Method and system are disclosed for statistical circuit simulation. In one embodiment, a computer implemented method for statistical circuit simulation includes providing descriptions of a circuit for simulation, wherein the descriptions include variations of statistical parameters of the circuit, partitioning the circuit into groups of netlists according to variations of statistical parameters of the circuit, simulating the groups of netlists using a plurality of processors in parallel to generate a plurality of output data files, and storing the plurality of output data files in a memory. The method of partitioning the circuit into groups of netlists includes forming the groups of netlists to be simulated in a single instruction multiple data environment, and forming the groups of netlists according to proximity of variations of statistical parameters of the circuit.