social and politics

Redox-responsive amphiphilic camptothecin prodrug nanoparticles for targeted liver tumor therapy

J. Mater. Chem. B, 2020, 8,3918-3928
DOI: 10.1039/D0TB00285B, Paper
Lu Lu, Bing Li, Chuanchuan Lin, Ke Li, Genhua Liu, Zengzilu Xia, Zhong Luo, Kaiyong Cai
A redox-responsive drug carrier with asialoglycoprotein receptor (ASGPR) targeting is fabricated for liver tumor therapy.
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Biodegradable MnFe-hydroxide nanocapsules to enable multi-therapeutics delivery and hypoxia-modulated tumor treatment

J. Mater. Chem. B, 2020, 8,3929-3938
DOI: 10.1039/D0TB00243G, Paper
Linhua Liao, Dong Cen, Yike Fu, Bin Liu, Chao Fang, Yifan Wang, Xiujun Cai, Xiang Li, Hao Bin Wu, Gaorong Han
Fine nanocapsules based on MnFe hydroxides, showing high loading capacity, O2 induction and biodegradation, were synthesized for effective synergistic therapies.
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A near-infrared light-responsive multifunctional nanocomposite hydrogel for efficient and synergistic antibacterial wound therapy and healing promotion

J. Mater. Chem. B, 2020, 8,3908-3917
DOI: 10.1039/D0TB00361A, Paper
Na Yang, Ming Zhu, Guochao Xu, Ning Liu, Cong Yu
A multifunctional nanocomposite hydrogel for synergistic antibacterial wound therapy and healing promotion.
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Molecular simulations and understanding of antifouling zwitterionic polymer brushes

J. Mater. Chem. B, 2020, 8,3814-3828
DOI: 10.1039/D0TB00520G, Paper
Yonglan Liu, Dong Zhang, Baiping Ren, Xiong Gong, Lijian Xu, Zhang-Qi Feng, Yung Chang, Yi He, Jie Zheng
Zwitterionic materials demonstrate the strong surface hydration to empower their antifouling property.
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Unravelling the nucleation, growth, and faceting of magnetite–gold nanohybrids

J. Mater. Chem. B, 2020, 8,3886-3895
DOI: 10.1039/C9TB02721A, Paper
Yulia A. Nalench, Igor V. Shchetinin, Alexander S. Skorikov, Pavel S. Mogilnikov, Michael Farle, Alexander G. Savchenko, Alexander G. Majouga, Maxim A. Abakumov, Ulf Wiedwald
The nucleation, growth and faceting of Fe3O4–Au nanoparticles is systematically monitored using liquid probes during reaction. Two consecutive processes are obtained, the growth of Fe3O4 spheres on Au seeds and faceting towards octahedral motifs.
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New forms of electrospun nanofiber materials for biomedical applications

J. Mater. Chem. B, 2020, 8,3733-3746
DOI: 10.1039/D0TB00271B, Review Article
Shixuan Chen, Johnson V. John, Alec McCarthy, Jingwei Xie
This review article discusses new forms of electrospun nanofiber materials and their biomedical applications.
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“Watson–Crick GC”-inspired supramolecular nanodrug of methotrexate and 5-fluorouracil for tumor microenvironment-activatable self-recognizing synergistic chemotherapy

J. Mater. Chem. B, 2020, 8,3829-3841
DOI: 10.1039/D0TB00468E, Paper
Meijin Chen, Shiduan Chen, Fukai Zhu, Fanfan Wang, Haina Tian, Zhongxiong Fan, Sunkui Ke, Zhenqing Hou, Yang Li
The “Watson–Crick G≡C”-inspired carrier-free nanodrug have excellent tumor microenvironment-triggered active self-targeting ability and enhanced synergistic chemotherapeutic effects.
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Tunable layer-by-layer films containing hyaluronic acid and their interactions with CD44

