Starting SPB 23.1, Allegro Package Designer Plus (APD+) has been rebranded as Allegro X Advanced Package Designer (Allegro X APD).

The splash screen for Allegro X APD will appear as shown below, instead of showing APD+ 2023:

For the Windows Start menu in 23.1, it will display as Allegro X APD 2023 instead of APD+ 2023, as shown below

23.1 Start menu 

In the Product Choices window for 23.1, you will see Allegro X Advanced Package Designer in the place of Allegro Package Designer +, as shown below: 

23.1 product title

Hello, SKILL experts. 

I'm studying SKILL language to build some useful function in APD+.

Now, I want to execute 'Import Sub-drawing' function in new form.

But I cannot find how to do execute APD+ embedded function in a field of new form. 

Has anyone experienced this or idea to solve this problem? 

Hi! I'm using EMX with 2 design kits. In one works fine. With another, I do not see the mesh or current view. The menu item is not shown. This happens only with one DK. With the other one I'm able to run Paraview without any issue. 

Besides, I would like to know if there is any way to see the 3D view without mesh and current. Just a nice 3D view. 

I've also tried to install the latest version (EMX2023_2) but nothing changes. 

Starting at 12 p.m. ET on Nov. 11, Walmart+ members can buy the Beats Solo3 wireless headphones for just $69.

Starting at noon ET on Nov. 11, Walmart+ members can buy a Keurig K-Express Essentials single-serve coffee maker for just $29.88.

Starting at noon ET, Walmart+ members can score the Dyson V12 Detect Slim for just $399.99.

The best two headphones deals ahead of Black Friday are the Bose QuietComfort Ultra earbuds on sale for $229 and the Sony WH-1000XM5 headphones for $102.99 off.

Disney+'s 2025 slate also includes new seasons of 'Andor' and 'Percy Jackson and the Olympians,' and originals like 'Chad Powers.'

Browse our favorite dad gift ideas for the holiday season. Try to think outside the gift card this year.

Georgia’s ruling party has put LGBTQI+ people firmly in the firing line ahead of next month’s election. On 17 September, parliament gave final approval to a highly discriminatory law that empowers the authorities to censor books and films with LGBTQI+ content, stop discussion of LGBTQI+ issues in schools, ban people from flying rainbow flags and […]

This edition of the ASEAN+3 Bond Market Guide series focuses on updates in the Republic of Korea’s (ROK) market since the publication of the previous guide for the ROK in 2018.

The orexigenic gut peptide ghrelin is an endogenous ligand for the growth hormone secretagogue receptor type 1a (GHSR1a). Systemic ghrelin administration has previously been shown to increase gastric motility and emptying. While these effects are known to be mediated by the vagus nerve, the cellular mechanism underlying these effects remains unclear. Therefore, the purpose of the present study was to investigate the signaling mechanism by which GHSR1a inhibits voltage-gated Ca²⁺ channels in isolated rat gastric vagal afferent neurons using whole-cell patch-clamp electrophysiology. The ghrelin pharmacological profile indicated that Ca²⁺ currents were inhibited with a log (Ic₅₀) = –2.10 ± 0.44 and a maximal inhibition of 42.8 ± 5.0%. Exposure to the GHSR1a receptor antagonist (D-Lys3)-GHRP-6 reduced ghrelin-mediated Ca²⁺ channel inhibition (29.4 ± 16.7% vs. 1.9 ± 2.5%, n = 6, P = 0.0064). Interestingly, we observed that activation of GHSR1a inhibited Ca²⁺ currents through both voltage-dependent and voltage-independent pathways. We also treated the gastric neurons with either pertussis toxin (PTX) or YM-254890 to examine whether the Ca²⁺ current inhibition was mediated by the Gα_i/o or Gα_q/11 family of subunits. Treatment with both PTX (Ca²⁺ current inhibition = 15.7 ± 10.6%, n = 8, P = 0.0327) and YM-254890 (15.2 ± 11.9%, n = 8, P = 0.0269) blocked ghrelin’s effects on Ca²⁺ currents, as compared with control neurons (34.3 ± 18.9%, n = 8). These results indicate GHSR1a can couple to both Gα_i/o and Gα_q/11 in gastric vagal afferent neurons. Overall, our findings suggest GHSR1a-mediated inhibition of Ca²⁺ currents occurs through two distinct pathways, offering necessary insights into the cellular mechanisms underlying ghrelin’s regulation of gastric vagal afferents.

