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Cops arrest three linked to taxi violence murders in EC




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‘The need for a strong and decisive response has never been greater’: Tourism operators on taxi patroller extortion




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WATCH: Police arrest taxi hitmen at Mall of Africa




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WANTED: Police are looking for man allegedly linked to the murder of Fredville Taxi Association chairperson




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Police crack down on taxi-related murders in East London




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Court delays R26 million tax fraud case against Duma ka Ndlovu




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Viewpoints: Is Tax Avoidance Destroying America?

Why don't the rich pay their fair share in taxes?




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BIR to monitor online sellers' tax compliance during holiday season

MANILA, Philippines – The Bureau of Internal Revenue (BIR) will closely monitor the tax compliance of online marketplaces and online sellers during the holiday season, Commissioner Romeo Lumagui Jr. has said. In a statement Wednesday, Lumagui warned that online businesses violating tax laws would be blocked. Section 115 of the National Internal Revenue Code, as […]...

Keep on reading: BIR to monitor online sellers' tax compliance during holiday season




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Corporate taxpayers frustrated with Sars over delays, aggressive penalties

Half of the participants in the Taxing Times survey still find compliance with tax obligations difficult





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How a ride in a friendly Waymo saw me fall for robotaxis

I have a confession to make. After taking a handful of autonomous taxi rides, I have gone from a hater to a friend of robot cars in just a few weeks, says Annalee Newitz




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Poverty May Tax Thinking Skills

Title: Poverty May Tax Thinking Skills
Category: Health News
Created: 8/29/2013 2:35:00 PM
Last Editorial Review: 8/30/2013 12:00:00 AM




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Factors Influencing the Central Nervous System (CNS) Distribution of the Ataxia Telangiectasia Mutated and Rad3-Related Inhibitor Elimusertib (BAY1895344): Implications for the Treatment of CNS Tumors [Metabolism, Transport, and Pharmacogenetics]

Glioblastoma (GBM) is a disease of the whole brain, with infiltrative tumor cells protected by an intact blood-brain barrier (BBB). GBM has a poor prognosis despite aggressive treatment, in part due to the lack of adequate drug permeability at the BBB. Standard of care GBM therapies include radiation and cytotoxic chemotherapy that lead to DNA damage. Subsequent activation of DNA damage response (DDR) pathways can induce resistance. Various DDR inhibitors, targeting the key regulators of these pathways such as ataxia telangiectasia mutated and Rad3-related (ATR), are being explored as radio- and chemosensitizers. Elimusertib, a novel ATR kinase inhibitor, can prevent repair of damaged DNA, increasing efficacy of DNA-damaging cytotoxic therapies. Robust synergy was observed in vitro when elimusertib was combined with the DNA-damaging agent temozolomide; however, we did not observe improvement with this combination in in vivo efficacy studies in GBM orthotopic tumor-bearing mice. This in vitro–in vivo disconnect was explored to understand factors influencing central nervous system (CNS) distribution of elimusertib and reasons for lack of efficacy. We observed that elimusertib is rapidly cleared from systemic circulation in mice and would not maintain adequate exposure in the CNS for efficacious combination therapy with temozolomide. CNS distribution of elimusertib is partially limited by P-glycoprotein efflux at the BBB, and high binding to CNS tissues leads to low levels of pharmacologically active (unbound) drug in the brain. Acknowledging the potential for interspecies differences in pharmacokinetics, these data suggest that clinical translation of elimusertib in combination with temozolomide for treatment of GBM may be limited.

SIGNIFICANCE STATEMENT

This study examined the disconnect between the in vitro synergy and in vivo efficacy of elimusertib/temozolomide combination therapy by exploring systemic and central nervous system (CNS) distributional pharmacokinetics. Results indicate that the lack of improvement in in vivo efficacy in glioblastoma (GBM) patient-derived xenograft (PDX) models could be attributed to inadequate exposure of pharmacologically active drug concentrations in the CNS. These observations can guide further exploration of elimusertib for the treatment of GBM or other CNS tumors.