J. Mater. Chem. B, 2020, 8,3880-3885
DOI: 10.1039/D0TB00407C, Paper
Sara Amorim, Iva Pashkuleva, Celso A. Reis, Rui L. Reis, Ricardo A. Pires
We developed hyaluronic acid (HA):poly-L-lysine (PLL) layer-by-layer (LbL) constructs whose viscoelastic properties and bioactivity can be finely tuned by using polyanions of different molecular weight and/or crosslinking.
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Human serum albumin-based doxorubicin prodrug nanoparticles with tumor pH-responsive aggregation-enhanced retention and reduced cardiotoxicity

J. Mater. Chem. B, 2020, 8,3939-3948
DOI: 10.1039/D0TB00327A, Paper
Boya Zhang, Shiyu Wan, Xinyu Peng, Mingying Zhao, Sai Li, Yuji Pu, Bin He
A nano-assembly of pH-sensitive doxorubicin prodrug and human serum albumin shows tumor pH-responsive aggregation, enhanced tumor retention and reduced cytotoxicity.
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H2S-Donating trisulfide linkers confer unexpected biological behaviour to poly(ethylene glycol)–cholesteryl conjugates

J. Mater. Chem. B, 2020, 8,3896-3907
DOI: 10.1039/C9TB02614B, Paper
Francesca Ercole, Yuhuan Li, Michael R. Whittaker, Thomas P. Davis, John F. Quinn
A comprehensive in vitro study into trisulfide-bearing PEG-conjugates was conducted. For these materials the combination of a cholesteryl group and an H2S donating moiety is required to confer cytoprotective and ROS-mitigating effects.
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Ternary hydrogels with tunable mechanical and self-healing properties based on the synergistic effects of multiple dynamic  bonds

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/C9TB02885D, Paper
Kun Li, Jingxi Wang, Ping Li, Yubo Fan
Ternary hydrogels with tunable mechanical properties were prepared based on the synergistic effects of hydrogen bonds and imine bonds.
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Platelet membrane-coated nanoparticles for targeted drug delivery and local chemo-photothermal therapy of orthotopic hepatocellular carcinoma

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00735H, Paper
Long Wu, Wei Xie, Hui-Ming Zan, Zhongzhong Liu, Ganggang Wang, Yanfeng Wang, Wei Liu, Wenfei Dong
Specific targeted drug delivery and controllable release of drugs at tumor regions are two of the main challenges for hepatocellular carcinoma (HCC) therapy, particularly post metastasis.
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Synthetic mycomelanin thin films as emergent bio-inspired interfaces controlling the fate of embryonic stem cells

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00623H, Paper
Paola Manini, Valeria Lucci, Valeria Lino, Stefania Sartini, Francesco Rossella, Geppino Falco, Cinzia Chiappe, Marco d’Ischia
Mycomelanin thin films from 1,8-dihydroxynaphthalene can serve as a biointerface inducing adhesion and proliferation of ESCs and promoting their differentiation towards endodermal lineages.
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Boron-based nanosheets for combined cancer photothermal and photodynamic therapy

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00070A, Paper
Yong Kang, Xiaoyuan Ji, Zhengjun Li, Zhiguo Su, Songping Zhang
Tumor phototherapy is of great significance for the expansion and advancement of cancer treatment methods.
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A fiber-shaped neural probe with alterable elastic moduli for direct implantation and stable electronic–brain interfaces

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00508H, Communication
Chengqiang Tang, Songlin Xie, Mengying Wang, Jianyou Feng, Zhengqi Han, Xiaoying Wu, Liyuan Wang, Chuanrui Chen, Jiajia Wang, Liping Jiang, Peining Chen, Xuemei Sun, Huisheng Peng
A fiber-shaped neural probe with alterable elastic moduli allows direct implantation and enables adaptive electronic–tissue interfaces post implantation.
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Discrimination of cysteamine from mercapto amino acids through isoelectric point-mediated surface ligand exchange of β-cyclodextrin-modified gold nanoparticles

