The XT4 compact crossover ends production in January after one generation The Cadillac Optiq electric crossover will take the place as the entry point into the Cadillac brand Production of the XT4 ends not longer after it ended on the Chevy Malibu as GM retools its Fairfax Assembly for the next Bolt EV A year after an interior glow-up, Cadillac...

What kind of vehicle is the 2025 Mercedes-Benz EQS SUV? What does it compare to? The EQS is Mercedes-Benz’s biggest all-electric SUV. Shop it against the Rivian R1S, Audi Q8 E-Tron, BMW iX, and Tesla Model X. Is the 2025 Mercedes-Benz EQS SUV a good car/SUV? The EQS has attractive styling and lots of features, though it is very expensive...

Cadillac Vistiq revealed as brand's “globally sized” electric three-row SUV Vistiq comes standard with 615 hp and 102 kwh Pricing starts at $78,790, including destination Cadillac's expansion of its electric vehicle lineup continues with the arrival of the 2026 Vistiq, a midsize SUV with third-row seats designed to fill the gap between...

Santa Fe Hybrid makes 231 hp and 271 lb-ft of torque Santa Fe Hybrid averaged 31 mpg combined over mostly highway miles Comfy seats, clever storage, and a spacious cargo area with the third-row folded make it a good family hauler My teen daughter’s a videographer. Whenever I test a big car, fast car, cool car, anything that’s not...

In its battle for regional dominance and ongoing rivalry with Shi'ite Iran, Sunni Saudi Arabia is currently involved in a number of strategic battles throughout the Middle East.

5500uv printers owners manual

5uvmee desktops owners manual

Kew scientists use paramotorists to collect rare plant species from Peruvian desert oases

Archaeologists have used AI to discover hundreds of large-scale drawings depicting figures like llamas, decapitated human heads and killer whales armed with knives

Cellular plasticity in adult multicellular organisms is a protective mechanism that allows certain tissues to regenerate in response to injury. Considering that aging involves exposure to repeated injuries over a lifetime, it is conceivable that cell identity itself is more malleable—and potentially erroneous—with age. In this review, we summarize and critically discuss the available evidence that cells undergo age-related shifts in identity, with an emphasis on those that contribute to age-associated pathologies, including neurodegeneration and cancer. Specifically, we focus on reported instances of programs associated with dedifferentiation, biased differentiation, acquisition of features from alternative lineages, and entry into a preneoplastic state. As some of the most promising approaches to rejuvenate cells reportedly also elicit transient changes to cell identity, we further discuss whether cell state change and rejuvenation can be uncoupled to yield more tractable therapeutic strategies.

Simplified methods of acquisition and quantification would facilitate the use of synaptic density imaging in multicenter and longitudinal studies of Alzheimer disease (AD). We validated a simplified tissue-to-reference ratio method using SUV ratios (SUVRs) for estimating synaptic density with [¹¹C]UCB-J PET. Methods: Participants included 31 older adults with AD and 16 with normal cognition. The distribution volume ratio (DVR) using simplified reference tissue model 2 was compared with SUVR at short scan windows using a whole-cerebellum reference region. Results: Synaptic density was reduced in AD participants using DVR or SUVR. SUVR using later scan windows (60–90 or 70–90 min) was minimally biased, with the strongest correlation with DVR. Effect sizes using SUVR at these late time windows were minimally reduced compared with effect sizes with DVR. Conclusion: A simplified tissue-to-reference method may be useful for multicenter and longitudinal studies seeking to measure synaptic density in AD.

