The Reds want to use Raisel Iglesias in the most intense moments, even if that means using someone else in the ninth.

Diabetes triggers peripheral nerve alterations at a structural and functional level, collectively referred to as diabetic peripheral neuropathy (DPN). This work highlights the role of the liver X receptor (LXR) signaling pathway and the cross talk with the reactive oxygen species (ROS)–producing enzyme NADPH oxidase-4 (Nox4) in the pathogenesis of DPN. Using type 1 diabetic (T1DM) mouse models together with cultured Schwann cells (SCs) and skin biopsies from patients with type 2 diabetes (T2DM), we revealed the implication of LXR and Nox4 in the pathophysiology of DPN. T1DM animals exhibit neurophysiological defects and sensorimotor abnormalities paralleled by defective peripheral myelin gene expression. These alterations were concomitant with a significant reduction in LXR expression and increase in Nox4 expression and activity in SCs and peripheral nerves, which were further verified in skin biopsies of patients with T2DM. Moreover, targeted activation of LXR or specific inhibition of Nox4 in vivo and in vitro to attenuate diabetes-induced ROS production in SCs and peripheral nerves reverses functional alteration of the peripheral nerves and restores the homeostatic profiles of MPZ and PMP22. Taken together, our findings are the first to identify novel, key mediators in the pathogenesis of DPN and suggest that targeting LXR/Nox4 axis is a promising therapeutic approach.

Yes, catcher Carson Kelly is new to the D-backs this spring, but this wasn't the first time he's gotten to see what the inside of Salt River Fields looks like.

OP-ED CONTRIBUTION: COVID-19 AND THE ECONOMY FOR MOST countries in the Caribbean, the current testing for COVID-19 has not reached levels suitable for ascertaining an accurate picture of the state of outbreak and spread of the infection. This...

Invitation Only Research Event

Event participants

Niels Engelschiøn, Director-General, Department for European Affairs, Norwegian Ministry of Foreign Affairs
Chair: Dr Robin Niblett, Director; Chief Executive, Chatham House

Although in many countries immigrants fill labor gaps in fields such as agriculture and construction, few legal migration pathways exist for low-skilled workers. As states meet to negotiate a Global Compact for Safe, Orderly, and Regular Migration, this policy brief takes stock of the channels available for such workers to move legally and take up work abroad, highlighting promising practices and policy gaps.

As the final phase of preparations for the historic adoption of a Global Compact for Safe, Orderly, and Regular Migration approaches, this webinar explores two central objectives of the compact: enhancing the availability and flexibility of pathways for regular migration, and investing in skills development. 

As the final phase of preparations for the historic adoption of a Global Compact for Safe, Orderly, and Regular Migration approaches, this webinar explores two central objectives of the compact: enhancing the availability and flexibility of pathways for regular migration, and investing in skills development.

Climate-related displacement is not hypothetical: An average of 21.5 million people per year have been displaced since 2008 by natural disasters, and thousands more have fled slow-onset environmental hazards. While migration can serve as a safety valve to adapt to changing conditions, few orderly, legal channels exist for climate migrants (also known as environmental migrants), as this article explores.

A young bull went wandering on a Massachusetts highway after escaping from a trailer and was captured without causing any incidents, police said.

Police and firefighters in Michigan came to the rescue of a family of baby geese that wandered out onto a busy highway and fell into a storm sewer.

Animal rescuers in California said they reached over the side of a freeway on-ramp to rescue a raccoon seen dangling from a metal beam under the ramp.

Boris Draznin
Jul 1, 2013; 36:1807-1814
Perspectives in Care

As European countries launch ambitious new legal migration partnerships with several origin and transit countries in Africa, this report takes stock of the long and mixed history of such projects. To make the most of their potential to encourage skills development and fill pressing labor gaps, policymakers will need to think carefully about the partners and sectors they choose, among other key considerations.