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00462F, Paper
Quanbao Ma, Xun Fang, Junting Zhang, Lili Zhu, Xiabing Rao, Qi Lu, Zhijun Sun, Huan Yu, Qunlin Zhang
A pI-mediated R6G-β-CD@AuNPs system was designed for the first time for the discrimination of CA from GSH/Cys/Hcy in human serum samples.
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Nanoscale dual-enzyme cascade metal–organic frameworks through biomimetic mineralization as ROS generators for synergistic cancer therapy

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00357C, Paper
Shuiling Jin, Lanling Weng, Zhi Li, Zhenzhen Yang, Lili Zhu, Jianxiang Shi, Wenxue Tang, Wang Ma, Hong Zong, Wei Jiang
Chemodynamic therapy (CDT) has been critically challenged by insufficient H2O2 in cancer tissues and inefficient reactive oxygen species (ROS) production.
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A bio-inspired injectable hydrogel as a cell platform for real-time glycaemic regulation

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00561D, Paper
Yu Zhang, Jun Yang, Jun Zhang, Shuangwen Li, Lisi Zheng, Yanlong Zhang, Huipeng Meng, Xinge Zhang, Zhongming Wu
A bio-inspired injectable hydrogel as a cell platform for real time glycemic regulation by mimicking the function of native islet β cells.
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One-pot synthesis of trypsin-based magnetic metal–organic frameworks for highly efficient proteolysis

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/C9TB02315A, Paper
Chao Zhong, Zhixian Lei, Huan Huang, Mingyue Zhang, Zongwei Cai, Zian Lin
A facile approach was developed for one-pot synthesis of trypsin-based magnetic ZIF-8, which could be applied as an immobilized enzyme microreactor for rapid digestion of proteins.
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Regulation of cell binding and entry by DNA origami mediated spatial distribution of aptamers

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00663G, Communication
Ke Liu, Cong Xu, Jinyao Liu
Customizing the spatial distribution of aptamers on DNA origami nanoboxes can regulate the internalization and proliferation of cancer cells.
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A decellularized scaffold derived from squid cranial cartilage for use in cartilage tissue engineering

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00483A, Paper
Thou Lim, Qian Tang, Zhen-Zhong Zhu, Yong Feng, Shi Zhan, Xiao-Juan Wei, Chang-Qing Zhang
Decellularized cartilage scaffold (DCS) is an emerging substitute for cartilage defect application.
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Shape memory materials for electrically-powered soft machines

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00392A, Review Article
Xiaonan Huang, Michael Ford, Zach J. Patterson, Masoud Zarepoor, Chengfeng Pan, Carmel Majidi
We review the recent progress of electrically-powered artificial muscles and soft machines using shape memory alloy and liquid crystal elastomer.
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Preparation and biological evaluations of collagen-like hierarchical Ti surface with superior osteogenic capabilities

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00799D, Paper
Weiwei Lao, Qiaojie Luo, Yadong Chen, Wei Yao, Jiajia Xu, Lijie Fan, Xiaodong Li
The construction of multiscale Ti surfaces of high osteogenic ability always attracts numerous attentions in oral implantology and implantable biomaterial field. However, so far, the absence of solid understanding of...
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Molecular imaging of extracellular vesicles in vitro via Raman metabolic labelling

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00620C, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Conor C. Horgan, Anika Nagelkerke, Thomas E. Whittaker, Valeria Nele, Lucia Massi, Ulrike Kauscher, Jelle Penders, Mads S. Bergholt, Steve R. Hood, Molly M. Stevens
Molecular imaging of extracellular vesicles in vitro via Raman metabolic labelling.
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Covalent Organic Framework as Nanocarrier for Synergistic Phototherapy and Immunotherapy

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00679C, Paper
Ying Zhou, Sainan Liu, Chunling Hu, Lihan Cai, Maolin Pang
As traditional cancer treatment methods, photodynamic therapy (PDT) and photothermal therapy (PTT) can eliminate primary tumor, but can't inhibit tumor extensive metastasis and local recurrence. Herein, in order to prevent...
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Coaxial mussel-inspired biofibers: Making of a robust and efficacious depot for cancer drug delivery

