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Enhanced Luminescence and Stability of TFMDSA Nanoparticles via Polymer-Induced aggregation for Bioimaging

J. Mater. Chem. B, 2024, Accepted Manuscript
DOI: 10.1039/D4TB01825G, Paper
Xiang Li, Xue Ren, Yuchao Luo, Haotian Shi, Zhigang Xie, Bin Xu, Wenjing Tian
In recent years, fluorescence imaging occupies a very important position in the life science and biomedical fields. However, achieving nanomaterials for bioimaging with both high fluorescence quantum efficiency and high...
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Polycyclic aromatic polymer nanoparticles show potent infectious particle adsorption capability

J. Mater. Chem. B, 2024, Accepted Manuscript
DOI: 10.1039/D4TB01793E, Paper
Yudai Oishi, Mako Toyoda, Nanami Hano, Chihiro Motozono, Takamasa Ueno, Makoto Takafuji
Nonspecific viral adsorption by polymer nanoparticles is more economical and superior in terms of operating cost and energy efficiency than viral adsorption using virus-specific antibodies and filtration techniques involving size...
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Research Progress of Nitroxide Radical-Based MRI Contrast Agents: From Structure Design to Application

J. Mater. Chem. B, 2024, Accepted Manuscript
DOI: 10.1039/D4TB02272F, Review Article
Tao Luo, Bo Wang, Runxin Chen, Qi Qi, Ruodai Wu, Shunzi Xie, Hanbing Chen, Jialei Han, Dalin Wu, Shuaishuai Cao
Magnetic resonance imaging (MRI) remains a cornerstone of diagnostic imaging, offering unparalleled insights into anatomical structures and pathological conditions. Gadolinium-based contrast agents have long been the standard in MRI enhancement,...
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Nano-Bio Interactions of Gum Arabic-Stabilized Lanthanide-based Upconverting Nanoparticles: In Vitro and In Vivo Study

J. Mater. Chem. B, 2024, Accepted Manuscript
DOI: 10.1039/D4TB01579G, Paper
Hana Mirmajidi, Hyojin Lee, Niepukolie Nipu, Jith Thomas, Zuzana Gajdosechova, David Kennedy, Jan A. Mennigen, Eva Hemmer
Lanthanide-based nanoparticles (Ln-NPs) are highly valued for their unique optical and magnetic properties, making them useful in various scientific fields, including materials science and biomedicine. This study investigated the use...
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Extracellular matrix mimetic supramolecular hydrogels reinforced with covalent crosslinked mesoporous silica nanoparticles

J. Mater. Chem. B, 2024, Advance Article
DOI: 10.1039/D4TB00499J, Paper
Open Access
Aygül Zengin, Shahzad Hafeez, Pamela Habibovic, Matthew Baker, Sabine van Rijt
Here we present a promising strategy to create hybrid, biomimetic supramolecular injectable hydrogels reinforced covalent crosslinked mesoporous silica nanoparticles for tissue engineering applications.
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Exchange of free and capsule conjugated cyanine dyes between cells

J. Mater. Chem. B, 2024, Advance Article
DOI: 10.1039/D4TB01874E, Paper
Zhanna V. Kozyreva, Polina A. Demina, Olga I. Gusliakova, Gleb B. Sukhorukov, Olga A. Sindeeva
Cells readily exchange free cyanine dyes when their membranes are in close contact. Photoconvertible capsules based on cyanine dyes are internalized into the cytoplasm with a low degree of exchange, allowing individual cell labeling and tracking.
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A water playground for peptide re-assembly from fibrils to plates

J. Mater. Chem. B, 2024, Advance Article
DOI: 10.1039/D4TB01727G, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Simone Adorinni, Marina Kurbasic, Ana M. Garcia, Slavko Kralj, Ottavia Bellotto, Erica Scarel, Paolo Pengo, Rita De Zorzi, Michele Melchionna, Attilivio V. Vargiu, Silvia Marchesan
Water plays a key role in the irreversible transition from peptide fibrils to plates.
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Mitochondrial membrane potential-independent near-infrared fluorescent probes for viscosity-exclusive imaging

