Oneida historian Heather Bruegl will discuss her Indigenous tribe's connection to the Continental Army's encampment at Valley Forge during a free community event at 7 p.m. on Nov. 12 in Penn State Great Valley's conference center. The event is part of Valley Forge Park Alliance's Speaker Series. 

Participate in a chat about how multimedia tools are transforming teaching and learning in core academic subjects.

Dubai-based airline Emirates has banned pagers and walkie-talkies onboard its planes following sabotage attacks in Lebanon, and extended flight cancellations for Middle East destinations due to regional escalation.

Eric Wicklund, co-author of "Through a Convict’s Eyes: An Overlooked View of the Criminal Justice System," will visit Penn State Fayette, The Eberly Campus at 12:15 p.m. on Oct. 29 to discuss his insights on criminal rehabilitation. He will be joined by his co-author, Lavarr McBride, who has worked in the criminal justice field for 39 years and serves as a professor of criminal justice at Penn State Fayette.

Michael Helbing, executive director of the Center for Energy Law and Policy and adjunct professor of law at Penn State, will give the talk, “Flying into the future: sustainable aviation fuel and the policies impacting its development,” at 4 p.m. on Monday, Oct. 7, in 112 Walker Building at Penn State University Park.

Elementary math specialist Kristin Gray helps her 2nd graders understand different subtraction strategies by talking through their thought processes.

What you say about the coronavirus depends on the child's developmental stage. Here are examples of the best age-appropriate language for discussing the pandemic.

Patrick Walsh, an economist at the U.S. Environmental Protection Agency, will give the talk, “Distributional Impacts of Flood Adaptation and Infrastructure Funding in New Zealand,” at noon on Wednesday, Dec. 4, in 157 Hosler Building on Penn State's University Park campus. 

Jack Kaye, associate director for research at NASA, is the speaker for the Department of Meteorology and Atmospheric Science’s colloquium scheduled for 3:30 p.m. on Wednesday, Nov. 13, in 112 Walker Building on the University Park campus. He will give the talk “Integration of Vantage Points, Programs, and Approaches for Space-Based Earth Remote Sensing.”

Lara Fowler, chief sustainability officer at Penn State, director of Penn State Sustainability, and teaching professor of law, will give the talk, “Decarbonizing Penn State: How Does Law, Policy, and Financing Fit In?” at 4 p.m. on Monday, Nov. 18, in 112 Walker Building on the University Park campus, as well as via Zoom.

The way education media and policymakers frame education debates can have longer-term effects on how the public thinks about students, and which policies they are likely to support to improve students' learning.

After a successful season of ´Generation X´, the OM Chile team decided to carry on with the activities for teenage boys living in a boys home in Santiago.

Iran will pursue whatever secures its interest, government spokesperson Fatemeh Mohajerani said on Tuesday, when asked if there could be direct talks with the Trump administration.

A New Castle man has been sentenced to life in prison following convictions in two domestic violence cases. On September 22, David Jewell, 47, was declared a habitual offender and sentenced to life in prison for convictions of felony Stalking, Harassment, and 24 counts of Terroristic Threatening, following an investigation into hundreds of violent phone calls and messages targeting two victims, one of whom was a […]

Ratan Tata, born on December 28, 1937, is the Chairman of Ratan Tata Trust, two of the largest private-sector-promoted philanthropic trusts in India.

The post details a highly restrictive environment where employees are forbidden from basic actions like looking away from their screens or using their phones.

Dear Community,

I have created a PCB layout with multiple high-speed nets, I want to check the SI like how signals are reflected and taken to each other.

I have the OrCAD X Professional, how to check the reflection and crosstalk using the OrCAD X Professional software version 24.1.

I want to create a topology flow to the PCB layout and perform the reflection and crosstalk.

Regards,

Rohit Rohan

ING Media names Tokyo, New York, London and Paris as global super brands for digital visibility.

Senior Chinese and US officials held multiple rounds of meetings in Malta on Saturday and Sunday, agreeing to maintain high-level exchanges and hold consultations on Asia-Pacific affairs, maritime affairs

