Restaurants struggling during the coronavirus pandemic are becoming grocery stores to survive. Here's where to score groceries around Indianapolis.

Here's how the self-employed, gig workers and others who don't typically qualify for state unemployment benefits can receive new federal benefits.

The Pacers didn't have their starting point guard for the last three games before the NBA went on hiatus, but he's able to play if/when it restarts.

MIC all-conference teams for basketball, wrestling and swimming

The Pacers didn't have their starting point guard for the last three games before the NBA went on hiatus, but he's able to play if/when it restarts.

Former Center Grove High School standout attended Stanford but will play for the Hoosiers in his remaining season.

Tottenham reach an agreement with Russian club Lokomotiv Moscow over the sale of striker Roman Pavlyuchenko.

Manchester United sign 19-year-old Swiss centre-back Frederic Veseli from local rivals Manchester City.

The BBC Health team talks through the NHS advice about protecting yourself from COVID-19.

Everybody should be avoiding non-essential contact, and you should stay at home wherever possible.

The former Bank of England governor says countries should invest in a cleaner economic recovery.

The "Americans" actress dived into the change of place to play "hidden" spice smuggler Zorii Bliss.

Zimbabwe market stall owner Aaron Makaya saw a business opportunity when President Emmerson Mnangagwa made face masks mandatory in public places to prevent the spread of coronavirus.

A Canadian grocery chain says its introducing a fleet of intelligent grocery carts that scan and weigh products as customers place them in the cart.

The rapper said she wanted to support women's and LGTBQ rights.

Numéricable has selected the Calix E7-2 Ethernet Service Access Platform and gigabit passive optical network technology to upgrade its service delivery platform in Belgium and Luxembourg. Calix, along with optical specialist Arcadiz Telecom, will work closely to roll out Numéricable’s new high-speed broadband networks to deliver business services across the region. The new platform will enable Numéricable’s customers to take advantage of advanced voice, video, and data services at symmetrical speeds ranging from 30 megabits per second (30 Mbps) up to 1 gigabit per second (1 Gbps).

Numéricable serves over 150,000 customers in Brussels with triple-play services for residential subscribers. Owned by Coditel and with a close relationship to the French Numéricable organization, with whom it shares a range of resources, Numéricable Belgium is a long-established operator with a highly dispersed coax cable network. The company has traditionally delivered triple-play residential services over its hybrid fiber coax infrastructure, but in recent years has moved increasingly towards using its fiber to connect businesses and has developed a number of specific niche markets. The company is now looking at ways to maximize the potential of its fiber infrastructure in Belgium and Luxembourg and deliver revenue-generating advanced services to its business customers.

Qatar Telecom has selected Mariner's IP video service oriented monitoring solution, Mariner xVu. The latest version of Mariner xVu is specifically designed for integration with IPTV probes. Qtel will use Mariner xVu for the Mozaic TV service, making this the first Mariner xVu deployment in the Middle East.

Alfalak Electronic Equipment & Supplies Co., partnered with Mariner to deploy xVu. Through easy integration with network probes — at the head-end and/or individual network element — Mariner xVu offers Qtel additional insights into the IPTV network by extending video service monitoring reach to each subscriber, allowing the operator to maintain the highest possible video quality while simultaneously reducing operating expenses. Statistics collected by external data sources such as probes are compiled and configured as status indicators on Mariner NetworkVu to enable a deeper understanding of IPTV traffic and customer experience issues. The probe enhancement is now a configurable option of NetworkVu, rather than a custom development, and was created based on service provider requests for integration with external data sources.

Some states still haven’t recovered from the last recession. They could face worse now.

It’s rather unfortunate that the best some of us can do in a time of a global pandemic is to stay at home in order to help. Quarantines for that matter, are tough challenges for the regular person. However, they don’t have to feel like an unproductive slog, why not treat yourself to some self-improvement […]

The post 12 Free Web Development Courses to Take While in Self-Isolation appeared first on SpyreStudios.

strataconf: Big data vs big reality http://t.co/D751jk0ntb Data itself has no quality. It’s what you do with it that counts

The controversial file hoster RapidShare has taken a first step towards entering the digital content business: The company launched a download store for video games last week, and it is promising its end users to enable the sale of any kind of file soon. Continue reading on Newteevee.com

As a digital company, your business is not bound by conventional borders and has the freedom and opportunity to reach customers anywhere in the world. And just as you look outward for new markets, customers are also looking beyond their physical borders for their goods and services. As a study by KPMG shows, online buyers […]

Hear about travel to Düsseldorf, Germany as the Amateur Traveler talks to Erik and Anne Hess about this city on the Rhine. Carnival, Christmas Markets and one of the most livable cities in the world.

Hear about travel to Basel, Switzerland as the Amateur Traveler talks to Claudia McCoy about her hometown.

A new year brings another run at my annual predictions: For 17 years now, I’ve taken a few hours to imagine what might happen over the course of the coming twelve months. And my goodness did I swing for the fences last year — and I pretty much whiffed. Batting .300 is great in the majors, but it … Continue reading "Predictions 2020: Facebook Caves, Google Zags, Netflix Sells Out, and Data Policy Gets Sexy"

Three months ago, Apple released a new credit card in partnership with Goldman Sachs that aimed to disrupt the highly regulated world of consumer finance. However, a well-known software developer tweeted that he was given 20x the credit line offered to his wife, despite the fact that they have been filing joint tax returns and […]

Finding a good system to be organized can be intimidating. There are so many options! Useful tips on how to get your life together are all over the internet. From minimalist planners to detailed systems, something is bound to draw you in. Choosing the best system to use will be the biggest decision you’ll have […]

The post The Simplest Hack to Be Your Most Organized Self appeared first on Dumb Little Man.

