Two high school softball coaches are immune from a student's privacy lawsuit because there was no clearly established law barring school officials from discussing a student's private matters with the student's parent.

A team led by researchers from the Penn State College of Medicine re-engineered immune cells with a light-activated switch that modulates protein function and cellular behavior. When exposed to blue light, the cells change shape, infiltrating solid tumors grown in the lab and killing them.

New blood tests can reveal whether your immune system is fighting fit by looking at the balance of different immune cells, but there may be a simpler way of gauging your immune health

They fight invaders, clear debris and tend neural connections, but sometimes microglia go rogue. Preventing this malfunction may offer new treatments for brain conditions including Alzheimer's

Title: Newborns' Immune Systems Ramp Up After Birth
Category: Health News
Created: 8/24/2018 12:00:00 AM
Last Editorial Review: 8/27/2018 12:00:00 AM

Title: Secret Tunnels Between Skull, Brain Speed Immune Cells After Stroke in Mice
Category: Health News
Created: 8/27/2018 12:00:00 AM
Last Editorial Review: 8/28/2018 12:00:00 AM

Title: J&J Says Booster Shot Ups Immune Response to COVID
Category: Health News
Created: 8/25/2021 12:00:00 AM
Last Editorial Review: 8/25/2021 12:00:00 AM

Neural reflexes occupy a central role in physiological homeostasis. The vagus nerve is a major conduit for transmitting afferent and efferent signals in homeostatic reflex arcs between the body and the brain. Recent advances in neuroscience, immunology, and physiology have revealed important vagus nerve mechanisms in suppressing inflammation and treating rheumatoid arthritis and other autoimmune conditions. Numerous clinical trials indicate that there is significant benefit to vagus nerve stimulation therapy. Although many questions are still unanswered, it will be important, even necessary, to pursue answers that will be useful in guiding interventions to modulate immunological and physiological homeostasis.

They fight invaders, clear debris and tend neural connections, but sometimes microglia go rogue. Preventing this malfunction may offer new treatments for brain conditions including Alzheimer's

Our immune cells change a lot as the decades progress, which could explain why we become more susceptible to certain conditions

A long-awaited study of people with ME/CFS revealed differences in their immune and nervous system. The findings may offer clues about long COVID

Allogeneic hematopoietic cell transplantation (HCT) serves as a widely recognized curative treatment option for patients suffering from inborn errors of immunity (IEI).

Highlights: Keto diet promotes gut bacteria that reduce inflammation in autoimmune diseases UC San Francisco stu

A newly developed platform mimics nature to enhance immune-based treatments in the fight against medlinkcancer/medlink. h2Fighting Cancer from

In the intricate ecosystem of the medlinkgut microbiome/medlink, where various bacteria influence immunity and health outcomes, understanding their

Researchers developed a vaccine that utilizes synthetically modified natural peptides to stimulate CD8 T regulatory cells. These cells, which are typically

Chromosome 18q deletion syndrome is a medlinkrare genetic disorder/medlink, affecting about 1 in 40,000 to 55,000 individuals. It results from the

Macrophages and microglia, the immune cells of the brain were found to increase hypertension, say researchers. The immune cells encounter the endothelium,

Using cryo-electron microscopy the atomic structure of the "APOBEC3G-Vif complex" has been unveiled by scientists (!--ref1--). h2 What is APOBEC3G

Blood stem cells contribute to maintaining the age-related imbalance of the two main types of immune cells innate and adaptive. Effective immune systems

Maternal medlinkZika virus/medlink infections can alter fetal immune development, resulting in long-term effects on children's immunity (!--ref1--).

Arjun Kapoor has spoken about suffering from autoimmune Hashimoto's disease that has led to fluctuations in his weight.

Scientist and Immunologist Dr. Shruti Naik answers the internet's burning questions about our immune systems. Are viruses alive? Is chicken soup actually good for the immune system? What does the spleen even do? Is playing in dirt good for your child's health?? Dr. Shruti answers all these questions and much more! Director: Justin Wolfson Director of Photography: Brad Wickham Editor: Chris Davies Expert: Dr. Shruti Naik Line Producer: Joseph Buscemi Associate Producer: Brandon White Production Manager: Eric Martinez Production Coordinator: Fernando Davila Camera Operator: Brittany Berger Audio: Sean Paulsen Production Assistant: Ryan Coppola Post Production Supervisor: Alexa Deutsch Post Production Coordinator: Ian Bryant Supervising Editor: Doug Larsen Assistant Editor: Andy Morell

Study finds macrophages talk to sensory nerves to elicit chronic pain caused by nerve damage

Study finds macrophages talk to sensory nerves to elicit chronic pain caused by nerve damage

It is that day when we celebrate motherhood, mothers, their unmatched love and every small and big thing they do for us. Bollywood celebrities have been sharing heart-warming photos and posts on social media, to mark the day. For Shilpa Shetty, however, it is an extra special day since her surrogate daughter Samisha came home a few months back, and she gets to celebrate the day with her two children now!