The antitumor effect of cardiotonic steroids (CTS) has stimulated the search for new methods to evaluate both kinetic and thermodynamic aspects of their binding to Na⁺/K⁺-ATPase (IUBMB Enzyme Nomenclature). We propose a real-time assay based on a chromogenic substrate for phosphatase activity (pNPPase activity), using only two concentrations with an inhibitory progression curve, to obtain the association rate (k_on), dissociation rate (k_off), and equilibrium (K_i) constants of CTS for the structure-kinetics relationship in drug screening. We show that changing conditions (from ATPase to pNPPase activity) resulted in an increase of K_i of the cardenolides digitoxigenin, essentially due to a reduction of k_on. In contrast, the K_i of the structurally related bufadienolide bufalin increased much less due to the reduction of its k_off partially compensating the decrease of its k_on. When evaluating the kinetics of 15 natural and semisynthetic CTS, we observed that both k_on and k_off correlated with K_i (Spearman test), suggesting that differences in potency depend on variations of both k_on and k_off. A rhamnose in C3 of the steroidal nucleus enhanced the inhibitory potency by a reduction of k_off rather than an increase of k_on. Raising the temperature did not alter the k_off of digitoxin, generating a H (k_off) of –10.4 ± 4.3 kJ/mol, suggesting a complex dissociation mechanism. Based on a simple and inexpensive methodology, we determined the values of k_on, k_off, and K_i of the CTS and provided original kinetics and thermodynamics differences between CTS that could help the design of new compounds.

We present a unique case of a single patient presenting with two mutationally distinct, PD-L1⁺ diffuse large B-cell lymphomas (DLBCLs). One of these DLBCLs demonstrated exceptionally high mutational burden (eight disease-associated variants and 41 variants of undetermined significance) with microsatellite instability (MSI) and an acquired PMS2 mutation with loss of PMS2 protein expression, detected postchemotherapy. This report, while highlighting the extent of possible tumor heterogeneity across separate clonal expansions as well as possible syndromic B-cell neoplasia, supports the notion that, although rare, PD-L1 expression and associated states permissive of high mutational burden (such as mismatch repair gene loss of function/MSI) should be more routinely considered in DLBCLs. Appropriate testing may be predictive of outcome and inform the utility of targeted therapy in these genetically diverse and historically treatment-refractory malignancies.

Anna gets her tentacle on, but doesn't notice any performance issues. Chris learns what a wheelbarrow is while putting his sink on the ceiling. And Kelley covers Vahn with cats and steals the unexpected Dragon Age: Inquisition!

The post RPG Cast – Episode 634: “That Bea Arthur Wig Gives Me a +5 to Int” appeared first on RPGamer.

Chris comes at you live from a muscle relaxer. Kelley eats the clay cake topper. Johnathon goes to the past, becomes toothless, and loses his kingdom to his nephew. Jason teaches us how to put wallpaper on the Switch.

The post RPG Cast – Episode 671: “40+ Cast” appeared first on RPGamer.

I first played Taiko no Tatsujin in an arcade (in Japan, because I am very cool), where it's controlled by hitting a recreation of an actual taiko drum. It was fun enough that I wish there was a taiko drum peripheral available for PC now the series is on our platform.

Taiko no Tatsujin: Rhythm Festival is out now via Steam, where it offers over 70 songs to drum through, and a subscription service through which to unlock over 700 more. Maybe I should try to get my Donkey Konga drums working on PC, but I'll probably settle for playing it with a gamepad.