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00052C, Paper
Javad Foroughi, Sepehr Talebian , In Kyoung Shim, Kara Vine, Song Cheol Kim, Geoffrey M Spinks
Biopolymer-based hydrogels have emerged as promising platforms for drug delivery systems (DDSs) due to their inherent biocompatibility, tunable physical properties and controllable degradability. Yet, drug release in majority of these...
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Surface functionalization strategies of extracellular vesicles

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00744G, Review Article
Sagar Rayamajhi, Santosh Aryal
Physical, biological, and chemical strategies of surface functionalization can add vital functionality in extracellular vesicles (EVs) for diverse biomedical applications.
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The Circadian Clock Gene PER2 Enhances Chemotherapeutic Efficacy in Nasopharyngeal Carcinoma When Combined with a Targeted Nanosystem

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00595A, Paper
Li Hou, Hailiang Li, Haiyan Wang, Dede Ma, Jing Liu, liqiong Ma, Zhihua Wang, Zhihua Yang, Faxuan Wang, Hechun Xia
Treatment failure occurs in more than 40% of advanced nasopharyngeal carcinoma (NPC) patients including local recurrence and distant metastasis due to chemoradioresistance. Circadian clock genes were identified as regulating cancer...
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Ag@S-nitrosothiols core-shell nanoparticles for chemo and photothermal synergistic tumor target therapy

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00734J, Paper
Xinlin Yang, Tuanwei Liu, Xiao Li, Jinan Wang, Ping Zhang, Xiaoying Huang, Zhide Zhang, Dian-Shun Guo
Along with development of the controlled delivery systems for target therapy, ‘single-strategy’ therapy often fails to achieve the desired performance in real body internal environment. In such case, it is...
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Hydrogels toughened by biominerals as energy-dissipative sacrificial bonds

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00833H, Communication
Kazuki Fukao, Kazuki Tanaka, Ryuji Kiyama, Takayuki Nonoyama, Jian Ping Gong
Inspired by bone tissues, hydrogels toughened by hydroxyapatite (HAp) working as energy-dissipative sacrifical bonds is created. The contribution of dissipated energy from HAp mineral was over 500 % higher than...
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Diblock Copolypeptoids: A Review of Phase Separation, Self-Assembly and Biological Applications

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00477D, Review Article
Sunting Xuan, Ronald N Zuckermann
Polypeptoids are biocompatible, synthetically accessible, chemically and enzymatically stable, chemically diverse, and structurally controllable. As a bioinspired and biomimetic material, it has attracted considerable attention due to its great potential...
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Calcium alendronate-coated composite scaffolds promote osteogenesis of ADSCs via integrin and FAK/ERK signalling pathways

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00571A, Paper
Lei Liu, Xianling Gao, Xiaoyu Li, Guanglin Zhu, Nanying Li, Xuetao Shi, Yingjun Wang
Bioceramic-biopolymer composites have been used extensively as bone tissue engineering scaffolds due to their bioactive properties. However, composite scaffolds are insufficient in inducing osteogenic differentiation of stem cells. In this...
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High-performance non-enzymatic glucose detection: using conductive Ni-MOF as an electrocatalyst

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00131G, Communication
Yanxia Qiao, Qian Liu, Siyu Lu, Guang Chen, Shuyan Gao, Wenbo Lu, Xuping Sun
Conductive metal−organic frameworks (MOFs) are studied extensively in applications like water electrolysis, gas storage, and supercapacitors due to their high conductivity and large pore volume, etc. In this communication, we...
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Securing persistent environment variables using ZEIT Now

I’m a big fan of ZEIT Now1 as an application hosting provider. The way the service abstracts all of the cloud computing details and allows teams to focus on building and deploying web applications is fantastic. That said, I had a lot of trouble setting up secure environment variables for my first application to use....




