We have previously published articles by the Australian AIDS-and-biology researcher Cal Crilly, and here is yet another installment. Cal is someone who digs into scientific studies. He does biological detective work and finds gems that hide in plain view, things we don't normally understand and that even the experts do not see as they are not trained to put discordant facts together and question basic assumptions. What this new article tells us is that retroviruses - the same kind that are thought to cause immune deficiency or AIDS - are useful and necessary for our immune system to function correctly. That of course tends to leave the hypothesis of a viral causation of AIDS in grave trouble. I say 'hypothesis' because no one has proven, or even come close to a coherent explanation for, the mechanism of AIDS causation by HIV. How does a retrovirus that is by nature a benign particle, cause devastation of the immune system? Here we have several scientific studies published in the world's finest journals, which attest to the fact that retroviruses are part and parcel of the human organism, that they are needed to provide certain defensive capabilities against invaders, and that they are not pathogenic. So we might ask ourselves why HIV tests (thought to indicate the presence of a retrovirus) are still performed, and why doctors are still recommending the use of toxic anti-retroviral drugs to kill what, rather than a foreign invader, appears to be part of normal human metabolic processes. Cal Crilly lays it out for you, citing and linking the sources......

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On Labor Day, Public Employees for Environmental Responsibility (PEER) issued a press release whose title summarizes its contents all too neatly: Bush Declares Eco-Whistleblower Law Void for EPA Employees. Here's some of it:

Washington, DC - The Bush administration has declared itself immune from whistleblower protections for federal workers under the Clean Water Act, according to legal documents released today by Public Employees for Environmental Responsibility (PEER). As a result of an opinion issued by a unit within the Office of the Attorney General, federal workers will have little protection from official retaliation for reporting water pollution enforcement breakdowns, manipulations of science or cleanup failures.

Foods that provide the human body with the correct fuel to boost and strengthen the immune system.

As Orthodox Christians in a non-Orthodox culture, we have questions: Who are we? What is "the Church"? What is our relationship to friends and family of other faiths? What is ecumenism? Who will be saved? In this special edition of Hearts and Minds, Fr John Oliver offers a few reflections.

The chancellor defends the rise in employer contributions telling BBC public finances had to be strengthened.

The new Activia+ Multi-Benefit Probiotic Yogurt Drinks4 are packed with billions of live and active probiotics that help support your gut health, plus are an excellent source (20% DV) of Vitamins C, D and Zinc to support your immune system.

GoodBelly Immune Support dials up an efficacious dose of probiotics that have been proven to support the body's immune system and reduce the frequency, duration and symptoms of the common cold. 

The water-dispersible forms join Kemin Human Nutrition and Health’s BetaVia™ line of algae-sourced beta-glucan that has been clinically validated to support the immune system while protecting against oxidative stress.1

With immunity a top priority, Honey Gardens released its new Elderberry Honey Immune Drink Mix featuring elderberry, honey and apple cider vinegar in convenient packets that make it easy to add to a daily regimen of wellness.

Super Multi+ combines vitamins and minerals with five vital blends to support overall health and the immune system.

Continuing to expand its popular Nature’s Garden line of products, Cibo Vita introduced Fruit Balls: Immune Booster, an innovative way to boost the immune system with vital minerals, vitamins and probiotics. The plant-based Fruit Balls are also filling, healthy and deliver flavor. 

LIFEWTR, a premium bottled water brand committed to advancing and showcasing sources of creativity, debuted LIFEWTR Immune Support, a new water beverage with 10% of the recommended daily value of Zinc, aiding normal immune function.

Immune health is one of the fastest growing supplement categories, and it is here to stay. After vitamins and minerals led the first wave of immunity supplements, protein is now emerging as a critical nutrient. 

GELITA will use this year’s virtual Natural Products Expo West event to discuss how GELITA Bioactive Collagen Peptides® (BCP®) are ideal for sports nutrition supplements. Strong ligaments and tendons, bones, and joints, also identified as “white tissue,” are a vital precondition for this. BCP® support white tissue and thus, help to build stamina, strength, athletic agility as well as performance. 

Blue California’s Taxifolin BC-DHQ® with super antioxidant and anti-inflammatory properties is now Generally Recognized As Safe (GRAS) in a range of foods and beverages following a letter of no objection from the US Food and Drug Administration (FDA). 