During a recent interview, Shilpa reveald that she always wanted two kids since she knows how impactful having a sibling can be, and did not want son Viaan to grow up alone. However, she developed an auto-immune condition called APLA which caused her miscarriages every time she got pregnant.

Before she decided to opt for surrogacy, Shilpa revealed she had also considered adoption as an option and put her name with an organisation for the same. However, it got pushed due to internal disputes and after waiting for four years, her patience got over and she and husband Raj Kundra decided to have a surrogate baby.

On Instagram, we keep coming across photos of the happy family, and Viaan always looks excited to have been promoted to a big brother.

Happy Mother's Day to you, Shilpa!

Inter-α-inhibitor is a proteoglycan essential for mammalian reproduction and also plays a less well-characterized role in inflammation. It comprises two homologous “heavy chains” (HC1 and HC2) covalently attached to chondroitin sulfate on the bikunin core protein. Before ovulation, HCs are transferred onto the polysaccharide hyaluronan (HA) to form covalent HC·HA complexes, thereby stabilizing an extracellular matrix around the oocyte required for fertilization. Additionally, such complexes form during inflammatory processes and mediate leukocyte adhesion in the synovial fluids of arthritis patients and protect against sepsis. Here using X-ray crystallography, we show that human HC1 has a structure similar to integrin β-chains, with a von Willebrand factor A domain containing a functional metal ion-dependent adhesion site (MIDAS) and an associated hybrid domain. A comparison of the WT protein and a variant with an impaired MIDAS (but otherwise structurally identical) by small-angle X-ray scattering and analytical ultracentrifugation revealed that HC1 self-associates in a cation-dependent manner, providing a mechanism for HC·HA cross-linking and matrix stabilization. Surprisingly, unlike integrins, HC1 interacted with RGD-containing ligands, such as fibronectin, vitronectin, and the latency-associated peptides of transforming growth factor β, in a MIDAS/cation-independent manner. However, HC1 utilizes its MIDAS motif to bind to and inhibit the cleavage of complement C3, and small-angle X-ray scattering–based modeling indicates that this occurs through the inhibition of the alternative pathway C3 convertase. These findings provide detailed structural and functional insights into HC1 as a regulator of innate immunity and further elucidate the role of HC·HA complexes in inflammation and ovulation.

After witnessing sharp weakness on Monday, Nifty shifted into a mixed trend with range bound action in the last couple of sessions.

The immune system of this mosquito is of great importance as scientists believe it plays a key role in controlling the transmission of viruses that cause

New Zealand must significantly increase its efforts to detect, investigate and prosecute foreign bribery. Since joining the Convention over 12 years ago, New Zealand has not prosecuted any cases of foreign bribery and only four allegations have surfaced to date. Outdated perceptions that New Zealand individuals and companies do not bribe may have also undermined detection efforts.

Hellbenders, aquatic salamanders from the eastern United States, are surprisingly good at dealing with unpredictable weather. In a recent study published in the Journal of […]

The post Zoo scientists find sudden stream temperature changes boost hellbender immune systems appeared first on Smithsonian Insider.

Thomas O'Loughlin, Antonina J. Kruppa, Andre L. R. Ribeiro, James R. Edgar, Abdulaziz Ghannam, Andrew M. Smith, and Folma Buss

Optineurin (OPTN) is a multifunctional protein involved in autophagy, secretion as well as NF-B and IRF3 signalling and OPTN mutations are associated with several human diseases. Here we show that, in response to viral RNA, OPTN translocates to foci in the perinuclear region, where it negatively regulates NF-B and IRF3 signalling pathways and downstream pro-inflammatory cytokine secretion. These OPTN foci consist of a tight cluster of small membrane vesicles, which are positive for ATG9A. Disease mutations linked to POAG cause aberrant foci formation in the absence of stimuli, which correlates with the ability of OPTN to inhibit signalling. Using proximity labelling proteomics, we identify the LUBAC complex, CYLD and TBK1 as part of the OPTN interactome and show that these proteins are recruited to this OPTN-positive perinuclear compartment. Our work uncovers a crucial role for OPTN in dampening NF-B and IRF3 signalling through the sequestration of LUBAC and other positive regulators in this viral RNA-induced compartment leading to altered pro-inflammatory cytokine secretion.

New research supports the hypothesis that parasites could have a role in preventing certain diseases.

Do your immune system a favor and go dig in the dirt. The bacteria, algae, fungi, protozoa and nematodes will do you good.

Until now, no one believed this kind of broad-spectrum cure for cancer was possible.

Scientists are at a loss to explain why infants seem largely resistant to the coronavirus, but new studies are providing clues.

Farm research focused on good bacteria in the gut is helping scientists understand asthma, allergies and the immune system.

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Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.