gen Intraneuronal beta-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation By www.jneurosci.org Published On :: 2006-10-04 Holly OakleyOct 4, 2006; 26:10129-10140Neurobiology of Disease Full Article
gen Neuregulin1 Nuclear Signaling Influences Adult Neurogenesis and Regulates a Schizophrenia Susceptibility Gene Network within the Mouse Dentate Gyrus By www.jneurosci.org Published On :: 2024-10-23T09:30:29-07:00 Neuregulin1 (Nrg1) signaling is critical for neuronal development and function from fate specification to synaptic plasticity. Type III Nrg1 is a synaptic protein which engages in bidirectional signaling with its receptor ErbB4. Forward signaling engages ErbB4 phosphorylation, whereas back signaling engages two known mechanisms: (1) local axonal PI3K-AKT signaling and (2) cleavage by -secretase resulting in cytosolic release of the intracellular domain (ICD), which can traffic to the nucleus (Bao et al., 2003; Hancock et al., 2008). To dissect the contribution of these alternate signaling strategies to neuronal development, we generated a transgenic mouse with a missense mutation (V321L) in the Nrg1 transmembrane domain that disrupts nuclear back signaling with minimal effects on forward signaling or local back signaling and was previously found to be associated with psychosis (Walss-Bass et al., 2006). We combined RNA sequencing, retroviral fate mapping of neural stem cells, behavioral analyses, and various network analyses of transcriptomic data to investigate the effect of disrupting Nrg1 nuclear back signaling in the dentate gyrus (DG) of male and female mice. The V321L mutation impairs nuclear translocation of the Nrg1 ICD and alters gene expression in the DG. V321L mice show reduced stem cell proliferation, altered cell cycle dynamics, fate specification defects, and dendritic dysmorphogenesis. Orthologs of known schizophrenia (SCZ)-susceptibility genes were dysregulated in the V321L DG. These genes coordinated a larger network with other dysregulated genes. Weighted gene correlation network analysis and protein interaction network analyses revealed striking similarity between DG transcriptomes of V321L mouse and humans with SCZ. Full Article
gen A miR-383-5p Signaling Hub Coordinates the Axon Regeneration Response to Inflammation By www.jneurosci.org Published On :: 2024-10-30T09:30:22-07:00 Neuroinflammation can positively influence axon regeneration following injury in the central nervous system. Inflammation promotes the release of neurotrophic molecules and stimulates intrinsic proregenerative molecular machinery in neurons, but the detailed mechanisms driving this effect are not fully understood. We evaluated how microRNAs are regulated in retinal neurons in response to intraocular inflammation to identify their potential role in axon regeneration. We found that miR-383-5p is downregulated in retinal ganglion cells in response to zymosan-induced intraocular inflammation. MiR-383-5p downregulation in neurons is sufficient to promote axon growth in vitro, and the intravitreal injection of a miR-383-5p inhibitor into the eye promotes axon regeneration following optic nerve crush. MiR-383-5p directly targets ciliary neurotrophic factor (CNTF) receptor components, and miR-383-5p inhibition sensitizes adult retinal neurons to the outgrowth-promoting effects of CNTF. Interestingly, we also demonstrate that CNTF treatment is sufficient to reduce miR-383-5p levels in neurons, constituting a positive-feedback module, whereby initial CNTF treatment reduces miR-383-5p levels, which then disinhibits CNTF receptor components to sensitize neurons to the ligand. Additionally, miR-383-5p inhibition derepresses the mitochondrial antioxidant protein peroxiredoxin-3 (PRDX3) which was required for the proregenerative effects associated with miR-383-5p loss-of-function in vitro. We have thus identified a positive-feedback mechanism that facilitates neuronal CNTF sensitivity in neurons and a new molecular signaling module that promotes inflammation-induced axon regeneration. Full Article
