The National Museum of Bermuda [NMB] is hosting three Artist Talks as part of the Bermuda Tourism Authority’s [BTA] Bermuda Art Month, which spans the month of October this year. A spokesperson said, “On Thursday, October 3 at 10am, join Lisa Howie, Co-Curator of NMB’s Alternative Voices: A Perspective on Contemporary Art from the Azores […]

Trinidadian soca superstar Destra Garcia, known for her electrifying performances and boundary-pushing music, spoke to us exclusively about her love for soca, her diverse heritage, and her return to Bermuda for “Soca in the City”, happening on Saturday, June 15. A Special Connection With Bermuda Destra’s connection with Bermuda is not just about the performances […]

When widespread looting and disorder arrived, the president did not act as decisively as many had hoped. He said little, he did less. Some voters felt undefended, some turned against him. Continue reading →

In the latest episode of their intrepid podcast, Ken and Robin talk Sense Trouble, fatbergs, William Stephenson, and doomsday predictor Albert Porta.

In the latest episode of their planchette-moving podcast, Ken and Robin talk historical isms, a man in a barrel, unsolicited seeds, and Ouija board inventor Elijah Bond.

In the latest episode of their dark and stormy podcast, Ken and Robin talk Gothic F20, Elon Musk's pig brain implants, and a contactless edition of Ken's Bookshelf.

Deion Sanders discusses the impressive growth of Shedeur Sanders from last season to this year, highlighting his development as Colorado’s QB and the strides he’s made on the field.

Shares of the company were down 39% at $1.8 after the bell. The stock has fallen nearly 80% this year, while the S&P 500 passenger airlines index jumped 52%. The ultra-low cost carrier is in advanced discussions with bondholders to hammer out a bankruptcy plan that would have support from a…

The European company had acquired Grubhub in 2020 in an all-stock deal for $7.8 billion, creating the world’s largest food delivery company outside China at the time. A deal for Grubhub could be finalized imminently, assuming the talks do not fall apart, the report said, adding that Grubhub is…

Convenience store operator receives rival buyout offer from members of founding family

I'm dreading the day when I have to explain to my children what a LOLcat was.

I’ve developed a survey to give to people who slipped me into their not-friend category. Since I’m a person with no ability to cope with nuance, answers to all questions are yes/no. 1. Were you ever my real friend?  I want to know if you needed me like I needed you, but I don’t want […]

The post Questionnaire for everyone who stopped talking to me appeared first on Penelope Trunk Careers.

As the James Webb Space Telescope delights stargazers with breathtaking images and groundbreaking discoveries, we connected with Princeton astrophysics luminaries Gillian “Jill” Knapp and Neta Bahcall, both contributors to a new book by women astronomers.

Conversation with emerging writer, art critic, curator and Princeton alum Simon Wu ’17 as he discusses his new book, Dancing on My Own, with Monica Youn ’93, Visiting Professor of Creative Writing. Followed by a book signing and reception. Current Princeton students can register to join writer and art curator Simon Wu ‘17 for a private dinner and career conversation from 4:30-5:30 PM.

What was the Versace’s Spring 2018 show like? If you did not have the time to see or attend the show, Helena Christensen and ’90s supermodels such as Claudia Schiffer, Cindy Crawford, Carla Bruni and Naomi Campbell walked the runway together in the honor to founder of Versace brand, Gianna Versace. Helena Christensen did not ... Read more

The post Talk with Helena Christensen appeared first on Star Two.

The following article, Pre-Election Pep Talk from Kevin Jackson – Part I, was first published on The Black Sphere.

I want to level-set about the next few days and remind Conservatives to start preparing for a big win.

Continue reading Pre-Election Pep Talk from Kevin Jackson – Part I ...

The following article, Pre-Election Pep Talk from Kevin Jackson – Part II, was first published on The Black Sphere.

Soon Conservatives will have much to celebrate, though many still fear the outcome of the election. Thus, I am reminding America of what’s about to happen.

