Fluoroquinolones are reported to possess immunomodulatory activity; hence, a novel benzoquinolizine fluoroquinolone, levonadifloxacin, was evaluated in lipopolysaccharide-stimulated human whole-blood (HWB) and mouse acute lung injury (ALI) models. Levonadifloxacin significantly mitigated the inflammatory responses in an HWB assay through inhibition of proinflammatory cytokines and in the ALI model by lowering lung total white blood cell count, myeloperoxidase, and cytokine levels. The immunomodulatory effect of levonadifloxacin, along with promising antibacterial activity, is expected to provide clinical benefits in the treatment of infections.

Of four genotypes of Encephalitozoon cuniculi, E. cuniculi genotype II is considered to represent a parasite that occurs in many host species in a latent asymptomatic form, whereas E. cuniculi genotype III seems to be more aggressive, and infections caused by this strain can lead to the death of even immunocompetent hosts. Although albendazole has been considered suitable for treatment of Encephalitozoon species, its failure in control of E. cuniculi genotype III infection has been reported. This study determined the effect of a 100x recommended daily dose of albendazole on an Encephalitozoon cuniculi genotype III course of infection in immunocompetent and immunodeficient mice and compared the results with those from experiments performed with a lower dose of albendazole and E. cuniculi genotype II. The administration of the regular dose of abendazole during the acute phase of infection reduced the number of affected organs in all strains of mice and absolute counts of spores in screened organs. However, the effect on genotype III was minor. Surprisingly, no substantial effect was recorded after the use of a 100x dose of albendazole, with larger reductions seen only in the number of affected organs and absolute counts of spores in all strains of mice, implying variations in albendazole resistance between these Encephalitozoon cuniculi genotypes. These results imply that differences in the course of infection and the response to treatment depend not only on the immunological status of the host but also on the genotype causing the infection. Understanding how microsporidia survive in hosts despite targeted antimicrosporidial treatment could significantly contribute to research related to human health.

In patients with renal impairment (n = 22 of 39), the median serum concentrations of linezolid, PNU-142300, and PNU-142586 were 1.6-, 3.3-, 2.8-fold higher, respectively, than in patients without renal impairment. Metabolite concentrations in paired samples were poorly correlated with linezolid concentrations (r² = 0.26 for PNU-142300 and 0.06 for PNU-142586). Linezolid and its metabolites share potential toxicophores that deserve characterization to mitigate higher myelosuppression risk in patients with renal impairment.

Plazomicin was tested against 697 recently acquired carbapenem-resistant Klebsiella pneumoniae isolates from the Great Lakes region of the United States. Plazomicin MIC₅₀ and MIC₉₀ values were 0.25 and 1 mg/liter, respectively; 680 isolates (97.6%) were susceptible (MICs of ≤2 mg/liter), 9 (1.3%) intermediate (MICs of 4 mg/liter), and 8 (1.1%) resistant (MICs of >32 mg/liter). Resistance was associated with rmtF-, rmtB-, or armA-encoded 16S rRNA methyltransferases in all except 1 isolate.

Amazon tự hào là chợ trực tuyến bán đủ mọi thứ mà chúng ta cần – kể cả những ngôi nhà tí hon cho phép người mua tự lắp ghép trong hai ngày.

Nintendo has released its latest hardware and software figures for the Nintendo Switch and Nintendo 3DS through March 31, 2020. Shipments figures for the Nintendo Switch reached 55.77 million units, while the Nintendo 3DS hit 75.77 million units shipped. As for lifetime software 356.24 million Switch games have been shipped and 383.11 million 3DS games. 

For the quarter Nintendo shipped 3.28 million Switch units and 45.59 million Switch games, as well as 0.07 million 3DS units and 0.89 million 3DS games. 

Nintendo forecasts it will ship 19 million Switch units in the fiscal year ending March 31, 2021.