J. Mater. Chem. B, 2024, Advance Article
DOI: 10.1039/D4TB01785D, Paper
Xiu Pan, Yu Zhao, Jia-Li Wang, Shun Feng, Xiao-Qi Yu, Ming-Yu Wu
A novel mitochondrial targeting mitochondrial membrane potential-independent near-infrared fluorescent probe, ACR-DMA, was developed which can be firmly immobilized in mitochondria for tracking of mitochondrial viscosity changes in vitro and in vivo.
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H2O2-activated mitochondria-targeting photosensitizer for fluorescence imaging-guided combination photodynamic and radiotherapy

J. Mater. Chem. B, 2024, Accepted Manuscript
DOI: 10.1039/D4TB01653J, Paper
Qiufen Tian, Zifan Zhu, Yun Feng, Shirui Zhao, Hui Lin, Wen Zhang, Zhiai Xu
Radiotherapy is a primary modality in cancer treatment but accompanied by severe side effects to healthy tissues and radiation resistance to some extent. To overcome these limitations, we developed a...
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Nanoparticles based image-guided thermal therapy and temperature feedback

J. Mater. Chem. B, 2024, Accepted Manuscript
DOI: 10.1039/D4TB01416B, Review Article
Carlos Jacinto, Wagner Ferreira Silva, Joel Garcia, Gelo P. Zaragosa, Carlo Nonato De Jesus Ilem, Tasso O. Sales, Harrison D. A. Santos, Blessed Isaac C. Conde, Helliomar Pereira Barbosa, Sonia Malik, Surender Kumar Sharma
Nanoparticles have emerged as versatile tools in the realm of thermal therapy, offering precise control and feedback mechanisms for targeted treatments. This review explores the intersection of nanotechnology and thermal...
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Surface-Enhanced Raman Scattering for HSP 70A mRNA Detection in the Live Cells Using Silica Nanoparticles and DNA-Modified Gold Nanoparticles

J. Mater. Chem. B, 2024, Accepted Manuscript
DOI: 10.1039/D4TB01514B, Paper
Ju Eun Cho, Dong-Kwon Lim
Real-time monitoring of mRNA in living cells is crucial for understanding dynamic biological processes. Traditional methods such as northern blotting, PCR, and sequencing require cell lysis and do not allow...
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Eco-Friendly Self-Clean Coatings: Fundamentals, Fabrication, Applications, and Sustainability

J. Mater. Chem. B, 2024, Accepted Manuscript
DOI: 10.1039/D4TB01392A, Review Article
Tanaji K. Chavan, Sushanta Kumar K. Sethi
Eco-friendly self-clean coatings have garnered significant attention due to their potential to address environmental concerns while offering remarkable properties. This review explores the dynamic field of such coatings, focusing on...
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Development of a Xanthene-Based NIR Fluorescent Probe for Accurate and Sensitive Detection of γ-Glutamyl Transpeptidase in Cancer Diagnosis and Treatment

J. Mater. Chem. B, 2024, Accepted Manuscript
DOI: 10.1039/D4TB01841A, Paper
Chia-Kai Lai, KUPPAN MAGESH, Sivan Velmathi, Shu-Pao Wu
γ-Glutamyl transpeptidase (GGT) regulates glutathione (GSH), essential for cell functions and linked to cancer. High GGT levels in tumors make it a valuable cancer biomarker. Current GGT detection methods often...
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Quantum DFT analysis and molecular docking investigation of various potential breast cancer drugs

J. Mater. Chem. B, 2024, Accepted Manuscript
DOI: 10.1039/D4TB01803F, Paper
Ashraf Ayub, Ankit Raj Tyagi, Sunil Kumar Srivastava, Pranveer Singh
Breast cancer is the most often diagnosed and deadliest type of cancer in the world. These days, the world is facing the threat of breast cancer. It is essential to...
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Cuproptosis in cancer therapy: mechanisms, therapeutic application and future prospects

