The Delaware Department of Agriculture is warning all residents about two deadly species of hemlock recently found in Sussex County. Environmental scientists have confirmed the presence of poison hemlock (Conicum maculatum) and spotted water hemlock (Cicuta maculata). All parts of the plants – leaves, stems, flowers, and roots – are poisonous to humans and animals.

Delaware announced its 25th consecutive round of easement selections by the Delaware Agricultural Lands Preservation Foundation. With the preservation of 3,695 acres, Delaware has permanently preserved more than 143,000 acres of farmland for future generations.

A steady downward trend over the past five years in the landowner discounts of permanent agricultural conservation easements selected for purchase in Delaware shows it’s a great time for landowners to preserve their farms.

Here Mudassar Khan has explained

The Delaware Department of Agriculture announced the 28th round of easement selections by the Delaware Agricultural Lands Preservation, preserving 40 farms and 2,262 acres of farmland. With this announcement, the Carney administration has preserved 403 farms, the highest number in the program’s history.

Fight back against sophisticated money launderers with these 3 techniques.

The post 3 techniques to improve AML transaction monitoring strategies appeared first on The Data Roundtable.

In Lahore on Sunday, Chaudhry Shafay Hussain, the leader of Pakistan Muslim League-Quaid (PML-Q), asserted that his party has no intentions of merging with any other political group. Hussain clarified, “While seat adjustments may occur in specific constituencies with the Pakistan Muslim League-Nawaz, the PML-Q is committed to maintaining its independent identity.” PML-Q’s commitment to ... Read more

The post PML-Q Affirms Independence and Tractor Symbol for Upcoming Elections appeared first on Pakistan Tribune.

Kremlin denies Putin spoke with Trump over de-escalation in Ukraine

The infinite monkey theorem states that illiterate primates could write great literature with enough time, but the amount of time needed is much longer than the lifespan of the universe

Sequence variation observed in populations of pathogens can be used for important public health and evolutionary genomic analyses, especially outbreak analysis and transmission reconstruction. Identifying this variation is typically achieved by aligning sequence reads to a reference genome, but this approach is susceptible to reference biases and requires careful filtering of called genotypes. There is a need for tools that can process this growing volume of bacterial genome data, providing rapid results, but that remain simple so they can be used without highly trained bioinformaticians, expensive data analysis, and long-term storage and processing of large files. Here we describe split k-mer analysis (SKA2), a method that supports both reference-free and reference-based mapping to quickly and accurately genotype populations of bacteria using sequencing reads or genome assemblies. SKA2 is highly accurate for closely related samples, and in outbreak simulations, we show superior variant recall compared with reference-based methods, with no false positives. SKA2 can also accurately map variants to a reference and be used with recombination detection methods to rapidly reconstruct vertical evolutionary history. SKA2 is many times faster than comparable methods and can be used to add new genomes to an existing call set, allowing sequential use without the need to reanalyze entire collections. With an inherent absence of reference bias, high accuracy, and a robust implementation, SKA2 has the potential to become the tool of choice for genotyping bacteria. SKA2 is implemented in Rust and is freely available as open-source software.

Animal germline development and fertility rely on paralogs of general transcription factors that recruit RNA polymerase II to ensure cell type-specific gene expression. It remains unclear whether gene expression processes downstream from such paralog-based transcription is distinct from that of canonical RNA polymerase II genes. In Drosophila, the testis-specific TBP-associated factors (tTAFs) activate over a thousand spermatocyte-specific gene promoters to enable meiosis and germ cell differentiation. Here, we show that efficient termination of tTAF-activated transcription relies on testis-specific paralogs of canonical polymerase-associated factor 1 complex (PAF1C) proteins, which form a testis-specific PAF1C (tPAF). Consequently, tPAF mutants show aberrant expression of hundreds of downstream genes due to read-in transcription. Furthermore, tPAF facilitates expression of Y-linked male fertility factor genes and thus serves to maintain spermatocyte-specific gene expression. Consistently, tPAF is required for the segregation of meiotic chromosomes and male fertility. Supported by comparative in vivo protein interaction assays, we provide a mechanistic model for the functional divergence of tPAF and the PAF1C and identify transcription termination as a developmentally regulated process required for germline-specific gene expression.