OBJECTIVE

Despite evidence of a relationship among obstructive sleep apnea (OSA), metabolic dysregulation, and diabetes, it is uncertain whether OSA treatment can improve metabolic parameters. We sought to determine effects of long-term continuous positive airway pressure (CPAP) treatment on glycemic control and diabetes risk in patients with cardiovascular disease (CVD) and OSA.

Test results suggest N95 masks can be safely disinfected through heating 50 times before their filtration efficiency begins to decline.

I'm trying to make a backup to an external harddrive, but when I go to update & security and then to back up, I don't find the option to 'add a drive'. It's completely empty, even though my computer is detecting the external harddrive.  Where do I find the option to backup files? I'm using windows 10 

I have 2500 worth of debt and most of it has been turned over into collections 

What band was he with before?

This event hosted by MPI Europe and the Research Unit of the Expert Council of German Foundations on Integration and Migration featured a discussion of research into legal migration pathways for work and training for low- and middle-skilled migrants.

While low-skilled workers generally have limited opportunities to legally migrate to the European Union, seasonal migration forms an important exception. This MPI Europe-SVR webinar explores lessons from Europe on managing seasonal worker programs that are responsive to labor market needs but also prioritize the well-being of seasonal workers and interests of receiving countries. 

Economists project a shortage of 5 million U.S. workers with postsecondary education and training by 2020. Yet 2 million immigrant college graduates in the United States are either unemployed or work in jobs that require no more than a high school degree. How can this skill underutilization, known as "brain waste," be remedied? MPI asked the experts, and this report summarizes their discussion and recommendations.

“Conversational receptiveness” can be learned

-- Read more on ScientificAmerican.com

In the courts and in Congress, Sen. Larry Craig is fighting to withdraw his guilty plea to a misdemeanor charge that may suggest he tried to solicit sex from a man in June at a Minneapolis airport bathroom. Rather than resign yesterday, as the senator had promised and Republicans had hoped, Craig...

Sen. John McCain's quest for the Republican presidential nomination was once seen as dead, but like those robots in the "Terminator" movies that reassemble themselves after being blown to smithereens, he came back. Five years ago, Sen. Barack Obama (Ill.) was a virtually unknown African American ...

When President-elect Barack Obama, an early opponent of the Iraq war, asked Sen. Hillary Rodham Clinton -- who helped to authorize the war -- to be his secretary of state, many liberals scratched their heads.

Experts on this webinar discussed the effects of trauma on the development of young refugee children, and how early child-care programs can address these traumatic experiences. The discussion featured practical strategies that child-care providers in Canada are implementing to support refugee children and families. 

A recent MPI study reveals that 48 percent of recent immigrants to the United States were college graduates, a sharp increase over earlier periods. How can the United States better leverage this brain gain? This commentary outlines some policies that could allow the United States to more fully utilize the professional and academic credentials that highly skilled immigrants have, for their benefit and that of the U.S. economy.

My first exposure to Robert Macfarlane happened a year ago when I picked up a battered copy of The Wild Places in order to shelve it. Instead, I checked it out from my branch and stayed up past midnight to read it. Thanks to Macfarlane, I was exposed to Roger Deakin's Wild Wood and Notes from Walnut Tree Farm. I found photos of Walnut Tree Farm, the late Deakin's house, much visited by Macfarlane, while searching for more information about both of them online.

