With increasing interest in Continuous Integration/Continuous Delivery (CI/CD), many SAS Users want to know what can be done for Visual Analytics reports. In this article, I will explain how to use Python and SAS Viya REST APIs to extract a report from a SAS Viya environment and import it into another environment.

Continuous Integration/Continuous Delivery – Using Python and REST APIs for SAS Visual Analytics reports was published on SAS Users.

Updated emergency declaration also bans gatherings of 50+ people statewide, and closes gaming in Delaware casinos WILMINGTON, Del. – Governor John Carney on Monday modified his March 12 emergency declaration to limit Delaware restaurants, taverns and bars to take-out and delivery service only to help prevent spread of the coronavirus (COVID-19). Governor Carney’s updated emergency […]

The BMW Contactless Experience goes live and will help ensure a great level of transparency while booking or servicing a vehicle.

FCA India will majorly rely on online sales and at the same time, also promote the work-from-home culture for its employees.

Days after the government eased restrictions on the sale of alcohol, Maharashtra government is mulling on allowing home delivery of alcohol to avoid people from gathering.

All PCB designers know the importance of proper power delivery for successful board design. Integrated circuits need the power to turn on, and ICs with marginal power delivery will not operate reliably. Since power planes can...(read more)

Citrix Application Delivery Controller and Citrix Gateway directory traversal remote code execution exploit.

Utilities and other energy experts convene each year at DISTRIBUTECH International (DTECH) to discuss the future of energy and this week Clarion Energy, organizer of the event, announced that the call for abstracts for the 2020 event is open.

Care Technology provides technological solutions to the needs of customers through innovations like energy-efficient LED lighting and transportable heat sources that operate without power racks or induction heaters. We spoke to co-founder Belinda Wong about the production of their sustainable offerings and the benefits of green technology.

Utilities and other energy experts convene each year at DISTRIBUTECH International (DTECH) to discuss the future of energy and this week Clarion Energy, organizer of the event, announced that the call for abstracts for the 2020 event is open.

What is the Digital Railway programme? The Digital Railway programme is a Network Rail led initiative to modernise train command, control and signalling systems used on the British railway network with the aim of substantially improving the capabili...

Photo from Fredy Builes/VIEWpress via Getty Images) Colombian delivery app Rappi is testing pilot robot deliveries in Colombia. Rappi operates in several Latin American countries, and last year SoftBank invested one billion dollars into the startup. Deliveries are made using Kiwibot, a delivery robot from a Colombian owned company in California. Visit Business...

Last week, the EV Infrastructure Taskforce (EVIT), which brings together experts from Transport for London and Greater London Authority, announced a new plan to deliver electric vehicle infrastructure for London. This follows engagement with various...

Gourmet takeaway delivered by a butler in a black sedan – Thailand’s super-rich have not forgone luxury during a pandemic which has locked the country down, crushed the economy and left millions unemployed.Thailand is one of the most unequal nations in the world and the chasm between rich and poor is widening as the coronavirus eviscerates jobs, leaving 22 million registering for a government cash handout.Hundreds line up daily for food donations across Bangkok, a grim sign of an economic…

ADB has a vacancy for the position of Intern - Solutions Delivery Division, OIST - 2012 in the Office of Information Systems and Technology. The deadline for submitting applications is on 15 September 2019.

AN3265 - UPD301A USB Power Delivery Operation

NEW DELHI: Builders in Noida are unable to hand over more than 30,000 completed homes to their buyers, because of a National Green Tribunal order forbidding the Noida Authority from giving completion certificates to projects within a 10-kilometre radius of the Okhla bird sanctuary. Developers in Noida say they have in the past seven months since the tribunal’s order lost close to Rs 1,000 crore as they have been holding on the flats, paying interest on their loans as well as penalty to home buyers. “Everyone is bleeding,” said Vineet Gupta, director of the Ajnara group, which has around 1,500 apartments waiting to be handed over to buyers. Projects of […]

Title: Magnetic Fields Concentrate Drug Delivery
Category: Health News
Created: 4/23/2010 6:10:00 PM
Last Editorial Review: 4/26/2010 12:00:00 AM

Title: Doctors Describe First Drone Delivery of Diabetes Meds to Patient
Category: Health News
Created: 3/30/2020 12:00:00 AM
Last Editorial Review: 3/31/2020 12:00:00 AM

Title: Patch Pump Device Could Offer Cheaper Insulin Delivery
Category: Health News
Created: 4/1/2020 12:00:00 AM
Last Editorial Review: 4/2/2020 12:00:00 AM

Multiple births are increasing in frequency related to advanced maternal age and fertility treatments, and they have an increased risk for congenital anomalies compared to singleton births. However, twins have the same congenital anomalies <15% of the time. Thus, having multiple births with discordant anomalies is a growing challenge for neonatologists. Although external anomalies can often be spotted quickly at delivery or sex differences between multiples can rapidly identify those with internal anomalies described on prenatal ultrasound, we present a case of male multiples, who would optimally receive different initial resuscitation strategies on the basis of the presence or absence of an internal anomaly. The similar size of 4 extremely preterm quadruplets raises concern for whether accurate, immediate identification of 1 neonate with a congenital diaphragmatic hernia will be reliable in the delivery room. Clinicians discuss the ethical considerations of an "all for one" approach to this resuscitation.