The following article, Univ of Pittsburg Researcher, China Native, Dr. Bing Liu, “On the verge” of COVID19 Breakthrough Is Murdered…Alleged Gunman, Hao Gu, Kills Himself, was first published on 100PercentFedUp.com.

A 37-year-old China native and "outstanding researcher" at the University of Pittsburgh...

Continue reading: Univ of Pittsburg Researcher, China Native, Dr. Bing Liu, “On the verge” of COVID19 Breakthrough Is Murdered…Alleged Gunman, Hao Gu, Kills Himself ...

Neoantimycins are anticancer compounds of 15-membered ring antimycin-type depsipeptides. They are biosynthesized by a hybrid multimodular protein complex of nonribosomal peptide synthetase (NRPS) and polyketide synthase (PKS), typically from the starting precursor 3-formamidosalicylate. Examining fermentation extracts of Streptomyces conglobatus, here we discovered four new neoantimycin analogs, unantimycins B–E, in which 3-formamidosalicylates are replaced by an unusual 3-hydroxybenzoate (3-HBA) moiety. Unantimycins B–E exhibited levels of anticancer activities similar to those of the chemotherapeutic drug cisplatin in human lung cancer, colorectal cancer, and melanoma cells. Notably, they mostly displayed no significant toxicity toward noncancerous cells, unlike the serious toxicities generally reported for antimycin-type natural products. Using site-directed mutagenesis and heterologous expression, we found that unantimycin productions are correlated with the activity of a chorismatase homolog, the nat-hyg5 gene, from a type I PKS gene cluster. Biochemical analysis confirmed that the catalytic activity of Nat-hyg5 generates 3-HBA from chorismate. Finally, we achieved selective production of unantimycins B and C by engineering a chassis host. On the basis of these findings, we propose that unantimycin biosynthesis is directed by the neoantimycin-producing NRPS–PKS complex and initiated with the starter unit of 3-HBA. The elucidation of the biosynthetic unantimycin pathway reported here paves the way to improve the yield of these compounds for evaluation in oncotherapeutic applications.

Martin R. Larsen
Jul 1, 2005; 4:873-886
Technology

S Xu
Jul 1, 1997; 38:1289-1298
Articles

Kainate and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors are two major, closely related receptor subtypes in the glutamate ion channel family. Excessive activities of these receptors have been implicated in a number of central nervous system diseases. Designing potent and selective antagonists of these receptors, especially of kainate receptors, is useful for developing potential treatment strategies for these neurological diseases. Here, we report on two RNA aptamers designed to individually inhibit kainate and AMPA receptors. To improve the biostability of these aptamers, we also chemically modified these aptamers by substituting their 2'-OH group with 2'-fluorine. These 2'-fluoro aptamers, FB9s-b and FB9s-r, were markedly resistant to RNase-catalyzed degradation, with a half-life of ∼5 days in rat cerebrospinal fluid or serum-containing medium. Furthermore, FB9s-r blocked AMPA receptor activity. Aptamer FB9s-b selectively inhibited GluK1 and GluK2 kainate receptor subunits, and also GluK1/GluK5 and GluK2/GluK5 heteromeric kainate receptors with equal potency. This inhibitory profile makes FB9s-b a powerful template for developing tool molecules and drug candidates for treatment of neurological diseases involving excessive activities of the GluK1 and GluK2 subunits.

Expert

Expert

Kainate and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors are two major, closely related receptor subtypes in the glutamate ion channel family. Excessive activities of these receptors have been implicated in a number of central nervous system diseases. Designing potent and selective antagonists of these receptors, especially of kainate receptors, is useful for developing potential treatment strategies for these neurological diseases. Here, we report on two RNA aptamers designed to individually inhibit kainate and AMPA receptors. To improve the biostability of these aptamers, we also chemically modified these aptamers by substituting their 2'-OH group with 2'-fluorine. These 2'-fluoro aptamers, FB9s-b and FB9s-r, were markedly resistant to RNase-catalyzed degradation, with a half-life of ∼5 days in rat cerebrospinal fluid or serum-containing medium. Furthermore, FB9s-r blocked AMPA receptor activity. Aptamer FB9s-b selectively inhibited GluK1 and GluK2 kainate receptor subunits, and also GluK1/GluK5 and GluK2/GluK5 heteromeric kainate receptors with equal potency. This inhibitory profile makes FB9s-b a powerful template for developing tool molecules and drug candidates for treatment of neurological diseases involving excessive activities of the GluK1 and GluK2 subunits.

Hilaf Hasson and Jeffrey Yelton
Trans. Amer. Math. Soc. 373 (2020), 3009-3030.
Abstract, references and article information

Mahmoud Benkhalifa
Proc. Amer. Math. Soc. 148 (2020), 2695-2706.
Abstract, references and article information

petrapetruta posted a reply:

jacquesjacobs:


Hello there and welcome!We hope to see some catchy contribution from you too! :-)