I am from probably the last generation of American children to be raised on English children's books. I know that there is a generation of Quidditch-playing adults that were weaned on the Harry Potter books of British-born J. K. Rowling. While the Harry Potter books are gripping, they lack an essential British characteristic shared by many successful authors of British children's books:

• Rudyard Kipling - the two Puck of Pook's Hill books
• Rosemary Sucliff - all of her books
• Elizabeth Goudge - Rowling helped get Linnets & Valerians and The Little White Horse republished
• L. M. Boston - the Greene Knowe series
• William Mayne
• Robert Westall
• Diana Wynne Jones - the British landscape of an alternative Britain
• J. R. R. Tolkein -The Hobbit
• Kenneth Graham - The Wind in the Willows
• T. H. White - The Once and Future King
• Susan Cooper - The Dark is Rising series

Macfarlane likes to walk. In The Wild Places, he visits mountains, woods, water. In The Old Ways, he follows the ancient paths that cross the British isles, that go through wood, by the sea shore, and over the downs. His England (and Scotland) however, is multilayered; he is aware not only of the physical landscape surrounding him but of the history of the land through which he walks. A walk take him from point A to point B in physical space, as well as through centuries of time. In his author's note, Macafarlane observes:

"It is an exploration of the ghosts and voices that haunt ancient paths, of the tales that tracks keep and tell, of pilgrimage and trespass, of songlines and their singers and of the strange continents that exist within countries" (p.xi).

While Americans are criticized for being such a highly mobile society, humans have always traveled. Early hunter-gatherers did not stay in one place, but roamed within a fairly wide territory. The early sea-farers such as the Phoenicians, the Greeks, the Carthaginians, the Romans (marine archaeology has shown that they sailed more than we have associated with them) and the Vikings all traveled the roads of the sea. The medieval Crusades were holy wars, but they were also the mass movement of men, women, and children walking across Europe, then by boat from southern Italian ports to the Holy Land. Within Europe itself, bands of pilgrims walked from their homes along the tracks to Canterbury or St. James de Campostela. Merchants in ancient and medieval times traveled in caravans along the land and sea routes of the Silk Roads.

The difference between the modern traveler of today and that of the past is that travelers today are less exposed to the world around them. When you are encased in a plane or enclosed in a fast car, you lose awareness of the physical world outside of you. The electronic devices that we use to distract ourselves during our journeys - our DVD players, Ipods, tablets and ebook readers, all cut us off from the landscape and  fellow travelers around us. Macfarlane deliberately chooses to travel on foot (and by small boat) to connect with the physical world around him during his modern secular pilgrimage.

Macfarlane's journey begins on the Icknield Way, which runs over the chalk downs of Sussex. He starts out on a bicycle along an old Roman road that runs past an Iron Age hill-fort. As he cycles past the hill-fort he falls, damages his bicyle, and breaks a rib.However, Macfarlane gets up and continues his journey. He views the accident as

A warning, I thought superstitiously, had been issued to me: that the going would not be easy and that romanticism would be quickly punished. It was only a few miles later that I remembered the letter a friend had sent me when I told him about my plan to walk the Icknield Way. Take care as you pass the ring-fort, he had written back. When I mentioned the fall later, he was unamazed."This was an entry fee to the old ways, charged at one of the usual tollbooths, " he said. "Now you can proceed. You're in. Bone for chalk: you've paid your due." It was the first of several incidents along the old ways that I still find hard to explain away rationally." (p.43).

Throughout the book, Macfarlane risks meeting the supernatural. He spends the nights camping near Iron Age barrows. He sleeps in circular Pictish shielings. Finally he decides to sleep in Chanctonbury RIng in Sussex because author Laurie Lee had slept there while walking over England in the 1930's.

I first learned about Chanctonbury Ring when I read about called Sussex Cottage written by Esther Meynell in 1936. The ring contains a temple built by the Romans on a previously inhabited Bronze and Iron Age fort site. According to legend, Julius Caesar and his legions ride around the ring. It is also possible to summon the devil by running around it a certain number of times. There are a number of internet sites with chilling stories of uncanny experiences in Chanctonbury Ring:

http://www.sussexarch.org.uk/saaf/chanctonbury.html#folk

http://www.delcoghosts.com/chanctonbury.html

http://www.telegraph.co.uk/earth/outdoors/6454719/Devils-Dyke-is-not-for-the-faint-hearted-walker.html

