How do different types of heaters impact indoor air humidity? And which types are better if you want to avoid overly dry air?

White label reputation management involves offering reputation management services under the name of another agency. An example would be a digital marketing agency that doesn’t specialize in reputation management entering a white label agreement with a specialist reputation management agency to deliver services on its behalf.  In some cases, certain […]

The post Should You White Label Reputation Management? It Depends appeared first on .

While legal abortions in the U.S. are safe, the likelihood that women will receive the type of abortion services that best meet their needs varies considerably depending on where they live, says a new report from the National Academies of Sciences, Engineering, and Medicine.

For all the COVID-19 safety guidelines circulating, some hundreds of pages long, basic best practices are straightforward and known by most Americans. Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases since 1984, recently recounted them in an interview with the Journal of the American Medical Association.

In 2024 FEVS results of senior leadership, there appears to be variation based on how closely situated employees are to their agency’s headquarters.

The post Leadership scores rise in 2024 FEVS, but it depends where feds work first appeared on Federal News Network.

Bill Clinton certainly qualifies as a liberal icon. Yet in many respects, his record belies the liberal tag.

Neurodegeneration in Parkinson's disease (PD) can be recapitulated in animals by administration of α-synuclein preformed fibrils (PFFs) into the brain. However, the mechanism by which these PFFs induce toxicity is unknown. Iron is implicated in PD pathophysiology, so we investigated whether α-synuclein PFFs induce ferroptosis, an iron-dependent cell death pathway. A range of ferroptosis inhibitors were added to a striatal neuron-derived cell line (STHdhQ7/7 cells), a dopaminergic neuron–derived cell line (SN4741 cells), and WT primary cortical neurons, all of which had been intoxicated with α-synuclein PFFs. Viability was not recovered by these inhibitors except for liproxstatin-1, a best-in-class ferroptosis inhibitor, when used at high doses. High-dose liproxstatin-1 visibly enlarged the area of a cell that contained acidic vesicles and elevated the expression of several proteins associated with the autophagy-lysosomal pathway similarly to the known lysosomal inhibitors, chloroquine and bafilomycin A1. Consistent with high-dose liproxstatin-1 protecting via a lysosomal mechanism, we further de-monstrated that loss of viability induced by α-synuclein PFFs was attenuated by chloroquine and bafilomycin A1 as well as the lysosomal cysteine protease inhibitors, leupeptin, E-64D, and Ca-074-Me, but not other autophagy or lysosomal enzyme inhibitors. We confirmed using immunofluorescence microscopy that heparin prevented uptake of α-synuclein PFFs into cells but that chloroquine did not stop α-synuclein uptake into lysosomes despite impairing lysosomal function and inhibiting α-synuclein toxicity. Together, these data suggested that α-synuclein PFFs are toxic in functional lysosomes in vitro. Therapeutic strategies that prevent α-synuclein fibril uptake into lysosomes may be of benefit in PD.

Voltage-gated Cav1 and Cav2 Ca2+ channels are comprised of a pore-forming α1 subunit (Cav1.1-1.4, Cav2.1-2.3) and auxiliary β (β1-4) and α2δ (α2δ−1−4) subunits. The properties of these channels vary with distinct combinations of Cav subunits and alternative splicing of the encoding transcripts. Therefore, the impact of disease-causing mutations affecting these channels may depend on the identities of Cav subunits and splice variants. Here, we analyzed the effects of a congenital stationary night blindness type 2 (CSNB2)-causing mutation, I745T (IT), in Cav1.4 channels typical of those in human retina: Cav1.4 splice variants with or without exon 47 (Cav1.4+ex47 and Cav1.4Δex47, respectively), and the auxiliary subunits, β2X13 and α2δ-4. We find that IT caused both Cav1.4 splice variants to activate at significantly more negative voltages and with slower deactivation kinetics than the corresponding WT channels. These effects of the IT mutation, along with unexpected alterations in ion selectivity, were generally larger in channels lacking exon 47. The weaker ion selectivity caused by IT led to hyperpolarizing shifts in the reversal potential and large outward currents that were evident in channels containing the auxiliary subunits β2X13 and α2δ-4 but not in those with β2A and α2δ-1. We conclude that the IT mutation stabilizes channel opening and alters ion selectivity of Cav1.4 in a manner that is strengthened by exclusion of exon 47 and inclusion of β2X13 and α2δ-4. Our results reveal complex actions of IT in modifying the properties of Cav1.4 channels, which may influence the pathological consequences of this mutation in retinal photoreceptors.