Here are the top 10 best-selling Switch first-party titles:

1. Mario Kart 8 Deluxe – 24.77 million
2. Super Smash Bros. Ultimate – 18.84 million
3. The Legend of Zelda: Breath of the Wild – 17.41 million
4. Super Mario Odyssey – 17.41 million
5. Pokemon Sword / Pokemon Shield – 17.37 million
6. Pokemon: Let’s Go, Pikachu! / Pokemon: Let’s Go, Eevee! – 11.97 million
7. Animal Crossing: New Horizons – 11.77 million (first 11 days) / 13.41 million (first six weeks)
8. Splatoon 2 – 10.13 million
9. Super Mario Party – 10.10 million
10. New Super Mario Bros. U Deluxe – 6.60 million

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel dedicated to gaming Let's Plays and tutorials. You can contact the author at wdangelo@vgchartz.com or on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/443417/switch-shipments-reach-5577-million-units-as-of-march-31-animal-crossing-new-horizons-sells-12-million/

A soundtrack to Nile Koetting’s 2016 installation of the same name at Maison Hermès, Tokyo. Following recommendations from the Amazon algorithm, artist Nile Koetting purchased a selection of devices, including a wireless LAN system, a Dyson humidifier, an air purifier, an aroma diffuser, a 5.1ch home theater speaker, a line array speaker system, and a […]

The post Nozomu Matsumoto turns punk lyrics into text-to-speech ambient on <em>Sustainable Hours</em> appeared first on FACT Magazine.

A sci-fi collection explores extreme corporate futures, such as a Tinder-run city where you can swipe left or right for everything from sex to teachers

An AI-powered application lets you create real-time deepfakes during video calls, making you appear to be speaking as anyone from Albert Einstein to the Mona Lisa

TfL as in Transport for London. Greeeeeaaat.

With the acquisition of a start-up specialising in encrypted messaging and cloud services, Zoom will finally be able to make good on its claims of offering end-to-end encryption.

Because Amazon movie purchases are really just long-term rentals that can disappear from your library at any time.

This film gives us insight into a community that’s already endured plenty even before the zombies arrived.

टेक कंपनी रियलमी (Realme) अपने खास स्मार्टफोन Narzo 10 और Narzo 10A को 11 मई के दिन भारत में लॉन्च करने वाली है। इस बात की जानकारी कंपनी के आधिकारिक ट्विटर अकाउंट से मिली है।

जूम वीडियो कॉलिंग एप को भारत में सबसे ज्यादा डाउनलोड किया गया है। जूम सबसे ज्यादा डाउनलोड होने वाला नॉन गेमिंग एप बन गया है। केवल अप्रैल में इसे 13.1 करोड़ लोगों ने डाउनलोड किया है।

Call of Duty Modern Warfare and Warzone update patch notes have been shared by Infinity Ward to clarify whats changed to the game on May 7.

Jingle bells, tarutaru smell, people played FF 14. Alex played more Xenoblade and Alice played Warframe. Happy Holidays!

As we gear up for E3, we get hyped about the latest games. That’s right, we’ve got some hot impressions on Harvester and Diablo II....

Happy Holidays! We wrap up the final podcast of the year affirming it's OK for Anna Marie to play casual games, even if Chris disagrees. While Josh and Kelley are making New Year's resolutions, Chris also disagrees about what should be a brief story. We'll see everyone in 2019!

Miniature devices that could be developed into safe, high-resolution imaging technology, with uses such as helping doctors identify potentially deadly cancers and treat them early, have been created.

The tech giant has often been accused of mistreating workers, but our desire for instant gratification is part of the problem

Tim Bray resigned as an Amazon vice-president last week. “Who he?” I hear you say. And why is this news significant? Answers: first, Bray is an ubergeek who’s an alumnus of many of the outfits in tech’s hall of fame (including DEC, Sun Microsystems, the OED project at the University of Waterloo, Google’s Android team and, eventually, Amazon Web Services); and second, he resigned on an issue of principle – something as rare as hen’s teeth in the tech industry.

In his blog, he wrote: “I quit in dismay at Amazon firing whistleblowers who were making noise about warehouse employees frightened of Covid-19.” It was an expensive decision. Bray said the decision to resign would probably cost him more than a million dollars in salary and shares, and that he regretted leaving a job he enjoyed, working with good colleagues. “So I’m pretty blue.”

Like dozens of women in the entertainment industry, the actor, model and writer Zoë Brock has claimed she had a traumatic encounter with the film producer Harvey Weinstein. Now she is faced with a settlement offer that she believes would allow him to escape blame for the alleged assaults. Also today: Lily Kuo on the spread of the deadly coronavirus in China

The actor, model and writer Zoë Brock was on a retreat in the New Zealand bush in 2017 when an email pinged into her inbox. It was from a friend sending a link to a breaking news story of allegations against Harvey Weinstein. The claims from several women against the film producer were eerily familiar to an incident that Brock alleges happened to her.