Dubai, United Arab Emirates — The chief of staff of Saudi Arabia's armed forces, Fayyad al-Ruwaili, visited Tehran on Sunday to meet with his Iranian counterpart and discuss defense ties, state media reported the Iranian Armed Forces General Staff as saying.  The visit follows the election of Donald Trump, who will take office for a second term as U.S. president in January, and who has promised to bring peace to the Middle East.  During his first term, Trump initiated normalizations between Arab states and Iran's regional arch-enemy Israel, known as the Abraham Accords.  Saudi Arabia has not established ties with Israel, but Trump's son-in-law Jared Kushner has discussed the possibility with Saudi Arabia’s Crown Prince Mohammed bin Salman multiple times over the last years, a source familiar with the discussions told Reuters on the condition of anonymity.  Iran's state media said al-Ruwaili headed a high-level Saudi military delegation in Tehran and met Armed Forces Chief of Staff Major General Mohammad Bagheri.  Iranian state media said the two military officials discussed various issues, including "the development of defense diplomacy and the expansion of bilateral cooperation."  State media added that Bagheri held a phone call with Saudi Arabia's Defense Minister Prince Khalid bin Salman Al Saud last year to discuss regional developments and improve defense cooperation between the two countries.  Separately, Iranian President Masoud Pezeshkian spoke with Saudi Crown Prince Mohammed bin Salman on the phone, Iranian media said.  Pezeshkian told the crown prince he would not be able to attend a summit of the Organization of Islamic Cooperation (OIC) in Riyadh due to his busy schedule and would be dispatching the Iranian first vice president as a representative, the Mehr news agency said.  Tehran and Riyadh agreed in March 2023, via Chinese intermediation, to reestablish relations after seven years of hostility that had threatened stability and security in the Gulf and helped to fuel conflicts in the Middle East from Yemen to Syria. 

Jerusalem/Beirut — Israel said on Monday there was progress in talks about a Lebanon cease-fire and indicated Russia could play a part by stopping Hezbollah rearming via Syria, although the Iran-backed group said it had not received any new truce proposals. Pummeled by Israel's offensive, Hezbollah said diplomatic contacts were under way involving its backers in Tehran, Washington and Moscow, whilst reiterating its readiness to fight on, saying it had enough weapons for a "long war." In Jerusalem, Israeli Foreign Minister Gideon Saar said the war against Hezbollah was not yet over. The main challenge facing any cease-fire deal would be enforcement, he said, though there was "a certain progress" in talks. After previous rounds of fruitless U.S.-led diplomacy to secure a Lebanon truce, the comments indicate renewed focus on the issue as President Joe Biden prepares to leave office in January, with President-elect Donald Trump set to replace him. Hopes of a Gaza truce have meanwhile suffered a setback, with Qatar suspending its mediation role. Ignited by the war in Gaza, the conflict at the Lebanese-Israeli border had been rumbling on for a year before Israel went on the offensive in late September, pounding wide areas of Lebanon with airstrikes and sending troops into the south. Saar, addressing a Jerusalem news conference, said Israel was working with the United States on a cease-fire. Israel wants Hezbollah north of the Litani river – some 30 km from the border - and unable to rearm, he said. Saar said a basic principle for any agreement had to be that Hezbollah would not be able to bring weapons into Lebanon from Syria. "It is vital to the success of any arrangement in Lebanon," he said. "And the Russians are, as you know, present in Syria. And if they are in agreement with this principle, I think they can contribute effectively to this objective." Russia deployed forces into Syria nearly a decade ago to support President Bashar al-Assad in the civil war there. Hezbollah also sent fighters to help Assad, and carved out big sway on the ground alongside other Iran-backed groups. Syria is widely seen as a major conduit for Iran to supply weapons to Hezbollah in Lebanon, and Israel has struck targets in Syria regularly during the conflict. An Israeli airstrike temporarily cut Syria's main Homs-Damascus highway on Monday, Syrian media reported. In Lebanon, relatives held funerals for 20 people killed in a strike on the southern town of Deir Qanoun-Ras al-Ain, including seven medics from rescue groups affiliated with Hezbollah and its Shiite ally Amal. 'Testing the waters' In Beirut, Hezbollah official Mohammad Afif linked intensified political contacts to the looming change of U.S. leadership. "There is a great movement between Washington and Moscow and Tehran and a number of capitals," he said. "We hear a lot of talk, but so far, according to my information, nothing official has reached Lebanon or us in this regard," he told a news conference. The contacts were "in the phase of testing the waters and presenting initial ideas." Israel Hayom reported on Sunday that substantial progress has been made in diplomatic negotiations over a proposed Lebanon cease-fire that would require Hezbollah to withdraw north of the Litani River, barring its military presence near the Israeli border, while the IDF would return to the international border. Yedioth Ahronoth, Israel's best-selling newspaper, reported on Monday that Israel and Lebanon have exchanged drafts through U.S. envoy Amos Hochstein, signaling progress in efforts to reach a final agreement. The Lebanese government, which includes Hezbollah, has repeatedly called for a cease-fire based on the full implementation of a U.N. resolution that ended a war between the group and Israel in 2006. The resolution calls for the area south of the Litani river to be free of all weapons other than those of the Lebanese state. Lebanon and Israel have accused each other of violating the resolution. Israel says its campaign aims to secure the return home of tens of thousands of people forced to evacuate the north due to rockets fired by Hezbollah, which opened fire on Oct. 8, 2003, in solidarity with Hamas. Israel's offensive has forced more than 1 million people to flee their homes in Lebanon in the last seven weeks. Since the eruption of hostilities a year ago, Israeli attacks have killed more than 3,189 people in Lebanon, the majority of them since late September, according to health ministry figures, which do not distinguish between civilians and combatants. Hezbollah attacks have killed roughly 100 civilians and soldiers in northern Israel, the Israeli-occupied Golan Heights, and southern Lebanon over the last year.

