The invention discloses a combined preparation containing IL-10 and rapamycin, able to induce immunosuppression and antigen-specific immune tolerance, and the use thereof in the treatment of diseases involving an excessive, dysfunctional or uncontrolled immune responses mediated by T cells.

The present invention is related to the use of secretagogue peptides repeatedly administered as part of a pharmaceutical composition that prevent and eradicate the deposition of pathological fibrotic material in parenchymal tissues of internal organs like the liver, lungs, esophagus, small intestine, kidneys, blood vessels, joints, and other systemic forms of cutaneous fibrosis of any etiopathogenesis. Additionally, these peptides prevent and eradicate deposition of amiloid and hyaline materials in any of their correspondent chemical forms and tissue manifestations in the brain, cerebellum, blood vessels, liver, intestines, kidneys, spleen, pancreas, joints and the skin, among others. By this way, cellular, tissular and organ dysfunctions generated by these depositions are corrected. The peptides of the present invention are infiltrated or topically applied, contributing to prevent and eradicate keloids and hypertrophic scars in the skin, derived as sequelae of burns and other cutaneous trauma.

The present invention relates to muscle repair promoters for local application that contain a colony-stimulating factor (CSF) as an active ingredient. The muscle repair promoters of the present invention exhibit their effect at low doses, particularly when they are administered intramuscularly.

The present inventors investigated the effects of anti-IL-6 receptor antibodies on improving the condition of infarcted areas in myocardial infarction, and on suppressing left ventricular remodeling after myocardial infarction. As a result, the administration of anti-IL-6 receptor antibodies significantly suppressed the increase of MPO activity in the infarcted area and suppressed myocardial MCP-1 expression in both the infarcted area and the non-infarcted area. Furthermore, echocardiography and histological examinations revealed that cardiac hypertrophy is also suppressed.

Administering message acknowledgements in a parallel computer that includes compute nodes, with each compute node including a processor and a messaging accelerator, includes: storing in a list, by a processor of a compute node, a message descriptor describing a message and an acknowledgement request descriptor describing a request for an acknowledgement of receipt of the message; processing, by a messaging accelerator of the compute node, the list, including transmitting, to a target compute node, the message described by the message descriptor and transmitting, to the target compute node, the request described by the acknowledgement request descriptor; receiving, by the messaging accelerator from the target compute node, an acknowledgement of receipt of the message, including notifying the processor of receipt of the acknowledgement; and removing, by the processor from the list, the message descriptor and the acknowledgment request descriptor.

Devices capable of deterring or preventing bulk extraction of drugs from, for example, drug-delivery systems are exemplarily disclosed. In one embodiment, such a device may include a package releasably retaining a drug and an agent. The agent is configured to suppress a physiological effect of the drug when the agent contacts the drug or is coadministered with the drug. The cell package is configured such that an amount of the drug is selectively releasable with respect to the agent when the package is operably proximate to an encoded key. The package, however, may be configured to impose a relatively high likelihood that either the drug will not be accessed or the drug will be contaminated by the agent if access to the contents of the package is sought without the use of an encoded key.

A method of enabling administration of a drug includes determining, within a drug-transfer device including cells, a location of at least one cell and generating information identifying the determined location. A user may be provided with the drug-transfer device. The drug is retained within the at least one cell when the user is provided with the drug-transfer device. The method also includes encoding a key with the information and providing the user with the key before, after or when the user is provided with the drug-transfer device. Drug retained within the at least one cell is selectively releasable when the key is operably proximate to the drug-transfer device and is encoded with the information. The key can be encoded with the information before and/or after being provided to the user. In some embodiments, the key is encoded based on instructions transmitted over a network.

In the case of a package (1) for single-dose films (2) containing active substances, comprising an upper packaging material element (3) and a lower packaging material element (4) which are connected together by a peripheral seal area or respectively sealing seam (5) such that a cavity (6) for holding the film (2) is formed, said cavity being enclosed on all sides, wherein the upper packaging material element (3) and the lower packaging material element (4) each have at least one cut (7, 8) in the region of the seal area or respectively, the sealing seam (5), said cuts being congruent, andat least one cut (7, 8) is crossed by a folding or bending line (10), the folding or bending line (10) is formed in a weakened manner.

The present disclosure provides a multiple chamber container that includes a container body sealed around a peripheral edge and having an outlet. The container also includes a first peel seal having a projecting portion and a second peel seal that isolates the outlet. The second peel seal may also include a projecting portion. The first and second peel seals may be configured to define a symmetrical chamber. The chamber may include an axis of symmetry extending between the first and second projecting portions. The chamber geometry of the container ensures a correct sequential opening of the first and second peel seals.