This single-center, single-arm, phase II trial (ChiCTR2100050057) investigated the ability of ¹⁸F-labeled fibroblast activation protein inhibitor ([¹⁸F]AlF-NOTA-FAPI-04, denoted as ¹⁸F-FAPI) PET/CT to predict the response to neoadjuvant camrelizumab plus chemotherapy (nCC) in locally advanced esophageal squamous cell carcinoma (LA-ESCC). Methods: This study included 32 newly diagnosed LA-ESCC participants who underwent ¹⁸F-FAPI PET/CT at baseline, of whom 23 also underwent scanning after 2 cycles of nCC. The participants underwent surgery after 2 cycles of nCC. Recorded PET parameters included maximum, peak, and mean SUVs and tumor-to-background ratios (TBRs), metabolic tumor volume, and total lesion FAP expression. PET parameters were compared between patient groups with good and poor pathologic responses, and the predictive performance for treatment response was analyzed. Results: The good and poor response groups each included 16 participants (16/32, 50.0%). On ¹⁸F-FAPI PET/CT, the posttreatment SUVs were significantly lower in good responders than in poor responders, whereas the changes in SUVs with treatment were significantly higher (all P < 0.05). SUV_max (area under the curve [AUC], 0.87; P = 0.0026), SUV_peak (AUC, 0.89; P = 0.0017), SUV_mean (AUC, 0.88; P = 0.0021), TBR_max (AUC, 0.86; P = 0.0031), and TBR_mean (AUC, 0.88; P = 0.0021) after nCC were significant predictors of pathologic response to nCC, with sensitivities of 63.64%–81.82% and specificities of 83.33%–100%. Changes in SUV_max (AUC, 0.81; P = 0.0116), SUV_peak (AUC, 0.82; P = 0.0097), SUV_mean (AUC, 0.81; P = 0.0116), and TBR_mean (AUC, 0.74; P = 0.0489) also were significant predictors of the pathologic response to nCC, with sensitivities and specificities in similar ranges. Conclusion: ¹⁸F-FAPI PET/CT parameters after treatment and their changes from baseline can predict the pathologic response to nCC in LA-ESCC participants.

Advancements in immunotherapy in the perioperative setting have revolutionised the treatment of resectable nonsmall cell lung cancer (NSCLC). Here we present the methodology and results of the clinical trial CheckMate 816 demonstrating the benefit of neoadjuvant therapy with nivolumab plus chemotherapy compared with chemotherapy alone. Furthermore, this article discusses the implications for future practice in resectable NSCLC and the need for future research.

The City of Vancouver council has reneged on a previous commitment to a living wage for its employees.

The post City of Vancouver to lowest paid workers: Let them eat cuts! appeared first on rabble.ca.

A robot mimics the clever fin-folding mechanism used by tuna fish, which increased the bot's turning velocity by almost 33 per cent

The author of Sapiens has turned his attention to the information networks that shape our societies, but when you stop and think about what he's saying, it's obvious

It says these components will enable "the industry's highest DRAM bit density".

Depending on PC config you may see up to a 30fps uplift with anti-tamper tech ditched.

The 90-second trailer, which was delayed several times before being released, offers minimal details but hints at themes of prophecy, betrayal, and resurrection

Combining DNA analysis, archeological techniques, and historical records overturns some assumptions of the people of Pompeii.

The rare type of cloud, whose name is Latin for "roughness," was first observed in 2006 by an amateur cloudspotter in Iowa.

Cadillac is adding to its fleet of EVs with a new luxury SUV. The 2026 Cadillac Vistiq is a three-row, all-electric SUV that will hit showrooms and dealerships sometime next summer with a starting price of $78,790.

The Vistiq’s dual-motor, all-wheel drive system runs on a 102 kWh battery pack with a range of 300 miles that produces 615 horsepower and 650 pound-feet of torque. The Vistiq also supports vehicle-to-home (V2H) bidirectional charging capabilities: it can charge at home, and also deliver electricity to your house during a power outage. Using the features requires buying the GM Energy V2H bundle though.

The SUV’s design borrows aesthetically from other Cadillac EVs. Like the Lyriq, it has flush door handles, and features similar looking lights and side panels. It also matches the Lyriq’s 300 mile range. The “swept-back windshield” and “Black Crystal Shield grill” evoke the Escalade IQ.

