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Connectivity map-based drug repositioning of bortezomib to reverse the metastatic effect of GALNT14 in lung cancer




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HIV reverse transcriptase

In vitro studies have identified indolylarylsulfone derivatives that could help treat HIV infection.




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Correction to ‘Genotyping of Malaysian G6PD-deficient neonates by reverse dot blot flow-through hybridisation’




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Carbon Offsets, Reversal Risk and U.S. Climate Policy

Abstract

Background: One controversial issue in the larger cap-and-trade debate is the proper use and certification of carbon offsets related to changes in land management. Advocates of an expanded offset supply claim that inclusion of such activities would expand the scope of the program and lower overall compliance costs, while opponents claim that it would weaken the environmental integrity of the program by crediting activities that yield either nonexistent or merely temporary carbon sequestration benefits. Our study starts from the premise that offsets are neither perfect mitigation instruments nor useless "hot air."

Results: We show that offsets provide a useful cost containment function, even when there is some threat of reversal, by injecting additional "when-flexibility" into the system. This allows market participants to shift their reduction requirements to periods of lower cost, thereby facilitating attainment of the least-cost time path without jeopardizing the cumulative environmental integrity of the system. By accounting for market conditions in conjunction with reversal risk, we develop a simple offset valuation methodology, taking into account the two most important factors that typically lead offsets to be overvalued or undervalued.

Conclusions: The result of this paper is a quantitative "model rule" that could be included in future legislation or used as a basis for active management by a future "carbon fed" or other regulatory authority with jurisdiction over the US carbon market to actively manage allowance prices.

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Authors

      
 
 




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How to Reverse the Trend of Concentrated Poverty

One of Cleveland's neighborhoods made the Washington scene earlier this month.

Alas, it wasn't up for a multibillion-dollar bailout.

Instead, the Central neighborhood and 15 other communities across the United States were the centerpiece of a new report published by the Federal Reserve System and the Brookings Institution.

These communities share a simple, disappointing characteristic. In 2000 - the peak of the last economic boom - at least 40 percent of their residents lived below the federal poverty line. That was about three times the national average.

No American needs to look very far to find places like these. Concentrated poverty affects manufacturing cities like Cleveland, and Albany, Ga.; immigrant gateways like Miami, Fla., and Fresno, Calif.; and rural areas like eastern Kentucky and northern Montana. About 4 million poor Americans live in these areas of extremely high poverty.

How did this happen? Policy decisions made decades ago - like clustering thousands of the Cleveland region's public housing units in the Central neighborhood - helped shape their trajectory. So too did economic changes, like the long-run loss of decent-paying manufacturing jobs, or - in rural areas - mining and agricultural jobs.

By allowing poverty to concentrate in these places, we've magnified the problems their poor residents face. For instance, many low-income children in these communities start school not yet "ready to learn." On top of that, though, they attend schools burdened with lots of other poor kids who face similar challenges, and deal with higher levels of neighborhood crime that affect their mental health and educational performance.

The challenges of concentrated poverty extend to many other areas: low adult work-force skills and employment, poor-quality housing and a lack of investment by mainstream businesses.

And that's in a good economy. Today, Central - and thousands of other high-poverty communities like it across the nation - faces even more significant challenges as the United States enters what may be its worst recession in decades.

So what should Washington do for these places and their residents in the face of such difficult circumstances?

First, we must not lose sight of them in the economic turmoil. That's especially true because the roots of this crisis, in the subprime mortgage market, grew in many very poor neighborhoods like Central. As a result, home foreclosure rates in high-poverty communities are more than double the national average.

To stabilize these hard-hit communities, Washington must adopt new measures to prevent foreclosure and provide additional resources and guidance for state and local governments to help them cope with the rising numbers of vacant properties.

Second, a forthcoming economic stimulus package from Washington that could amount to half a trillion dollars or more should not bypass these neighborhoods and their residents.

That implies the need for immediate federal aid to sustain basic public services in states like Ohio, where the deficit for this year already tops $1 billion. It also suggests providing direct assistance to struggling workers and their families, through enhanced unemployment benefits and tax credits.

At the same time, the infrastructure dollars in the package - which could amount to more than $100 billion - must be spent strategically. States should not be permitted to go on expanding highway capacity at the metropolitan fringe, to the detriment of poor communities near the urban core. Cities like Cleveland, and metropolitan organizations like the Northeast Ohio Areawide Coordinating Agency, should get their fair share of new transportation funds. And funds should be set aside for training programs that provide low-income residents with a pathway to decent jobs.