Inositol 1,4,5-triphosphate receptor type 1 (ITPR1) is an endoplasmic reticulum–bound intracellular inositol triphosphate receptor involved in the regulation of intracellular calcium. Pathogenic variants in ITPR1 are associated with spinocerebellar ataxia (SCA) types 15/16 and 29 and have recently been implicated in a facial microsomia syndrome. In this report, we present a family with three affected individuals found to have a heterozygous missense c.800C > T (predicted p.Thr267Met) who present clinically with a SCA29-like syndrome. All three individuals presented with varying degrees of ataxia, developmental delay, and apparent intellectual disability, as well as craniofacial involvement—an uncommon finding in patients with SCA29. The variant was identified using clinical exome sequencing and validated with Sanger sequencing. It is presumed to be inherited via parental germline mosaicism. We present our findings to provide additional evidence for germline mosaic inheritance of SCA29, as well as to expand the clinical phenotype of the syndrome.

TP53 plays a critical role as a tumor suppressor by controlling cell cycle progression, DNA repair, and apoptosis. Post-translational modifications such as acetylation of specific lysine residues in the DNA binding and carboxy-terminus regulatory domains modulate its tumor suppressor activities. In this study, we addressed the functional consequences of the germline TP53 p.K164E (NM_000546.5: c.490A>G) variant identified in a patient with early-onset breast cancer and a significant family history of cancer. K164 is a conserved residue located in the L2 loop of the p53 DNA binding domain that is post-translationally modified by acetylation. In silico, in vitro, and in vivo analyses demonstrated that the glutamate substitution at K164 marginally destabilizes the p53 protein structure but significantly impairs sequence-specific DNA binding, transactivation, and tumor cell growth inhibition. Although p.K164E is currently considered a variant of unknown significance by different clinical genetic testing laboratories, the clinical and laboratory-based findings presented here provide strong evidence to reclassify TP53 p.K164E as a likely pathogenic variant.

T-lymphoblastic lymphoma (T-LLy) is the most common lymphoblastic lymphoma in children and often presents with a mediastinal mass. Lymphomatous suprarenal masses are possible but rare. Here, we discuss the case of a previously healthy 3-yr-old male who presented with mediastinal T-LLy with bilateral suprarenal masses. Following initial treatment, surgical biopsy of persisting adrenal masses revealed bilateral neuroblastoma (NBL). A clinical genetics panel for germline cancer predisposition did not identify any pathogenic variants. Combination large panel (864 genes) profiling analysis in the context of a precision oncology study revealed two novel likely pathogenic heterozygous variants: SMARCA4 c.1420-1G > T p.? and EZH2 c.1943G > C p.(Ile631Phefs*44). Somatic analysis revealed potential second hits/somatic variants in EZH2 (in the T-LLy) and a segmental loss in Chromosome 19p encompassing SMARCA4 (in the NBL). Synchronous cancers, especially at a young age, warrant genetic evaluation for cancer predisposition; enrollment in a precision oncology program assessing germline and tumor DNA can fulfill that purpose, particularly when standard first-line genetic testing is negative and in the setting of tumors that are not classic for common cancer predisposition syndromes.

You can purchase Steven Camley's cartoons by calling 0141 302 7000 or visiting thepicturedesk.co.uk.

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Manufacturing efficiency has always been a priority. As competition grows, optimizing every aspect of production becomes critical. Manufacturers turn to experts to make the right improvements and introduce systems that boost overall performance. One key area where many businesses seek help is through Manufacturing Execution Systems (MES). MES consultants play a pivotal role in achieving […]

The post The Role of MES Consultants in Streamlining Manufacturing Operations appeared first on Chart Attack.

Lionel Messi's first trip to the MLS playoffs ended in shock disappointment but the World Cup winner has injected new life into Inter Miami and the North American top-flight, even as he finishes his first full season without the league title.