Of course, the Vistiq's power and price are different from its Cadillac EV's. The new Cadillac EV SUV is less expensive than an Escalade IQ ($129,990) but more than a Lyriq ($58,595), and the Escalade IQ has a higher peak battery range at 450 miles.

The Vistiq comes with a 23-speaker AKG7 Studio Audio system with Dolby Atmos. The Android-powered infotainment system is baked into a 33-inch high resolution LED display. The Verge also reported that the new EV’s navigation system uses Google Maps and can run other apps from the Google Play Store.

Apple CarPlay and Android Auto won’t be available in Cadillac’s newest EV. General Motors is phasing out Apple CarPlay and Android Auto from its EVs and plans to go with Android Automotive. GM’s Executive Director of Digital Cockpit Experience Edward Kummer said in a Reuters interview that the carmaker didn’t want any features in its EVs “that are dependent on a person having a cellphone.”

Le grand requin blanc attaque souvent ses proies par en dessous, confondant parfois la silhouette d’un surfeur avec celle d’un phoque.

Jeremy Roenick nous a offert le moment le plus touchant de l’intronisation des membres de la cuvée 2024 du Temple de la renommée du hockey.

Non aux rencontres amoureuses, au sexe, au mariage ou à élever des enfants avec un homme.

Le corps ligoté en état de décomposition retrouvé le 30 octobre dans l’un des parcs les plus achalandés de Montréal est celui de Kevin Mirshahi.

Amoury Lapointe a résisté à son arrestation lors d’une intervention de routine à laquelle il refusait de se soumettre dans son «véhicule diplomatique»

Florence et Marianne seront finalement au concert de leur idole, vendredi, à Toronto, mais elles ont eu toute une frousse.

Une ancienne boîte de poulet St-Hubert, retrouvée par hasard dans l’entretoit d’un chalet, a été remise à la famille Martin en échange d'un don.

Donald Trump a indiqué mardi qu’il comptait nommer Elon Musk à la tête d’un ministère nouvellement créé de l’«efficacité gouvernementale»

La nouvelle saison sera déposée sur illico+ le 13 novembre.

La vedette colombienne du reggaeton Karol G s’est excusée pour des paroles de son nouveau single «+57» jugées offensantes.

Chris Martin a intrigué les badauds lundi en embrassant le tarmac de l’aéroport de Sydney.

Une découverte biochimique intrigante pourrait permettre d’identifier rapidement les patients à haut risque.

<p>On 19&nbsp;September 2024, the European Medicines Agency’s (EMA) Committee for Medicinal Products for Human Use (CHMP)&nbsp;adopted a positive opinion,&nbsp;recommending the granting of marketing authorization&nbsp;for&nbsp;two aflibercept biosimilars:&nbsp;&nbsp;Sandoz’s Afqlir and Samsung Bioepis’s Opuviz.&nbsp;These products are biosimilars of the reference product Eylea, developed by Regeneron and Bayer.</p>

Edmunds.com�s roundup of new vehicles at the 2014 LA Auto Show

Visitez notre agence connect�e

D�couvrez la tour EQHO en vid�o

ITW Fr�d�ric Verdavaine

Stag�s Leap Wine Cellars celebrates the 40th anniversary of The Judgment of Paris, which helped to elevate the esteem of American wine worldwide

Dr Aluvihare

Video 1 Preview Image Caption

Hear from Professor Stefan M�ller-H�lsbeck, M.D., PhD, MAJESTIC trial principal investigator

Tailoring Anti-Aging Treatments To Patients' Needs

In a significant public health initiative, the Tamil Nadu government plans to screen 80 lakh people diagnosed with diabetes for medlinktuberculosis/medlink (TB).

New research based on patient health records on lowering high cholesterol suggests that rosuvastatin can harm the kidneys, especially at high doses of the medicine.