To celebrate the release of Tim Baker's EP 'The Eighteenth Hole Variations' and the new video featuring the live vocal trio

Technology isn't permanently harming our ability to concentrate, despite the widely held belief that our devices and the internet are making us worse at focusing, according to a cognitive psychology expert.

Chick Corea, Stanley Clarke, Jean Luc Ponty, Lennie White and Aussie Frank Gambale

The modern motoring experience is one of self-parking vehicles, multi-storey car parking complexes and stacking systems, but in many Australian country towns, reverse angle parking remains.

Police believe a woman was helping children in the back of the car when it began to reverse, hitting and killing a three-year-old girl at the Kiddy Palace childcare centre in Melbourne's north.

Batemans Bay was once an isolated coastal frontier settlement that grew on the back of oyster farming, timber cutting, and as a port servicing nearby goldfields. As the closest coastal town to Canberra it's now dominated by large shopping malls servicing surrounding suburbs of retirees and holiday homes. The architecture of its heritage has been lost, but two of its earliest and most significant buildings remain hidden and unknown behind 1960s shopfront facades. Will they be saved and restored?

Spraying graffiti on heritage listed buildings is something that is usually frowned upon. But when it is done in an environmentally sound way, does no actual damage and delivers an important message about sustainability, the results are surprisingly well received.

In August 1978, someone entered Ballarat's art gallery, grabbed a 92-year-old painting off the wall, and walked out the front door. Now, the once cash-strapped gallery hosts international artists.

Two South Australian police officers will continue to be prosecuted for allegedly assaulting a 17-year-old boy on the Eyre Peninsula in 2013, after the state's top judge finds the investigation was legal.

Almost 10 years after being thrown from a motorbike and losing the ability to walk, the ABC's Charles Brice is about to return to the crash site for the first time before handcycling more than 300 kilometres to raise spinal research funds.

South Australia's Opposition says it will reverse the State Government's plan to privatise Adelaide's train and tram services if elected in 2022.

An 80-year-old woman dies in hospital after succumbing to injuries she suffered when falling out of her vehicle in the car park of a hotel on Thursday morning.

A call of six-again is reversed with eight minutes left on the clock during the 2019 NRL Grand Final between the Sydney Roosters and Canberra Raiders.

You can talk about the 2019 NRL grand final until you feel like you've rubbed your larynx with sandpaper but there are only two words you will ever need to say 'six again'.

Why have so many leveraged and inverse ETFs reverse split their shares lately?

Laguna Beach Singer/guitarist Awarded Recording Time With Orange County Production House

The actors star in TD Jakes's "Not Easily Broken."

He spoke about the 2020 census and voting.

The Elle UK cover girl hints at her future plans.

At last, we can write headlines with all the letters intact

For a company defined by design and attention to detail, the Butterfly keyboard was a tremendous humiliation for Apple. Conceived in 2015, it replaced the previous scissor-switch mechanism for one with a smaller profile, allowing Cupertino to continue shrinking already-svelte laptops.…

Glimpses through Ginny Weasley's mind during the last months of her fifth years at Hogwarts. Missing scenes from Harry Potter and the Half-Blood Prince.

Happy 40th birthday to me! I'm currently in Connecticut visiting with the whole family, which is only somewhat coincidentally on my 40th birthday weekend. The main thing is the pizza! Two quick updates from this month, strawberry-related:

One of my all-time favorite games, Celeste, just got a new free 9th chapter (which is sized more like three chapters). This was a mixed blessing since over a year ago I finished all its hardest levels (all achievements) and then managed to pry myself from it. So I felt compelled to get the two new achievements to get back to 100%, but it was a somewhat hypnotizing and RSI-inducing grind. (Especially since I had gotten pretty rusty. I even forgot that you can hold onto walls, which made the first few levels much harder...) The worst part was that the final level was rumored to be kinda ridiculous, and the "WOW" achievement even moreso, so I was feeling worried about that the whole week it took to get through the prior 99. All told it was pretty worthwhile; the level design is really admirable as usual, and it stays true to the signature difficulty curve. I recommend it.

