Durante el programa 6AM de Caracol Radio, Andrés Camacho, ministro de Minas y Energía conversó sobre el futuro que tiene legalmente la decisión de impugnar la suspensión de exploraciones del pozo Uchuva 2

El embajador de Estados Unidos en Colombia, Francisco Palmieri aseguró en entrevista con 6AM que Carlos Vives nunca estuvo en la famosa lista Clinton.

En 6AM Hoy por Hoy de Caracol Radio estuvo Alejandro Castañeda, presidente de Andeg, quien habló sobre cuál es la situación energética actual de Colombia y por qué es tan preocupante la disminución de los embalses.

Alfred Ballesteros, director de la CAR, indico en 6AM, cuál es el nivel de los embalses, en Cundinamarca 

En Caracol Radio estuvo Catherine Juvinao conversando sobre el papel del Congreso

Padre de Sofía Delgado habló en 6AM de Caracol Radio, sobre la cruel muerte de la niña y sobre si había una relación con el asesino 

A Vancouver-based ad agency placed $3 million cash between the glass in a bus shelter, unguarded on the street - to demonstrate a point.

A quick, transitional recording for the veteran MC.

Malware delivered through fake UPS tracking page, attached as an HTML file.

Perhaps, years from now, if existing trends are reversed and more police officers start to be held accountable for using excessive force against Black people, we will be able to look back at this verdict as a turning point. But that would have to be a retrospective judgment based on change.

Watch the actress in her film debut, Sunday at 8P/7C.

The Bermuda Zoological Society will be holding a Virtual Lecture Series installment titled “The health assessment of juvenile green turtles in Bermuda.” The lecture will held via Zoom on Tuesday, August 16 at 7.00pm and will be presented by Dr Gaelle Roth, MRCVS, Co-Director of the Bermuda Turtle Project. The event flyer says, “Discover something […]

Southlands Park in Warwick was bursting with vibrant energy this weekend as a lively crowd of people gathered to celebrate at the Jab J’Ouvert event early in the morning. Paint, music, and dancing filled the air as attendees enjoyed the festivities. Related Stories Photos & Video: TMQ Jazz Event At Victoria Park Photos/Video: Summer Sunday […]

Ředitel České televize Jan Souček vyrukoval do boje za zvýšení koncesionářských poplatků. Zatím ke zvýšení jejich efektivity nic nepředvedl, naopak chtěl peněz mnohem víc. Jeho plán pro případ neschválení poplatků s rušením televizních kanálů nepočítal. Proč až teď?

Piráti musí přestat řešit vnitřní spory a vrátit se k tomu, co voliče nejvíc zajímá, říká nový předseda strany Zdeněk Hřib v prvním rozhovoru po zvolení v podcastu Padni komu padni. Nejdůležitější je dle něj zlepšit kampaně, aby pirátští voliči přišli k volbám. Bez nich by dle Hřiba ze sněmovny zmizel liberální hlas.

1. Kanguva Box Office Day 1 Advance Sales: 568% Higher Than Suriya’s Last Release ET In USA, Selling 5,460 Tix/Hr In India!  Koimoi
2. Kanguva morning show: Tamilians miffed as other states get earlier shows for Suriya, Bobby Deol's film  Hindustan Times
3. 5 Reasons To Watch Suriya and Bobby Deol Starrer 'Kanguva' In Theatres  Zee News
4. Kanguva’s second half to be very crisp  123telugu
5. Kanguva advance booking: Suriya's film earns over Rs 4 crore ahead of release  India Today

Refine your chops in 1-on-1 sessions with Yuval Boim! Sign up for a slot on Monday evenings to work on skills such as monologue preparation, scene work, and auditioning, or to discuss career and graduate school plans. Sign-up required.