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ITPR1-associated spinocerebellar ataxia with craniofacial features--additional evidence for germline mosaicism [RESEARCH ARTICLE]

Inositol 1,4,5-triphosphate receptor type 1 (ITPR1) is an endoplasmic reticulum–bound intracellular inositol triphosphate receptor involved in the regulation of intracellular calcium. Pathogenic variants in ITPR1 are associated with spinocerebellar ataxia (SCA) types 15/16 and 29 and have recently been implicated in a facial microsomia syndrome. In this report, we present a family with three affected individuals found to have a heterozygous missense c.800C > T (predicted p.Thr267Met) who present clinically with a SCA29-like syndrome. All three individuals presented with varying degrees of ataxia, developmental delay, and apparent intellectual disability, as well as craniofacial involvement—an uncommon finding in patients with SCA29. The variant was identified using clinical exome sequencing and validated with Sanger sequencing. It is presumed to be inherited via parental germline mosaicism. We present our findings to provide additional evidence for germline mosaic inheritance of SCA29, as well as to expand the clinical phenotype of the syndrome.





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Taxman joins gold rush

The Bank of Mum and Dad has been a major sponsor of Olympic athletes for more than a century, but may be about to be superseded.




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Sega are delisting over 60 'classic' games from Steam, including Crazy Taxi and Streets Of Rage

Sega are delisting several bundles of 'classic' games from digital stores, along with "select individual" games. On Steam specifically, this adds up to over 60 games in total, including several actual classics including the original Streets Of Rage trilogy, Crazy Taxi, and Jet Set Radio.

The games will be removed on December 6th but will remain playable to those who already own them.

Read more




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BBC Morning Live expert gives 'double tax' warning on new Labour pensions raid



Finance guru Laura Pomfret explained how changes to inheritance tax in the budget may hit people in a way they hadn't realised




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What the new tax year means for your finances - from income to ISAs



Benefit increases, new investment opportunities, and several tax changes are due to come into effect in April.




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Elon Musk's Tesla Cybercab is a hollow promise of a robotaxi future

Autonomous taxis are already operating on US streets, while Elon Musk has spent years promising a self-driving car and failing to deliver. The newly announced Tesla Cybercab is unlikely to change that




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How a ride in a friendly Waymo saw me fall for robotaxis

I have a confession to make. After taking a handful of autonomous taxi rides, I have gone from a hater to a friend of robot cars in just a few weeks, says Annalee Newitz




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Top 9 Mistakes to Avoid When Filing Your Swiss Tax Return

Filing your Swiss tax return can be a complicated process, especially if you aren’t aware of the common pitfalls. Mistakes are easy to make and can result in delays, additional fees, or even penalties. Getting the details right will help you save time and avoid unnecessary issues. This article outlines the top mistakes to avoid […]

The post Top 9 Mistakes to Avoid When Filing Your Swiss Tax Return appeared first on Chart Attack.




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Former U.S. commerce secretary says he 'can't imagine' Trump would tax Canadian energy

Donald Trump's former commerce secretary says he 'can't imagine' the U.S. president-elect would want to tax Canadian energy, despite campaign promises about imposing a global tariff when he takes office in January.




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Europe’s Carbon Border Tax Advances the Fight Against Climate Change

At first glance, the European Union’s Carbon Border Adjustment Mechanism may look like a potential source of international discord. But a closer look suggests that the EU’s strict carbon-pricing regime may be the best chance the world has to achieve the Paris climate agreement’s ambitious emissions-reduction goals.






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Income Tax Act Revamp: An Introduction

The Committee for Comprehensive Review of the Income Tax Act, 1961 has been now formed under the chairmanship of Mr V K Gupta, Chief Commissioner of Income Tax.




