The requests put the nation's special education administrators in conflict with disability rights advocates who fear waivers will place millions of special education students at risk.

Vice President Kamala Harris received a grand welcome to the White House on Tuesday afternoon — cheered on by hundreds of administration staff as her SUV pulled up to the West Wing.

Iran will pursue whatever secures its interest, government spokesperson Fatemeh Mohajerani said on Tuesday, when asked if there could be direct talks with the Trump administration.

Suit comes at a time when Delaware response rates are lagging. Attorney General Kathy Jennings has joined a large coalition of attorneys general, cities, counties, and the bipartisan U.S. Conference of Mayors in taking legal action against the Trump Administration’s impairment of the 2020 Decennial Census. The coalition filed an amicus brief in National Urban League v. […]

NEW CASTLE (Julio 12, 2022) – El Departamento de Salud y Servicios Sociales (DHSS) anunció hoy que ha seleccionado tres compañias para operar su Programa de Atención Administrada de Medicaid. La División de Medicaid y Asistencia Médica (DMMA) del DHSS continuará su asociación de MCO con Highmark Health Options Blue Cross Blue Shield, que empezó […]

The Delaware Department of Agriculture announced today that Mark Short has been named the new Delaware Standardbred Breeders’ Fund (DESBF) administrator. He will begin his new role as the DESBF administrator on November 1.

The Delaware Department of Agriculture announced the 28th round of easement selections by the Delaware Agricultural Lands Preservation, preserving 40 farms and 2,262 acres of farmland. With this announcement, the Carney administration has preserved 403 farms, the highest number in the program’s history.

DOVER, Del. – Governor Carney joined Lieutenant Governor Bethany Hall-Long, Department of Transportation Secretary Nicole Majeski, Department of Natural Resources and Environmental Control Secretary Shawn Garvin, elected officials and advocates on Friday afternoon to outline investments in the state’s electric vehicle infrastructure. With a combination of state and federal funding, charging stations for electric vehicles will be […]

DEPARTMENT OF STATE: Division of Professional Regulation

Afghan NGOs have also struggled to attend the climate negotiations in recent years.

ADB has a vacancy for the position of Senior Administration and Communications Assistant in the Strategy, Policy and Partnerships Department. The deadline for submitting applications is on 26-NOV-2024.

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Title: Obama Administration Offers New Rules for Religious Objections to Health Care Law
Category: Health News
Created: 8/25/2014 9:35:00 AM
Last Editorial Review: 8/25/2014 12:00:00 AM

Clinical reports suggest that the most effective strategies for managing opioid use disorder comprise a comprehensive treatment program of both pharmacological and nonpharmacological approaches. However, the conditions under which these combinations are most effective are not well characterized. This study examined whether the presence of an alternative reinforcer could alter the efficacy of Food and Drug Administration–approved opioid antagonist or agonist medications, as well as the nonopioid flumazenil, in decreasing oxycodone choice self-administration in nonhuman primates. Adult squirrel monkeys (n = 7; four females) responded under concurrent second-order fixed-ratio (FR)-3(FR5:S);TO45s schedules of reinforcement for intravenous oxycodone (0.1 mg/kg) or saline on one lever and 30% sweetened condensed milk or water on the other. Doses of naltrexone (0.00032–1.0 mg/kg), nalbuphine (0.32–10 mg/kg), buprenorphine (0.0032–0.032 mg/kg), methadone (0.32–1.0 mg/kg), or flumazenil (1–3.2 mg/kg) were administered intramuscularly prior to oxycodone self-administration sessions that occurred with either milk or water as the alternative. Naltrexone, a μ-opioid receptor antagonist, was >30-fold more potent when milk was available compared with water and abolished oxycodone intake (injections/session) while concomitantly increasing milk deliveries at the highest dose tested. Pretreatment with the low-efficacy μ-agonist nalbuphine was most effective in the presence of milk compared with water, decreasing oxycodone preference to <50% of control values. The higher efficacy μ-agonists, methadone and buprenorphine, and the benzodiazepine antagonist flumazenil did not appreciably alter the reinforcing potency of oxycodone under either condition. These results suggest that antagonist medications used in combination with alternative reinforcers may be an effective strategy to curtail opioid abuse–related behaviors.

Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of chemotherapy treatment, routinely manifesting as increased pain sensitivity (allodynia) in distal extremities. Despite its prevalence, effective treatment options are limited. Cannabinoids are increasingly being evaluated for their ability to treat chronic pain conditions, including CIPN. While previous studies have revealed sex differences in cannabinoid-mediated antinociception in acute and chronic pain models, there is a paucity of studies addressing potential sex differences in the response of CIPN to cannabinoid treatment. Therefore, we evaluated the long-term antiallodynic efficacy of cannabinoid receptor type 1 (CB₁)-selective, cannabinoid receptor type 2 (CB₂)-selective, and CB₁/CB₂ mixed agonists in the cisplatin CIPN model, using both male and female mice. CB₁ selective agonism was observed to have sex differences in the development of tolerance to antiallodynic effects, with females developing tolerance more rapidly than males, while the antiallodynic effects of selective CB₂ agonism lacked tolerance development. Compound-specific changes to the female estrous cycle and female plasma estradiol levels were noted, with CB₁ selective agonism decreasing plasma estradiol while CB₂ selective agonism increased plasma estradiol. Chronic administration of a mixed CB₁/CB₂ agonist resulted in increased mRNA expression of proinflammatory cytokines and endocannabinoid regulatory enzymes in female spinal cord tissue. Ovarian tissue was noted to have proinflammatory cytokine mRNA expression following administration of a CB₂ acting compound while selective CB₁ agonism resulted in decreased proinflammatory cytokines and endocannabinoid regulatory enzymes in testes. These results support the need for further investigation into the role of sex and sex hormones signaling in pain and cannabinoid-mediated antinociceptive effects.

Optimal patient management protocols for metastatic castration-resistant prostate cancer (mCRPC) are poorly defined and even further complexified with new therapy approvals, such as radiopharmaceuticals. The prostate-specific membrane antigen (PSMA)–targeted agent ¹⁷⁷Lu vipivotide tetraxetan ([¹⁷⁷Lu]Lu-PSMA-617), approved after the phase III VISION study, presents physicians with additional aspects of patient management, including specific adverse event (AE) monitoring and management, as well as radiation safety. Drawing on our experience as VISION study investigators, here we provide guidance on best practices for delivering PSMA-targeted radiopharmaceutical therapy (RPT) to patients with mCRPC. After a comprehensive review of published evidence and guidelines on RPT management in prostate cancer, we identified educational gaps in managing the radiation safety and AEs associated with [¹⁷⁷Lu]Lu-PSMA-617. Our results showed that providing sufficient education on AEs (e.g., fatigue and dry mouth) and radiation safety principles is key to effective delivery and management of patient expectations. Patient counseling by health care professionals, across disciplines, is a cornerstone of optimal patient management during PSMA-targeted RPT. Multidisciplinary collaboration is crucial, and physicians must adhere to radiation safety protocols and counsel patients on radiation safety considerations. Treatment with [¹⁷⁷Lu]Lu-PSMA-617 is generally well tolerated; however, additional interventions may be required, such as dosing modification, medications, or transfusions. Urinary incontinence can be challenging in the context of radiation safety. Multidisciplinary collaboration between medical oncologists and nuclear medicine teams ensures that patients are monitored and managed safely and efficiently. In clinical practice, the benefit-to-risk ratio should always be evaluated on a case-by-case basis.

Friday on the RealClearPolitics radio show -- weeknights at 6:00 p.m. on SiriusXM's POTUS Channel 124 and then on Apple, Spotify, and here on our website -- Tom Bevan, Andrew Walworth, and Carl Cannon look at the latest count to determine the final popular vote and House majority.

Robert F. Kennedy Jr. launched a "Nominees for the People" forum to crowdsource 4,000 positions in the Trump administration to Make America Healthy Again.

The Fox News Politics newsletter, with the latest updates on the Trump transition, exclusive interviews and more Fox News politics content.

The State Department said Tuesday that the Biden-Harris administration would not cut off weapons supplies to Israel in reaction to what it said was a declining humanitarian situation in the Gaza Strip, due to Israeli mitigation efforts.