University of Coimbra Failure by immune cells worsens Alzheimer's disease, reveals study by the University of Coimbra A team from the Center for Neuroscience and Cell Biology (CNC), University of Coimbra (UC) in Portugal discovered how some cells of the immune system lose the ability to fight Alzheimer's disease. This new knowledge can help to find a definitive diagnosis. Ana Luísa Cardoso, the coordinator of the research group, explains that "We found that monocytes (the innate immune system cells) of Alzheimer's patients are unable to move when stimulated by substances produced in the brain, which may lead to reduction of cells that can be recruited to the nervous tissue and participate in fighting the disease."

These miniature immune system models -- known as human immune organoids -- mimic the real-life environment where immune cells learn to recognize and attack harmful invaders and respond to vaccines. Not only are these organoids powerful new tools for studying and observing immune function in cancer, their use is likely to accelerate vaccine development, better predict disease treatment response for patients, and even speed up clinical trials.

These miniature immune system models -- known as human immune organoids -- mimic the real-life environment where immune cells learn to recognize and attack harmful invaders and respond to vaccines. Not only are these organoids powerful new tools for studying and observing immune function in cancer, their use is likely to accelerate vaccine development, better predict disease treatment response for patients, and even speed up clinical trials.

To enhance and coordinate its research on autoimmune diseases, the National Institutes of Health should create an Office of Autoimmune Disease/Autoimmunity Research and a plan that spans all institutes and centers to provide an overall NIH strategy for autoimmune disease research.

Ganeden, already known as a leader in probiotic technology, has used its patented probiotic strain to develop an immune health ingredient: Staimune.

As more consumers are recognizing the link between immune-health and overall health, experts note that the demand for functional beverages that support immunity has never been higher.

With its complex formulas helping consumers further their pursuit of a healthier lifestyle, the functional beverage market has thrived. Detox drinks have benefited from this interest, but is not without its challenges.

Ingredient suppliers release innovations to support immune health, plant-based food and beverages.

New Peer Reviewed Science Links Increasing Incidence of Lymphatic Cancers to COVID-19 Virus as well as the mRNA Vaccines

Dr. Richard Ruhling is an expert on Biblical prophecy and is also the author of 'The Alpha & Omega Bible Code'

Brain tumors or glioblastomas are one of the most difficult cancer types to treat. These masses are malignant tumors that are made up of abnormal neuronal

The tumor microenvironment (TME) is a major obstacle that limits effective cancer treatments. Various cells around the tumor promote immunosuppression and

Viruses are invading pathogens that infect host cells and rapidly replicate throughout the body. They carry a small piece of genetic material such as DNA o

Salt has been used for a myriad of reasons throughout history. Not only did individuals use it to preserve food, but it was also used to garden, to constru

Brain tumors or glioblastomas are one of the most difficult cancer types to treat. These masses are malignant tumors that are made up of abnormal neuronal

Most know the word “cancer” as a negative thing.  As a disease characterized by the body’s cells growing uncontrollably, cancer rema

The tumor microenvironment (TME) is a major obstacle that limits effective cancer treatments. Various cells around the tumor promote immunosuppression and

Inflammation represents a long-conserved biological process characterized by the release of chemical messengers that regulate the immune response.  Wh

Increased expression of gene PRDM1-S triggers loss of immune regulation seen in autoimmune conditions like multiple sclerosis (MS)

Increased expression of gene PRDM1-S triggers loss of immune regulation seen in autoimmune conditions like multiple sclerosis (MS)

Inflammation represents a long-conserved biological process characterized by the release of chemical messengers that regulate the immune response.  Wh

Most know the word “cancer” as a negative thing.  As a disease characterized by the body’s cells growing uncontrollably, cancer rema

Viruses are invading pathogens that infect host cells and rapidly replicate throughout the body. They carry a small piece of genetic material such as DNA o

Immersed in authenticity, RC Publisher Jill Bloom delved into Gary Brecka's podcast, "The Ultimate Human," discovered hydrogen water's benefits for energy, endurance, and immunity and explores how it relates to our industry.

Dana Laake and her special guest Caitlin Higgins will discuss immune-supportive supplements and specific nutrients that have been shown in recent studies related to COVID-19 to reduce the risk of respiratory tract infections.