Continue reading Pre-Election Pep Talk from Kevin Jackson – Part II ...

President Trump on Tuesday instructed his administration to stop negotiating with House Speaker Nancy Pelosi (D-CA) on future coronavirus stimulus relief package until after the November election. In a series of four tweets, Trump called out Pelosi for not “negotiating in good faith” by wanting a $2.4 Trillion stimulus package that focuses on funding issues […]

The post Trump Halts COVID-19 Relief Bill Talks Until After Election appeared first on Hispolitica.

Iran will pursue whatever secures its interest, government spokesperson Fatemeh Mohajerani said on Tuesday, when asked if there could be direct talks with the Trump administration.

velocityconf: Who's up for a 5 minute lightning talk. Last day to get your #Ignite proposal in for #velocityconf CA. http://t.co/pzL0WJtQH5

"I realised I could sustain the writing life, whether anyone reads it or not. It’s what separates writers from civilians. It’s probably a mental disorder."

Jude Law added that people in middle age should start to reflect on their relationship patterns.

Video: Merlin Mann - "Time & Attention Talk (improvised)"

Audio (mp3): "Merlin Mann - 'Rutgers Time & Attention Talk'"

This is a talk I did at Rutgers earlier this month. I kinda like it, but for a weird reason. Something something, perfect storm of technology Ragnarok, and yadda yadda, I had to start the talk 20 minutes late with no slides. Nothing.

So, I riffed.

And, I ended up talking about a lot of the new stuff you can expect to see in the Inbox Zero book—work culture, managing expectations, the 3 deadly qualities of email, and one surprising reason email's not as much fun as Project Runway.

Some people liked it. I think. I liked it. I hope you do, too.

Here's the slides I would have shown. ;-)

Many thanks, again, to my great pal, Dr. Donald Schaffner, for bringing me in for this visit. I had a great time and met some fantastic, passionate people. Much appreciated.

update 2010-04-27_13-50-00

Apologies—my friends at Rutgers (inexplicably) have placed this video under lock and key. Fortunately, I have a lock-picker called Firefox. Samizdat video available soon...

update 2010-04-27_14-42-24

Yay, fixed! Many thanks to my hero, Jesse Schibilia.

Transatlantic Tech Talks: Cooperation or sovereignty? Audio bhorton.drupal 15 December 2021

A new mini-series from Undercurrents explores international cooperation on regulating the tech sector.

Transatlantic Tech Talks is a three part mini-series on the Undercurrents podcast feed, produced with the support of Microsoft, which explores the state of international cooperation on digital governance between the United States, the UK and Europe.

As technological innovation accelerates, and new digital tools and business models arise, governments are working to develop a framework of regulations to safeguard the rights and interests of their citizens. Not all stakeholders agree, however, on the best way to achieve this. While some advocate a ‘digital cooperation’ approach based on transparency and data-sharing, others are more concerned with maintaining ‘digital sovereignty’.

In the first episode of this series, Ben is joined by Casper Klynge, Harriet Moynihan and Marianne Schneider-Petsinger, who set out the broad context for these debates. They assess where the major government, private sector and civil society actors stand on the question of digital governance, and how they are approaching the international negotiations.

The functional mechanisms of multidomain proteins often exploit interdomain interactions, or “cross-talk.” An example is human Pin1, an essential mitotic regulator consisting of a Trp–Trp (WW) domain flexibly tethered to a peptidyl-prolyl isomerase (PPIase) domain, resulting in interdomain interactions important for Pin1 function. Substrate binding to the WW domain alters its transient contacts with the PPIase domain via means that are only partially understood. Accordingly, we have investigated Pin1 interdomain interactions using NMR paramagnetic relaxation enhancement (PRE) and molecular dynamics (MD) simulations. The PREs show that apo-Pin1 samples interdomain contacts beyond the range suggested by previous structural studies. They further show that substrate binding to the WW domain simultaneously alters interdomain separation and the internal conformation of the WW domain. A 4.5-μs all-atom MD simulation of apo-Pin1 suggests that the fluctuations of interdomain distances are correlated with fluctuations of WW domain interresidue contacts involved in substrate binding. Thus, the interdomain/WW domain conformations sampled by apo-Pin1 may already include a range of conformations appropriate for binding Pin1's numerous substrates. The proposed coupling between intra-/interdomain conformational fluctuations is a consequence of the dynamic modular architecture of Pin1. Such modular architecture is common among cell-cycle proteins; thus, the WW–PPIase domain cross-talk mechanisms of Pin1 may be relevant for their mechanisms as well.

