stoneman Douglas High School and the surrounding area after the shootings shifted from chaos and panic to grief, anger, and calls for swift and aggressive action to prevent other school attacks.

Back is Martin Luther King Jr.'s "I Have a Dream" speech. Back is Roe v. Wade. Back is climate change. and the word "democratic." A new proposal incorporating those revisions was presented to the Michigan board of education last week.

Endogenous neuropeptide Y (NPY) and corticotrophin-releasing factor (CRF) modulate the responses of the basolateral amygdala (BLA) to stress and are associated with the development of stress resilience and vulnerability, respectively. We characterized persistent effects of repeated NPY and CRF treatment on the structure and function of BLA principal neurons in a novel organotypic slice culture (OTC) model of male rat BLA, and examined the contributions of specific NPY receptor subtypes to these neural and behavioral effects. In BLA principal neurons within the OTCs, repeated NPY treatment caused persistent attenuation of excitatory input and induced dendritic hypotrophy via Y₅ receptor activation; conversely, CRF increased excitatory input and induced hypertrophy of BLA principal neurons. Repeated treatment of OTCs with NPY followed by an identical treatment with CRF, or vice versa, inhibited or reversed all structural changes in OTCs. These structural responses to NPY or CRF required calcineurin or CaMKII, respectively. Finally, repeated intra-BLA injections of NPY or a Y₅ receptor agonist increased social interaction, a validated behavior for anxiety, and recapitulated structural changes in BLA neurons seen in OTCs, while a Y₅ receptor antagonist prevented NPY's effects both on behavior and on structure. These results implicate the Y₅ receptor in the long-term, anxiolytic-like effects of NPY in the BLA, consistent with an intrinsic role in stress buffering, and highlight a remarkable mechanism by which BLA neurons may adapt to different levels of stress. Moreover, BLA OTCs offer a robust model to study mechanisms associated with resilience and vulnerability to stress in BLA.

SIGNIFICANCE STATEMENT Within the basolateral amygdala (BLA), neuropeptide Y (NPY) is associated with buffering the neural stress response induced by corticotropin releasing factor, and promoting stress resilience. We used a novel organotypic slice culture model of BLA, complemented with in vivo studies, to examine the cellular mechanisms associated with the actions of NPY. In organotypic slice cultures, repeated NPY treatment reduces the complexity of the dendritic extent of anxiogenic BLA principal neurons, making them less excitable. NPY, via activation of Y5 receptors, additionally inhibits and reverses the increases in dendritic extent and excitability induced by the stress hormone, corticotropin releasing factor. This NPY-mediated neuroplasticity indicates that resilience or vulnerability to stress may thus involve neuropeptide-mediated dendritic remodeling in BLA principal neurons.

New research indicates that Iron Age Britons venerated brown hares and chickens long before modern Easter celebrations

The institution took decades to come to grips with the trauma of the killing of four students 50 years ago

On Patriots' Day, we celebrate musician, publisher, and patriot Josiah Flagg (1737-1794), a friend of Paul Revere and major figure in Early American music.

The post Reverse Engineering to Fix the Laser Cutter appeared first on SOLIDWORKS Education Blog.

The last crew of the Logos reunites for a never-to-be-forgotten weekend.

One teacher embraced the technique, with encouragement from a former district administrator. But he was told he had to reverse course, in part because of parent complaints.

Malaria parasites invade and replicate within red blood cells (RBCs), extensively modifying their structure and gaining access to the extracellular environment by placing the plasmodial surface anion channel (PSAC) into the RBC membrane. Expression of members of the cytoadherence linked antigen gene 3 (clag3) family is required for PSAC activity, a process that is regulated epigenetically. PSAC is a well-established route of uptake for large, hydrophilic antimalarial compounds and parasites can acquire resistance by silencing clag3 gene expression, thereby reducing drug uptake. We found that exposure to sub-IC50 concentrations of the histone methyltransferase inhibitor chaetocin caused substantial changes in both clag3 gene expression and RBC permeability, reversing acquired resistance to the antimalarial compound blasticidin S that is transported through PSAC. Chaetocin treatment also altered progression of parasites through their replicative cycle, presumably by changing their ability to modify chromatin appropriately to enable DNA replication. These results indicate that targeting histone modifiers could represent a novel tool for reversing epigenetically acquired drug resistance in P. falciparum.

Carbapenem-resistant Gram-negative pathogens are a critical public health threat and there is an urgent need for new treatments. Carbapenemases (β-lactamases able to inactivate carbapenems) have been identified in both serine β-lactamase (SBL) and metallo β-lactamase (MBL) families. The recent introduction of SBL carbapenemase-inhibitors has provided alternative therapeutic options. Unfortunately, there are no approved inhibitors of MBL-mediated carbapenem-resistance and treatment options for infections caused by MBL-producing Gram-negatives are limited. Here, we present ZN148, a zinc-chelating MBL-inhibitor capable of restoring the bactericidal effect of meropenem and in vitro clinical susceptibility to carbapenems in >98% of a large international collection of MBL-producing clinical Enterobacterales strains (n=234). Moreover, ZN148 was able to potentiate the effect of meropenem against NDM-1-producing Klebsiella pneumoniae in a murine neutropenic peritonitis model. ZN148 showed no inhibition of the human zinc-containing enzyme glyoxylase II at 500 μM and no acute toxicity was observed in an in vivo mouse model with cumulative dosages up to 128 mg/kg. Biochemical analysis showed a time-dependent inhibition of MBLs by ZN148 and removal of zinc ions from the active site. Addition of exogenous zinc after ZN148 exposure only restored MBL activity by ~30%, suggesting an irreversible mechanism of inhibition. Mass-spectrometry and molecular modelling indicated potential oxidation of the active site Cys221 residue. Overall, these results demonstrate the therapeutic potential of a ZN148-carbapenem combination against MBL-producing Gram-negative pathogens and that ZN148 is a highly promising MBL inhibitor, capable of operating in a functional space not presently filled by any clinically approved compound.

