House Speaker Nancy Pelosi (D-CA) in an interview with MSNBC called the New York Times report on President Trump taxes a question of “national security issues,” citing owed money to foreign interests. In an interview with MSNBC host Andrea Mitchell, Pelosi sounded the alarm that foreign governments might have “leverage” on the president due to […]

The post Pelosi says Trump’s Taxes Are a ‘National Security’ Issue appeared first on Hispolitica.

The molecular mechanisms of reduced frataxin (FXN) expression in Friedreich's ataxia (FRDA) are linked to epigenetic modification of the FXN locus caused by the disease-associated GAA expansion. Here, we identify that SUV4-20 histone methyltransferases, specifically SUV4-20 H1, play an important role in the regulation of FXN expression and represent a novel therapeutic target. Using a human FXN–GAA–Luciferase repeat expansion genomic DNA reporter model of FRDA, we screened the Structural Genomics Consortium epigenetic probe collection. We found that pharmacological inhibition of the SUV4-20 methyltransferases by the tool compound A-196 increased the expression of FXN by ∼1.5-fold in the reporter cell line. In several FRDA cell lines and patient-derived primary peripheral blood mononuclear cells, A-196 increased FXN expression by up to 2-fold, an effect not seen in WT cells. SUV4-20 inhibition was accompanied by a reduction in H4K20me2 and H4K20me3 and an increase in H4K20me1, but only modest (1.4–7.8%) perturbation in genome-wide expression was observed. Finally, based on the structural activity relationship and crystal structure of A-196, novel small molecule A-196 analogs were synthesized and shown to give a 20-fold increase in potency for increasing FXN expression. Overall, our results suggest that histone methylation is important in the regulation of FXN expression and highlight SUV4-20 H1 as a potential novel therapeutic target for FRDA.

Nuclear, gas and green finance taxonomies in the EU and UK 23 February 2022 — 10:00AM TO 11:00AM Anonymous (not verified) 20 January 2022 Online

Experts discuss EU, UK, and international perspectives on green taxonomy.

This event will address the controversial additions to the EU green finance taxonomy, including the labelling of some nuclear and gas power sources as “green”. Hear perspectives from the UK, EU and international experts.

The UK has committed to creating a green taxonomy to provide a shared understanding of which economic activities count as sustainable. It should be robust and evidence-based, taking an objective and science-based approach to assessing sustainability.

Technical Screening Criteria (TSCs) for the climate change mitigation, and climate change adaptation objectives within the UK green taxonomy will be based on those in the EU Taxonomy. The Government is currently reviewing these and expects to consult on UK draft TSCs in the first quarter of 2022, ahead of legislating by the end of 2022.

In recent weeks the European Commission has proposed controversial additional TSCs for the EU taxonomy, most notably the inclusion of nuclear and natural gas in power generation, which are currently being discussed by Member States and the European Parliament.

The inclusion of controversial power sources not only risks affecting investment and deployment patterns in the net-zero transition, but may also be a threat to the authority of the taxonomy as a whole

Key questions for the UK now include whether and how to address these issues in its own taxonomy, and how to promote a science-based ‘race to the top’ between jurisdictions that can lead to robust international standards.

This Environment and Society Discussion Series event brings expert voices together to discuss EU, UK, and international perspectives, and is co-organized with E3G.

Frederic Heihoff
Proc. Amer. Math. Soc. 152 (), 5229-5247.
Abstract, references and article information

NSun2 is an RNA methyltransferase introducing 5-methylcytosine into tRNAs, mRNAs, and noncoding RNAs, thereby influencing the levels or function of these RNAs. Autotaxin (ATX) is a secreted glycoprotein and is recognized as a key factor in converting lysophosphatidylcholine into lysophosphatidic acid (LPA). The ATX-LPA axis exerts multiple biological effects in cell survival, migration, proliferation, and differentiation. Here, we show that NSun2 is involved in the regulation of cell migration through methylating ATX mRNA. In the human glioma cell line U87, knockdown of NSun2 decreased ATX protein levels, whereas overexpression of NSun2 elevated ATX protein levels. However, neither overexpression nor knockdown of NSun2 altered ATX mRNA levels. Further studies revealed that NSun2 methylated the 3'-UTR of ATX mRNA at cytosine 2756 in vitro and in vivo. Methylation by NSun2 enhanced ATX mRNA translation. In addition, NSun2-mediated 5-methylcytosine methylation promoted the export of ATX mRNA from nucleus to cytoplasm in an ALYREF-dependent manner. Knockdown of NSun2 suppressed the migration of U87 cells, which was rescued by the addition of LPA. In summary, we identify NSun2-mediated methylation of ATX mRNA as a novel mechanism in the regulation of ATX.