gen Retinal Input to Macaque Superior Colliculus Derives from Branching Axons Projecting to the Lateral Geniculate Nucleus By www.jneurosci.org Published On :: 2024-10-30T09:30:22-07:00 The superior colliculus receives a direct projection from retinal ganglion cells. In primates, it remains unknown if the same ganglion cells also supply the lateral geniculate nucleus. To address this issue, a double-label experiment was performed in two male macaques. The animals fixated a target while injection sites were scouted in the superior colliculus by recording and stimulating with a tetrode. Once suitable sites were identified, cholera toxin subunit B-Alexa Fluor 488 was injected via an adjacent micropipette. In a subsequent acute experiment, cholera toxin subunit B-Alexa Fluor 555 was injected into the lateral geniculate nucleus at matching retinotopic locations. After a brief survival period, ganglion cells were examined in retinal flatmounts. The percentage of double-labeled cells varied locally, depending on the relative efficiency of retrograde transport by each tracer and the precision of retinotopic overlap of injection sites in each target nucleus. In counting boxes with extensive overlap, 76–98% of ganglion cells projecting to the superior colliculus were double labeled. Cells projecting to the superior colliculus constituted 4.0–6.7% of the labeled ganglion cell population. In one particularly large zone, there were 5,746 cells labeled only by CTB-AF555, 561cells double labeled by CTB-AF555 and CTB-AF488, but no cell labeled only by CTB-AF488. These data indicate that retinal input to the macaque superior colliculus arises from a collateral axonal branch supplied by ~5% of the ganglion cells that project to the lateral geniculate nucleus. Surprisingly, there exist no ganglion cells that project exclusively to the SC. Full Article
gen How Century-Old Paintings Reveal the Indigenous Roots and Natural History of New England Landscapes By www.smithsonianmag.com Published On :: Thu, 19 Sep 2024 12:00:00 +0000 Seven guest collaborators bring new eyes to a Smithsonian museum founder’s collection of American art Full Article
gen How an Indigenous Weaver’s Mastery of Color Infuses Her Tapestries With a Life Force By www.smithsonianmag.com Published On :: Wed, 16 Oct 2024 18:17:46 +0000 The work of Diné artist DY Begay, now on view at the National Museum of the American Indian, blends tradition and modernity Full Article
gen FAO Director-General applauds UN Secretary-General's stance on hunger By www.fao.org Published On :: Wed, 07 May 2014 00:00:00 GMT FAO Director-General José Graziano da Silva today praised UN Secretary-General Ban Ki Moon for his support in the fight against hunger at a meeting with FAO member countries, the Committee [...] Full Article
gen FAO Director-General to visit 7 countries and to attend 3 multilateral conferences in the next seven weeks By www.fao.org Published On :: Fri, 18 Jul 2014 00:00:00 GMT FAO Director-General José Graziano da Silva will be away from Rome during the next few weeks. During this period he will be involved in a range of [...] Full Article
gen Food security tops agenda of FAO Director-General's meeting with India's Prime Minister Modi By www.fao.org Published On :: Wed, 10 Sep 2014 00:00:00 GMT The [...] Full Article
gen Rome Based Agencies making an impact in Burkina Faso By www.fao.org Published On :: Tue, 07 Oct 2014 00:00:00 GMT FAO, IFAD and WFP/Burkina [...] Full Article
gen FAO Director-General appoints Jacques Diouf as FAO Special Envoy for the Sahel and the Horn of Africa By www.fao.org Published On :: Wed, 12 Nov 2014 00:00:00 GMT FAO Director-General José Graziano da Silva today appointed Jacques Diouf as Special Envoy for the Horn of Africa and the Sahel. In his new role, the former Director-General Jacques Diouf will [...] Full Article
gen Director General opens FAO Council meeting By www.fao.org Published On :: Mon, 01 Dec 2014 00:00:00 GMT FAO Director-General Graziano da Silva today opened the 150th session of the FAO Council, highlighting the successful conclusion of the Second International Conference on Nutrition (ICN2), held last month in [...] Full Article
gen FAO Council closure: Director-General urges Members to focus on implementation early in 2015 By www.fao.org Published On :: Fri, 05 Dec 2014 00:00:00 GMT 5 December 2014, Rome – At the closure of the FAO Council held today, the [...] Full Article
gen FAO Director-General highlights International Year of Soils to Agriculture Ministers in Berlin By www.fao.org Published On :: Mon, 19 Jan 2015 00:00:00 GMT Berlin- FAO Director-General José Graziano da Silva has highlighted some of the most important events on the organization’s 2015 calendar during meetings with agriculture ministers who attended the Global Forum [...] Full Article
gen GRULAC endorses FAO Director-General's candidature for a second term By www.fao.org Published On :: Fri, 23 Jan 2015 00:00:00 GMT Just announced by the Group of Latin America and the Caribbean Countries (GRULAC) The Group of Latin American and Caribbean Countries (GRULAC) of FAO in Rome is pleased to endorse the [...] Full Article
gen Incumbent Director-General only candidate for election By www.fao.org Published On :: Sun, 01 Feb 2015 00:00:00 GMT Rome - José Graziano da Silva, the [...] Full Article