Bone morphogenetic protein-9 (BMP-9) is a circulating cytokine that is known to play an essential role in the endothelial homeostasis and the binding of BMP-9 to the receptor activin-like kinase 1 (ALK-1) promotes endothelial cell quiescence. Previously, using an unbiased screen, we identified ALK-1 as a high-capacity receptor for low-density lipoprotein (LDL) in endothelial cells that mediates its transcytosis in a nondegradative manner. Here we examine the crosstalk between BMP-9 and LDL and how it influences their interactions with ALK-1. Treatment of endothelial cells with BMP-9 triggers the extensive endocytosis of ALK-1, and it is mediated by caveolin-1 (CAV-1) and dynamin-2 (DNM2) but not clathrin heavy chain. Knockdown of CAV-1 reduces BMP-9–mediated internalization of ALK-1, BMP-9–dependent signaling and gene expression. Similarly, treatment of endothelial cells with LDL reduces BMP-9–induced SMAD1/5 phosphorylation and gene expression and silencing of CAV-1 and DNM2 diminishes LDL-mediated ALK-1 internalization. Interestingly, BMP-9–mediated ALK-1 internalization strongly re-duces LDL transcytosis to levels seen with ALK-1 deficiency. Thus, BMP-9 levels can control cell surface levels of ALK-1, via CAV-1, to regulate both BMP-9 signaling and LDL transcytosis.

The Phillies have been the favorites in the Bryce Harper sweepstakes for months, and that speculation heated up over the weekend.

Mike Trout and owner Arte Moreno met separately with the media on Monday, but neither would confirm that extension talks have begun between the Angels and Trout's agent, Craig Landis.

ATLANTA, Nov. 7, 2024 — As the high-performance computing (HPC) community gathers in Atlanta for SC24, the world’s largest HPC conference, the event will feature presentations from thought leaders and […]

The post SC24 Invited Talks to Spotlight HPC’s Role in AI, Quantum Computing, and Sustainability appeared first on HPCwire.

We are so beholden to the 'arrow of time', moving us inevitably from the past into the future, that we hardly notice it.

In this ode to improvisation, musician and comedian Reggie Watts beatboxes, raps, loops his own rhythms and reflects upon the everyday power of turning the mundane into magic. After all, he says, we're all just making it up as we go along.

Kansas State football coach Chris Klieman talks about what the Wildcats did during the open week ahead of their home game against Arizona State.

Watch how a mother rhesus makes funny faces to her infant child to grab its attention

One week after the lockout began at B.C.'s ports, the federal labour minister is again urging the employers and the union, back to the table.

Penn State Mont Alto has announced a lineup of events for the spring semester, including the Evening Talks lecture series and planetarium programming. Events are open to the public and cover a broad range of topics, from forestry during the Civil War to the nighttime sky.

Hungarian students learn about dating, sex and marriage during a Bus4Life visit.

OM EAST shares about a significant event in the Georgian church: OM EAST’s publication of the Right Choices Bible.

Spotlight Education week continues with "Frontline" reports on for-profit colleges and a "TED Talks" special featuring a mix of education voices.

In the latest Auditor-General report, what stands out is persistent underperformance and the level of desperation in local governments. Reliance on consultants who don't solve the underlying problem is no longer sustainable, says Khaya Sithole.

Teachers in the Texas Mindset Initiative talk about how they are trying to help students learn and grow from a period of dramatic and disruptive change.