The post Biden-Harris Administration Decides Not to Cut Arms to Israel, After Threat appeared first on Breitbart.

President-elect Donald Trump has made many selections to lead his administration as his transition gets underway, ranging from chief of staff to head of the Environmental Protection Agency (EPA). At the same time, a number of crucial positions have yet to be filled just one week removed from the landslide election.

The post Donald Trump’s Administration Takes Shape After 15 Official or Expected Picks appeared first on Breitbart.

Un «faucon» anti-Chine à la diplomatie, une gouverneure «tueuse de chiens» à la sécurité intérieure.

Those who work in public administration and defence operate in the most heavily unionised sector of the labour market.

The new Trump administration is likely to reduce subsidies for Affordable Care Act insurance plans and roll back Medicaid coverage. Public health authorities worry that antivaccine activist Robert F. Kennedy, Jr., will be empowered

A fee created to push oil and gas companies to plug methane leaks could be axed by the incoming Trump administration, hampering efforts to curb the potent greenhouse gas

The Pew Charitable Trusts joined dozens of research, health care, and nonprofit stakeholders in urging President-elect Joe Biden to prioritize and strengthen the national response to antibiotic resistance.

Mar 13, 2024

David Kearn argues that even in the absence of restrictive resource and budgetary constraints, a focus on identifying and achieving concrete objectives that will position the United States and its allies to effectively deter aggression in critical regional flashpoints should be the priority given the stressed nature of the defense industrial base and the nuclear enterprise.

SDA Bocconi - 1-year Full-Time MBA - Master of Business Administration

Elliott Vichinsky, MD, University of California, San Francisco (UCSF) Benioff Children's Hospital Oakland

Efforts to shape the policies of President-elect Donald Trump through Elon Musk are already underway. On Friday, Americans for Responsible Innovation (ARI), a nonprofit AI advocacy group, initiated a public petition urging Trump to appoint Musk as his special adviser on

In a surprising twist, Elon Musk is joining the Trump administration: not to advise on artificial intelligence or space innovation, but to lead an ambitious new project focused on government efficiency. Alongside entrepreneur Vivek Ramaswamy, Musk will head up the Department

China has set out the priorities of the Belt and Road Initiative Tax Administration Cooperation Mechanism (BRITACOM) Council over the next five years, at the 36-country grouping's second forum.

Hong Kong tabled the Inland Revenue (Amendment) (Miscellaneous Provisions) Bill 2021 in parliament on March 24.

On May 15, 2020, the Belgian tax authority announced that taxpayers who timely filed their value-added tax declarations but were then informed that they submitted late or made an error in their submission to ignore such notifications due to technical issues with the VAT filing system.

China has set out the priorities of the Belt and Road Initiative Tax Administration Cooperation Mechanism (BRITACOM) Council over the next five years, at the 36-country grouping's second forum.

Hong Kong tabled the Inland Revenue (Amendment) (Miscellaneous Provisions) Bill 2021 in parliament on March 24.

The British Virgin Islands' Inland Revenue Department is to introduce a new platform from early next year to automate the administration of all taxes and licenses.

Women take two types of pills for abortion during their pregnancy: medlinkmisoprostol/medlink, which causes the womb to contract, and medlinkmifepristone/medlink,

Oramed Pharmaceuticals Reports Results in Phase 2b Trial of Oral Insulin Administration to Type 2 Diabetes Patients

Sandata Chosen to Implement Florida Agency for Health Care Administration Telephonic Home Health Project

Centene Corporation to Acquire Arkansas Health Plan Administrator

US President-elect Donald Trump has shut the door on Nikki Haley declaring that he won't be inviting her to join his administration, but another Indian American, Vivek Ramaswamy, may get a senior role.

US President-elect Donald Trump has selected former New York Representative Lee Zeldin to serve as his administrator of the Environmental Protection Agency.

Announcement Number: DOE-19-EI-ES-00871
Closing Date: 17 September 2014

Announcement Number: DOE-HQ-EI-18-00800-SES
Closing Date: 21 February 2018

New York Governor Kathy Hochul explores reviving a USD 15 congestion pricing toll for Manhattan before President-elect Trump takes office.