Elections can only be representative if all members of society, including women, play a role, the head of the U.N. mission in Afghanistan said Wednesday.

Trust must be strong in your team: your trust in your team members; and their trust in you.

Sure, it’s great to have clear blue skies but for most of the world the pandemic spells famine and disease, not the planet fighting back

• Coronavirus latest updates
• See all our coronavirus coverage

Cormorants are hunting fish in the now clear waters of Venice. Wild boars roam the avenues of Barcelona and wild goats the streets of Llandudno. Above Los Angeles are blue skies. From smogless Delhi, you can once more glimpse the Himalayas.

“The Earth is healing, we are the virus,” runs the meme spreading fast across the internet. It’s a sentiment echoed by many policymakers, commentators and celebrities.

Spain is emerging from a challenging period. The good news is that the economy has returned to moderate growth and unemployment rates are falling. Yet Spain’s progress along the path to inclusive growth may well falter if steps are not taken today to boost skills outcomes.

The Korean economy has seen significant growth in the past decades. However, much of the economic growth has been supported by intensive labour resource utilisation. Korean workers work the second longest hours among OECD countries. This is not sustainable in the long-term because Korea’s working age population is projected to decline from 2017 onwards.

A nonlinear least-squares method for refining a parametric expression describing the estimated errors of reflection intensities in serial crystallographic (SX) data is presented. This approach, which is similar to that used in the rotation method of crystallographic data collection at synchrotrons, propagates error estimates from photon-counting statistics to the merged data. Here, it is demonstrated that the application of this approach to SX data provides better SAD phasing ability, enabling the autobuilding of a protein structure that had previously failed to be built. Estimating the error in the merged reflection intensities requires the understanding and propagation of all of the sources of error arising from the measurements. One type of error, which is well understood, is the counting error introduced when the detector counts X-ray photons. Thus, if other types of random errors (such as readout noise) as well as uncertainties in systematic corrections (such as from X-ray attenuation) are completely understood, they can be propagated along with the counting error, as appropriate. In practice, most software packages propagate as much error as they know how to model and then include error-adjustment terms that scale the error estimates until they explain the variance among the measurements. If this is performed carefully, then during SAD phasing likelihood-based approaches can make optimal use of these error estimates, increasing the chance of a successful structure solution. In serial crystallography, SAD phasing has remained challenging, with the few examples of de novo protein structure solution each requiring many thousands of diffraction patterns. Here, the effects of different methods of treating the error estimates are estimated and it is shown that using a parametric approach that includes terms proportional to the known experimental uncertainty, the reflection intensity and the squared reflection intensity to improve the error estimates can allow SAD phasing even from weak zinc anomalous signal.

According to a new survey of residents living near two major national parks in Panama, jaguars deserve increased protection. Nature and wildlife are considered national […]

The post Jaguar conservation depends on neighbor attitudes appeared first on Smithsonian Insider.

While legal abortions in the U.S. are safe, the likelihood that women will receive the type of abortion services that best meet their needs varies considerably depending on where they live, says a new report from the National Academies of Sciences, Engineering, and Medicine.

A new German study suggests that residents??? level of satisfaction with their urban neighbourhood can be predicted from their perceptions of multiple and co-occurring burdens, such as poor air quality, lack of green space, noise and low cleanliness.

Environmental changes in the future, such as an increase in floods, land degradation and drought could result in changes in migration patterns in Europe, researchers write in a recent analysis. It is difficult to predict these exact migration patterns, however, as they are determined by a complex interplay of economic, political and social factors with environmental change, as well as adaptive capacity.

Food security is being threatened by loss of soil nutrients that are essential for the high yield of crops. A recent study outlines strategies to ensure the sustainable production of food through a holistic approach to soil nutrient management.

New technology that makes energy capture from waste water and re-use of grey water possible can contribute to energy- and resource efficiency — but the widespread application of such technology requires a new, collaborative approach, shows a new study. Taking radical innovation in urban water systems beyond the pilot stage will require cooperation between a variety of stakeholders, suggest the findings of expert interviews and workshops.