A method of modulating oxygen saturation levels can include measuring oxygen saturation levels in a patient, administering inhaled nitric oxide, adjusting the dose of oxygen in real time to a second dose based on the inhaled nitric oxide.

Disclosed herein are vials and devices containing a ketorolac solution for intranasal administration and a head space comprising no more than about 10% v/v oxygen and which vials and devices are stored in an oxygen-impermeable pouch. Also disclosed are processes for preparing the vials and devices.

President Trump excoriated the administration of President Barack Obama as “human scum” who attempted to undermine him by “targeting” former national security adviser Michael Flynn. 

Mothercare in March reported making a profit of 28.3 million pounds (USD 36.6 million, 32.8 million euros) from more than 1,000 stores it has worldwide.

The New Yorker contributor Jenna Krajeski recently met with a woman who calls herself Esperanza. In her home country, Esperanza was coerced and threatened into prostitution, and later was trafficked into the United States, where she was subjected to appalling conditions. Esperanza eventually obtained legal help, and applied for something called a T visa. The T visa contains unusual provisions that recognize the unique circumstances of human-trafficking victims in seeking legal status. It has also been a crucial tool to obtaining victims’ coöperation in prosecuting traffickers. The Trump Administration claims to want to fight the problem of human trafficking, but Krajeski notes that its policies have done the opposite: T-visa applicants can now be deported if their applications are rejected. This dramatic change in policy sharply reduced the number of applications from victims seeking help. “If what [the Administration] cares about is putting traffickers in prison, which is what they say they care about, their prosecutions are going down and will go down further,” Martina Vandenberg, the president of the Human Trafficking Legal Center, says. “Trafficking victims under the circumstances can’t actually coöperate.”

The Trump administration has revived the debate over "end-to-end encryption" — systems so secure that the tech companies themselves aren't able to read the messages, even when police present them with a warrant. "It is hard to overstate how perilous this is," U.S. Attorney General William Barr said in a speech last fall. "By enabling dangerous criminals to cloak their communications and activities behind an essentially impenetrable digital shield, the deployment of warrant-proof encryption is already imposing huge costs on society." Barr has been concerned about this for years, but he has become more vocal recently as encryption goes mainstream. It's now built into popular services such as Skype and WhatsApp, and even Facebook may soon be encrypted . Republican senator and Trump ally Lindsey Graham recently floated legislation that would strip tech companies of their liability protection under Section 230 of the Communications Decency Act unless they comply with as-of-yet undefined

Indiana University's Global Network Operations Center is looking to hire multiple people into their systems engineering and software development group. Are you a sysadmin who's capable of dev? Are you a dev who's capable of sysadmin? Know some of both? Want to learn more? Want to have a hand in supporting research and education-focussed networking in the US and across the world?

Full time, professional, permanent appointments. Great benefits.

Have questions? You can reply to this post, memail me, or send email to careers@globalnoc.iu.edu.

Lots more info and how to apply.

I've read it and you are absolutely right, thanks. There is a letsencrypt certificate already which is being renewed and all - I need to sort out some stuff first though before I can put it in.

From The New Deal until the present moment the architecture of The United States formed around some basic principles of public policy; principles that will no longer apply under a Trump administration. With all the questions that are on the table when it comes to this transition, Dr. James K. Galbraith asks: “Is the study...

Speaking to allies on a private call, the former president took a sharper line toward the Trump administration than he typically does in public.

WASHINGTON (AP) — The Trump administration is tightening visa guidelines for Chinese journalists in response to the treatment of U.S. journalists in China, as tensions flare between the two nations over the coronavirus. The Department of Homeland Security has issued new regulations, set to take effect Monday, that will limit visas for Chinese reporters to […]

WASHINGTON (AP) — The Trump administration is tightening visa guidelines for Chinese journalists in response to the treatment of U.S. journalists in China, as tensions flare between the two nations over the coronavirus. The Department of Homeland Security has issued new regulations, set to take effect Monday, that will limit visas for Chinese reporters to […]

The largest local council in New South Wales, whose patch includes the Darling River town that experienced mass fish kills, will spend another four years in administration.

Sydney arts centre Carriageworks says the coronavirus pandemic has caused an "irreparable loss of income" after six months of events were cancelled or postponed.

Around one person dies on Victoria's rail lines every week, with most long-term train drivers experiencing at least one fatality in their career.

The future of one of outback Australia's tourist drawcards, the National Transport Hall of Fame, is in doubt after an independent audit found financial irregularities by management.