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Key actions - businesses can take to adjust their tax liabilities before the final deadline

Businesses can adjust their tax liabilities by issuing credit notes to adjust output tax liabilities, claiming unclaimed ITC and correcting any errors or omissions in GSTR-1 and GSTR-3B.<




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LONG TERM CAPITAL GAIN TAX REG

I AM AN INDIVIDUAL AND TATA MOTORS A ORDINARY SHARES DEMERGER WITH TATA MOTORS LTD AND THEY GIVE DEEMED DIVIDEND AMOUNT OF Rs.59000/FOR 200 SHARES AND ALSO THEY GIVE CONSIDERATION AMOUNT FOR THE SAID SHARES Rs.229000/ AFTER DEDUCTING DEEMED DIVIDEND BALANCE AMOUNT OF Rs.179000/ TO BE TREATED AS LON




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CA Intermediate Taxation Question Paper New Course September 2024

Download CA Intermediate Taxation Question Papers New Course Sep 2024 in PDF. For other question papers of CA Inter May 2024, Nov 2023, May 2023, Nov 2022, May 2022, Dec 2021, July 2021, Nov 2020, Nov 2019, May 2019, Nov 18, May 2018, Nov 2017, Nov 2016, May 2016, May 17, may 2016, CA IPC Nov 2015, CA IPC may 2015, CA IPC Nov 2014 check similar section. Previous years Taxation CA IPCC IPC question papers can also be downloaded using Search. You can also search and download may 2015 Final question papers here. We are providing ca final question papers of may 2016 for Financial Reporting FR, Advanced Financial Management AFM, Advanced Auditing and Professional Ethics, Taxation, Corporate & Allied Laws,Advanced & Management Accounting AMA, Direct Tax Laws DT, Indirect Tax Laws IDT and IPCC/IPC may 2015 question papers for Advanced Accounting , Business, Law, Ethics & Communications, Taxation, Advanced Accounting , Auditing & Assurance, Information Technology & Strategic Management ITSM.




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CA Final Direct Tax Laws and International Taxation (DT) Question Paper New Course Nov 2024

Download Direct Tax Laws & International Taxation (DT) Question Papers New Course Nov 2024 in PDF. For older question papers of CA final May 2024, Nov 2023, May 2023, Nov 2022, May 2022, Dec 2021, July 2021, Nov 2020, Nov 2019, May 2019, Nov 2018,CA final May 2018, Nov 2017, May 2017, CA final may 2016, CA final Nov 2016 check similar section. Previous years CA final Financial Reporting FR question papers can also be downloaded using Search. You can also search and download may 2015 IPCC & IPC question papers here. We are providing ca final question papers of may 2016 for Financial Reporting FR, Advanced Financial Management AFM, Advanced Auditing, Assurance And Professional Ethics, Direct Tax Laws DT, Indirect Tax Laws IDT,Integrated Business Solutions (Multidisciplinary Case Study with Strategic Management) and IPCC/IPC Nov 2023 question papers for Accounting, Business, Law, Ethics & Communications , Cost Accounting & Financial Management CAFM, Taxation, Advanced Accounting , Auditing & Assurance, Information Technology & Strategic Management ITSM.




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Assessee can avail ITC only on tax paid on services for leasing/ renting/ hiring of motor vehicles for women's safety

The AAR, Tamil Nadu in the case of M/s. CMA CGM Global Business Services (India) (P.) Ltd., In Re [Order No. 15/ARA/2024 dated July 15, 2024] ruled that an Assessee is eligible to avail input services in respect of leasing/ renting/ hiring of motor vehicles of motor vehicles to provide transportatio




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Technical Consultancy for Project Development and Management Support Services to MJP are taxable under GST at the rate of 18%

The AAR Maharashtra, in the case of M/s. The Nisarga Consultancy, In Re [Order No. GST-ARA-21 of 2023-24/2024-25/B-55 dated July 31, 2024] ruled that no tax will be leviable on work allotted by Maharashtra Jeevan Pradhikar ("MJP") as per of Jal Jeevan Mission ("JJM") which is a mission of Government




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Application of GST registration cancellation cannot be rejected based on scrutiny proceeding against Assessee for determining tax liability of past period

The Hon'ble Delhi High Court in the case of M/s Sanjay Sales India v. Principal Commissioner of Department of Trade and Taxes, Government of NCT, Delhi [Writ Petition (Civil) No. 10234 of 2024 dated July 26, 2024] held that the application for the cancellation of the GST registration cannot be denie




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Regarding Service Tax Payment.

