Cybersecurity researchers have uncovered nearly two dozen security flaws spanning 15 different machine learning (ML) related open-source projects. These comprise vulnerabilities discovered both on the server- and client-side, software supply chain security firm JFrog said in an analysis published last week. The server-side weaknesses "allow attackers to hijack important servers in the

The post Wicker Kremlin appeared first on English Russia.

The Princeton microbiologist has also created a non-infectious version of the COVID-19 virus that researchers can study safely.

The hot Glass Animals from Oxford, England have carved a niche in the indie rock universe with their unique conceptual pop sound Their journey through career highs and lows of thrilling experiences about changing lives and birthed their most acclaimed project to date — the Dreamland album Dreamland The creative forces behind it came up with an equally ambitious project called Dreamland Tours. The Glass Animals Dreamland Tour has been hailed as an unparalleled experience for fans, going beyond the traditional concept of a concert. The tour is characterized by immersive visuals, interactive performances, and the tangible personal connection the band shares with its listeners This combination is a magical fan experience which continues to echo over the limits of the concert venue. As we delve into the highlights of the Glass Animals Dreamland Tour, we’ll see why it stands true to the ultimate fan experience.   Glass Animals Visiting the Land of Dreams: An Art Journey Glass helps with the back of the Dreamland album Musical journeys viewed by mirror animals Stained glass animals have made an indelible mark on the canvas of contemporary music. Rising from humble beginnings in 2010, the four-man band from Oxford have grown into a powerhouse with indie musical talent, marrying smooth beats and eclectic lyricism Their rise has been fueled by critically acclaimed albums, and taking on an ever-changing soundscape. Introduction to the Dreamland album and its themes “Dreamland,” their third album, due out in 2020, is a mosaic of memories, introspection and intimate stories. Explores topics such as nostalgia, personal growth, and the complexity of the human spirit. Songs like “Heat Waves” resonate with fans, not only because they are catchy, but because they are heartfelt. The transition to touring: The importance of dreamland in live performances The Dreamland Tour elevates the album from a purely listening experience to a multi-sensory event. Gives fans the chance to step into the world imagined by the lyrics on the album. The tour takes on more meaning as it marks the album’s life in a haunting place, inviting fans to share in the band’s most personal moments. Basically, a Dreamland tour isn’t just about performance. It’s a gateway to the true heartbeat of Glass Animals, delivering an immersive experience lifted straight from the kaleidoscopic world of the Dreamland album. The Unique Aspects of the Dreamland Tour Visuals and Stage Design One unmissable aspect of the Dreamland tour by Glass Animals is the impeccable visuals and stage design. Strikingly vivid and meticulously crafted, the stage becomes a living, pulsating extension of the Dreamland album itself. The stage setup incorporates a remarkable array of LED screens and lighting, bathed in a dreamy palette of pastels and bursts of neon. The visual effects transcend the typical, showcasing visuals that immerse fans in a psychedelic landscape filled with soaring palm trees and retro television sets. Imbued within these visuals are the specific themes and narratives of the Dreamland album, transforming songs into vibrant vignettes that captivate audiences. Interactive Performances Beyond the sensory feasts of the visuals and stage design, the Dreamland Tour stands out for its engaging and interactive performances. The band’s authenticity shines through each performance, fostering an intimate connection with the audience. During shows, the band members often break the metaphorical fourth wall, engaging directly with fans through candid banter, shared stories, and common jokes. Notable moments from the tour include frontman Dave Bayley’s famed crowd surfing, and encouragement for fans to join the band in singing along, creating a collective auditory experience. Setlist and Musical Arrangements The craft and care put into the setlist and musical arrangements have played a significant part in the tour’s resounding success. The setlist is composed not merely as a linear progression of songs but as a journey through Glass Animals’ discography, carefully curated to engage fans new and old. Signature hits from their previous albums such as “Gooey” from ZABA and “Youth” from How To Be A Human Being are woven seamlessly with tracks from Dreamland. Exclusive to the tour are special renditions of select tracks, including acoustic versions and extended instrumental segments that offer fans a unique and novel listening experience. In essence, the Dreamland Tour is marked by a synthesis of compelling visuals, engaging performances, and thoughtful setlist selection – offering fans a truly immersive and memorable experience. fan experiences and testimonials Personal information The Dreamland trip has left an indelible mark on fans, many of whom share fond stories of their experiences. These stories reflect not only the enjoyment of the concert, but also the deep emotional connection fans have made to the music of Glass Animals and the memories they remember while on