The post Immune-supportive supplements and specific nutrients that have been shown in recent studies related to COVID-19 and reducing the risk of respiratory tract infections first appeared on Federal News Network.

CRISPR Immune Cells Not Only Survive, They Thrive After Infusion Into Cancer Patients

In neonatal mice, the neurotransmitter serotonin mobilizes immune cells that promote tolerance to antigens.

A new algorithm detects when immunotherapies create surges of T cell responses in melanoma patients.

Specialized neurons in the brainstem and vagus nerve provide potential therapeutic targets for treating inflammatory disorders.

Farnesol, a fungal signaling molecule, alters lipid synthesis in dendritic cells, causing mitochondrial dysfunction and decreased inflammatory responding.

Communication between individuals via molecules, termed chemosignaling, is widespread among animal and plant species. However, we lack knowledge on the specific functions of the substances involved for most systems. The femoral gland is an organ that secretes a waxy substance involved in chemical communication in lizards. Although the lipids and volatile substances secreted by the femoral glands have been investigated in several biochemical studies, the protein composition and functions of secretions remain completely unknown. Applying a proteomic approach, we provide the first attempt to comprehensively characterize the protein composition of femoral gland secretions from the Galápagos marine iguana. Using samples from several organs, the marine iguana proteome was assembled by next-generation sequencing and MS, resulting in 7513 proteins. Of these, 4305 proteins were present in the femoral gland, including keratins, small serum proteins, and fatty acid-binding proteins. Surprisingly, no proteins with discernible roles in partner recognition or inter-species communication could be identified. However, we did find several proteins with direct associations to the innate immune system, including lysozyme C, antileukoproteinase (ALP), pulmonary surfactant protein (SFTPD), and galectin (LGALS1) suggesting that the femoral glands function as an important barrier to infection. Furthermore, we report several novel anti-microbial peptides from the femoral glands that show similar action against Escherichia coli and Bacillus subtilis such as oncocin, a peptide known for its effectiveness against Gram-negative pathogens. This proteomics data set is a valuable resource for future functional protein analysis and demonstrates that femoral gland secretions also perform functions of the innate immune system.

Ventilator-associated pneumonia (VAP) is a common hospital-acquired infection, leading to high morbidity and mortality. Currently, bronchoalveolar lavage (BAL) is used in hospitals for VAP diagnosis and guiding treatment options. Although BAL collection procedures are invasive, alternatives such as endotracheal aspirates (ETA) may be of diagnostic value, however, their use has not been thoroughly explored. Longitudinal ETA and BAL were collected from 16 intubated patients up to 15 days, of which 11 developed VAP. We conducted a comprehensive LC–MS/MS based proteome and metabolome characterization of longitudinal ETA and BAL to detect host and pathogen responses to VAP infection. We discovered a diverse ETA proteome of the upper airways reflective of a rich and dynamic host-microbe interface. Prior to VAP diagnosis by microbial cultures from BAL, patient ETA presented characteristic signatures of reactive oxygen species and neutrophil degranulation, indicative of neutrophil mediated pathogen processing as a key host response to the VAP infection. Along with an increase in amino acids, this is suggestive of extracellular membrane degradation resulting from proteolytic activity of neutrophil proteases. The metaproteome approach successfully allowed simultaneous detection of pathogen peptides in patients' ETA, which may have potential use in diagnosis. Our findings suggest that ETA may facilitate early mechanistic insights into host-pathogen interactions associated with VAP infection and therefore provide its diagnosis and treatment.

Coronavirus disease 2019 (COVID-19) is a highly contagious infection and threating the human lives in the world. The elevation of cytokines in blood is crucial to induce cytokine storm and immunosuppression in the transition of severity in COVID-19 patients. However, the comprehensive changes of serum proteins in COVID-19 patients throughout the SARS-CoV-2 infection is unknown. In this work, we developed a high-density antibody microarray and performed an in-depth proteomics analysis of serum samples collected from early COVID-19 (n = 15) and influenza (n = 13) patients. We identified a large set of differentially expressed proteins (n = 132) that participate in a landscape of inflammation and immune signaling related to the SARS-CoV-2 infection. Furthermore, the significant correlations of neutrophil and lymphocyte with the CCL2 and CXCL10 mediated cytokine signaling pathways was identified. These information are valuable for the understanding of COVID-19 pathogenesis, identification of biomarkers and development of the optimal anti-inflammation therapy.