When the drug Taxol® was approved by the United States Food and Drug Administration in 1993, it was a game changer for cancer patients. The compound, which arrests cell division by preventing the disassembly of tubulin microfibers, has been used over the past three decades to treat millions of cases of breast, lung, and ovarian cancer as well as Kaposi's sarcoma. In 1990, Bristol Myers Squibb applied to trademark the name Taxol, which was approved in 1992, changing the drug's generic name to paclitaxel.At the time that Taxol was entering clinical trials in the late 1970s, it also proved to be a valuable tool for cytoskeletal research. Tubulin had been discovered in the late 1960s, but it was still unclear how the soluble protein dimer polymerized (Fig. 1) to form the long, complex structures of the cytoskeleton.jbc;295/41/13994/F1F1F1Figure 1.Strands of tubulin, a protein in the cell's skeleton, photographed using a high-resolution microscopy technique. Image made by Pakorn Kanchanawong (National University of Singapore) and Clare Waterman (NHLBI, National Institutes of Health).“Back then, people were just discovering the most basic functions of tubulin and how it polymerized, and then they found a drug that affected this,” said Velia Fowler, a cell biologist at the University of Delaware and former Associate Editor at the Journal of Biological Chemistry.The drug and its cytoskeletal activity intersected in the 1981 JBC paper “Taxol-induced polymerization of purified tubulin” (1), the subject of this JBC Classic. In the single-author paper, Nirbhay Kumar, then a postdoctoral fellow at the National...

Recent efforts in gut microbiome studies have highlighted the importance of explicitly describing the ecological processes beyond correlative analysis. However, we are still at the early stage of understanding the organizational principles of the gut ecosystem, partially because of the limited information provided by currently used analytical tools in ecological modeling practices. Proteomics and metaproteomics can provide a number of insights for ecological studies, including biomass, matter and energy flow, and functional diversity. In this Mini Review, we discuss proteomics and metaproteomics-based experimental strategies that can contribute to studying the ecology, in particular at the mucosal-luminal interface (MLI) where the direct host-microbiome interaction happens. These strategies include isolation protocols for different MLI components, enrichment methods to obtain designated array of proteins, probing for specific pathways, and isotopic labeling for tracking nutrient flow. Integration of these technologies can generate spatiotemporal and site-specific biological information that supports mathematical modeling of the ecosystem at the MLI.

Glycosylation is a highly diverse set of co- and post-translational modification of proteins. For mammalian glycoproteins, glycosylation is often site-, tissue- and species-specific, and diversified by microheterogeneity. Multitudinous biochemical, cellular, physiological and organismic effects of their glycans have been revealed, either intrinsic to the carrier proteins or mediated by endogenous reader proteins with carbohydrate recognition domains. Furthermore, glycans frequently form the first line of access by or defense from foreign invaders, and new roles for nucleocytoplasmic glycosylation are blossoming. We now know enough to conclude that the same general principles apply in invertebrate animals and unicellular eukaryotes – different branches of which spawned the plants or fungi and animals. The two major driving forces for exploring the glycomes of invertebrates and protists are (i) to understand the biochemical basis of glycan-driven biology in these organisms, especially of pathogens, and (ii) to uncover the evolutionary relationships between glycans, their biosynthetic enzyme genes, and biological functions for new glycobiological insights. With an emphasis on emerging areas of protist glycobiology, here we offer an overview of glycan diversity and evolution, to promote future access to this treasure trove of glycobiological processes.

Congress is voting on a bill Tuesday that will empower the executive branch to remove the tax-exempt status from any nonprofit it deems to be supporting terrorists.

Montana's highest court has struck down a tuition tax-credit program which, as enacted by that state's legislature, allowed tuition scholarships to benefit students at private religious schools as well as secular schools.

The U.S. Supreme Court agreed to review a decision by Montana's highest court that struck down a tuition tax-credit program allowing tuition scholarships to benefit students at private religious schools.

The justices ruled 5-4 that a Montana state constitutional provision barring aid to religion discriminated against religious schools and families seeking to benefit from a tax credit for donations for scholarships.

The 5-4 decision involving a dispute in Montana appears to cast doubt on as many as 30 state constitutions that bar aid to religious schools.