tour Emotional resonance: A fan described a moment during “Heat Waves” when the crowd’s combined singing spoke of a sense of shared experience and understanding, bringing many to tears. Memorable connection: Another recounted a pre-concert meeting in which band member Dave Belle remembered their names from previous concerts, revealing the real connection the band has with its audience . community and stakeholders One of the outstanding features of the Dreamland tour is its ability to create a vibrant and inclusive community among fans. From the concert lineup to the final notes of fading music, belonging and shared passion is palpable. Before the concert: Fans often share information online, detailing their interests, clothing choices and itineraries, building anticipation and camaraderie even before the concert begins. During the performance: The interactive aspects of the show, such as music, crowd surfing, immediately become mainstream events in society, forcing connections with them the intensity of the desired interval. After the event: Social media platforms are buzzing with concert photos, videos and personal reflections, allowing the community to relive the experience and maintain the relationships built during the event. Through the power of music and shared experiences, the Dreamland tour has created a sense of community that extends beyond concert venues is not limited to Fans walking away with memories of a performance. Behind-the-Scenes Elements that Make the Tour Special Preparation and Inspiration The Dreamland Tour, as recounted by the members of Glass Animals, is not just a series of concerts but a deeply immersive experience designed to transport fans into the very essence of their latest album, Dreamland. The planning and creative process behind the tour was both exhaustive and exhilarating. Creative Process: The band members spent countless hours discussing and experimenting with different visual and auditory elements to ensure that the live experience would accurately reflect the album’s intimate and entrancing vibe. Band Quotes: “We wanted to pull the audience into Dreamland, to make them feel the nostalgia, the melancholy, and the euphoria that the album speaks to,” said Dave Bayley. “Every detail, from the visuals to the setlist, was crafted with this in mind.” Challenges and Triumphs Like many others, the Dreamland Tour faced its fair share of hurdles, most notably, the global pandemic. The uncertainties and health concerns posed significant challenges, leading to postponed dates and constant reevaluation of plans. Overcoming Obstacles: The band and their crew demonstrated remarkable resilience in the face of these challenges. With a deep commitment to their fans and the music, they navigated through the uncertainty, enforcing strict health protocols to ensure the safety of everyone involved. Milestones: Despite the initial setbacks, the tour emerged triumphant. Sold-out shows and critical acclaim became testaments to the band’s hard work and the fans’ undying enthusiasm. “Seeing fans come together safely after such a difficult time has been incredibly touching and reinforces why we do what we do,” Bayley commented on the success of the tour. The behind-the-scenes preparation, boundless creativity, and relentless determination to overcome challenges underscore the Dreamland Tour’s success, making it not just a series of live performances, but a truly memorable and impactful experience for both the band and their fans. The lasting impact of a visit to dreamland Glass Animals’ Dreamland Tour not only captivated audiences around the world, it left an indelible mark on the music industry and its fans. This volume explores the transformative power of touring and its contribution to live music. It’s about the music industry The Dreamland tour set a new standard for live music, emphasizing the importance of an immersive concert experience. Here are some of the initiatives that have impacted the industry. New platform activities: The tour introduced new forms of drama and visual storytelling, turning the concert into an emotional experience. Fan interaction: Leveraging technology and social media, the team created more interactive and personal experiences, setting the trend for future tours It’s about the fans and the attendees Beyond the phenomenon, the Dreamland tour created a deep and lasting connection with fans and impacted them in many profound ways: Emotional resonance: Many attendees described the concert as emotionally transformative, providing a sense of escape and connection during difficult times. Community building: The tour has been a catalyst for community building, and fans have bonded over shared experiences, both online and in concert. conclusion The key to appreciating the Dreamland Tour was its unique blend of immersive storytelling, interactive performances and profound emotional journey for attendees not just a series of concerts; It was a public trip to the heart of the Glass Animals’ musical universe, and a program was designed to provide the ultimate fan experience. Visiting Dreamland with innovative stage design, personalized fan interaction and exciting performances reaffirmed what it means to attend a live concert Its legacy extends beyond nights out under neon lights and businesses the standards it has raised Reflecting on the impact of the Dreamland tour, it’s clear that his legacy will continue to inspire fans and artists alike, shaping the future of live performance and fan engagement in the music industry.