Third, we have to rethink neighborhood policy over the longer term.

For too long, government has funded housing, schools and economic development in these communities as though they were islands unto themselves.

That's not how the real economy works. These neighborhoods are part of larger regional labor and housing markets. Decisions made across the Cleveland region, such as where firms locate new jobs, or where families buy homes and send their kids to school, ultimately dictate whether neighborhoods like Central can become real neighborhoods of choice and better connected to economic opportunity.

Public policy must leverage that real economy for the benefit of lower-income residents, by building on smart regional strategies like the Fund for Our Economic Future and WIRE-Net in Northeast Ohio. It should diversify housing in poor communities, but also encourage affordable housing development in wealthier parts of metropolitan areas.

Cleveland's Central neighborhood, like other high-poverty communities across the United States, faces a tough road ahead. Short-term opportunities, and long-term strategies, are needed to help its next generation of residents overcome the challenges of concentrated poverty.

Authors

Publication: Cleveland Plain Dealer
     
 
 




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AMLO reverses positive trends in Mexico’s energy industry

Mexican President Andrés Manuel López Obrador, known as AMLO, has now been in office for about one year. It’s a good time to review his policies, and in particular his approach to the energy sector. The previous administration of President Enrique Peña Nieto undertook significant energy sector reforms, which AMLO generally opposed at the time…

       




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Reverse mortgages: Promise, problems, and proposals for a better market

Many households approach retirement age with inadequate financial resources, but substantial equity in their residence along with a preference to remain in their homes. For these households, retirement planning presents the challenge of deciding between staying in their home or having sufficient income. In theory, reverse mortgages offer a solution whereby older homeowners can “age…

       




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The unfulfilled promise of reverse mortgages: Can a better market improve retirement security?

Abstract With the gradual disappearance of private-sector pensions and gradually increasing life expectancy, Americans must increasingly take responsibility for managing their own retirement. Many older households end their working years with limited financial resources, but have accumulated substantial equity in their homes—making home equity a potential source of retirement income. Reverse mortgages offer one avenue…

       




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Annuity-enhanced reverse mortgage loans

abstract This paper proposes a way to make reverse mortgage loans more attractive to both borrowers and lenders by reducing the risk that the loan balance grows to exceed the value of the mortgaged home. In particular, loan amounts would be increased at origination to purchase a life annuity. The annuity would be used to…

       




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Unlocking housing wealth for older Americans: Strategies to improve reverse mortgages

Housing wealth is a largely untapped resource that can help older adults supplement their incomes and buffer financial shocks in retirement. According to the 2016 Survey of Consumer Finances, more than 6 million homeowners age 62 and older in the U.S. have less than $10,000 in non-housing financial wealth but have at least $20,000 in…

       




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The great reversal: How America gave up on free markets

American markets, once a model of competition for the world, have experienced a growing concentration of economic power in a few large corporations. The rise of corporate economic—and political—power has emerged as one of the most important issues of our time. It is destined to be a key point of debate in the coming U.S.…

       




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Humans are warming atmosphere and climate change is irreversible unless we act now.

The Intergovernmental Panel on Climate Change (IPCC) has released its fifth assessment report (AR5), which surely must be one of the most important science documents of all time.




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EPA catches Dow in weed-killer lie, asks court to reverse approval

The agro giant made contradictory claims to the government about the herbicide Enlist Duo, the EPA isn’t happy.




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President introduces new climate actions to reverse last president's actions (yawn)

Many of Obama's rules never came into force, and many of Trump's will never make much difference.




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How to make apples last (almost) forever

No more excuses for soft, moldy apples in your fruit bowl!




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Solar-powered plane stuck in Hawaii until 2016 because of "irreversible" damage to batteries

There are worse places to be stuck than in Hawaii... I'm starting to think they did it on purpose!




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Here's how to reverse teen sleep problems in just a week

A new study shows how adolescents quickly improved their sleep time and quality in just one week's time.




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All of Existence Should Be Revered: Hinduism & The Environment

Hinduism is the oldest




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Spirit, Science, Art, Reverence Combined Will Build a Better Green Movement

After reviewing the major religions of the world's stances on the environment, it seems pretty clear to me that there are more commonalities than differences. In the realm of metaphysics there are genuine and significant




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Eco-Mobius is a modular, 'forever' smart phone

Phonebloks was a great idea - mix-and-match pieces means upgrading from a basic platform is forever. Now it has a first competitor - the Eco-Mobius.