Last week, Gameloft announced the next major and free Disney Dreamlight Valley update for PC and consoles alongside Disney Dreamlight …

Continue reading "‘Disney Dreamlight Valley’ Dapper Delights Update Now Available for Apple Arcade, Consoles, and PC"

MLAs in Karnataka have on average assets worth ₹34.6 crore, the highest among all the States

The infinite monkey theorem states that illiterate primates could write great literature with enough time, but the amount of time needed is much longer than the lifespan of the universe

lurking…

Germany has completed the domestic ratification procedures necessary to soon notify the OECD of its intention to bring into effect the BEPS multilateral instrument (BEPS MLI) for its covered double tax treaties.

Germany and Pakistan have deposited their instrument of ratification with the OECD to bring into force the BEPS multilateral instrument for their networks of tax treaties.

The BEPS multilateral convention entered into force for treaties signed by Cyprus and Saudi Arabia on May 1, 2020.

African state Burkina Faso has ratified the BEPS multilateral instrument, to make changes to its double tax agreements to counter tax base erosion and profit shifting (BEPS).

Germany and Pakistan have deposited their instrument of ratification with the OECD to bring into force the BEPS multilateral instrument for their networks of tax treaties.

Extensive costs of salt-damaged soils include $27 billion+ in lost crop value per year.

The post Press Release: World Losing 2,000 Hectares of Irrigated Farmland to Salt-Induced Degradation Daily first appeared on International Water Management Institute (IWMI).

Recent research has demonstrated that a widely prescribed hypertension medication, medlinkamlodipine/medlink, is safe for patients. This finding contradicts

medlinkAlzheimer's disease/medlink, while the most common cause of dementia, is not the only one. The complexity of dementia, often involving multiple

Before we start, let’s have a brief introduction on HTML5 framework. A HTML5 mobile application is a web page or series of web pages...

In, rapid enhancement of telecommunication industry, it is quite drastic job to deliver right solutions. CSPs aren’t finding the perfect telecom service providers, and so it has become one of...

Thousands of people came together from 22 different countries around the world to witness a two-day second International Film Festival in the hill town of Shimla (Himachal Pradesh).

Artificial intelligence (AI) service software provider Freshworks has announced a workforce reduction of 13 per cent to streamline its operations, affecting at least 660 employees worldwide.

To further ensure high-speed and ultra-low latency services required in 5G, the Department of Telecommunications (DoT) on Saturday said it has signed an agreement with Linearized Amplifier Technology Services and Vedang Radio Tech.

Following the tragic death of a victim from the recent grenade blast in Srinagar, NC MLA Shamima Ferdous calls for a thorough investigation into the sudden rise in terror incidents, questioning why violence has resurged in Srinagar and nearby areas after years of peace and the recent Assembly elections.

TikTok wants to determine its users’ appetite for mobile gaming with the launch of “mini-games” that can be played inside the social video app and discovered through creators’ videos. TechCrunch learned and has now confirmed TikTok’s new gaming pilot quietly launched just weeks ago with a variety of new partners, including game developers Vodoo, Nitro […]

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The Court :The affidavit of service is taken on record. This is an application under Section 11 of the Arbitration and Conciliation Act, 1966 (hereinafter referred to as the 'said Act'). The petitioner was engaged by the respondent to execute some piling work. The petitioner contends that the work could not be completed as NTPC had stopped the petitioner from carrying out the same on account of certain disputes between NTPC and the respondent. It is submitted that non- payments of the amounts due and other disputes between the petitioner and the respondent could not be resolved as a proceeding was before an arbitrator for resolution of a dispute between NTPC and the respondent. The petitioner claims to have also approached NTPC and were allegedly informed that the claim of the petitioner would be liquidated by the respondent as the money awarded by the arbitrator in the arbitration proceedings between the respondent and NTPC, had been paid to the respondents.The petitioner had invoked the arbitration clause and the respondent replied to the notice, thereby denying the claim of the petitioner. The respondent suggested the name of a learned Retired Judge to act as the sole arbitrator, in response to the notice invoking arbitration. In reply to such letter, the petitioner suggested the names of three learned Retired Judges.

