tom

White Matter Disease and Outcomes of Mechanical Thrombectomy for Acute Ischemic Stroke [INTERVENTIONAL]

BACKGROUND AND PURPOSE:

The increased severity of white matter disease is associated with worse outcomes and an increased rate of intracerebral hemorrhage in patients with ischemic stroke undergoing thrombolytic treatment. However, whether white matter disease is associated with outcomes in patients undergoing endovascular treatment remains unclear.

MATERIALS AND METHODS:

In this prespecified exploratory analysis of our prospective multi-institutional study that enrolled consecutive adult patients with anterior circulation ischemic stroke undergoing endovascular treatment from November 2017 to September 2018, we compared the following outcomes between patients with none-to-minimal (van Swieten score, 0–2) and moderate-to-severe (van Swieten score, 3–4) white matter disease using logistic regression: 90-day mRS 3–6, death, intracerebral hemorrhage, successful recanalization, and early neurologic recovery.

RESULTS:

Of the 485 patients enrolled in the Blood Pressure after Endovascular Stroke Therapy (BEST) study, 389 had white matter disease graded (50% women; median age, 68 years; range, 58–79 years). A van Swieten score of 3–4 (n = 74/389, 19%) was associated with a higher rate of 90-day mRS of 3–6 (45% versus 18%; adjusted OR, 2.73; 95% CI, 1.34–5.93; P = .008). Although the death rate was higher in patients with van Swieten scores of 3–4 (26% versus 15%), the adjusted likelihood was not significantly different (adjusted OR, 1.14; 95% CI, 0.56–2.26; P = .710). Ordered regression revealed a shift toward worse mRS scores with increasing van Swieten scores (adjusted common OR, 3.04; 95% CI, 1.93–4.84; P < .001). No associations between white matter disease severity and intracerebral hemorrhage, successful recanalization, and early neurologic recovery were observed.

CONCLUSIONS:

Moderate-to-severe white matter disease is associated with worse outcomes in patients undergoing endovascular treatment without a significant increase in hemorrhagic complications. Studies comparing patients with and without endovascular treatment are necessary to determine whether the benefit of endovascular treatment is attenuated with greater white matter disease.




tom

Save the Brain First: CTA and Mechanical Thrombectomy in Patients at Risk for Contrast-Induced Nephropathy [article-commentary]




tom

Discrimination between Glioblastoma and Solitary Brain Metastasis: Comparison of Inflow-Based Vascular-Space-Occupancy and Dynamic Susceptibility Contrast MR Imaging [FUNCTIONAL]

BACKGROUND AND PURPOSE:

Accurate differentiation between glioblastoma and solitary brain metastasis is of vital importance clinically. This study aimed to investigate the potential value of the inflow-based vascular-space-occupancy MR imaging technique, which has no need for an exogenous contrast agent, in differentiating glioblastoma and solitary brain metastasis and to compare it with DSC MR imaging.

MATERIALS AND METHODS:

Twenty patients with glioblastoma and 22 patients with solitary brain metastasis underwent inflow-based vascular-space-occupancy and DSC MR imaging with a 3T clinical scanner. Two neuroradiologists independently measured the maximum inflow-based vascular-space-occupancy–derived arteriolar CBV and DSC-derived CBV values in intratumoral regions and peritumoral T2-hyperintense regions, which were normalized to the contralateral white matter (relative arteriolar CBV and relative CBV, inflow-based vascular-space-occupancy relative arteriolar CBV, and DSC-relative CBV). The intraclass correlation coefficient, Student t test, or Mann-Whitney U test and receiver operating characteristic analysis were performed.

RESULTS:

All parameters of both regions had good or excellent interobserver reliability (0.74~0.89). In peritumoral T2-hyperintese regions, DSC-relative CBV (P < .001), inflow-based vascular-space-occupancy arteriolar CBV (P = .001), and relative arteriolar CBV (P = .005) were significantly higher in glioblastoma than in solitary brain metastasis, with areas under the curve of 0.94, 0.83, and 0.72 for discrimination, respectively. In the intratumoral region, both inflow-based vascular-space-occupancy arteriolar CBV and relative arteriolar CBV were significantly higher in glioblastoma than in solitary brain metastasis (both P < .001), with areas under the curve of 0.91 and 0.90, respectively. Intratumoral DSC-relative CBV showed no significant difference (P = .616) between the 2 groups.