This week, Weinstein goes on trial charged with rape and sexual assault. But for dozens of women with claims against him, their only recourse is to civil courts. Brock tells Anushka Asthana that while she is part of the class action suit against Weinstein, she is deeply unhappy with the terms of the proposed settlement, which she believes would allow him to accept no blame for the allegations.

A visually distinctive, semi-effective Canadian thriller pits a First Nation community against a zombie invasion

Given how movies about the undead refuse to die, a tweak on what’s become a decaying formula is always a welcome surprise, especially if said tweak involves a little more than “what about zombies but strippers”. Back in the 60s, and at rare times since, the zombie subgenre has been used as a way of sneaking social commentary into horror, the set-up of an invading force destroying a community allowing for a range of sly metaphors.

Related: 'I'm indigenizing zombies': behind gory First Nation horror Blood Quantum

Messenger Rooms will be free for all users, with no time limit

Saar Gur is adept at identifying the next big consumer trends earlier than most: The San Francisco-based general partner at CRV has led investments into leading consumer internet companies like Niantic, DoorDash, Bird, Dropbox, Patreon, Kapwing and ClassPass. His own experience stuck at home during the COVID-19 pandemic spurred his interest in three new investment […]

Chennai, May 09: Tamil Nadu government has announced some relaxations in the Coronavirus lockdown in non-containment zones from May 11. The extension includes working hours of standalone and neighbourhood shops and allowing private establishments to function with a reduced number of employees

Getting less sleep for five nights in a row can make you view other people’s expressions more negatively, including facial reactions seen over video calls

Mykhailo Pinchuk takes a short walk around his empty zoo, greeting some animals with a stroke and a morsel of food.

The Italian is reportedly set to leave Stamford Bridge at the end of his contract..

Amazon Prime Video today announced the trailer launch of its...

The post Watch: Amazon Prime Video Releases Paatal Lok Trailer appeared first on Man's World India.

Formerly owned by Joe Exotic, G.W park has been reopened...

The post Joe Exotic’s Old Zoo Renamed As ‘Tiger King Park’ appeared first on Man's World India.

Congratulations to first-time mother Echo the cheetah!

Consumer Gmail users are seeing a "Google Meet" section in the sidebar.

Amid the intense scrutiny on the company over working conditions at its fulfillment centers, an Amazon employee has died from COVID-19, Fox News has confirmed.

Juili Kale's dreams to receive her master's degree diploma in a ceremony cheered on by her family were dashed by the coronavirus - until robots came to the rescue.

((This April 30 story has been corrected to say Starship can carry more than 100 metric tonnes of cargo, not 100 pounds in paragraph 9. The error occurred in a previous version as well.))

When David Haye agreed to swap the boxing gym for a poker table and challenge the world's best, the former heavyweight and cruiserweight world champion admits he did not know what he was letting himself in for.

Follow our live coronavirus updates HERE Coronavirus: The symptoms

Live coronavirus updates here

This is the heartwarming moment a new dad watched the birth of his first child on Zoom after coronavirus social distancing rules stopped him from being in hospital with his wife.

A Zoom blunder from Wales's health minister left fellow politicians with their heads in their hands as he was heard swearing about a colleague with his microphone still on.

Several calls on Zoom, the video conferencing app whose popularity has soared since the coronavirus lockdown meant a huge rise in home working, have been disrupted by abusive footage.

Elephants at Chester Zoo will be treated to a pool party in this week's virtual tour of the attraction which is currently closed to the public during the coronavirus lockdown.

A further four tigers and three lions have tested positive for coronavirus at the Bronx Zoo after a four-year-old Malaysian tiger contracted the disease earlier this month.

The drive to ease lockdowns across Europe intensified today as several countries set out blueprints for how to restore normality in everyday life.

In today's Diary: Jude Kelly leads review of coronavirus impact on women in arts / Sophie Raworth's blue moment / Kerry Godliman struggles with tech / Philip Tetlock on Dominic Cummings and his reputation