The choice for adjuvant chemotherapy in stage II colorectal cancer (CRC) is controversial as many patients are cured by surgery alone and it is difficult to identify patients with high-risk of recurrence of the disease. There is a need for better stratification of this group of patients. Mass spectrometry imaging could identify patients at risk. We report here the N-glycosylation signatures of the different cell populations in a group of stage II CRC tissue samples. The cancer cells, compared to normal epithelial cells, have increased levels of sialylation and high-mannose glycans, as well as decreased levels of fucosylation and highly branched N-glycans. When looking at the interface between cancer and its microenvironment, it seems that the cancer N-glycosylation signature spreads into the surrounding stroma at the invasive front of the tumor. This finding was more outspoken in patients with a worse outcome within this sample group.

Paramphistomosis, caused by the rumen fluke, Calicophoron daubneyi, is a parasitic infection of ruminant livestock which has seen a rapid rise in prevalence throughout Western Europe in recent years. Following ingestion of metacercariae (parasite cysts) by the mammalian host, newly-excysted juveniles (NEJs) emerge and invade the duodenal submucosa which causes significant pathology in heavy infections. The immature larvae then migrate upwards, along the gastrointestinal tract, and enter the rumen where they mature and begin to produce eggs. Despite their emergence, and sporadic outbreaks of acute disease, we know little about the molecular mechanisms used by C. daubneyi to establish infection, acquire nutrients and to avoid the host immune response. Here, transcriptome analysis of four intra-mammalian life-cycle stages, integrated with secretome analysis of the NEJ and adult parasites (responsible for acute and chronic disease respectively), revealed how the expression and secretion of selected families of virulence factors and immunomodulators are regulated in accordance with fluke development and migration. Our data show that whilst a family of cathepsins B with varying S2 sub-site residues (indicating distinct substrate specificities) are differentially secreted by NEJs and adult flukes, cathepsins L and F are secreted in low abundance by NEJs only. We found that C. daubneyi has an expanded family of aspartic peptidases, which is up-regulated in adult worms, although they are underrepresented in the secretome. The most abundant proteins in adult fluke secretions were helminth defence molecules (HDMs) that likely establish an immune environment permissive to fluke survival and/or neutralise pathogen-associated molecular patterns (PAMPs) such as bacterial lipopolysaccharide in the microbiome-rich rumen. The distinct collection of molecules secreted by C. daubneyi allowed the development of the first coproantigen-based ELISA for paramphistomosis which, importantly, did not recognise antigens from other helminths commonly found as co-infections with rumen fluke.

Prince Laurent of Belgium was today appointed FAO Special Ambassador for Forests and the Environment.

The announcement was made by FAO Director-General José Graziano da Silva at the Organization’s Committee on [...]

Yacouba Sawadogo, a farmer from Burkina Faso, has become a pioneer in the fight against desertification – succeeding where many international agencies have failed

Ramac Analyzes Design With SolidWorks SustainabilityXpress, Finds Alternatives That Consume Fewer Resources

U.K. firm cuts design time for products used by BP, ExxonMobil, and Chevron

The effectiveness of national voluntary programs asking companies to pledge to lower their pollution and greenhouse gas emissions depends on pressure from the public, according to a new study led by a Penn State researcher.

Three new hawks have joined the flock at the Klingsberg Aviary at Shaver’s Creek Environmental Center, including a forest-dwelling goshawk and two rough-legged hawks native to Pennsylvania’s grasslands.

Four educators share their experiences of blended learning. They suggest elements needed to make it work in remote teaching such as emphasizing relationship-building and minimizing the number of online tools.

Along with the Delaware Nutrient Management Program’s annual report mailing, Delaware farmers are being encouraged to complete an additional 16-question implementation questionnaire. The questionnaire aims to measure nutrient applications and environmental deeds, allowing Delaware to recognize farmers for their stewardship efforts in 2020.

During the first day of Delaware Ag Week, the Delaware Department of Agriculture’s Nutrient Management Program Administrator Chris Brosch presented three honorees with the 2022 Delaware Environmental Stewardship Awards.

DOVER, Del. (April 19, 2023) – The Delaware Association for Environmental Education (DAEE) is hosting the Fourteenth Annual DAEE Environmental Education Conference on Saturday, May 13, 2023 at Brandywine Springs Elementary, Wilmington, DE. This year’s conference theme, “Nature’s Best Hope, Our Role as Educators” will showcase a full day of sessions intended to connect people with nature, integrate […]

DOVER, Del. (December 13, 2023) – The Delaware Association for Environmental Education (DAEE) is holding its 15th Annual Conference with a focus on “Nature Access for All!” on February 24, 2024, at Fred Fifer III Middle School in Camden. The keynote speaker will be Dr. McKay Jenkins, noted author and University of Delaware professor. Todd […]

In a very daring, encouraging and so also a very pragmatic step, we see that none other than the Jaipur Bench of Rajasthan High Court while taking suo motu cognizance of the illegal constructions and encroachments on river beds and many other water bodies in a most learned, laudable, landmark, logic

DNREC has extended the nomination deadline for its 2024 Young Environmentalist of the Year Awards. The new deadline is set for 4:30 p.m., Friday, July 5, giving the public an additional week to recognize outstanding young environmentalists in Delaware.