J. Mater. Chem. B, 2024, Advance Article
DOI: 10.1039/D4TB01877J, Review Article
Jiawei Hu, Junfei Zhu, Tao Chen, Yudie Zhao, Qingwen Xu, Yan Wang
Cuproptosis is a regulated form of cell death induced by the accumulation of metal ions and is closely linked to aspects of cellular drug resistance, cellular metabolism, and signalling pathways.
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MnO2-mineralized milk exosomes as a novel nanoplatform for glutathione detection

J. Mater. Chem. B, 2024, Advance Article
DOI: 10.1039/D4TB01662A, Paper
Xudong Wang, Xue Wu, Jiuheng Shen, Xian Zhao, Peifen Gao, Wantong Zhou, Wenlin An
This study introduces a novel nanoplatform by surface manganese dioxide (MnO2) mineralization of milk exosomes and labelling with curcumin, enhancing their utility in the detection of GSH.
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Functionalities of pH-responsive DNA nanostructures in tumor-targeted strategies

J. Mater. Chem. B, 2024, Advance Article
DOI: 10.1039/D4TB01883D, Review Article
Liyue Wen, Min Wang
Design and application of various pH-responsive DNA nanostructures for tumor-targeted strategies toward extracellular and intracellular environments are comprehensively reviewed. Their potential and challenges are also critically discussed.
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Fluorescence sensing techniques for quality evaluation of traditional Chinese medicines: a review

J. Mater. Chem. B, 2024, Advance Article
DOI: 10.1039/D4TB01886A, Review Article
Yanyu Xiao, Hui Wang, Chenxia Gao, Xinyi Ye, Yuting Lai, Meiling Chen, Xiaoliang Ren
We summarized the advantages and advanced applications of fluorescence sensing technology compared with other analytical techniques, as well as the challenges and prospects of current application in the field of TCM quality evaluation.
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Advancing cancer therapy with a heptamethine carbocyanine dye-conjugated radionuclide drug

J. Mater. Chem. B, 2024, Advance Article
DOI: 10.1039/D4TB01798F, Paper
Mingxing Huang, Weichen Wang, Yingwei Wang, Rang Wang, Lili Pan, Xin Li, Bo Li, Jingsong Zhang, Ruoxiang Wang, Yi Zhang, Rong Tian
Malignant tumors pose substantial treatment challenges due to their heterogeneity, metastatic potential, and therapeutic resistance, underscoring the urgent need for more effective treatment options.
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Illuminating cisplatin-induced ferroptosis in non-small-cell lung cancer with biothiol-activatable fluorescent/photoacoustic bimodal probes

J. Mater. Chem. B, 2024, Advance Article
DOI: 10.1039/D4TB01656D, Paper
Li Xu, Hongwen Liu, Yi Kong, Lingyun Li, Jia Li, Kang Li, Shuzhi Liang, Bolin Chen
Using activatable NIR fluorescent/PA bimodal probes, we successfully monitored real-time biothiol changes during ferroptosis in NSCLC cells and tumors, revealing enhanced ferroptosis with the combined use of erastin and cisplatin.
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Bimetallic doped carbon dot nanozymes for enhanced sonodynamic and nanocatalytic therapy

J. Mater. Chem. B, 2024, Accepted Manuscript
DOI: 10.1039/D4TB01916D, Paper
Yandong Huang, Lanting Jia, Shiqi Zhang, Lan Yan, Lei Li
The conventional inorganic semiconductors are not suitable for acting as nanozymes or sonosensitizers for in vivo therapeutic nanomedicine owing to the lack of excellent biocompatibility. Biocompatible carbon dots (CDs) exhibit...
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Recent Advances in Polymer-based Thin-film Electrode for ECoG Applications