BAKU, Azerbaijan — World leaders are converging Tuesday at the United Nations annual climate conference in Baku, Azerbaijan although the big names and powerful countries are noticeably absent, unlike past climate talks which had the star power of a soccer World Cup. But 2024's climate talks are more like the International Chess Federation world championship, lacking recognizable names but big on nerd power and strategy. The top leaders of the 13 largest carbon dioxide-polluting countries will not appear. Their nations are responsible for more than 70% of 2023's heat-trapping gases. The world's biggest polluters and strongest economies — China and the United States — aren't sending their No. 1s. India and Indonesia's heads of state are also not in attendance, meaning the four most populous nations with more than 42% of all the world's population aren't having leaders speak. “It’s symptomatic of the lack of political will to act. There’s no sense of urgency,” said climate scientist Bill Hare, CEO of Climate Analytics. He said this explains “the absolute mess we’re finding ourselves in.” Transition to clean energy The world has witnessed the hottest day, months and year on record “and a master class in climate destruction,” United Nations Secretary-General Antonio Guterres told the world leaders who did show up. But Guterres held out hope, saying, in a veiled reference to Donald Trump's re-election in the United States, that the “clean energy revolution is here. No group, no business, no government can stop it.” United Nations officials said in 2016, when Trump was first elected, there were 180 gigawatts of clean energy and 700,000 electric vehicles in the world. Now there are 600 gigawatts of clean energy and 14 million electric vehicles. Host Azerbaijan President Ilham Aliyev kicked off two scheduled days of world leaders' speeches by lambasting Armenia, western news media, climate activists and critics who highlighted his country's rich oil and gas history and trade, calling them hypocritical since the United States is the world's biggest oil producer. He said it was “not fair” to call Azerbaijan a “petrostate” because it produces less than 1% of the world's oil and gas. Oil and gas are “a gift of the God” just like the sun, wind and minerals, Aliyev said. “Countries should not be blamed for having them. And should not be blamed for bringing these resources to the market because the market needs them.” As the host and president of the climate talks, called COP29, Aliyev said his country will push hard for a green transition away from fossil fuels, “but at the same time, we must be realistic.” Lack of star power Aliyev, United Kingdom’s Prime Minister Keir Starmer and Turkey’s President Recep Tayyip Erdogan are the headliners of around 50 leaders set to speak on Tuesday. There'll also be a strong showing from the leaders of some of the world’s most climate-vulnerable countries. Several small island nations presidents and over a dozen leaders from countries across Africa are set to speak over the two-day World Leaders’ Summit at COP29. As a sense of how the bar for celebrity has lowered, on Tuesday morning photographers and video cameras ran alongside one leader walking through the halls of the meeting. It was the emergency management minister for host country Azerbaijan. United Nations officials downplayed the lack of head of state star power, saying that every country is represented and active in the climate talks. One logistical issue is that next week, the leaders of the most powerful countries have to be half a world away in Brazil for the G20 meetings. The United States recent election, Germany's government collapse, natural disasters and personal illnesses also have kept some leaders away. The major focus of the negotiations is climate finance, which is rich nations trying to help poor countries pay for transitioning their economies away from fossil fuels, coping with climate change's upcoming harms and compensating for damages from weather extremes. Nations are negotiating over huge amounts of money, anywhere from $100 billion a year to $1.3 trillion a year. That money “is not charity, it's an investment,” Guterres said. “Developing countries must not leave Baku empty-handed,” Guterres said. “A deal is a must.”

Joe Biden pledged a peaceful transfer of power Thursday after Donald Trump's decisive US election win, while the Republican showed his intent to ditch the outgoing president's policies by suggesting he would talk to Vladimir Putin.

Iran's state media said al-Ruwaili headed a high-level Saudi military delegation in Tehran and met Armed Forces Chief of Staff Major General Mohammad Bagheri.