Two lawsuits were filed Monday challenging a proposition that Arizona voters approved to impose an additional 3.5% tax on individuals earning above $250,000 to pay school teacher salaries and training.

Washington lawmakers last week reached a deal to lift the state's "levy lid," blunting tighter limits on voter-approved local taxes for schools that were set to take effect this year. Gov. Jay Inslee, a Democrat, was expected to sign the legislation that Republicans had criticized.

The court declined to take up an appeal backed by school groups of a ruling allowing some property taxpayers challenge their assessments in federal court.

No one was injured in the blast, and authorities are investigating why the ordnance detonated after so many years underground

Windsor's push to tax people that own houses that sit empty in a city dealing with an affordable housing crunch has led to some surprising early results.

Toronto's redesigned vacant home tax rollout has begun, with over 59,000 people filing their paperwork in the first week. Some councillors say they were left responding to complaints about the rollout, after the city's online declaration portal experienced technical problems shortly after launch.

The Ontario Liberal Party is pledging to reduce the income tax rate for middle class families and eliminate provincial sales tax on hydro bills, if they win in the 2026 election.

Donald Trump's victory in the 2024 US presidential election is likely to usher in a raft of economic changes at home and abroad, touching everything from foreign trade to the independence of the US central bank.

SA's tax ombud has had "informal discussions" with its counterpart in Australia over combating refund scams as it investigates the hijacking of eFiling profiles.

Minister of Communications and Digital Technologies Solly Malatsi has said his department will look into scrapping luxury tax on smartphones.

National Treasury has said it is considering a wealth tax on high-net-worth individuals to boost government revenue.

Explosives, chemicals and fertiliser group Omnia reported a 17% surge in interim operating profit on Monday thanks largely to standout performances from its mining segment and its South African agriculture business.

The version of the tax bill passed by the Republican-led Senate would double the amount teachers can deduct for classroom supplies.

SARS continues to deny amaBhungane and the Financial Mail's requests for access to former president Jacob Zuma's tax records despite the seminal judgment of the Constitutional Court handed down in May 2023.

Kenya plans to re-introduce some of the tax hikes that sparked deadly protests earlier this year, the government announced Friday, while a new deputy president was sworn in after weeks of drama.

Nov 6 - With Donald Trump heading back to the White House, Wall Street is anticipating the potential for lower taxes, deregulation and a U.S. president who is quick to sound off on everything from the stock market to the dollar. Trump made tariffs a

One small prayer for a taxi leads to a divine encounter.

The LIHTC was created in 1986 to encourage private/public investment to preserve and construct affordable rental housing nationwide. Alone and combined with tax-exempt private activity bonds, the LIHTC has been the most productive source of affordable housing financing in the nation's history. 

DOVER, DE— Veterans with a 100 percent disability rating may be eligible for a tax credit against 100 percent of non-vocational school district property tax. House Bill 214 with House Amendment 1, which was signed into law by Governor John Carney on August 10th, 2021, allows school districts to grant a Disabled Veterans School Property […]

All 50 states reach agreement with Intuit for deceiving low-income Americans into paying for free tax services Attorney General Kathy Jennings today secured over $400,000 for low-income Delawareans from the owner of TurboTax, Intuit Inc. (Intuit), for deceiving Delaware consumers into paying for tax services that should have been free. As a result of a […]

Two Delaware women have been sentenced to probation and suspended prison time for tax-related crimes after falsely claiming thousands of dollars in itemized deductions on their tax returns and submitting falsified documents during their respective audits. The cases represent the first prosecutions brought under the new initiative between the Department of Justice and the Department of Finance targeting state tax fraud “These convictions are the result of great work by our prosecutors and our […]

Division of Revenue Director David Gregor has announced that Delaware tax season filing deadline this year is Monday, May 1, 2017. Citizens are encouraged to file their 2016 State of Delaware Personal Income Taxes or file an extension to Monday, October 16, 2017 by using our online services at www.delaware.gov.