New EU-funded research has provided useful guidelines for re-introducing threatened species, using a waterfowl case study. The Spanish researchers developed a method for deciding the best time of year to release the species into their original habitat.

New low cost methods using bacteria to remove toxic metals from groundwater have been investigated using both actual contaminated groundwater and artificially controlled systems. Environmental conditions, such as changing levels of acidity or alkalinity, can have a significant effect on the removal of toxins, results show.

If you are trying to decide which TV is better for your life style, just take a look at your viewing styles

...the concept of 'foreign' plays a crucial role in determining whether income, income taxes, physical presence or accounts qualify for respective exclusions, credits, residency or disclosure.

India Cellular and Electronics Association (ICEA) Chairman Pankaj Mohindroo said that the two-week lockdown extension notification issued by the Ministry of Home Affairs (MHA) appropriately undertakes significant measures whereby economic and manufacturing activities have been reopened in a calibrated manner.

During the COVID-19 lockdown, and during the gradual re-opening of communities, cities and businesses there is a lot information you've got that your listeners need. And, they are looking … more

Agencies, local authorities and national governments do not agree on who should be quarantined or what that should actually look like. Here’s what we do know. By Maya Miller, Caroline Chen and Joshua Kaplan ProPublica People who have been exposed to the coronavirus are being given incomplete or misleading information about whether they should quarantine themselves, exposing major gaps in the public health response to the pandemic and illuminating disagreement among officials about how useful the tactic even is at this point in the disease’s spread.…

Billy Bragg is many things: a poet, punk rocker, folk musician, and singer-songwriter. He’s also an activist, music historian, and best-selling author. In the words of another poet, he contains multitudes. Bragg’s newest work, The Three Dimensions of Freedom , is a slim volume that makes a weighty argument. It’s a pamphlet in the tradition of Thomas Paine, whose influential polemics helped spark the American Revolution, and later got him convicted of sedition.

1. Should You Get A Nintendo Switch Lite If You Can’t Find Switch Availability? It Depends  Forbes
2. Nintendo Switch Lite is in stock at Amazon and Best Buy: Latest inventory update  CNET
3. Best Switch Games So Far In 2020  Trusted Reviews
4. Nintendo Switch Capture Cards: How to Record Video of Your Gameplay  Screen Rant
5. View Full coverage on Google News

Which school has the most No. 1 NFL draft picks of all-time? This is where the rivalry between USC and Notre Dame flares up once again.

UNIVERSAL CREDIT claims have soared in recent weeks, as Britons have begun to feel the financial impact of the coronavirus crisis. How much is Universal Credit? The amount depends on whether certain circumstances apply.

NBC has rolled out a new feature that allows people to shop while they watch television, but a question remains: will anybody use it?

Changes to a program designed to reunite refugees with family in the U.S. have slowed -- and in some cases outright denied -- legitimate entries into the country.

Sean Newcomb entered last June as an All-Star candidate and exited the regular season wondering if he had done enough to earn a spot on Atlanta's postseason roster. The inconsistent nature of his first full Major League season enhances the difficulty of projecting how valuable he might be to the Braves from both an immediate and long-term perspective.

When freedom fighters in India inspired by Mahatma Gandhi turned violent in a clash with police in 1922, the nonviolent leader took personal responsibility, called off nationwide protests and starved himself for five days in a penitential fast. Gandhi was nearly alone in thinking an apology of such...

Assuming that the shares are in the nature of ESOPs, they shall be taxed at two stages, once as perquisites in the hands of employees upon allotment and subsequently as capital gains upon sale of the shares.

The Nintendo Switch is out of stock everywhere, but the Switch Lite is much easier to find availability. Should you get a Switch Lite if you can't find the main model? It depends. ......

We thought the Amazon got the essential nutrient phosphorus from Saharan dust. Now it appears it mainly comes from forest fires and people burning wood

As winter fades and spring breaks over Sweden, a high-stakes experiment in self-responsibility is underway.

The AFL and NRL will both play matches this weekend, but both leagues are taking different approaches to dealing with the coronavirus outbreak.