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1. This is an appeal challenging the judgment and order of the Additional Sessions Judge, Nagpur in Sessions Trial No.39/2018 (State Vs. Kamlesh Dube and Others) thereby questioning the legality of judgment and order of convicting both the appellants under Section 235(2) of the Code of Criminal Procedure for the offence punishable under Section 302 2 cr.appeal.128.2022-JF.odt read with Section 34 of the Indian Penal Code, and sentencing both of them for life imprisonment alongwith fine of Rs.5000/- in default to suffer 3 months imprisonment.

2. The facts in short are as under :

On 19.09.2017, one Sumit Kamble died at about 1.46 p.m. It is alleged that appellant Kamlesh Dube and Shekhar Dube committed his murder. It is the prosecution case that both accused and the deceased were working as a driver on garbage vehicle at Kanak Resources Company. On the day of incident i.e. on 19.09.2017 at about 1.46 p.m. Sumit along with his friend Rahul and Yogiraj went to the Bhandewadi Dumping Yard by riding on the motorcycle of Sumit. At said place, the sister of informant Rahul and other women were picking the garbage. Kamlesh and Shekhar both accused also went there to unload the garbage by their garbage vehicle. Kamlesh was on driving seat whilst Shekhar was sitting beside him. Kamlesh has married with the sister of deceased Sumit. Kamlesh and sister of Sumit namely Tanu were having love affair, which was not liked by Sumit. Both of them ran away and performed marriage before 15 days. On their return, sister of Sumit was staying with Kamlesh. Because of said marriage, there was dispute between Kamlesh and Sumit. They used to quarrel with each other. On the date of occurrence, when Sumit saw Kamlesh, he went to him and there was hot exchange of words between them. At that time, Shekhar alighted from truck and assaulted Sumit with

The MLB team that has the most drafted players on its roster is the San Francisco Giants, with 13, according to Stats LLC. The league average is 7.8.

JK MLA Qaiser Jamshaid Lone: বিধানসভায় কাইসার বলেন, যখন ছোট তখন আমাদের এলাকায় তল্লাশি চালাচ্ছিল সেনা। সেইসময় ক্লাস টেনে পড়ি। প্রায় ৩৬ জনকে ধরে এক জায়গায় জড়ো করা হয় জিজ্ঞাসাবাদের জন্য

ఆర్‌ఎక్స్ 100 లాంటి చిత్రంతో యూత్‌లో ఎనలేని క్రేజ్‌ను సంపాదించుకున్నాడు హీరో కార్తికేయ. ముఖ్యంగా లేడీ ఫాలోయింగ్‌ను పెంచుకున్న ఈ యంగ్ హీరో.. హిప్పీ, గుణ 369 అంటూ విభిన్న కథా చిత్రాలతో పలకరించి విజయాలు అందుకున్నాడు. మరోసారి ప్రేక్షకులను అలరించేందుకు ఓ యూత్‌ఫుల్ ఎంటర్‌టైనర్‌ 90ML అంటూ ఈ వారం థియేటర్స్‌లోకి వచ్చేశాడు. మరి ఈ చిత్రం ఏ మేరకు ఆకట్టుకుందో ఓ సారి చూద్దాం.

BEML Q2 Results: शेयर बाजार में लिस्टेड कंपनियां सितंबर तिमाही के नतीजे जारी कर रही. इस कड़ी में डिफेंस सेक्टर की सरकारी कंपनी BEML ने भी तिमाही नतीजे जारी कर दिए हैं. FY25 की दूसरी तिमाही नतीजों की जानकारी कंपनी ने

कई लोगों को अलग-अलग तरह के आचार खाना पसंद होता है। जिसके लिए वो अपने घर में ही कई तरह के आचार बना कर रखते हैं। आम से लेकर कटहल के आचार तक लोग अपने घर में बना कर

Streaming has become a staple in our daily lives, offering endless entertainment at our fingertips. However, buffering and lag can ruin the experience. Optimising your home network is crucial for seamless streaming. This guide explores advanced techniques to enhance your network's

Intel is introducing a new dimension to the way we interact with multiple computers. With the advent of Thunderbolt Share, users will soon have the capability to effortlessly drag and drop files between two PCs, share keyboards, mice, screens, and other