CONCLUSIONS:

Inflow-based vascular-space-occupancy has the potential to discriminate glioblastoma from solitary brain metastasis, especially in the intratumoral region.




tom

The Lateral Ventricles: A Detailed Review of Anatomy, Development, and Anatomic Variations [review-article]

SUMMARY:

The cerebral ventricles have been studied since the fourth century BC and were originally thought to harbor the soul and higher executive functions. During the infancy of neuroradiology, alterations to the ventricular shape and position on pneumoencephalography and ventriculography were signs of mass effect or volume loss. However, in the current era of high-resolution cross-sectional imaging, variation in ventricular anatomy is more easily detectable and its clinical significance is still being investigated. Interpreting radiologists must be aware of anatomic variations of the ventricular system to prevent mistaking normal variants for pathology. We will review of the anatomy and development of the lateral ventricles and discuss several ventricular variations.




tom

The Last of Us Part II New Trailer Drops Tomorrow, May 6

Developer Naughty Dog announced via Twitter a new trailer for the upcoming PlayStation 4 exclusive, The Last of Us Part II, will be released tomorrow, May 6 at 7am PT / 10am ET.

05.06.20. 7:00am PT. pic.twitter.com/zSrS3SOZ6U

— Naughty Dog (@Naughty_Dog) May 5, 2020

Here is an overview of the game:

Five years after their dangerous journey across the post-pandemic United States, Ellie and Joel have settled down in Jackson, Wyoming. Living amongst a thriving community of survivors has allowed them peace and stability, despite the constant threat of the infected and other, more desperate survivors. When a violent event disrupts that peace, Ellie embarks on a relentless journey to carry out justice and find closure. As she hunts those responsible one by one, she is confronted with the devastating physical and emotional repercussions of her actions.

Key Features:

  • A Complex and Emotional Story – Experience the escalating moral conflicts created by Ellie’s relentless pursuit of vengeance. The cycle of violence left in her wake will challenge your notions of right versus wrong, good versus evil, and hero versus villain.

    A Beautiful Yet Dangerous World – Set out on Ellie’s journey, taking her from the peaceful mountains and forests of Jackson to the lush, overgrown ruins of greater Seattle. Encounter new survivor groups, unfamiliar and treacherous environments, and terrifying evolutions of the infected. Brought to life by the latest iteration of the Naughty Dog engine, the deadly characters and world are more realistic and meticulously detailed than ever before.

  • Tense and Desperate Action-Survival Gameplay – New and evolved gameplay systems deliver upon the life-or-death stakes of Ellie’s journey through the hostile world. Feel her desperate struggle for survival through improved features such as high-intensity melee combat, fluid movement, and dynamic stealth. A broad variety 

The Last of Us Part II will launch for the PlayStation 4 on June 19.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel dedicated to gaming Let's Plays and tutorials. You can contact the author at wdangelo@vgchartz.com or on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/443393/the-last-of-us-part-ii-new-trailer-drops-tomorrow-may-6/




tom

Deepmind AI can understand the unusual atomic structure of glass

Glass has an unusual atomic structure that resembles a liquid frozen in place, making it hard to predict how it will behave. DeepMind has developed an AI capable of doing so, which may also be able to predict traffic jams




tom

Solar Orbiter will give us our best views of the sun’s top and bottom

The Solar Orbiter spacecraft, set to launch on 7 February, will give us our first clear views of the sun’s poles and help unravel the mystery of the solar wind




tom

NY Has Mismanaged COVID-19 From Top to Bottom

There is something deeply unsettling about the lionization of Andrew Cuomo and his handling of the epidemic, especially in the light of the raw statistics




tom

U.S. Energy Department is First Customer for World’s Biggest Chip

Cerebras aims to speed deep learning at supercomputing centers




tom

AI and the Future of Work: The Prospects for Tomorrow’s Jobs

MIT conference considers companies that have implemented job-friendly AI



  • robotics
  • robotics/artificial-intelligence

tom

A Champagne Bottle Sized 'My Personal Bottomless Mimosa' Glass

Just in time for Mother's Day/continued at-home quarantine comes this 750mL 'My Personal Bottomless Mimosa' glass from BigMouth, Inc and available on Amazons. The surprisingly all-glass drinkware (but still hand-wash only on account of the decorations) combines the shape of a champagne bottle with a mimosa glass to holds 8 (read: 2-3) servings, and is perfect for letting the rest of your family know you're not to be bothered for the rest of the day because it may still be early here but, dammit, it's 5 o'clock somewhere that's nine and half hours ahead. Thanks to Tracey H, who informed me she can't count the number of times she's been asked to leave a bottomless brunch for really putting its bottomlessness to the test. Heck yeah, that's called doing God's work.