DOVER, DEL. (July 8, 2024) – The Delaware Division of Public Health (DPH) invites the public to explore My Healthy Community, a platform for Delaware’s environmental health data, during National Environmental Public Health Tracking Awareness Week. This annual observance, from July 8 to July 12, is dedicated to empowering communities to use heath data to […]

Two Delaware students were recognized today with Young Environmentalists of the Year Awards, presented by Governor John Carney and DNREC Secretary Shawn M. Garvin at the Delaware State Fair, along with three winners of the annual Youth Fishing Tournament.

In early June, DNREC kicked off a summer internship program to offer accomplished college students and recent graduates an opportunity to work alongside experts in public service and science.

DNREC announced today the 2025 Community Environmental Project Fund (CEPF) grants will have a focus on equity. This change comes after the CEPF grant process was revamped to better address community needs and strengthen partnerships.

Government employees charged with monitoring environmental compliance face a downpour of information, wading through countless reports and stacks of paperwork to accomplish their mission. To help these dedicated public servants increase productivity, agencies should consider a broader set of tools to control pollution, enforce regulations and improve compliance. Although foundational [...]

The post Time for government agencies to embed data and AI into environmental compliance appeared first on Government Data Connection.

A new Python library has been written to facilitate an interface between Python and AWR software using a command structure that adheres more closely to Python coding conventions. This library is labeled "pyawr-utils" and it is installed using the standard Python pip command. Comprehensive documentation for installing and using pyawr-utils is available.(read more)

When starting a new design, it's important to take the time to consider design recommendations that prevent problems that can arise later in the design cycle. This two-part compilation of guidelines for starting a new design is the result of years of Cadence AWR Design Environment platform Support experience with designs. Pre-design decisions for user interface, simulation, layout, and library configuration lay the groundwork for a successful and efficient AWR design. This blog covers the user interface (UI) and simulation considerations designers should note prior to starting a design.(read more)

The Cadence AWR Design Environment V22.1 production release is now available for download at Cadence Downloads with design environment, AWR Microwave Office, AWR VSS, AWR Analyst, and other enhancements.(read more)

AWR V22.1 software introduces the Pointer-Hybrid optimization method which uses a combination of optimization methods, switching back and forth between methods to efficiently find the lowest optimization error function cost. The optimization algorithm automatically determines when to switch to a different optimization method, making this a superior method over manual selection of algorithms. This method is particularly robust in regards to finding the global minima without getting stuck in a local minima well.(read more)

When starting a new design, it's important to take the time to consider design recommendations that prevent problems that can arise later in the design cycle. This two-part compilation of guidelines for starting a new design is the result of years of Cadence AWR Design Environment platform Support experience with designs. Pre-design decisions for user interface, simulation, layout, and library configuration lay the groundwork for a successful and efficient AWR design. This blog, part 2, covers the layout and component library considerations designers should note prior to starting a design.(read more)

A recording of a training webinar on Microwave Office is available. Topics show the design environment, with special emphasis placed on electromagnetic (EM) simulation. Normal 0 false false false EN-US JA X-NONE ...(read more)

Hi,

I found that under the Dark Theme of PCB Environment Editor 17.4,

the window background is not all dark, resulting in unclear text display。

As shown in the figure below：

When analyzing multiple sessions simultaneously Verisium Manager crashed and reported below error messages:

# A fatal error has been detected by the Java Runtime Environment:
#
#  SIGSEGV (0xb) at pc=0x00007efc52861b74, pid=14182, tid=18380
#
# JRE version: OpenJDK Runtime Environment Temurin-17.0.3+7 (17.0.3+7) (build 17.0.3+7)
# Java VM: OpenJDK 64-Bit Server VM Temurin-17.0.3+7 (17.0.3+7, mixed mode, sharing, tiered, compressed oops, compressed class ptrs, g1 gc, linux-amd64)
# Problematic frame:
# C  [libucis.so+0x238b74]

......

For more details please refer to the attached log file "hs_err_pid21143.log".

Two approaches were tried to solve this problem but neither has worked.
Method.1:

Setting larger heap size of Java process by "-memlimit" options.For example "vmanager -memlimit 8G".