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Scheduling Jekyll posts with Netlify and GitHub Actions

Last year, I wrote about how to schedule Jekyll posts using Netlify and AWS Lambda[^1]. I used that approach from the moment I wrote that blog post up until today. What changed? In the past year, GitHub has introduced GitHub Actions[^2], a way to run container jobs triggered by different GitHub events. One of those...




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How I think about solving problems

Early on in my career as a software developer I thought my primary contribution was writing code. After all, software engineers are paid to ship software and writing code is a key component of that. It took several years for me to realize that there are numerous other contributions that go into shipping software (if...




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CSS3 transitions and z-index

You can apply CSS3 transitions to the z-index property, but it may work in a way you don't expect.




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Bookmarklets for accessibility testing

I've created two simple bookmarklets to reveal whether CSS background images are being used in an inaccessible way on a page. Use them yourself, or help me learn how to improve them.




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Putting Flexbox into Practice presentation at Blend Conference

Download the slides and view the demo page for my presentation on Putting Flexbox into Practice for Blend Conference 2013, as well as get links to related articles, tutorials, and tools on Flexible Box Layout.




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Help me declutter before I move overseas

I'm moving from the US to the Netherlands, and as part of paring down pre-move, I'd like to get rid of several copies of my book Stunning CSS3 before I leave. Find out how to get a copy.




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Leveling Up With Flexbox presentation at Smashing Conference

Download the slides and view the demos for my presentation on practical flexbox progressive enhancement, "Leveling Up With Flexbox" for Smashing Conference in Oxford, as well as get links to related articles, tutorials, and tools on Flexible Box Layout.




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#663399Becca

In memory of Eric Meyer's daughter Becca.




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Full-width pinned layouts with flexbox

Learn how to use flexbox to pin two things to opposite ends of the viewport with a heading centered in between. Using media queries and flexbox's re-ordering capabilities, we can make this layout pattern even more responsive.




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Enhancing Responsiveness with Flexbox presentation at RWD Summit

Download the slides and view the demos for my presentation on practical flexbox progressive enhancement for RWD, "Enhancing Responsiveness with Flexbox" for the RWD Summit, as well as get links to related articles, tutorials, and tools on Flexible Box Layout.




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We need more moms in web design and development

I've noticed that there are very few moms speaking at conferences in our industry. I'd like us to do our little part to make it easier for women to work in technology fields by making web design and development conferences more mom-friendly. This can help all of us, not just the moms.




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Using Modernizr with Flexbox

The Modernizr feature-detection script now includes four tests for flexbox support, which you can use to target browsers with varying levels of support more precisely.




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HTML5 and Video: 4 part video series

I’ve had a couple people ask me to link on my blog to my four part video series on HTML5 and video. Currently, it’s a feature on the AdobeTV home page, but I reckon that will be for just a little while. After that, you can link directly to Part 1 (7:18), Part 2 (10:31), [...]




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CSS3 Flexible Box Model…Layout Coolness…also Oddities & Confusion

In August, due to a twitter discussion with Molly, and of course while partying on a Saturday night, Dave Gregory and I were looking at whether the Flexible box layout module (still a working draft) is getting close to ready for prime time yet. Our hope was that it will solve some of the frustrations [...]




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Changing a Background-image with CSS3 Transitions

As you may have read, outside of gradients, you can’t change a background-image with CSS transitions. Or can you? At InControl Conference last week, Greg Rewis spoke about Transitions, Transforms and Animations. A question was asked about showing one background-image on load and transitioning to another in a subsequent pseudo-state. You can always change the [...]




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Firefox multi-column layout bug… and a unicorn

Last night, I was getting a file ready to share with Estelle Weyl, one of my co-presenters for our CSS3 workshop at SXSW11. The page was a silly little demo that used media queries, multiple backgrounds, transitions, generated content, multi-column layout and, well, a unicorn. I had only viewed the file in Chrome since that’s [...]