Second is a font sighting sent by a friendly Internet stranger. This one is from a fairly popular (18M views this month) music video called Fresa, which features Columbian Reggaeton artist Lalo Ebratt. A sighting in such a video would be interesting, but the wildest thing is where it is:

We played another successful “reverse” game recently, so I want to document them in one place. Sushi No (Sushi Go) Play normally. Goal is to have the lowest score at the end of the game. 7 Blunders (7 Wonders) Play … Continue reading →

When Ed and Leigh approached Colorado-based architecture firm F9 Productions to design their custom Rocky Mountain home, the couple wanted a residence that could last well into the future. This meant that the forever home not only had to be engineered with ADA-compliant features, but it also needed to be robust enough to weather the region’s extreme winter conditions for years to come. As a result, the architects crafted the Eastwatch House, a highly durable home that also takes advantage of passive solar conditions to reduce energy demands.[...]

Proposing rational modifications to quarantine measures is not like denying science or saying Jesus is your vaccine.

Major League Baseball has informed teams they no longer need to advise fans to hold on to tickets for games affected by the coronavirus shutdown.

John Prine, who survived cancer and heart issues, died from COVID-19 complications. The Grammy winner was known for his keen observations and mordant humor.

The coronavirus changed our lives. Health experts discuss how we might get back to normal.

The coronavirus outbreak has closed malls and most stores. Disputes are brewing over rent. Retail may look quite different in the future, experts say.

A writer criticized atheist activist Ron Reagan. In a sign of the times, that letter drew howls of protest from readers.

THE GOVERNMENT is to enforce a new rule which will see all travellers arriving into the UK being instructed to go into a 14-day quarantine period. It is not yet known how this rule will be enforced, or for how long, but it has the potential to change the way we experience holidays.

THE GOVERNMENT is to enforce a new rule which will see all travellers arriving into the UK being instructed to go into a 14-day quarantine period. It is not yet known how this rule will be enforced, or for how long, but it has the potential to change the way we experience holidays.

MAYBE it's because on my BBC Radio London Breakfast Show we currently talk of almost nothing else from 7-10am every day - we do try to slot in other subjects but no one calls about them - that by the time I emerge from the studio I'm so acutely aware of steadily encroaching coronavirus that I jump three feet in the air if somebody so much as sneezes.

Walter Goudy, 51, reached a settlement with the city of Anderson and the state of Indiana, according to city officials and and his attorney.

Carbon monoxide (CO) remains the most common cause of human poisoning. The consequences of CO poisoning include cardiac dysfunction, brain injury, and death. CO causes toxicity by binding to hemoglobin and by inhibiting mitochondrial cytochrome c oxidase (CcO), thereby decreasing oxygen delivery and inhibiting oxidative phosphorylation. We have recently developed a CO antidote based on human neuroglobin (Ngb-H64Q-CCC). This molecule enhances clearance of CO from red blood cells in vitro and in vivo. Herein, we tested whether Ngb-H64Q-CCC can also scavenge CO from CcO and attenuate CO-induced inhibition of mitochondrial respiration. Heart tissue from mice exposed to 3% CO exhibited a 42 ± 19% reduction in tissue respiration rate and a 33 ± 38% reduction in CcO activity compared with unexposed mice. Intravenous infusion of Ngb-H64Q-CCC restored respiration rates to that of control mice correlating with higher electron transport chain CcO activity in Ngb-H64Q-CCC–treated compared with PBS-treated, CO-poisoned mice. Further, using a Clark-type oxygen electrode, we measured isolated rat liver mitochondrial respiration in the presence and absence of saturating solutions of CO (160 μm) and nitric oxide (100 μm). Both CO and NO inhibited respiration, and treatment with Ngb-H64Q-CCC (100 and 50 μm, respectively) significantly reversed this inhibition. These results suggest that Ngb-H64Q-CCC mitigates CO toxicity by scavenging CO from carboxyhemoglobin, improving systemic oxygen delivery and reversing the inhibitory effects of CO on mitochondria. We conclude that Ngb-H64Q-CCC or other CO scavengers demonstrate potential as antidotes that reverse the clinical and molecular effects of CO poisoning.