Method.2:

Enlarging stack memory size limit of the Coverage engine by setting "IMC_NATIVE_STACKSIZE" environment variable to a larger value. For example "setenv IMC_NATIVE_STACKSIZE 1024000"

According to "hs_err_pid*.log" it is almost certain that the memory overflow triggered Java's CrashOnOutOfMemoryError and caused Verisium Manager to crash. There are some arguments about memory management of Java like "Xms, Xmx, ThreadStackSize, Xss5048k etc" and maybe this problem can be fixed by setting these arguments during analysis. However, how exactly does Verisium Manager specify these arguments during analysis? I tried to set them by the form of setting environment variables before analysis but it didn't work in analysis and their values didn't change.

Is there something wrong with my operation or is there a better solution?

Thank you very much.

The Warming Arctic: How Thawing Permafrost Challenges Environmental Governance The Warming Arctic: How Thawing Permafrost Challenges Environmental Governance

The study surveyed 1,180 participants in Israel about their knowledge and attitudes regarding climate change and its effects on the environment.

The current conflict in the Middle East will leave a lasting environmental impact, prompting calls for urgent restoration and cross-border cooperation.

Israel showcases climate tech at COP29 but misses deeper environmental focus.

Juan López was gunned down on 14 September. An environmental activist, community leader and member of the Municipal Committee in Defence of the Commons and Public Goods of Tocoa, he was the latest victim of extractive greed in Honduras. Communities protecting the rivers that flow through the Bajo Aguán region have seen several of their […]

The Asian Development Bank (ADB) has provided loans to financial intermediaries to support projects “whose individual financing requirements are not large enough to warrant the direct supervision of ADB.”

To attract infrastructure investment to meet national goals for providing electricity to consumers, India needs continued macroeconomic stability as well as an improved policy and regulatory environment.

This study finds that investing in sanitation not only improved children’s health, but also created valuable time-savings for all household members.

The project is aligned with the following impact: Livability of Gia Nghia city in Dak Nong province enhanced. The project will have the following outcome: access to urban environmental infrastructure and services in Gia Nghia improved. The project is expected to benefit approximately 68,215 residents through an improved environment and the establishment of public green spaces around the lakes, and approximately 20,810 residents additionally through access to networked sewer services by 2028.

Highland and lowland populations in Papua New Guinea have different gene variants derived from Denisovan archaic humans, indicating possible adaptations for lower oxygen levels and higher malaria risk

Obidoxime chloride is an antidote for nerve gas intoxication. As an emergency medicine, it is being stored by the Israel Defense Forces (IDF) scattered throughout Israel in depots without a controlled environment (field conditions), thus being exposed to high and fluctuating temperatures. These conditions do not meet the manufacturer’s requirements. In addition, due to possible supply shortages, the utilization of expired batches was suggested. The current work investigated these matters. Long-term (15 years) storage under different conditions was initiated. Chemical stability and toxicity in rats were assessed. No difference was found between field conditions vs the controlled environment. The obidoxime assay remained >95% for 5 years and >90% for 7 years. The pH remained above the lower specification limit for 7–8 years. The major degradation product, 4-pyridinealdoxime, surpassed the allowed limit at 5 years. The content of total unknown impurities reached its maximum allowed by the IDF limit at 4–5 years. Threefold higher than clinically utilized doses of valid-to-date Toxogonin batches administered to rats did not cause any abnormality. However, expired batches produced significant toxic effects. Although no difference was found between storage of obidoxime ampoules when adhering to manufacturer’s recommendations vs field conditions, accumulation of degradants over the limit allowed by the IDF at 4–5 years of storage and the toxicity of the expired batches observed in rats led the IDF to a decision to shorten the shelf-life of this product from 5 to 4 years when stored in an uncontrolled environment of the Mediterranean climate.

Eliminating this pernicious policy should be on the Trump administration's first week to-do list.

EPICS in IEEE, a service learning program for university students supported by IEEE Educational Activities, offers students opportunities to engage with engineering professionals and mentors, local organizations, and technological innovation to address community-based issues.

The following two environmentally focused projects demonstrate the value of teamwork and direct involvement with project stakeholders. One uses smart biodigesters to better manage waste in Colombia’s rural areas. The other is focused on helping Turkish olive farmers protect their trees from climate change effects by providing them with a warning system that can identify growing problems.

No time to waste in rural Colombia

Proper waste management is critical to a community’s living conditions. In rural La Vega, Colombia, the lack of an effective system has led to contaminated soil and water, an especially concerning issue because the town’s economy relies heavily on agriculture.

The Smart Biodigesters for a Better Environment in Rural Areas project brought students together to devise a solution.

Vivian Estefanía Beltrán, a Ph.D. student at the Universidad del Rosario in Bogotá, addressed the problem by building a low-cost anaerobic digester that uses an instrumentation system to break down microorganisms into biodegradable material. It reduces the amount of solid waste, and the digesters can produce biogas, which can be used to generate electricity.

