Bitcoin has been reaching new all-time highs almost daily, fueling a parabolic bull run that’s pushing various cryptocurrencies to surge… Continue reading Flockerz Capitalizes on Bitcoin Rally, Raising $1.6M in Presale

The post Flockerz Capitalizes on Bitcoin Rally, Raising $1.6M in Presale appeared first on ReadWrite.

Mark Fisher was co-founder of the Rhode Island chapter of BLM. He voted for Joe Biden in 2020. Does he have buyers remorse? Yeah, you could say so. His viral video is causing a stir... but there's more to that story.

The post Former BLM Chapter Co-Founder Switches To Trump In ’24 … What Changed His Mind? appeared first on Clash Daily.

A.F. Branco Cartoon – Trump supporters are rooting for Rick Scott to be the next Senate Majority Leader, hoping he..

For more A.F. Branco cartoons, go to WesternJournal.com/cartoons.

The post Ditch Mictch Clones appeared first on The Western Journal.

Recent studies have suggested that innate immune responses exhibit characteristics associated with memory linked to modulations in both vertebrates and invertebrates. However, the diverse evolutionary paths taken, particularly within the invertebrate taxa, should lead to similarly diverse innate immunity memory processes. Our understanding of innate immune memory in invertebrates primarily comes from studies of the fruit fly Drosophila melanogaster, the generality of which is unclear. Caenorhabditis elegans typically inhabits soil harboring a variety of fatal microbial pathogens; for this invertebrate, the innate immune system and aversive behavior are the major defensive strategies against microbial infection. However, their characteristics of immunological memory remains infantile. Here we discovered an immunological memory that promoted avoidance and suppressed innate immunity during reinfection with bacteria, which we revealed to be specific to the previously exposed pathogens. During this trade-off switch of avoidance and innate immunity, the chemosensory neurons AWB and ADF modulated production of serotonin and dopamine, which in turn decreased expression of the innate immunity-associated genes and led to enhanced avoidance via the downstream insulin-like pathway. Therefore, our current study profiles the immune memories during C. elegans reinfected by pathogenic bacteria and further reveals that the chemosensory neurons, the neurotransmitter(s), and their associated molecular signaling pathways are responsible for a trade-off switch between the two immunological memories.

After ejaculation, mammalian spermatozoa must undergo a process known as capacitation in order to successfully fertilize the oocyte. Several post-translational modifications occur during capacitation, including sialylation, which despite being limited to a few proteins, seems to be essential for proper sperm-oocyte interaction. Regardless of its importance, to date, no single study has ever identified nor quantified which glycoproteins bearing terminal sialic acid (Sia) are altered during capacitation. Here we characterize sialylation during mouse sperm capacitation. Using tandem MS coupled with liquid chromatography (LC–MS/MS), we found 142 nonreductant peptides, with 9 of them showing potential modifications on their sialylated oligosaccharides during capacitation. As such, N-linked sialoglycopeptides from C4b-binding protein, endothelial lipase (EL), serine proteases 39 and 52, testis-expressed protein 101 and zonadhesin were reduced following capacitation. In contrast, mitochondrial aconitate hydratase (aconitase; ACO2), a TCA cycle enzyme, was the only protein to show an increase in Sia content during capacitation. Interestingly, although the loss of Sia within EL (N62) was accompanied by a reduction in its phospholipase A₁ activity, a decrease in the activity of ACO2 (i.e. stereospecific isomerization of citrate to isocitrate) occurred when sialylation increased (N612). The latter was confirmed by N612D recombinant protein tagged with both His and GFP. The replacement of Sia for the negatively charged Aspartic acid in the N612D mutant caused complete loss of aconitase activity compared with the WT. Computer modeling show that N612 sits atop the catalytic site of ACO2. The introduction of Sia causes a large conformational change in the alpha helix, essentially, distorting the active site, leading to complete loss of function. These findings suggest that the switch from oxidative phosphorylation, over to glycolysis that occurs during capacitation may come about through sialylation of ACO2.

Bilingual individuals demonstrate different personality characteristics when speaking different languages. Marketers making media and language decisions when addressing multilingual markets should add this finding to their list of influencing factors.

The post Cultural Frame Switching: Different Language, Different Personality appeared first on Neuromarketing.

Two rural North Dakota school districts will switch to a four-day school week to save costs and improve student and teacher morale.

Wisconsin is one of a handful of states where how much schools will get this fall is still being debated in the state capitol.

From the microwave to the food processor, the book author and television personality tried many appliances and devices to figure out the best ways to use them for her audience

What fueled the frenzy that sent so many to their deaths in colonial America? And how did Americans reckon with the aftermath of the panic? --- For more videos from Smithsonian Magazine: https://www.smithsonianmag.com/videos/ Digital Editorial Director: Brian Wolly Supervising Producer & Scriptwriter: Michelle Mehrtens Video Editor: Sierra Theobald

From the kitchen of his new restaurant in Brooklyn, the chef talks about what it takes to fuse Asian cuisine with an American twist

This sacred shrine in India feeds over 100,000 people a day regardless of race, religion and class.