Touch down in Vancouver and it was raining. Listening to friends from the Pacific Northwest talk, I always kind of suspected that they were lying when they complained about how grey it was and how much it rains. I’d been to the region four or five times, at across all time of the year and always […]

The article A Perfect Day in Vancouver (Finally!) originated at EverInTransit.com

The molecular mechanisms of reduced frataxin (FXN) expression in Friedreich's ataxia (FRDA) are linked to epigenetic modification of the FXN locus caused by the disease-associated GAA expansion. Here, we identify that SUV4-20 histone methyltransferases, specifically SUV4-20 H1, play an important role in the regulation of FXN expression and represent a novel therapeutic target. Using a human FXN–GAA–Luciferase repeat expansion genomic DNA reporter model of FRDA, we screened the Structural Genomics Consortium epigenetic probe collection. We found that pharmacological inhibition of the SUV4-20 methyltransferases by the tool compound A-196 increased the expression of FXN by ∼1.5-fold in the reporter cell line. In several FRDA cell lines and patient-derived primary peripheral blood mononuclear cells, A-196 increased FXN expression by up to 2-fold, an effect not seen in WT cells. SUV4-20 inhibition was accompanied by a reduction in H4K20me2 and H4K20me3 and an increase in H4K20me1, but only modest (1.4–7.8%) perturbation in genome-wide expression was observed. Finally, based on the structural activity relationship and crystal structure of A-196, novel small molecule A-196 analogs were synthesized and shown to give a 20-fold increase in potency for increasing FXN expression. Overall, our results suggest that histone methylation is important in the regulation of FXN expression and highlight SUV4-20 H1 as a potential novel therapeutic target for FRDA.

Pyruvate kinase muscle isoform 2 (PKM2) is a key glycolytic enzyme and transcriptional coactivator and is critical for tumor metabolism. In cancer cells, native tetrameric PKM2 is phosphorylated or acetylated, which initiates a switch to a dimeric/monomeric form that translocates into the nucleus, causing oncogene transcription. However, it is not known how these post-translational modifications (PTMs) disrupt the oligomeric state of PKM2. We explored this question via crystallographic and biophysical analyses of PKM2 mutants containing residues that mimic phosphorylation and acetylation. We find that the PTMs elicit major structural reorganization of the fructose 1,6-bisphosphate (FBP), an allosteric activator, binding site, impacting the interaction with FBP and causing a disruption in oligomerization. To gain insight into how these modifications might cause unique outcomes in cancer cells, we examined the impact of increasing the intracellular pH (pHi) from ∼7.1 (in normal cells) to ∼7.5 (in cancer cells). Biochemical studies of WT PKM2 (wtPKM2) and the two mimetic variants demonstrated that the activity decreases as the pH is increased from 7.0 to 8.0, and wtPKM2 is optimally active and amenable to FBP-mediated allosteric regulation at pHi 7.5. However, the PTM mimetics exist as a mixture of tetramer and dimer, indicating that physiologically dimeric fraction is important and might be necessary for the modified PKM2 to translocate into the nucleus. Thus, our findings provide insight into how PTMs and pH regulate PKM2 and offer a broader understanding of its intricate allosteric regulation mechanism by phosphorylation or acetylation.

The Vancouver Canucks take on the Calgary Flames on Tuesday night.

The U.S. Supreme Court took up the question of whether courts must find a juvenile offender permanently incorrigible before a sentence of life without parole.

An investigation by David D. Kirkpatrick of the New York Times revealed the buyer's identity

The British explorer named dozens of geographical features and sites in the region, ignoring the traditions of the Indigenous peoples who’d lived there for millennia

An 18-year-old man is scheduled to make a court appearance on Tuesday, after being charged by the OPP with attempted murder and aggravated assault on a 16-year-old female victim. The charges follow a violent incident in Cobalt, Ont., on Nov 3.

LAFC opened the series with a narrow 2-1 victory in California and Vancouver replied with a decisive 3-0 win at home to set up a do-or-die matchup on Friday, but they failed to overcome L.A. and suffered a 1-0 defeat.

A Saskatoon woman is accused of damaging multiple vehicles and assaulting a man with a baseball bat on Nov. 11.

A blaze at an apartment building has displaced residents and led to two injuries, almost two years after a fire at the same building displaced dozens.

Several firearms, body armour, diamonds and fentanyl shaped like dog treats were among the items seized in a recent bust, say Metro Vancouver Transit Police.

"It's just like a big blur. It doesn't seem real," says the mother of 16-year-old Kaylie Smith.