tom

RPGCast – Episode 304: “Castomel and Order”

We remember Andrew Long. We’ll miss you, buddy. But the show must go on and we talk about Happy Meals, luminescent children, Kemco games, and...




tom

RPGCast – Episode 420: “Not that kind of Ottomon!”

This is the end of an era. No longer will we be able to look forward to episode 420. You could say our ambitions have...




tom

RPG Cast – Episode 527: “Chris Should Play Nier Automata”

It's Alice's first appearance of the decade! Ther crew is rounded out by Alex, Anna Marie, Chris, Kelley and Peter who are back to discuss your treasured memories of the last decade, as well as the news, reviews, and releases from the last few weeks. Wasn't there supposed to be a break from releases...?



  • News
  • Podcasts
  • RPG Cast
  • Atelier Ryza
  • Dragon Quest Monsters
  • Everreach: Project Eden
  • Final Fantasy II
  • Final Fantasy II PSP
  • Final Fantasy IV
  • Final Fantasy IV Advance
  • Final Fantasy IV DS
  • Final Fantasy IV: The After Years
  • Final Fantasy IV: The Complete Collection
  • Path of Exile
  • Persona 3 Portable
  • Pokémon Mystery Dungeon
  • Ring Fit Adventure
  • Zwei


tom

Why are men more likely to get worse symptoms and die from covid-19?

More men die of covid-19 than women. Reasons for this may include differences in smoking, general health, immune defences, hormones and even hygiene




tom

Ends Tomorrow: Save 15% on All Pullover Fleece at the IGN Store




tom

Revisiting AC Odyssey? Find Every Tomb and Ainigmata With This Map

This interactive map for Assassin's Creed Odyssey will help you find everything you need, like ainigmata ostraka and tombs.





tom

Businesses must promote diversity – not just because it's good for the bottom line | Tim Ryan

Too many of America’s workplaces are not representative of our communities. In a divided country, we have a duty to advance diversity and inclusion

We’re living in a country of growing division and tension, and it’s having an impact at work. But it’s often the case that when we walk into the office – where we spend the majority of our time – we don’t address these issues.

And yet there’s so much to talk about – from growing societal inequality and America’s racial divide to single-digit minority representation in corporate America. (Just 1% of the nation’s Fortune 500 CEOs are black, only 4% are women, and even fewer are openly gay).

Continue reading...




tom

Caterers bringing customers to them due to COVID-19

Catering companies are having to get creative to stay in business during COVID-19.




tom

WHO readies coronavirus app for checking symptoms, possibly contact tracing

The World Health Organization (WHO) plans to launch an app this month to enable people in under-resourced countries to assess whether they may have the novel coronavirus, and is considering a Bluetooth-based contact tracing feature too, an official told Reuters on Friday.




tom

Tom Cruise aims higher with movie shot on space station

Action star Tom Cruise is working on a movie shot in outer space, the National Aeronautics and Space Administration said on Tuesday.




tom

Fiona Phillips opens up on &apos;horrible&apos; coronavirus symptoms which left her bedridden

Read our live updates on coronavirus HERE Cornavirus: The symptoms




tom

Man with Covid-19 symptoms jailed after coughing in NHS nurses&apos; faces and urinating on hospital floor

Follow our live Covid-19 updates HERE Coronavirus: The symptoms




tom

Three hospital workers and two nurses confirmed dead with coronavirus symptoms as death toll of healthcare workers rises

Read our live coronavirus updates HERE




tom

War veteran Tom Moore, 99, raises more than £1.5m to help NHS fight coronavirus

Follow our live coronavirus updates HERE Coronavirus: The symptoms




tom

One in ten hospital nurses off sick with coronavirus symptoms or in isolation

Coronavirus: the symptoms Read our LIVE updates on the coronavirus here




tom

Woman who could only stomach crumpets during chemotherapy is sent van full of them by Warburtons