6 January 2020

CJ Fielding
Feb 1, 1995; 36:211-228
Reviews

Carbon monoxide (CO) remains the most common cause of human poisoning. The consequences of CO poisoning include cardiac dysfunction, brain injury, and death. CO causes toxicity by binding to hemoglobin and by inhibiting mitochondrial cytochrome c oxidase (CcO), thereby decreasing oxygen delivery and inhibiting oxidative phosphorylation. We have recently developed a CO antidote based on human neuroglobin (Ngb-H64Q-CCC). This molecule enhances clearance of CO from red blood cells in vitro and in vivo. Herein, we tested whether Ngb-H64Q-CCC can also scavenge CO from CcO and attenuate CO-induced inhibition of mitochondrial respiration. Heart tissue from mice exposed to 3% CO exhibited a 42 ± 19% reduction in tissue respiration rate and a 33 ± 38% reduction in CcO activity compared with unexposed mice. Intravenous infusion of Ngb-H64Q-CCC restored respiration rates to that of control mice correlating with higher electron transport chain CcO activity in Ngb-H64Q-CCC–treated compared with PBS-treated, CO-poisoned mice. Further, using a Clark-type oxygen electrode, we measured isolated rat liver mitochondrial respiration in the presence and absence of saturating solutions of CO (160 μm) and nitric oxide (100 μm). Both CO and NO inhibited respiration, and treatment with Ngb-H64Q-CCC (100 and 50 μm, respectively) significantly reversed this inhibition. These results suggest that Ngb-H64Q-CCC mitigates CO toxicity by scavenging CO from carboxyhemoglobin, improving systemic oxygen delivery and reversing the inhibitory effects of CO on mitochondria. We conclude that Ngb-H64Q-CCC or other CO scavengers demonstrate potential as antidotes that reverse the clinical and molecular effects of CO poisoning.

Tratamento genético foi testado em Layla Richards que estava desenganada pelos médicos. Especialistas ressaltam que os resultados são iniciais e podem não ocorrer em outros pacientes.

The post Terapia inédita reverte leucemia incurável em bebê de 1 ano appeared first on Saúde Próspera.

Kristian K Kristensen
Apr 23, 2020; 0:jlr.ILR120000780v1-jlr.ILR120000780
Images in Lipid Research

Multidrug resistance (MDR) in cancer arises from cross-resistance to structurally- and functionally-divergent chemotherapeutic drugs. In particular, MDR is characterized by increased expression and activity of ATP-binding cassette (ABC) superfamily transporters. Sphingolipids are substrates of ABC proteins in cell signaling, membrane biosynthesis, and inflammation, for example, and their products can favor cancer progression. Glucosylceramide (GlcCer) is a ubiquitous glycosphingolipid (GSL) generated by glucosylceramide synthase, a key regulatory enzyme encoded by the UDP-glucose ceramide glucosyltransferase (UGCG) gene. Stressed cells increase de novo biosynthesis of ceramides, which return to sub-toxic levels after UGCG mediates incorporation into GlcCer. Given that cancer cells seem to mobilize UGCG and have increased GSL content for ceramide clearance, which ultimately contributes to chemotherapy failure, here we investigated how inhibition of GSL biosynthesis affects the MDR phenotype of chronic myeloid leukemias. We found that MDR is associated with higher UGCG expression and with a complex GSL profile. UGCG inhibition with the ceramide analog d-threo-1-(3,4,-ethylenedioxy)phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol (EtDO-P4) greatly reduced GSL and monosialotetrahexosylganglioside levels, and co-treatment with standard chemotherapeutics sensitized cells to mitochondrial membrane potential loss and apoptosis. ABC subfamily B member 1 (ABCB1) expression was reduced, and ABCC-mediated efflux activity was modulated by competition with nonglycosylated ceramides. Consistently, inhibition of ABCC-mediated transport reduced the efflux of exogenous C6-ceramide. Overall, UGCG inhibition impaired the malignant glycophenotype of MDR leukemias, which typically overcomes drug resistance through distinct mechanisms. This work sheds light on the involvement of GSL in chemotherapy failure, and its findings suggest that targeted GSL modulation could help manage MDR leukemias.

Reverse innovation may sound like some attempt to return to the dark ages - but it has a specific meaning, especially when it comes to med-tech. It’s about where we look for innovation - and overturning our preconceived ideas of where new ideas come from. Mark Skopec, and Matthew Harris - both from Imperial College London are two of the authors...