More than 500 workers in Sydney have their jobs terminated after the collapse of the Red Lea chicken company, leaving staff without pay and "eating two-minute noodles for dinner", one former manager says.

r/Coronavirus: In December 2019, a novel coronavirus strain (SARS-CoV-2) emerged in the city of Wuhan, China. This subreddit seeks to monitor the …

(California Court of Appeal) - Affirmed the dismissal of a telecommunication company's lawsuit seeking a refund of California sales and use taxes. Held that the tax exclusion for telephone lines does not extend to pre-installation component parts that may one day be incorporated into completed telephone systems.

(United States First Circuit) - Reversing a district court decision relating to the release of private individuals' medical documents under the Freedom of Information Act in a case brought by a journalist conducting research because the balancing of public interest in disclosure and the relevant privacy interests was flawed due to the court's application of the wrong standard because the release of the documents was unlikely to advance a valid public interest and substantial privacy interests implicated by the records outweighed the interest in disclosure.

(United States Fourth Circuit) - Affirming the district court's grant of a declaratory judgment to the plaintiff that it hadn't breached any contractual agreement with Korea, but refusing a permanent injunction barring Korea from suing them in Korean courts in a contract suit between a US defense contractor and Korea in a complex set of exchanges involved in upgrading the country's fighter planes.

(United States Second Circuit) - Held that the Social Security Administration was justified in imposing an assessment and penalty on a recipient of disability benefits who failed to report work activity. The benefit recipient disputed that his failure to report earnings was material. While rejecting his legal challenge, the Second Circuit held that the agency lacked substantial evidence to support the amounts of the assessment and penalty, and therefore vacated and remanded.

(United States Second Circuit) - Held that the Social Security Administration erred in denying an individual's disability insurance benefits application. Reversed the district court and remanded for further proceedings.

(United States Ninth Circuit) - In a lawsuit alleging that federal agencies acted arbitrarily and capriciously in dismissing plaintiffs' rulemaking petitions, which requested that each agency promulgate regulations that would require all egg cartons to identify the conditions in which the egg-laying hens were kept during production, the district court's summary judgment in favor of federal agencies is affirmed where: 1) the Food Safety and Inspection Service did not act arbitrarily or capriciously in denying plaintiffs' rulemaking petition because the agency correctly concluded that it lacked authority to promulgate plaintiffs' proposed labeling regulations for shell eggs: 2) the Agricultural Marketing Service did not act arbitrarily or capriciously in denying plaintiffs’ rulemaking petition because the agency correctly concluded that it lacked the authority to promulgate mandatory labeling requirements for shell eggs; 3) the Federal Trade Commission did not act arbitrarily or capriciously in denying plaintiffs' rulemaking petition; and 4) the Food and Drug Administration barely met its low burden to clearly indicate that it considered the potential problem identified in plaintiffs' petition, and provide a reasonable explanation for not initiating rulemaking.

(United States DC Circuit) - Remanded. A final rule issued by the National Credit Union Administration intended to make it easier for community credit unions to expand their coverage that was opposed by bankers was largely affirmed, but remanded to consider a portion that might impact poor and minority urban residents.

Actress and left-wing activist Alyssa Milano has promoted a deceptively edited video about Vice President Mike Pence that was created by late-night talk show host Jimmy Kimmel -- even though the video has been debunked and Kimmel has publicly apologized for it.

A 77-year-old Michigan barber said he won't stop working "unless he is tasered by the police or Jesus Christ himself walks in" and will continue defying Gov. Gretchen Whitmer's executive orders.

For some reason, there are multiple functions in WordPress that do similar things but require different approaches. On the surface, you’d think the admin_body_class function would work the same as…

The post Working with the WordPress admin_body_class function appeared first on bavotasan.com.

Advertise your open positions here for free, no catch, and find opportunities within

Job Alert This week we've got job openings from all over the globe to tempt you, your friends or your past colleagues back into work, or indeed into new ventures.…

Trump’s Failed Coronavirus Response

The Trump administration’s response to the coronavirus pandemic has been a deliberate disaster from the beginning. But don’t take my word for it – just look at the facts.

Here’s the timeline: 

In 2018, he let the pandemic-preparedness office in the National Security Council simply dissolve, and followed up with budget cuts to HHS and CDC this year. That team’s job was to follow a pandemic playbook written after global leaders fumbled their response to Ebola in 2014. Trump was briefed on the playbook’s existence in his first year - had he listened, the government would’ve started getting equipment to doctors two months ago.

The initial outbreak of the coronavirus began in Wuhan, China, in December, 2019.  

By mid-January, 2020, the White House had intelligence reports that warned of a likely pandemic.