Human adenoviruses have many attractive features for gene therapy applications. However, the high prevalence of preexisting immunity against these viruses in general populations worldwide has greatly limited their clinical utility. In addition, the most commonly used human adenovirus, human adenovirus subgroup C serotype 5 (HAd5), when systemically administered, triggers systemic inflammation and toxicity, with the liver being the most severely affected organ. Here, we evaluated the utility and safety of a new low-seroprevalence gorilla adenovirus (GAd; GC46) as a gene transfer vector in mice. Biodistribution studies revealed that systemically administered GAd had a selective and robust lung endothelial cell (EC) tropism with minimal vector expression throughout many other organs and tissues. Administration of a high dose of GAd accomplished extensive transgene expression in the lung yet elicited no detectable inflammatory histopathology in this organ. Furthermore, GAd, unlike HAd5, did not exhibit hepatotropism or induce liver inflammatory toxicity in mice, demonstrating the exceptional safety profile of the vector vis-à-vis systemic utility. We further demonstrated that the GAd capsid fiber shared the flexibility of the HAd5 equivalent for permitting genetic modification; GAd with the pan-EC-targeting ligand myeloid cell-binding peptide (MBP) incorporated in the capsid displayed a reduced lung tropism and efficiently retargeted gene expression to vascular beds in other organs.

IMPORTANCE In the aggregate, our mouse studies suggest that GAd is a promising gene therapy vector that utilizes lung ECs as a source of therapeutic payload production and a highly desirable toxicity profile. Further genetic engineering of the GAd capsid holds the promise of in vivo vector tropism modification and targeting.

PURPOSE

Although cesarean delivery is the most common surgical procedure in the United States, postoperative opioid prescribing varies greatly. We hypothesized that patient characteristics, procedural characteristics, or both would be associated with high vs low opioid use after discharge. This information could help individualize prescriptions.

Oncolytic virotherapy can lead to systemic antitumor immunity, but the therapeutic potential of oncolytic viruses in humans is limited due to their insufficient ability to overcome the immunosuppressive tumor microenvironment (TME). Here, we showed that locoregional oncolytic virotherapy upregulated the expression of PD-L1 in the TME, which was mediated by virus-induced type I and type II IFNs. To explore PD-1/PD-L1 signaling as a direct target in tumor tissue, we developed a novel immunotherapeutic herpes simplex virus (HSV), OVH-aMPD-1, that expressed a single-chain variable fragment (scFv) against PD-1 (aMPD-1 scFv). The virus was designed to locally deliver aMPD-1 scFv in the TME to achieve enhanced antitumor effects. This virus effectively modified the TME by releasing damage-associated molecular patterns, promoting antigen cross-presentation by dendritic cells, and enhancing the infiltration of activated T cells; these alterations resulted in antitumor T-cell activity that led to reduced tumor burdens in a liver cancer model. Compared with OVH, OVH-aMPD-1 promoted the infiltration of myeloid-derived suppressor cells (MDSC), resulting in significantly higher percentages of CD155⁺ granulocytic-MDSCs (G-MDSC) and monocytic-MDSCs (M-MDSC) in tumors. In combination with TIGIT blockade, this virus enhanced tumor-specific immune responses in mice with implanted subcutaneous tumors or invasive tumors. These findings highlighted that intratumoral immunomodulation with an OV expressing aMPD-1 scFv could be an effective stand-alone strategy to treat cancers or drive maximal efficacy of a combination therapy with other immune checkpoint inhibitors.

Chronic obstructive pulmonary disease (COPD) is an inflammatory lung condition, causing progressive decline in lung function leading to premature death. Acute exacerbations in COPD patients are predominantly associated with respiratory viruses. Ribavirin is a generic broad-spectrum antiviral agent that could be used for treatment of viral respiratory infections in COPD. Using the Particle Replication In Nonwetting Templates (PRINT) technology, which produces dry-powder particles of uniform shape and size, two new inhaled formulations of ribavirin (ribavirin-PRINT-CFI and ribavirin-PRINT-IP) were developed for efficient delivery to the lung and to minimize bystander exposure. Ribavirin-PRINT-CFI was well tolerated in healthy participants after single dosing and ribavirin-PRINT-IP was well tolerated in healthy and COPD participants after single and repeat dosing. Ribavirin-PRINT-CFI was replaced with ribavirin-PRINT-IP since the latter formulation was found to have improved physicochemical properties and it had a higher ratio of active drug to excipient per unit dose. Ribavirin concentrations were measured in lung epithelial lining fluid in both healthy and COPD participants and achieved target concentrations. Both formulations were rapidly absorbed with approximately dose proportional pharmacokinetics in plasma. Exposure to bystanders was negligible based on both the plasma and airborne ribavirin concentrations with the ribavirin-PRINT-IP formulation. Thus, ribavirin-PRINT-IP allowed for an efficient and convenient delivery of ribavirin to the lungs while minimizing systemic exposure. Further clinical investigations would be required to demonstrate ribavirin-PRINT-IP antiviral characteristics and impact on COPD viral-induced exacerbations. (The clinical trials discussed in this study have been registered at ClinicalTrials.gov under identifiers NCT03243760 and NCT03235726.)

A military exercise in Australia demonstrates how small drones can airdrop critical medical supplies to soldiers in combat

Coronavirus: the symptoms Read our LIVE updates on the coronavirus here

Hospital leaders have criticised the Government after a shipment which contained vital equipment for NHS staff was delayed.

The CEO of the NHS Confederation said the supply could have been enough to 'avert an absolute crisis'

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The Spring Sale is now here with fresh offers across a range of top content! Don't forget, Epic Coupons acquired in our Holiday Sale are expiring May 1, 2020 2:59am EST and able to be used on any eligible purchase $14.99 or above!

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