Read more

Just in time to watch with the whole family over Thanksgiving.

Beginning today, Apple will have released one new Apple Vision Pro game, one App Store Great, and upgrading an App …

Continue reading "NFL Retro Bowl 25, Monster Train+, and Puzzle Sculpt Release Today on Apple Arcade Alongside Major Game Updates This Week"

Actor Elliot Page and musician Rufus Wainwright were among the stars who honoured 2SLGBTQ+ charities at the inaugural PTP Pink Awards in Toronto Thursday, in the shadow of a U.S. election that has many worried about queer and trans rights.

Ampacet has introduced ProVital+ Gamma-Protect, a medical-grade additive designed to preserve mechanical and optical properties of polypropylene-based medical and pharmaceutical articles during gamma and e-beam sterilisation processes.

2016 IIHS TOP SAFETY PICKS

Power washing is made even easier with POWERflow+ Technology by Briggs & Stratton. This pressure washer allows you to do deep cleaning, remove mold and mildew and reach second stories.

Let's say you have a PlayStation, either because it was already in your closet or because you decided to spend ten thousand dollars for one after the virus arrived. How can you get the most out of the console in 2020?

Fans are waiting in anticipation for Landman‘s release team on Paramount+. The series, centered on the energy industry, is set to make a bold debut with its first two episodes available simultaneously. With much buzz around the series, knowing the exact Landman release date, time, and schedule will help fans tune in at the right time. Here […]

The post What Time Will Landman Release on Paramount+? Schedule Explained appeared first on ComingSoon.net - Movie Trailers, TV & Streaming News, and More.

The merger between Reliance Jio's Viacom18 and Star India Private Limited is set to transform India's streaming landscape. This collaboration will introduce a new OTT platform, likely named Jio Star, combining JioCinema and Disney+ Hotstar. The domain jiostar.com is live, hinting

The call to action highlighted in Nature this week cites recent scientific breakthroughs on
groundwater’s vital role in supporting rivers globally.

The post Press Release: Groundwater in Peril – IWMI joins 700+ scientists and practitioners in urgent call for action on global groundwater first appeared on International Water Management Institute (IWMI).

Over 1,600 individuals in Rwanda, including those at high risk and contacts of infected cases, have received vaccinations against the Marburg virus disease,

As competition from newcomers like Bluesky and Threads increases, X launched a “Radar” trend analysis tool that aims to offer subscribers real-time insights into emerging trends and conversations on the platform. The tool, previously known as Insights, was initially targeted at Verified Organizations (businesses), allowing marketers to track topics and trends on the app. If […]

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భారత్‌ మార్కెట్‌లో ఐకూ 13 స్మార్ట్‌ఫోన్‌ డిసెంబర్‌ 3 వ తేదీన విడుదల కానుంది. ఇప్పటికే ఈ హ్యాండ్‌సెట్‌కు సంబంధించిన కొన్ని కీలక వివరాలు వెల్లడయ్యాయి. ఈ హ్యాండ్‌సెట్ ఇప్పటికే చైనాలో అందుబాటులో ఉంది. అయితే భారత్‌ వేరియంట్ స్మార్ట్‌ఫోన్‌ స్నాప్‌డ్రాగన్‌ 8 Elite SoC చిప్‌సెట్‌తో పనిచేస్తుంది. మరియు 144Hz రీఫ్రెష్‌ రేట్‌తో 2K LTPO

ఓటీటీ మార్కెట్‌లో కీలక మార్పులు రానున్నాయి. ప్రముఖ ఓటీటీ ప్లాట్‌ఫాంలు జియో సినిమా, డిస్నీ + హాట్‌స్టార్‌ విలీన ప్రక్రియ చివరి దశకు చేరుకుంది. ఈ రెండింటి విలీనం ఈ సంవత్సరం తొలి రోజుల్లోనే ప్రారంభమైంది. విలీనం అనంతరం జియో స్టార్‌ పేరుతో అందుబాటులో ఉంటుంది. ఈ విలీన ప్రక్రియ నవంబర్‌ 13 నాటికి పూర్తవుతుందని తెలుస్తోంది.