Division of Revenue Director Jennifer R. Hudson has announced that the Delaware individual income tax season will begin on Monday, January 29, 2018, concurrently with the opening of the federal individual tax season announced by the IRS. While this is slightly later than previous years, the January 29 date was set to ensure the security […]

The Delaware Division of Revenue would like to alert taxpayers to a new and growing scam involving fraudulent tax refunds being deposited into real taxpayer bank accounts. After the money is deposited, the crooks use various tactics to con taxpayers into turning over those funds. How does it work? Thieves are using schemes, including phishing, […]

Getting Tax Credit for Your Employees Just Got Easier: Introducing the New Delaware CertLink Delaware Businesses can receive up to $9,600 in tax credits per employee for hiring members of target groups by visiting the newly updated Delaware CertLink, located at https://certlink.delaware.gov/ Many businesses have struggled as a result of the ongoing pandemic and finding ways […]

  FOR IMMEDIATE RELEASE   WILMINGTON, DE – The Delaware Department of Labor (DOL) is announcing the new Employer Unemployment Insurance and new Construction employer tax rates for 2022, effective January 1, 2022. New Employer and new Construction employer rates are maintained at 2020 levels Establish 2022 merit rate at lower of 2020, 2021, or […]

WILMINGTON, DE – The Delaware Department of Labor (DOL) announced the revised Taxable Wage Base, Assessment Rate Tables, Cap Earned Rate for Calendar Year 2023, and the New Employer Rates for 2023, effective January 1, 2023. The taxable wage base will be $10,500 in 2023. With the unanimous support of the Unemployment Insurance Advisory Council, […]

The Division of Unemployment Insurance (UI) recently mailed 2024 UI tax rate letters that contained incorrect information. We apologize for the error. We are working to correct the issue and will mail new letters with the correct rate as quickly as possible. All employers will receive updated letters even if their rate does not change. […]

The Division of Unemployment Insurance has corrected the issue related to the 2024 UI tax rate letters mailed in January. Corrected letters have been mailed to employers the week of February 5, 2024. The corrected letters have a date of February 1, 2024. The Division of Unemployment would like to thank all employers for their […]

The Delaware Division of Revenue is warning the public of a new tax scam that’s happening in Delaware. Victims receive a letter from the “Tax Processing Unit” that threatens property seizure and wage garnishment unless the victim calls a toll-free number to “avoid enforcement.”

MONEY MATCH is One of Several Ongoing Initiatives to Increase the Return of Unclaimed Property to Owners The second week of September means it is time for back-to-school, pumpkin spice lattes, football, cool fall weather, and the State of Delaware’s annual MONEY MATCH check program. This week, the Delaware Office of Unclaimed Property will return […]

Hi everyone,

I'm new to using Innovus and I'm encountering an issue while trying to perform the "init_design" command. My goal is to perform the place and route. Here are the commands I'm using:

``
set init_verilog ./test.v
set init_top_cell TEST
set init_pwr_net {VDD VDD_2 VDD_3}
set init_gnd_net {VSS VSSA}
set init_lef_file { /home/laumecha/uw_openroad_free45/pdk/Drexel-ECEC575/Encounter/NangateOpenCellLibrary/Back_End/lef/NangateOpenCellLibrary.lef}
set init_mmmc_file {./viewDefinition.tcl}
init_design
```

However, I receive the following error:

```
#% Begin Load netlist data ... (date=06/04 12:07:50, mem=1478.7M)
*** Begin netlist parsing (mem=1439.0M) ***
Created 0 new cells from 0 timing libraries.
Reading netlist ...
Backslashed names will retain backslash and a trailing blank character.
**ERROR: (IMPVL-209):   In Verilog file './test.v', check line 16 near the text # for the issue: 'syntax error'.  Update the text accordingly.
Type 'man IMPVL-209' for more detail.
Verilog file './test.v' has errors!  See above.

*** Memory Usage v#1 (Current mem = 1439.027M, initial mem = 634.098M) ***
#% End Load netlist data ... (date=06/04 12:07:50, total cpu=0:00:00.0, real=0:00:00.0, peak res=1478.7M, current mem=1478.7M)
**ERROR: (IMPVL-902):   Failed to read netlist ./test.v. See previous error messages for details.  Resolve the issues and reload the design.
```

However, the file works perfectly in Genus.

It seems there is a syntax error in my Verilog file at line 16, but I'm not sure how to resolve it. Any guidance or suggestions would be greatly appreciated.

Thanks in advance!

On top of EU access, an impressive quality of life, talented labour and a thriving tourism sector, Madeira offers a white-listed preferential tax regime that is conducive to long-term, productive investments. Sebastian Shehadi reports.

Good news for games developers: the Australian Government is introducing a 30% tax offset for local and international businesses that develop digital games in Australia.

The Nigerian Guild of Editors has called on the Federal Government to urgently mitigate the negative impact of fuel subsidy removal and the exchange rate volatility on the economy. Arising from a three-day All Nigeria Editors Conference in Yenagoa, the Bayelsa State capital, the body noted the economic constraints and rising operational costs. It, therefore,