Coronavirus: the symptoms Read our LIVE updates on coronavirus here




tom

War veteran Captain Tom Moore, 99, raises over £7m for NHS by walking lengths of his garden

UPDATE: War veteran, 99, hits £9 million for NHS as Matt Hancock calls him an 'inspiration'




tom

How to donate to Captain Tom Moore&apos;s NHS fundraiser

Coronavirus: the symptoms Read our live updates here




tom

Captain Tom Moore says knighthood would be &apos;marvellous&apos; as campaign for honour continues

Read our live coronavirus updates HERE




tom

War veteran Captain Tom Moore, 99, hits £14 million for NHS as Matt Hancock calls him an &apos;inspiration&apos;

Follow our live Covid-19 updates HERE Coronavirus: The symptoms




tom

Captain Tom Moore completes final fundraising lap for NHS as donations soar past £12m

Follow our live coronavirus updates HERE Coronavirus: The symptoms




tom

Royals send thank you letters to hero Captain Tom Moore, 99, after fundraiser for NHS hits £15 million

The Duke of Cambridge and his stepmother the Duchess of Cornwall have both written to Captain Tom Moore, 99, to congratulate him on smashing his NHS fundraising target.




tom

War veteran Captain Tom Moore, 99, raises £16m for NHS as Boris Johnson looks at ways to honour &apos;heroic efforts&apos;

Follow our live coronavirus updates HERE Coronavirus: The symptoms




tom

War veteran Captain Tom Moore, 99, says he&apos;d be &apos;amazed&apos; to meet Queen amid petitions for knighthood

Live coronavirus updates here




tom

NHS staff and Carrie Symonds thank &apos;inspirational&apos; war veteran Captain Tom Moore during weekly applause

NHS staff and Carrie Symonds are among those who have thanked "inspirational" war veteran Captain Tom Moore during the weekly clap for carers.




tom

Captain Tom Moore hits £18 million in NHS fundraiser as Prince William donates to cause

Read our live coronavirus updates HERE




tom

Pensioner, 90, attempting to climb height of Suilven mountain on stairs raises £100,000 after being inspired by Captain Tom Moore

Read our coronavirus live updates HERE Coronavirus: The symptoms




tom

War veteran Captain Tom Moore, 99, raises more than £20 million for NHS during coronavirus crisis

War veteran Captain Tom Moore has now raised more than £20 million to help the NHS during the coronavirus crisis - twenty thousand times his initial target.




tom

Tom Moore could receive Spitfire flypast for 100th birthday as coronavirus fundraiser passes £21 million

The 99-year-old war veteran has raised an incredible £21 million for charity




tom

War veteran Captain Tom Moore, 99, to be &apos;guest of honour&apos; at new Nightingale Hospital opening

National treasure Captain Tom Moore, 99, will help open the newest NHS Nightingale hospital as a "guest of honour."




tom

Hero Captain Tom Moore shares message of hope: We will get through this and come out stronger

He has raised more than £25 million




tom

Prince Harry hails &apos;wonderfully British response&apos; to Covid-19 and gives shout-out to &apos;amazing&apos; Captain Tom Moore

The Duke of Sussex has said he's "incredibly proud" of the British public as the country rallies together to tackle the coronavirus crisis.




tom

Gene Deitch dead: Tom and Jerry director and Oscar-winning illustrator dies aged 95

Oscar-winning illustrator and film director Gene Deitch has died at the age of 95.




tom

One World Together at Home: Little Mix and Tom Jones among stars paying tribute to NHS in global online concert

Little Mix, Michael Buble and Sir Elton John were among the stars playing tribute to the NHS in a special online concert.




tom

Fundraising hero Captain Tom Moore&apos;s charity cover on course for number one

Captain Tom Moore and Michael Ball are on course to score a number one single for their cover of You'll Never Walk Alone.




tom

Metro Bank agrees to pay customers back £10million in overdraft fees




tom

Homeless man with Covid-19 symptoms left sleeping on London buses

The man contacted several government-funded services tasked with helping the homeless, but was told there was "no space for him," human rights journalists at Liberty Investigates found.