ವಿವೋ ಮೊಬೈಲ್‌ ಬ್ರ್ಯಾಂಡ್‌ನ ಸಬ್‌ ಬ್ರ್ಯಾಂಡ್‌ ಆಗಿರುವ ಐಕ್ಯೂ (iQOO) ಸಂಸ್ಥೆಯ ಕೆಲವು ಫೋನ್‌ ಮಾಡೆಲ್‌ಗಳು ಭಾರೀ ಮೆಚ್ಚುಗೆ ಪಡೆದಿದ್ದು, ಕೆಲವು ಬಜೆಟ್‌ ದರದ 5G ಮಾಡೆಲ್‌ಗಳು ಸಹ ಜನಪ್ರಿಯತೆಯಲ್ಲಿ ಇವೆ. ಆ ಪೈಕಿ ಐಕ್ಯೂ ಸಂಸ್ಥೆಯ ಐಕ್ಯೂ Z9s 5G (iQOO Z9s 5G) ಫೋನ್‌ ಸ್ಟೈಲಿಶ್‌ ಲುಕ್‌ ಹಾಗೂ ಬೊಂಬಾಟ್‌ ಫೀಚರ್ಸ್‌ಗಳ ಮೂಲಕ ಗ್ರಾಹಕರ ಗಮನ

Disney+ Hotstar has introduced an AI-driven video optimization technology to enhance its streaming service. This advanced encoding feature adjusts video quality based on user habits and scene complexity, offering a tailored viewing experience. The new technology promises sharper visuals while using

Qualcomm has unveiled the new Snapdragon X Plus 8-core SoC for Copilot+ PCs, following the release of a 10-core version this year. This announcement was made ahead of the IFA 2024 event. The Snapdragon X Plus 8-Core is powered by an

சென்னை: குரு பகவானின் வக்ர பெயர்ச்சி காரணமாக மீன ராசிக்கு என்ன நடக்கும் என்று பார்க்கலாம். அக்டோபர் 9ம் தேதி குரு பகவான் ரிஷப ராசியில் வக்ர பயணம் மேற்கொள்ள உள்ளார். கிட்டத்தட்ட 4 மாதங்கள்.. அதாவது பிப்ரவரி மாதம் 4ம் தேதி வரை இந்த பயணம் நீடிக்கும். ரிஷப ராசியில் ரோகிணி, கார்த்திகை நட்சத்திரங்களில் குரு வக்ரம்

X, the social media platform formerly known as Twitter, has rolled out a significant update to its top-tier subscription plan, Premium+. This move eliminates ads entirely for subscribers of this $16 per month plan, offering a more streamlined user experience. No

Samsung recently unveiled the Galaxy S24 FE, Galaxy Tab S10+, and Tab S10 Ultra globally including in India. All devices are now available for purchase around the world. If you are planning to get one of these, here's everything including price

Ayushman Bharat: ఆయుష్మాన్ భారత్ పథకం దేశంలో వృద్ధులకు ఆరోగ్య ప్రయోజనాలను అందిస్తుంది. ఈ కార్యక్రమం ఆధార్ కార్డు ప్రకారం 70 ఏళ్లు లేదా అంతకంటే ఎక్కువ వయస్సు ఉన్న ఎవరైనా ప్రయోజనాలు పొందేందుకు నేటి నుంచి అర్హులు. గతంలో ఈ వయస్సు పరిమితి తక్కువగా ఉండేది. ఇది అప్లికేషన్ ఆధారిత స్కీమ్ కాబట్టి ప్రజలు PMJAY

PM Modi met with Chinese President Xi Jinping on the sidelines of the BRICS+ Summit. This was the first meeting between Modi and Xi after the military standoff between both countries in Galwan in 2020 (the previous one being in Mahabalipuram in 2019).

London : Methuen Drama, 2022.