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Reverend Billy invites you to an organic Thanksgiving dinner at Monsanto HQ

Want to do something really different for Thanksgiving this year? Come have an organic dinner on the lawn of Monsanto's World Headquarters and watch the latest show from Rev. Billy and the Stop Shopping Choir.




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Bumble bees could vanish forever within a few decades

The most important pollinators on the planet are disappearing in areas where temperatures are getting hotter.




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Asian Carp Study Largest Since Reversal of Chicago River

This $2 million project, funded mostly with private money, is billed as the most comprehensive look at the Chicago waterway system since the reversal of the Chicago River more than 100 years ago. This




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Headline of the week: Suburbs will thrive forever

Forever is a very long time.




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How to reverse desertification. With rocks.

Could strategically-placed rock walls help to re-green the desert?




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Forever Frugal? Survey Confirms Persistent Frugality

50% of Americans had reduced their electronics and apparel expenditures in the past 12 months, according to a survey conducted by management consulting firm, Booz & Company. They sum up their findings saying that "the impact




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Happy 50th birthday to the Boeing 747; it changed aviation forever

Flying went from being expensive and elite to being mass-market. Enjoy it while you can.




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10 ways to reduce (or reverse) your car's carbon skidmark

Cars spit out tons of pollution. Luckily there are many ways to reduce your emissions - we've summarized the top tips for you.




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Reverb Turns 100, Gives Away Wiz Khalifa Tickets, More

What do you do when you turn 100? If you're Keith Richards, who go on tour. The same goes for the enviros at Reverb, a Portland, Maine, outfit that greens concert tours and venues. The nonprofit is taking votes on who to support for its 100th tour,




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Junk food causes irreversible damage to young men's fertility

New research shows that a Western-style diet can permanently kill off sperm-producing cells by age 18.




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Alienware introduces the forever laptop

It's a crazy expensive, overpowered gaming machine, but it turns laptop design on its head.




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Can planting a trillion trees reverse the damage of climate change?

Restoration ecologist Karen Holl explains why it's not that simple.






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Supreme Court reverses fraud convictions of Christie aides in NJ 'Bridgegate' scandal

The Supreme Court reversed the fraud convictions of two aides to former New Jersey Gov. Chris Christie involved in the "Bridgegate" scandal.




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Oil reverses gains and turns negative as supply glut weighs

Oil moved between gains and losses on Wednesday amid hopes for a recovery in demand as some countries ease coronavirus lockdowns, while oversupply fears continued to weigh.




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Financial forevers

The countdown to The Suze Orman Show series finale kicks off with timeless money lessons to keep forever.




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Suze's top 5 'forever nevers'

Suze Orman counts down the five money mistakes you should never make.




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Leon Cooperman says the coronavirus crisis will change capitalism forever and taxes have to go up

The Omega Family Office chairman and CEO said on CNBC's "Squawk Box" that taxes will need to go up regardless of who wins the upcoming presidential election.




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Op-ed: For Big Oil, this crisis will be different, and it may be irreversible

Oil and gas companies delayed in transitioning from fossil fuels and lost investors. The oil price crash caused by the coronavirus threatens to make this shift permanent.




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Disney hit by 'shocking reversal of fortune' The New York Times' Jim Stewart warns

James Stewart, The New York Times columnist, on whether Disney can make up for its parks shutdown. With CNBC's Melissa Lee and the Fast Money traders, Guy Adami, Tim Seymour, Steve Grasso and Karen Finerman.




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Reversal of GST

I have taken input of GST on March, 19 and paid to the supplier on March,2020. I have also file our 3B return till Jan,2020 without any reversal of ITC.As i am the defaulter of not payment to supplier within 180 days what can i do now. What should be the action taken by me now.




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remake every show ever forever

Today on Toothpaste For Dinner: remake every show ever forever


WE NEED YOUR HELP: Please chip in $1 or more on Patreon so I can continue to update Toothpaste For Dinner, Married To The Sea & The Worst Things For Sale online and updating daily. I can not do this without your support on Patreon.







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(B)logging Off: Feministing Forever

After 15 incredible years, Feministing is shutting down. From the bottom of our hearts, thank you to the readers who joined us for this journey. As digital media has become corporatized, many independent news sites and blogs have been forced to shutter. As the New York Times reports today, unfortunately, we find ourselves among these. […]




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Can't Stay Mad Forever





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Airline middle seats won't stay empty forever in the name of social distancing. Here's why

Permanently blocking middle seats and limiting the number of passengers per flight is a costly move for airlines and would increase ticket prices.