J. Mater. Chem. B, 2024, Accepted Manuscript
DOI: 10.1039/D4TB02090A, Review Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Zhengchen Xiang, Liangtao Yang, Bin Yu, Qi Zeng, Tao Huang, Shuo Shi, Hao Yu, Yi Zhang, Jinglong Wu, Meifang Zhu
Electrocorticography (ECoG) has garnered widespread attention due to its superior signal resolution compared to conventional electroencephalogram (EEG). While ECoG signal acquisition entails invasiveness, the invasive rigid electrode inevitably inflicts damage...
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Bioinspired programmable coacervate droplets and self-assembled fibers through pH regulation of monomers

J. Mater. Chem. B, 2024, Accepted Manuscript
DOI: 10.1039/D4TB01550A, Paper
Satyajit Patra, Sushmitha Chandrabhas, Subi J. George
Phase separation or phase transitions pervade the biological domain, where proteins and RNA engage in liquid-liquid phase separation (LLPS), forming liquid-like membraneless organelles. The misregulation or dysfunction of these proteins...
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Dual-functional PCN-242 (Fe2Co) MOF for sensitive bacterial endotoxin detection

J. Mater. Chem. B, 2024, Advance Article
DOI: 10.1039/D4TB01944J, Paper
Sivasankar Kulandaivel, Yung-Kang Lu, Chia-Her Lin, Yi-Chun Yeh
This work introduces a novel bimetallic MOF with superior endotoxin detection and enhanced catalytic activity for broader diagnostic applications.
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NIR emissive probe for fluorescence turn-on based dead cell sorting and in vivo viscosity mapping in C. elegans

J. Mater. Chem. B, 2024, Advance Article
DOI: 10.1039/D4TB01945H, Paper
Goraksha T. Sapkal, Farhan Anjum, Abdul Salam, Bodhidipra Mukherjee, Shilpa Chandra, Purabi Bala, Richa Garg, Shagun Sharma, Kush Kaushik, Chayan Kanti Nandi
An NIR emissive probe plays a pivotal role for in vitro and in vivo dead cell sorting.
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Creating a JavaScript promise from scratch, Part 7: Unhandled rejection tracking

When promises were introduced in ECMAScript 2015, they had an interesting flaw: if a promise didn’t have a rejection handler and was later rejected, you would have no idea. The rejection silently occurred behind the scenes and, therefore, could easily be missed. The best practice of always attaching rejection handlers to promises emerged due to...




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Introducing Env: a better way to read environment variables in JavaScript

If you write server-side JavaScript, chances are you’ve need to read information from environment variables. It’s considered a best practice to share sensitive information, such as access tokens, inside of environment variables to keep them secure. However, the way environment variables are read from JavaScript is error-prone in subtle ways that might take you hours...




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Two approaches to win an argument as a software engineer

If you’ve spent any time developing software professionally and then you are probably used to the spirited debates that take place between software engineers as well as between software engineers and management, design, and product. Software engineers are not known for being shy about their opinions on any particular subject, and especially when it comes...




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The lazy-loading property pattern in JavaScript

Traditionally, developers have created properties inside of JavaScript classes for any data that might be needed within an instance. This isn’t a problem for small pieces of data that are readily available inside of the constructor. However, if some data needs to be calculated before becoming available in the instance, you may not want to...




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How to talk to your company about sponsoring an open source project

Open source sustainability is a topic that is just starting to get the attention that it deserves. So much of the technology sector is run on software that can be used for free without any further obligation. However, as companies profit from using this software for free, the maintainers of the software often struggle to...




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Making your open source project sponsor-ready, Part 1: Companies and trust

Early on, it was a battle to get sponsorship for open source projects. What used to require phone calls and drawn-out discussions has now been streamlined thanks to efforts like Open Collective1 and GitHub Sponsors2. Companies and individuals can now know if a project accepts donations just by looking at the project page on GitHub,...