The Edmonton Oilers may have found the break they were looking for. After struggling through the first month of the NHL season, the Oilers trounced the Vancouver Canucks 7-3 on Saturday.

One person is dead after a motorcycle and an SUV collided in Mount Albert, Ont., on Monday, Ontario Provincial Police say.

U.K. operation reduces design time, designs better products by switching from 2D drawings to 3D CAD

With a team of 6 people, OM Peru recently went on an outreach to an area called Alto Piura.

The Penn State Behrend women’s bowling team won two matches against D’Youville on Oct. 26. The Lions lost the Baker-format match, 1-4.

WILMINGTON – Delaware’s Ferris School has been selected as finalist for the 2021 PbS Barbara Allen-Hagen Award in the juvenile correction program category. This prestigious annual award, through the national continuous improvement program Performance-based Standards (PbS), is given in three categories: correction, detention, and community residential programs. Programs are recognized based on practices that exemplify […]

The film will release on November 14

From highly-anticipated blockbusters to critically acclaimed indie darlings, our comprehensive guide has got you covered

Shraddha dropped a string of sweaty face and head slamming emojis

Members will submit recommendations to the Governor, Legislature and Criminal Justice Council by March 2018 WILMINGTON, Del. – Governor John Carney on Wednesday released the following statement after signing Executive Order #11 to reestablish the Juvenile Justice Advisory Group, which will examine ways to prevent youth from entering or re-entering the juvenile and criminal justice […]

DNREC's proposed user fees for Deauville Beach have been approved by the Parks and Recreation Council and DNREC Secretary Shawn M. Garvin. A daily entrance fee or a Deauville annual pass will be required for use of the beach from Memorial Day weekend though Nov. 30 in 2024. Deauville Beach annual passes will be available for sale starting Wednesday, May 15.

A man was on Monday arrested for driving his car, a Mahindra Thar, on a railway track in Rajasthan's Jaipur. The man, said to be drunk, had taken his SUV on to railway tracks to shoot a reel for social media.

I'm trying to simulate a practice code . Verilog verification of my code do not give any error.But when I try to elaborate, this error is being showed:

ncelab: *E,CUVHNF (./FSM_test.v,17|20): Hierarchical name component lookup failed at 'l'

What does this mean? How can I debug this error ? Is there any archive or list of possible error list so that I don't have to ask in forum to understand the errors. 

Hi,

Do anyone know if it's possible in simvision waveform viewer to see a timestamp of where uvm_errors/$errors occurred in a simulation via post-processing? 

Cheers,

Antonio

Hello,

I have been running this `uvm_reg_hw_reset_seq` sequence for the AHB protocol. My UVM Adapter looks like:

Issue: When I use basic reg.write, my write access are working well, as that is managed by the driver i.e. once adapter gives the packet to the driver, the driver supplies the address and the control signals to the DUT on the first clock cycle and then the write data on the next clock cycle. But when I am performing the read operation, somehow the UVM adapter is reading the data at the same clock cycle where read address + Controls are supplied and this is triggering read failure messages from the `uvm_reg_hw_reset_seq` sequence. What should I modify in the driver/sequencer/adapter so that the UVM adapter can read the data on the next cycle instead of the same clock cycle.

Just FYI: The waveforms of the read operation are correct, it is just the Adapter and the `uvm_reg_hw_reset_seq`. The AHB Driver + AHB Monitor is fully proven and verified to be working correctly.

Hello,

I am aware of command script .svcf file that saves signals and loads them in while opening Simvision.

I am wondering, if there is a way for saving signals while we are in an interactive session and loading them next time when we open Simvision interactively.

Any ideas on how to do this?

Thank you in advance.

Swetha. C

I am running simulation in gui mode using Indago and every time there is UVM_ERROR occur simulation stops. I have to resume it manually. is there any way to disable this feature. 

Jeep Wrangler sets the bar for off-roading capability Larger Ford Bronco has a more modern suspension Both SUVs have removable doors and tops When Ford relaunched the Bronco for the 2021 model year, it had one target in its sights: The Jeep Wrangler. The Wrangler has been the American benchmark for off-roading capability in the 80-plus years since...