Blinken heads to Brussels for urgent talks on Ukraine after Trump win

“It’s been horrible; I’ve been sick on and off for the last 10 days,” said 29-year-old asthmatic Natasha Sohail, who teaches A-Level students at three private schools in Lahore. Last week, her condition worsened with a vertigo attack and fever. “It’s criminal what is happening here,” said an incensed Sohail, referring to the “band-aid measures” […]

This week, we journey to the early 2030s, when machine learning first allowed us to communicate with sperm whales. Rowan Hooper tells us what they have to say

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α-Synuclein (α-Syn) aggregation in Lewy bodies and Lewy neurites has emerged as a key pathogenetic feature in Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. Various factors, including posttranslational modifications (PTMs), can influence the propensity of α-Syn to misfold and aggregate. PTMs are biochemical modifications of a protein that occur during or after translation and are typically mediated by enzymes. PTMs modulate several characteristics of proteins including their structure, activity, localization, and stability. α-Syn undergoes various posttranslational modifications, including phosphorylation, ubiquitination, SUMOylation, acetylation, glycation, O-GlcNAcylation, nitration, oxidation, polyamination, arginylation, and truncation. Different PTMs of a protein can physically interact with one another or work together to influence a particular physiological or pathological feature in a process known as PTMs crosstalk. The development of detection techniques for the cooccurrence of PTMs in recent years has uncovered previously unappreciated mechanisms of their crosstalk. This has led to the emergence of evidence supporting an association between α-Syn PTMs crosstalk and synucleinopathies. In this review, we provide a comprehensive evaluation of α-Syn PTMs, their impact on misfolding and pathogenicity, the pharmacological means of targeting them, and their potential as biomarkers of disease. We also highlight the importance of the crosstalk between these PTMs in α-Syn function and aggregation. Insight into these PTMS and the complexities of their crosstalk can improve our understanding of the pathogenesis of synucleinopathies and identify novel targets of therapeutic potential.

Writer-director partners Scott Beck and Bryan Woods dive into the biggest spoilers of their new Hugh Grant thriller.

Jade Ho explains what is possible for university students when they are given opportunities to learn about –and get involved with– social justice and labour issues in their own communities.

The post Students can be agents of change: Talking about activism in universities with Jade Ho appeared first on rabble.ca.

Chris gets trolled by the bear cave. Jason sets optics to stun. Josh is hiding in a rest stop bathroom. Kelley stretches harder than she did for The Witch and the Hundred Knight. Also, find out how to increase your poop by 10 and express your opinions about Dragon Quest Soundtracks.

The post RPG Cast – Episode 664: “We Need to Talk About Gambit” appeared first on RPGamer.

Emma Raducanu struck a deal to return to one of her favourite tournaments.

NASA said Thursday that the study of UFOs will require new scientific techniques, including advanced satellites as well as a shift in how unexplained sightings are perceived.

"I did not say I was uncomfortable talking about it. I said we're not going to talk about it."

In the final broadcast of TOTN, NPR senior Washington editor Ron Elving, senior business editor Marilyn Geewax and science correspondent Richard Harris discuss the big stories they're covering. Callers talk about the issues that have their communities and social circles abuzz.

Released in 1993 and directed by the Abbas-Mustan duo, ‘Baazigar’ was a game-changer for Shah Rukh Khan’s career, marking his debut in an anti-hero role that diverged sharply from typical Bollywood protagonists of that era

Over the years, I’ve been able to interview some of my favorite developers ever including a few I never though …

Continue reading "Sukeban Games 2024 Interview: Christopher Ortiz AKA kiririn51 Talks .45 PARABELLUM BLOODHOUND, Inspirations, Fan Reactions, VA-11 Hall-A, The Silver Case, and Much More"

THE reasons behind a decision to release a secret expletive-laden recording of former Chief Justice Tim Carmody are almost as juicy as the tape is expected to be.

Contract negotiations in a labour dispute that has paralyzed container cargo shipping at British Columbia's ports since Monday have been called off. It comes as more than 100 organizations representing industries from automotive and fertilizer to retail and mining urged the government to do whatever it takes to end the work stoppage.

THIS footage of the US Open winner’s wife’s short skirt was far too long or not long enough depending on who you ask.

The Pharmaceutical Services Negotiating Committee is in talks with the government over potential plans to distribute COVID-19 treatments in primary care.

ISLAMABAD — The International Monetary Fund's Pakistan mission chief Nathan Porter on Tuesday (Nov 12) opened unusual talks with Pakistan over a US$7 billion (S$9.4 billion) bailout approved by its board in September, the finance ministry and sources said. The unscheduled visit of the IMF mission and talks beginning with meeting the country's finance team are too early for first review of the IMF's Extended Fund Facility (EFF), which is due in the first quarter of 2025. The chiefs of Pakistan's central bank and federal board of revenue also attended the meeting besides other officials from both the sides, the statement said. The ministry and the IMF have not officially released details of the visit. Sources in the finance ministry said the Nov 11-15 visit will discuss recent developments and programme performance to date, adding the mission was not part of the first review. The sources declined to be identified as they were not authorised to speak with the media. Pakistan has been struggling with boom-and-bust economic cycles for decades, leading to 23 IMF bailouts since 1958.

Several Muslim leaders in the State expressed displeasure at the parleys that a group of Jamaat-e-Islami Hind leaders held with their RSS counterparts in New Delhi in January.