The post Why the Glass Animals Dreamland Tour Is the Ultimate Fan Experience appeared first on Geeky Traveller.

The government may send envoys to oversee decisions taken by the independent mayor of Tower Hamlets.

You can write fast, modern, responsive web applications by generating your HTML on the server, and delivering that (with a little help) directly to the browser. You don’t need JSON as an in-between format. You don’t need client-side MVC frameworks. You don’t need complicated bundling and transpiling pipelines. But you do need to think different.… keep reading

Rubén Medina and Andrés Quilis
Proc. Amer. Math. Soc. 152 (), 5137-5148.
Abstract, references and article information

Systemic antibody light chains (AL) amyloidosis is characterized by deposition of amyloid fibrils derived from a particular antibody light chain. Cardiac involvement is a major risk factor for mortality. Using MAS solid-state NMR, we studied the fibril structure of a recombinant light chain fragment corresponding to the fibril protein from patient FOR005, together with fibrils formed by protein sequence variants that are derived from the closest germline (GL) sequence. Both analyzed fibril structures were seeded with ex-vivo amyloid fibrils purified from the explanted heart of this patient. We find that residues 11-42 and 69-102 adopt β-sheet conformation in patient protein fibrils. We identify arginine-49 as a key residue that forms a salt bridge to aspartate-25 in the patient protein fibril structure. In the germline sequence, this residue is replaced by a glycine. Fibrils from the GL protein and from the patient protein harboring the single point mutation R49G can be both heterologously seeded using patient ex-vivo fibrils. Seeded R49G fibrils show an increased heterogeneity in the C-terminal residues 80-102, which is reflected by the disappearance of all resonances of these residues. By contrast, residues 11-42 and 69-77, which are visible in the MAS solid-state NMR spectra, show 13Cα chemical shifts that are highly like patient fibrils. The mutation R49G thus induces a conformational heterogeneity at the C terminus in the fibril state, whereas the overall fibril topology is retained. These findings imply that patient mutations in FOR005 can stabilize the fibril structure.

On October 24 and 25, SophosAI presents ideas on how to use models large and small—and defend against malignant ones.

Babunageswararao Kanuri
Nov 17, 2020; 0:jlr.RA120001101v1-jlr.RA120001101
Research Articles

Smith-Lemli-Opitz Syndrome (SLOS) is a developmental disorder (OMIM #270400) caused by autosomal recessive mutations in the Dhcr7 gene, which encodes the enzyme 3β-hydroxysterol-7 reductase. SLOS patients present clinically with dysmorphology and neurological, behavioral and cognitive defects, with characteristically elevated levels of 7-dehydrocholesterol (7-DHC) in all bodily tissues and fluids. Previous mouse models of SLOS have been hampered by postnatal lethality when Dhcr7 is knocked out globally, while a hypomorphic mouse model showed improvement in the biochemical phenotype with ageing, and did not manifest most other characteristic features of SLOS. We report the generation of a conditional knockout of Dhcr7 (Dhcr7flx/flx), validated by generating a mouse with a liver-specific deletion (Dhcr7L-KO). Phenotypic characterization of liver-specific knockout mice revealed no significant changes in viability, fertility, growth curves, liver architecture, hepatic triglyceride secretion, or parameters of systemic glucose homeostasis. Furthermore, qPCR and RNA-Seq analyses of livers revealed no perturbations in pathways responsible for cholesterol synthesis, either in male or female Dhcr7L-KO mice, suggesting hepatic disruption of post-squalene cholesterol synthesis leads to minimal impact on sterol metabolism in the liver. This validated conditional Dhcr7 knockout model may now allow us to systematically explore the pathophysiology of SLOS, by allowing for temporal, cell and tissue-specific loss of DHCR7.

Homologous recombination (HR) repairs DNA double-strand breaks using intact homologous sequences as template DNA. Broken DNA and intact homologous sequences form joint molecules (JMs), including Holliday junctions (HJs), as HR intermediates. HJs are resolved to form crossover and noncrossover products. A mismatch repair factor, MLH3 endonuclease, produces the majority of crossovers during meiotic HR, but it remains elusive whether mismatch repair factors promote HR in nonmeiotic cells. We disrupted genes encoding the MLH3 and PMS2 endonucleases in the human B cell line, TK6, generating null MLH3−/− and PMS2−/− mutant cells. We also inserted point mutations into the endonuclease motif of MLH3 and PMS2 genes, generating endonuclease death MLH3DN/DN and PMS2EK/EK cells. MLH3−/− and MLH3DN/DN cells showed a very similar phenotype, a 2.5-fold decrease in the frequency of heteroallelic HR-dependent repair of restriction enzyme–induced double-strand breaks. PMS2−/− and PMS2EK/EK cells showed a phenotype very similar to that of the MLH3 mutants. These data indicate that MLH3 and PMS2 promote HR as an endonuclease. The MLH3DN/DN and PMS2EK/EK mutations had an additive effect on the heteroallelic HR. MLH3DN/DN/PMS2EK/EK cells showed normal kinetics of γ-irradiation–induced Rad51 foci but a significant delay in the resolution of Rad51 foci and a 3-fold decrease in the number of cisplatin-induced sister chromatid exchanges. The ectopic expression of the Gen1 HJ re-solvase partially reversed the defective heteroallelic HR of MLH3DN/DN/PMS2EK/EK cells. Taken together, we propose that MLH3 and PMS2 promote HR as endonucleases, most likely by processing JMs in mammalian somatic cells.

MLB Network's countdown of baseball's best players at each position came to a conclusion with the final installment of the "Top 10 Right Now!" series, featuring the game's top relief pitchers and shortstops.