We have taken registration number in central excise and want to pay service tax demand , however the code for that service is not available on the site then whether other duties code can be used or new registration is required??




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Tax rules for NRI

Sir,
Please advise. My son is an NRI for last 9 years. When he was in India, he was filing ITR. Now he has no income of any kind in India. Is it compulsory now to file nil tax returns in India, as he has not filing any return. Thanks for early reply.
He is holding Indian passport




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CPC Processing IT Return for AY 2023-24 without recognizing the Taxation Option under New Regime

My ITR3 for AY 2023-24 has been processed by CPC under OLD REGIME without recognizing the Taxation Option exercised undersection 115BAC for NEW REGIME by filing FORM 10IE during AY 2022-23 on 01-Jun-2022, which has been CONTINUED for AY 2023-24, as EVIDENT in the ITR3 filed for this Assessment Year. I have also Registered my grievance in this regard in the e-portal of the IT Department and have sought RECTIFICATION FIVE TIMES under Section 154 but have got the same RECTIFICATION ORDER repeating the same MISTAKE with processing done under OLD REGIME with TAX DEMAND of Rs.87,000. (Similar thing had happened in AY 2022-23 but it was corrected by RECTIFICATION). I am in continuous correspondence through email and written communication several times with the Department, including grievances raised on E-PORTAL, but the issue remains UNRESOLVED. I have also registered my grievance in this regard in CPGRAMS Portal of GOI which is pending.
I request advice on further course of action to resolve the issue including as to whether i can file an Appeal under Section 264 .
G S Prakash




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CII Urges Tax Reforms and Increased Capital Investment in Union Budget 2025-26

In a pre-Budget meeting with Revenue Secretary Sanjay Malhotra, the Confederation of Indian Industry (CII) urged the government to continue tax reforms and boost capital expenditure in the Union Budget for 2025-26....




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Centre Likely to Retain Direct Tax Revenue Estimates in Revised Projections

As per sources within the Finance Ministry, the Centre is likely to maintain its original budgeted estimate of ₹22.07 lakh crore for direct tax collection when it revises estimates in February. ...




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Income Tax Department Cracks Down on Bogus Refund Claims, Sends Notices to Taxpayers

The Income Tax Department has intensified scrutiny on dubious tax refund claims for the assessment years 2021-22 and 2022-23, issuing notices to multiple taxpayers across the country. ...




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How many farms will be affected by Budget tax rises?

Estimates of the number of farms affected range from 100 to 70,000.




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Wales pushes ahead with tourism tax plans

New law would allow councils to charge tourists to stay overnight in Welsh hotels.




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Musk promises self-driving Tesla taxis, but are they safe?

BBC Tech Correspondent Lily Jamali analyses the 'robocabs' and if their technology is up to par.




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Blade Runner 2049 maker sues Musk over robotaxi images

Alcon Entertainment says it denied a request to use material from the film at the Tesla cybercab event.




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Tax-News.com: COVID-19: Philippines Further Extends Multiple Tax Deadlines

The Philippines has announced that it will again extend tax filing and payment deadlines, following the prolongation of restrictive measures during the coronavirus outbreak.




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Tax-News.com: Philippines Moots Digital Tax

A proposal has been put forward for a digital services tax regime in the Philippines.




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Tax-News.com: India Announces More COVID-19 Measures

On May 13, 2020, the Indian Government announced new tax relief measures and administrative concessions.




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Tax-News.com: India Hikes Threshold For Country-by-Country Reporting

India has enacted legislation to hike the turnover threshold for filing a country-by-country report.




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Tax-News.com: COVID-19: UK Extends Deadlines For Input On Tax Reforms

The UK tax agency has extended various deadlines for responses to consultations and for other work on tax reform, in light of COVID-19.




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Tax-News.com: Russia To Terminate Cyprus Double Tax Agreement

The Russian Ministry of Finance has announced that it will seek to terminate the country's double tax agreement with Cyprus, after negotiations broke down on a revision to increase tax on cross-border dividends and interest income.