http://ufofreeparanormal.com/node/62


Oblivious to the possibility that he may be rousing some kind of supernatural being, Macfarlane spends a night in Chanctonbury Ring, but gets little rest. First he walks around the ring, then beds down for the night. He is awoken by  human-sounding voices moving around the ring until two voices meet directly over his head. Eventually the voices go away and he is able to go back to sleep although he does not feel rested in the morning. Later in the day Macfarlane meets up up with an archaeologist friend and they discuss why it was a bad idea to sleep in the ring. However, it is not until he gets home that Macfarlane researches the folklore of Chanctonbury Ring and realizes that it is one of the most malevolently haunted spots in England.

What's interesting is that while Macfarlane is aware of the many centuries of human history that his paths have run through, and of the theories that the paths exist throughout time, he does little research on the supernatural history of the places where he travels. These places seem to do their best to make him aware of their history and their special qualities. The supernatural seems to forcibly come to him although he does his best to remain ignorant of its existence.

This recipe features on Foodie Tuesday, a weekly segment on 774 Drive at 3.30PM. It was shared by Monique Bowley, director of Podcasts at Mamamia Womens Network, and one-time Great Australian Bake Off contestant.

Growing numbers of African and Asian migrants are moving through Latin America, many hoping to reach the United States or Canada after expensive, arduous, and often dangerous journeys that can take months or even years. As more extracontinental migrants transit through South and Central America, Colombia, Panama, and Costa Rica have developed the most comprehensive policies to manage these flows, sometimes working in coordination with the U.S. government.

This event hosted by MPI Europe and the Research Unit of the Expert Council of German Foundations on Integration and Migration featured a discussion on research into legal migration pathways for work and training for low- and middle-skilled migrants.

As the European Union prepares to review the implementation of its Seasonal Workers Directive, as well as countries such as the United Kingdom continue to explore new approaches to selecting seasonal workers, this webinar features findings from a policy brief on the topic. 

One of the primary reasons people seek therapy is to get help with mental health issues. Some of the more common mental disorders affecting individuals today include depression, anxiety, post traumatic stress (PTSD), phobias, addiction, and attention deficit hyperactivity (ADHD). Depending on the type and intensity of your issue, your therapist may adjust his treatment […]

NBA legend and recreational gambler Charles Barkley is presented with the following hypothetical on ESPN radio: You are winning big at the poker table when a beautiful woman sits down next to you. “Do you stay with the hands or do you leave?” Barkley: “Bro, gambling is so fickle, I love to gamble, when you [...]

What if we could help people in crisis anytime, anywhere with a simple text message? That's the idea behind Crisis Text Line, a free 24-hour service that connects people in need with trained, volunteer crisis counselors -- "strangers helping strangers around the world, like a giant global love machine," as cofounder and CEO Nancy Lublin puts it. Learn more about their big plans to expand to four new languages, providing a third of the globe with crucial, life-saving support. (This ambitious plan is a part of the Audacious Project, TED's initiative to inspire and fund global change.)

What if we could harness the ocean's movement to protect coastal communities from rising sea levels? Designer and TED Fellow Skylar Tibbits shows how his lab is creating a dynamic, adaptable system of underwater structures that uses energy from ocean waves to accumulate sand and restore eroding shorelines -- working with the forces of nature to build rather than destroy.

Injustice in our education system was normalized long before the pandemic, writes Bettina L. Love. Now is the time to radically dream for a better future.

North Dakota and Wyoming state superintendents said this week that they will soon hire new testing vendors.

Fidelity is often seen as a bad word in school, but it doesn't have to be that way. In this guest blog by George Toman, the concept of fidelity is explained and defended.

Injustice in our education system was normalized long before the pandemic, writes Bettina L. Love. Now is the time to radically dream for a better future.

Policy Analysis for California Education has been a premier ed policy organization for three decades. As Daisy Gonzales writes, it is in the forefront of shaping current reforms and interpreting them for audiences such as 'On California.'