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Making your open source project sponsor-ready, Part 2: Project hygiene

In part 11 of this series, I described how companies make decisions about spending their money and why they might (or might not) sponsor an open source project. If you haven’t yet read that post, I’d suggest going back to do so now before continuing. Everything in this post builds off the topics discussed in...




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Making your open source project sponsor-ready, Part 3: Accepting sponsorships

In the previous two posts in this series, I described why companies sponsor open source projects1 and how following some basic project hygiene can help attract sponsors2. Now that your project is functioning at a high level and is attractive to companies, it’s time to talk specifics about accepting sponsorships from companies. Making it easy...




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Sponsoring dependencies: The next step in open source sustainability

When the JavaScript Standard Style (StandardJS) project1 decided to show ads during installation, the backlash was swift and harsh. The project is an opinionated JavaScript style guide, formatter, and linter all in one, and it was also the first npm project to try and raise money by inserting an ad in the command line.2 The...




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Setting up a Rust development environment with Visual Studio Code

When I decided to teach myself Rust, I naturally started looking around at what editors I could use. It turned out that most of the folks I asked online were still using Visual Studio Code for Rust. To my surprise, though, setting up a complete development environment in Visual Studio Code wasn’t as straightforward as...




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Updates to the Google Photos APIs: Picker API launch and Library API changes

The new Picker API enables secure photo selection, while the Library API will focus on managing photos and videos uploaded by your application.




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Updated production-ready Gemini models, reduced 1.5 Pro pricing, increased rate limits, and more

Learn about the latest updates to Google's Gemini models, including reduced pricing for Gemini 1.5 Pro, increased rate limits, faster performance, enhanced quality, and more.




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Enhance your prompts with Vertex AI Prompt Optimizer

Vertex AI Prompt Optimizer, a new managed automated prompt engineering service, can help save time and effort in prompt engineering while ensuring performing prompts ready for your generative AI applications.




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Announcing Build with Google AI release 3: A Season of Gemma!

The season showcases new applications of Gemma, including a personal AI code assistant and projects for non-English tasks and business email processing.




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Gemini 1.5 Flash-8B is now production ready

Google is rolling out (in GA) a new Gemini model, 1.5 Flash-8B, our smallest production model with SOTA performance for its size.




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Towards Global Understanding – Advancing Multilingual AI with Gemma 2 and a $150K Challenge

Google is building AI models, focusing on Gemma, to bridge communication gaps across languages.




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Want a smoother checkout with Google Pay? Configure your payment options!

Configure accepted payment methods for Google Pay, with options for authentication methods, card networks, and card types, and upcoming features for enhanced control and customization.




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Now in Developer Preview: Enhancing Chat with the Google Chat API

The Google Chat API has been launched, allowing developers to build Chat apps that enable real-time collaboration between Google Chat and other systems.




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People of AI: Season 3 Takeaways and Season 4 Previews

The People of AI podcast Season 3 highlighted inspiring stories and career anecdotes from individuals shaping the future of AI, focusing on themes of democratizing AI, AI for Good, redefining intelligence, and AI's impact on work.




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Compare Mode in Google AI Studio: Your Companion for Choosing the Right Gemini Model

Compare Mode is a powerful new feature designed to help you make informed decisions about which Gemini model best suits your needs.




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Save the date for Firebase Demo Day 2024!

Firebase Demo Day is back! Join us virtually on November 19, 2024 for a showcase of cutting-edge Firebase technology.




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Introducing Keras Hub: Your one-stop shop for pretrained models

KerasHub is a new unified library for pretrained models fostering a more cohesive ecosystem for developers.




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Evolving the Responsible Generative AI Toolkit with new tools for every LLM

The Responsible Generative AI Toolkit is being expanded with new features to support responsible AI development across all LLMs, including SynthID Text for watermarking.




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Chrome on Android to support third-party autofill services natively

Chrome on Android will soon natively support third-party autofill services, providing a smoother user experience.




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Bringing AI Agents to production with Gemini API

AgentOps uses the Gemini API to provide cost-effective and powerful LLM-powered agent observability for enterprises.