Google's reverse image search is a breeze on a desktop, but what about when you're on a mobile device? Google, Bing, and others have options.

The chain will be shutting 300-350 stores as part of its global business overhaul.

Increasing access to the overdose-reversing medication naloxone has been a key priority for the Delaware Department of Health and Social Services (DHSS) as state and local partners work together to develop solutions to address the opioid epidemic. In support of that, the Department’s Division of Public Health (DPH) is announcing sustained funding for naloxone for first responder agencies statewide.

NEW CASTLE (Feb. 13, 2019) – In an effort to reduce the number of individuals overdosing, and dying from drug overdoses in Delaware, the Division of Public Health (DPH) is announcing the Community Naloxone Distribution Initiative. DPH will distribute free naloxone kits to members of the general public, at events in each county in March. […]

GEORGETOWN (March 1, 2019) – In an effort to reduce the number of individuals dying from drug overdoses in Delaware, the Division of Public Health (DPH) will hold Community Naloxone Distribution events in each county throughout the month of March. DPH will distribute free naloxone kits to members of the general public from 10 a.m. […]

The Division of Public Health launched a new smartphone app that provides lifesaving step-by-step instructions on how to use naloxone during an opioid overdose.

The Division of Public Health will distribute free naloxone kits to members of the general public from 5:30 p.m. to 8:30 p.m., on Wednesday, March 20, 2019, at Delaware Technical Community College, Terry Campus, 100 Campus Drive, Dover, DE 19904. The distribution event will be held in the Corporate Training Center, Rooms 408 and 412. Individuals are encouraged to stop by at any time during the event. Training takes approximately 15 minutes. 

n response to six suspected overdose deaths, including four in Sussex County, that occurred over the holiday weekend, the Division of Public Health (DPH) will hold a Community Naloxone Training and Distribution event in Millsboro on Friday, Sept. 6, 2019. DPH will distribute free naloxone kits to members of the public from 10 a.m. to 2 p.m. at Millsboro Fire Company, 109 East State St., Millsboro, DE 19966.

Delhi Government with Maruti Suzuki has introduced a new computerised driving test that applicants must complete in order to get a driving license. The Automated Driving Test Centres have been set up in 12 locations in Delhi and they test applicants with different parameters like Reverse S, Figure of 8 (8 Formation), overtaking, red light, […]

Banks have been facing difficulty due to the shutdown following COVID-19 pandemic and a cut in LCR requirement is likely to manage their liquidity effectively.

The APMC officials pointed out workers usually come to the market yard on pick-up trucks, however, the police have been acting against them as social distancing is not maintained onboard the pick-ups.

Kerala has decided to place people aged over 65 under reverse quarantine in the third phase of lockdown, as the magnitude of reverse migration to the state seems larger than what was anticipated.

Kerala has decided to send people aged above 65 years on reverse quarantine during lockdown 3.0 as the magnitude of reverse migration to the state seems larger than what was anticipated.

91 bytes small Linux/x86 reverse shell NULL free 127.0.0.1:4444 shellcode.

157 bytes small Linux/MIPS64 reverse (localhost:4444/TCP) shell shellcode.

120 bytes small Linux/x86_64 reverse (127.0.0.1:4444/TCP) shell (/bin/sh) + password (pass) shellcode.

Linux/x86 TCP reverse shell 127.0.0.1 nullbyte free shellcode.

188 bytes small Lnux/x64 reverse TCP stager shellcode.

80 bytes small Linux/x86 reverse shell generator shellcode with customizable TCP port and IP address.

Consulting firms in the Middle East are likely to take a hit in 2020 due to the coronavirus, after two strong years.

FDI into Brazil has increased by 66.48% in a little under two years. Jonathan Wildsmith reports.

We spent some time in the 2020 BMW 8-Series Gran Coupe; we drove the 2020 Genesis G70; and coronavirus has affected the 2020 Chevrolet Corvette. It's the Week in Reverse, right here at Motor Authority. The 2020 BMW 8-Series Gran Coupe is a more stylish four-door alternative to the 7-Series. We found it has a Teutonic rumble from its twin-turbo...

Sales of which electric car plunged the steepest leading into the U.S. pandemic slowdown? Which automaker reaffirmed its commitment to hydrogen fuel cells? This is our look back at the Week In Reverse—right here at Green Car Reports—for the week ending May 8, 2020. Our biggest combination of stories this week related to the most...

Trillions of dollars will be invested in renewable energy over the next 25 years, driving some of the most profound changes yet in how humans get their electricity. That's according to a new forecast by Bloomberg New Energy Finance that plots out global power markets to 2040. 

Humans are causing irreversible damage to the planet from burning fossil fuels, the biggest ever study of the available science concluded in a report designed to spur the fight against climate change.

Humans are causing irreversible damage to the planet from burning fossil fuels, the biggest ever study of the available science concluded in a report designed to spur the fight against climate change.