“Anaerobic digestion is a natural biological process that converts organic matter into two valuable products: biogas and nutrient-rich soil amendments in the form of digestate,” Beltrán says. “As a by-product of our digester’s operation, digestate is organic matter that can’t be transferred into biogas but can be used as a soil amendment for our farmers’ crops, such as coffee.

“While it may sound easy, the process is influenced by a lot of variables. The support we’ve received from EPICS in IEEE is important because it enables us to measure these variables, such as pH levels, temperature of the reactor, and biogas composition [methane and hydrogen sulfide]. The system allows us to make informed decisions that enhance the safety, quality, and efficiency of the process for the benefit of the community.”

The project was a collaborative effort among Universidad del Rosario students, a team of engineering students from Escuela Tecnológica Instituto Técnico Central, Professor Carlos Felipe Vergara, and members of Junta de Acción Comunal (Vereda La Granja), which aims to help residents improve their community.

“It’s been a great experience to see how individuals pursuing different fields of study—from engineering to electronics and computer science—can all work and learn together on a project that will have a direct positive impact on a community.” —Vivian Estefanía Beltrán

Beltrán worked closely with eight undergraduate students and three instructors—Maria Fernanda Gómez, Andrés Pérez Gordillo (the instrumentation group leader), and Carlos Felipe Vergara-Ramirez—as well as IEEE Graduate Student Member Nicolás Castiblanco (the instrumentation group coordinator).

The team constructed and installed their anaerobic digester system in an experimental station in La Vega, a town located roughly 53 kilometers northwest of Bogotá.

“This digester is an important innovation for the residents of La Vega, as it will hopefully offer a productive way to utilize the residual biomass they produce to improve quality of life and boost the economy,” Beltrán says. Soon, she adds, the system will be expanded to incorporate high-tech sensors that automatically monitor biogas production and the digestion process.

“For our students and team members, it’s been a great experience to see how individuals pursuing different fields of study—from engineering to electronics and computer science—can all work and learn together on a project that will have a direct positive impact on a community. It enables all of us to apply our classroom skills to reality,” she says. “The funding we’ve received from EPICS in IEEE has been crucial to designing, proving, and installing the system.”

The project also aims to support the development of a circular economy, which reuses materials to enhance the community’s sustainability and self-sufficiency.

Protecting olive groves in Türkiye

Türkiye is one of the world’s leading producers of olives, but the industry has been challenged in recent years by unprecedented floods, droughts, and other destructive forces of nature resulting from climate change. To help farmers in the western part of the country monitor the health of their olive trees, a team of students from Istanbul Technical University developed an early-warning system to identify irregularities including abnormal growth.

“Almost no olives were produced last year using traditional methods, due to climate conditions and unusual weather patterns,” says Tayfun Akgül, project leader of the Smart Monitoring of Fruit Trees in Western Türkiye initiative.

“Our system will give farmers feedback from each tree so that actions can be taken in advance to improve the yield,” says Akgül, an IEEE senior member and a professor in the university’s electronics and communication engineering department.

“We’re developing deep-learning techniques to detect changes in olive trees and their fruit so that farmers and landowners can take all necessary measures to avoid a low or damaged harvest,” says project coordinator Melike Girgin, a Ph.D. student at the university and an IEEE graduate student member.

Using drones outfitted with 360-degree optical and thermal cameras, the team collects optical, thermal, and hyperspectral imaging data through aerial methods. The information is fed into a cloud-based, open-source database system.

Akgül leads the project and teaches the team skills including signal and image processing and data collection. He says regular communication with community-based stakeholders has been critical to the project’s success.

“There are several farmers in the village who have helped us direct our drone activities to the right locations,” he says. “Their involvement in the project has been instrumental in helping us refine our process for greater effectiveness.

“For students, classroom instruction is straightforward, then they take an exam at the end. But through our EPICS project, students are continuously interacting with farmers in a hands-on, practical way and can see the results of their efforts in real time.”

Looking ahead, the team is excited about expanding the project to encompass other fruits besides olives. The team also intends to apply for a travel grant from IEEE in hopes of presenting its work at a conference.

“We’re so grateful to EPICS in IEEE for this opportunity,” Girgin says. “Our project and some of the technology we required wouldn’t have been possible without the funding we received.”

A purpose-driven partnership

The IEEE Standards Association sponsored both of the proactive environmental projects.

“Technical projects play a crucial role in advancing innovation and ensuring interoperability across various industries,” says Munir Mohammed, IEEE SA senior manager of product development and market engagement. “These projects not only align with our technical standards but also drive technological progress, enhance global collaboration, and ultimately improve the quality of life for communities worldwide.”

For more information on the program or to participate in service-learning projects, visit EPICS in IEEE.

On 7 November, this article was updated from an earlier version.