On this opening week of Spring Training, all 30 Major League teams have one thing in common: optimism. Here's an optimism cheat sheet for each of them.

Spring Training is imminent, Opening Day is within sight and the big league season isn't complete for fans without a subscription to MLB.TV. The most comprehensive streaming service in professional sports is now available for the 2019 season.

MLB.com looked at each team's two highest-ranked position players in WAR, according to the Steamer projections. Here are the top 10, but keep in mind that things could change once Manny Machado and Bryce Harper find homes.

On this opening week of Spring Training, all 30 Major League teams have one thing in common: optimism. Here's an optimism cheat sheet for each of them.

MLCommons this week issued the results of its latest MLPerf Inference (v3.1) benchmark exercise. Nvidia was again the top performing accelerator, but Intel (Xeon CPU) and Habana (Gaudi1 and 2) […]

The post MLPerf Releases Latest Inference Results and New Storage Benchmark appeared first on HPCwire.

There are really two stories packaged in the most recent MLPerf  Training 4.0 results, released today. The first, of course, is the results. Nvidia (currently king of accelerated computing) wins […]

The post MLPerf Training 4.0 – Nvidia Still King; Power and LLM Fine Tuning Added appeared first on HPCwire.

A blockbuster exhibition in Paris is showcasing 500 artifacts and artworks in honor of the Surrealist Manifesto, which sparked a new artistic style that spread around the world

The Art Gallery of New South Wales is showcasing works full of the Surrealist artist's signature motifs—such as apples, pipes and bowler hats—in addition to lesser-known pieces

While testing the "infinite monkey theorem," mathematicians found that the odds of a chimpanzee typing even a short phrase like "I chimp, therefore I am" before the death of the universe are 1 in 10 million billion billion

Kamloops RCMP say they are investigating the fire that destroyed the Red Bridge Thursday as an arson.

Concerns are mounting over the potential environmental impact on fish populations following the destruction of Kamloops' historic Red Bridge, which collapsed into the South Thompson River during a fire.

The Interior B.C. city is reviewing its policies for public hearings following the incident.

A jury has found a Naramata, B.C., man guilty on two counts of second-degree murder in the deaths of two brothers. Wade Cudmore, 35, was one of two men accused in the May 2021 drug deal killings of Kamloops, B.C., brothers Erick and Carlo Fryer.

The office of Kamloops Mayor Reid Hamer-Jackson is being relocated to the basement of city hall.

Lawyer David McMillan alleges the mayor owes him payment for services provided between 2021 and 2024.

The pay cut comes after city council had already taken a number of steps against the mayor, including stripping him of his duties as a city spokesperson, removing him from the Thompson Nicola Regional District board and Shuswap Watershed Council and relocating his office to the basement of city hall. 

The re-elected chief of the Tk'emlúps te Secwépemc First Nation says she's hoping to forge connections within her community as she looks ahead to her next term.

U.S. president-elect Donald Trump spoke with Russian President Vladimir Putin and advised him not to escalate the Ukraine war, a source familiar with the conversation said, but the Kremlin denied the two had spoken.

Kamloops, B.C., has been selected as the host city of the 2023 Scotties Tournament of Hearts.

Customized valve and cylinder maker sees 420 percent increase in online transactions in the first three months

Leading UK pneumatic product maker is deploying SolidWorks Office Professional to help automate such vital business processes as billing, scheduling

Leading assembly automation and testing company to standardize on SolidWorks Office Professional, securely manage design data with PDMWorks

MatWeb's new export engine pipes data from its 47,000 material information sheetsdirectly into SolidWorks and COSMOSWorks

Besser Company has significantly compressed its mold design cycle

Geographically dispersed workgroups can now access, store, change, and approve

Investment improves coordination and accuracy

Global workholding product supplier increases sales, reduces development time and costs, and designs better products with 3D CAD software

Penn State’s Commonwealth Campuses and Westmoreland County Community College, building upon a long-standing relationship, have entered into a new articulation agreement designed to enhance educational opportunities and improve the rate at which students obtain undergraduate degrees in Pennsylvania.

Penn State Great Valley is offering a streamlined 33-credit MBA with highly flexible delivery and the opportunity to specialize by earning up to three graduate certificates as part of the program.

Asus ROG Phone 9 will be officially launched later this week. Following Qualcomm's unveiling of the Snapdragon 8 Elite chipset last month, Asus confirmed that the ROG Phone 9 would use the flagship SoC. Now, ahead of the launch, the handset has been reportedly spotted in the Geekbench ML online database suggesting key specifications.

Delaware announces 24th consecutive round of easement selections for Aglands Program DOVER, Del.  — Delaware announced its 24th consecutive round of easement selections by the Delaware Agricultural Lands Preservation Foundation. With the preservation of another 5,500 acres, Delaware has permanently preserved more than 139,000 acres of farmland for future generations. In a recent report by […]