On January 18th, HHS Secretary Azar spoke with Trump to emphasize the threat of the virus just as US Diplomats were being evacuated from Wuhan.

Two days later, the virus was confirmed in both the US and South Korea.

That week, South Korean officials immediately drafted medical companies to develop test kits for mass production. The WHO declared a global health emergency. But Trump … did nothing.

As Hubei Province went on lockdown, Trump, who loves any excuse to enact a racist travel ban, barred entry of any foreigners coming from China (it was hardly proactive) but took no additional steps to prepare for infection in the United States.

He said, “We pretty much shut it down, coming in from China,”

He didn’t ramp up production of test kits so we could begin isolating the virus.

By February, the US had 14 confirmed cases but the CDC test kits proved faulty; there weren’t enough of them, and they were restricted to only people showing symptoms. The US pandemic response was already failing.

Trump then began actively downplaying the crisis and baselessly predicting it would go away when the weather got warmer.

Trump decided there was nothing to see here, and on February 24th, took time out of his day to remind us that the stock markets were soaring.

A day later, CDC officials sounded the alarm that daily life could be severely disrupted. The window to get ahead of the virus by testing and containment was closing. 

Trump’s next move: He compared Coronavirus to the seasonal flu…and called the emerging crisis a hoax by the Democrats.

With 100 cases in the US, Trump declined to call for a national emergency.

Meanwhile, South Korea was now on its way to testing a quarter million people, while the US was testing 40 times slower.

When a cruise ship containing Americans with coronavirus floated toward San Francisco, Trump said he didn’t want people coming off the ship to be tested because they’d make the numbers look bad.

It wasn’t until the stock market reacted to the growing crisis and took a nosedive that Trump finally declared a national emergency.

By this time, South Korea had been using an app for over a month that pulled government data to track cases and alert users to stay away from infected areas.

Over the next weeks, as the virus began its exponential spread across the US, and Governors declared states of emergency, closing schools and workplaces and stopping the American economy in its tracks –  Trump passed on every opportunity to get ahead of this crisis.

Trump’s priority was never public health. It was about making the virus seem like less of a nuisance so that the “numbers” would “look good” for his reelection.

Only when the stock market crashed did Trump finally begin to pay attention…and mostly to bailing out corporations in the form of a massive $500 billion slush fund, rather than to helping people. And then, with much of America finally and belatedly in lockdown, he said at a Fox News town hall that he would “love” to have the country “opened up, and just raring to go” by Easter.

At every point, Trump has used this crisis to compliment himself.

This is not leadership. This is the exact opposite of leadership. 

The Badminton World Federation said the 2021 world championships will run from Nov. 29-Dec. 5 to avoid a schedule conflict with the Tokyo Olympics.

USA Badminton has been taken off probation by the U.S. Olympic and Paralympic Committee, which tried to decertify the organization for noncompliance to protect athletes from sexual abuse.

1. Trump admin working to temporarily ban work-based visas: Report  Top Live News
2. US lawmakers want H-1B visas and foreign students internship suspended to protect American jobs  Times of India
3. US likely to temporarily ban work-based visas like H-1B due to rise in unemployment  Zee News
4. US Mulls Temporary Ban on Work Visas Amid Unemployment: Reports  The Quint
5. 5 US lawmakers ask Trump to suspend new H-1B visas  The Tribune India
6. View Full coverage on Google News

I had to use PHPMyadmin a few days ago to delete old tables in my WordPress Database. They were created by a plugin that I tried but decided not to use. Normally when you uninstall a plugin the developer deletes the tables in your database that they create. In this case this author didn’t. It […]

LAS VEGAS (Jan. 21, 2020) — Today, Environmental Protection Agency (EPA) Administrator Andrew Wheeler and U.S. Department of Agriculture (USDA) Secretary Sonny Perdue announced the addition of six new U.S. Food Loss and Waste 2030 Champions. These champions are U.S.

Add Dr. Rick Bright to the list of coronavirus whistleblowers silenced or sidelined for trying to push truth over politics as we battle this deadly scourge. He was just ousted from his post as director of the HHS agency working on a COVID-19 vaccine for what he claims was his refusal to support a “game-changing” supposed cure President Trump and friends have been touting. CDC chief Robert Redfield suffered a similar rebuke for warning of a second wave of the virus next winter, contradicting the more rosy picture the president wants trying to paint. Not fired (yet), but clearly pressured to toe the line, truth and science be damned.

New rules from federal Education Secretary Betsy DeVos would severely limit students' ability to clear debt by burying them in bureaucratic red tape, according to a new federal lawsuit.