The Kyoto museum will feature interactive exhibits, gaming artifacts, workshop spaces and oversized controllers inspired by iconic video games

Across the country, revelers are dressing in costumes and gliding across bodies of water on stand-up paddleboards to ring in the spooky season

Renaissance paintings, medieval archives, cloistered orchards—how one Italian scientist is uncovering secrets that could help combat a growing agricultural crisis

The New Brunswick Military History Museum is in possession of a unique piece of history that was once used to raise money for frontline soldiers.

Bo Levi Mitchell is a CFL all-star for the third time. The Hamilton Tiger-Cats quarterback and East Division finalist for the CFL's outstanding player award was named to the 2024 all-star squad on Thursday.

A 15-year-old from Kitchener, Ont., faces 29 charges in connection to a line of swatting calls between May and October 2024, police announced Monday. The charges come after officers investigated calls made threats to schools, businesses, public areas and residences but all turned out to be false.

Make The Season Kind is a month of giving in support of The Food Bank of Waterloo Region. Join CBC K-W for a kick-off show on Friday, Dec. 6 at TheMuseum in downtown Kitchener with performances by I, The Mountain, singer-songwriter Mandippal, local chef Terry Salmond and more.

A Veterans Affairs Canada education and training benefit is helping retired soldiers, sailors and airmen fit into a new uniform at Ottawa's Le Cordon Bleu.

Company purchases 80 licenses of SolidWorks after benchmark testing demonstrates 3x to 7x performance advantage

Monorail and plant automation company uses SolidWorks software to work faster and smarter, and detect collisions earlier

New 3D CAD software increases productivity, quality, and efficiency

Software will ease design of complex surfaces, speed innovations to market

North America's largest supplier of switches, plugs, lighting management systems, etc. to standardize on 300 licenses of SOLIDWORKS 3D CAD software

Bitcoin prices have passed a record $84,000 in what could be the start of its post-halving rally after the presidential elections last week.

A kill switch can help prevent your privacy from being breached when your encrypted VPN connection stops working. This is why your VPN needs it.

A Malagasy witch doctor comes to faith in Christ during an OM outreach and is baptised just one week before his death.

Lighthouse Ministries builds a kitchen to transform a community in Panama.

Just under a quarter of the more than 7 000 independent drivers for Shoprite's newly acquired Pingo last-mile delivery platform are South African.

A team from OM Costa Rica hikes three days in the jungle of Talamanca to meet a witch doctor.

A sweet dessert infused with tropical flavors took home the top prize in the 6th Annual Start Up Lehigh Valley pitch competition held on Oct. 15 at Baker Hall, Zoellner Arts Center in Bethlehem. The annual event recognizes and encourages new business ventures in the greater Lehigh Valley

Donald Trump has pledged to make the United States the "bitcoin and cryptocurrency capital of the world"

The cryptocurrency climbed as much as 4.3% to an unprecedented $79 771 on Sunday.

Bitcoin soared to a record high above $81 000 on Monday on expectations that cryptocurrencies will boom in a favourable regulatory environment following the election of Donald Trump as U.S. president and pro-crypto candidates to

The Transform outreach team in Durres witnesses God's light over the city.

Penn State Brandywine’s Student Spotlight series highlights the remarkable work being done by students in leadership, academics, service, athletics and more.

Penn State Brandywine’s and Penn State Berks’ LaunchBoxes, powered by Penn State, collaborated with Penn State Great Valley to hold the fall 2024 Idea TestLab Pitch Competition on Nov. 4. Six startup entrepreneurs participated in the competition, which was held at Great Valley.

The overall crypto market grew by 1.42 percent in the last 24 hours. Bitcoin was joined by Dogecoin, Cardano, Ripple, and Tron on the profit-making side of the crypto charts on Monday, November 11.

Prosecutors said Bitcoin Fog processed more than $400 million in untraceable transactions, including $78 million involving known darknet markets. Defense lawyer Tor Ekeland called the verdict “disappointing” and said they will appeal.

Bitcoin created its third all-time high in the past week, surging past $89,900 (roughly Rs. 75.9 lakh) in the last 24 hours, amid an ongoing surge spurred by Donald Trump's victory in the recently concluded US Presidential elections.  Here's why investors are optimistic about US President-elect Donald Trump's return to the White House in January 2025.

Kendall Jenner's 29th birthday photos feature three unique cakes. See her Instagram post inside.

We have found a delicious new place in South Delhi for your weekend brunch and lunch dates.

If you love the show 'Friends' and adore your kitchen, dearest reader, you might be the real-life Monica Geller!

Tired of throwing rotten veggies? With these genius storage hacks, your produce will remain fresh for long!

Online cross-stitch embroidery program from the Zwaanendael Museum during January 2021.

By Leoné Cahill-Krout, site supervisor at Cooch’s Bridge Historic Site Every day, thousands of cars drive through the intersection of Old Baltimore Pike and Sunset Lake Drive. They often take […]

WILMINGTON, Del. – Governor Carney and First Spouse Tracey Quillen Carney joined Senator Coons, members of the General Assembly, Mayor Mike Purzycki, the Christina School District, the Delaware Department of Education, the Wilmington Learning Collaborative, educators, students, families, and community members to celebrate the grand opening of the Maurice Pritchett Sr. Academy. “The brand-new Maurice Pritchett Sr. Academy […]