gen Africa Regional Group endorses FAO Director-General's candidature for a second term By www.fao.org Published On :: Mon, 09 Feb 2015 00:00:00 GMT Rome, The Africa Regional Group of Ambassadors and Permanent Representatives accredited to the Rome based UN Agencies have announced the endorsement of the candidature of Dr. José Graziano da Silva [...] Full Article
gen Near East Group endorses FAO Director-General's candidature for a second term By www.fao.org Published On :: Mon, 02 Mar 2015 00:00:00 GMT Rome, 02 March 2015 - In a letter addressed to the Director-General, the Chairperson of the Near East Regional Group has announced their endorsement of the candidature [...] Full Article
gen Asia Regional Group endorses FAO Director-General's candidature for a second term By www.fao.org Published On :: Fri, 13 Mar 2015 00:00:00 GMT In a letter addressed to the Director-General, the Ambassador of Malaysia to FAO, on behalf of the Chair of the Asia Group, has announced the endorsement of the [...] Full Article
gen Statement of the FAO Secretariat under agenda item 12 “Proposal of the Republic of Korea for the establishment of an FAO World Fisheries University” By www.fao.org Published On :: Wed, 13 Jul 2016 00:00:00 GMT Mr Chairman, I wish to convey, through you, to the Committee on Fisheries, the considered views of the FAO Secretariat on the item on the proposed Fisheries University. So far, the [...] Full Article
gen FAO Director-General listed among the most influential Latin Americans By www.fao.org Published On :: Thu, 09 Feb 2017 00:00:00 GMT FAO Director-General José Graziano da Silva has been selected as one of the world's most influential Latin Americans for his work against hunger and malnutrition in the world. In its [...] Full Article
gen Follow the Director-General's meetings at the Pre-Summit By www.fao.org Published On :: Sun, 25 Jul 2021 00:00:00 GMT The Pre-Summit will bring together the global efforts to shape the transformation of agri-food systems. Full Article
gen FAO Director-General addresses G7 Agriculture Ministers on Global Food Markets and Prices By www.fao.org Published On :: Thu, 10 Mar 2022 00:00:00 GMT Click here to access the presentation by QU Dongyu. Full Article
gen 171st Session of the FAO Council Statement By Dr QU Dongyu, FAO Director-General By www.fao.org Published On :: Mon, 05 Dec 2022 00:00:00 GMT A statement by FAO Director-General QU Dongyu Full Article
gen FAO in review: The first fully digital United Nations agency By www.fao.org Published On :: Tue, 06 Dec 2022 00:00:00 GMT Read the series on how FAO increased efficiency, effectiveness and transparency to better support its Members in the transformation of agrifood systems. Full Article
gen FAO in Review: Emergency and humanitarian response By www.fao.org Published On :: Fri, 09 Dec 2022 00:00:00 GMT Read the series on how FAO increased efficiency, effectiveness and transparency to better support its Members in the transformation of agrifood systems Full Article
gen Candidates for the post of FAO Director-General announced By www.fao.org Published On :: Fri, 03 Mar 2023 00:00:00 GMT FAO member nations to choose head of the UN specialized agency in July during the 43rd session of the FAO Conference Full Article
gen Weird Science: Gender Bending Fish By www.smithsonianmag.com Published On :: Wed, 25 Sep 2024 00:00:00 -0000 Sometimes, in fact, nature is stranger than fiction Full Article
gen Ask Smithsonian: Can Chimps Be Genetically Engineered to Be Like Humans? By www.smithsonianmag.com Published On :: Wed, 25 Sep 2024 00:00:00 -0000 Human beings and chimps share as much as 98 percent of their DNA. If our species are so similar, can chimps be genetically engineered to be more like us? Full Article
gen Gene Therapy Experts Look Ahead in Treating Blindness By www.smithsonianmag.com Published On :: Mon, 21 Oct 2024 00:00:00 -0000 Two of the preeminent researchers of gene therapy hope to improve their patients' sight in an experimental operation (Stephen Voss/WPN) Full Article
gen These Gentle Giants Would Rather Be Left Alone By www.smithsonianmag.com Published On :: Mon, 21 Oct 2024 00:00:00 -0000 Historically feared by humans, brown bears were once aggressively hunted in the contiguous U.S. Because of this, 95% of these majestic creatures live in Alaska. Full Article
gen Constructing the Guggenheim By www.smithsonianmag.com Published On :: Thu, 31 Oct 2024 00:00:00 -0000 Videos from the 1950s show architect Frank Lloyd Wright at the site of the Guggenheim Museum Full Article
gen World Science Festival: Misunderstood Geniuses—William Harvey By www.smithsonianmag.com Published On :: Thu, 31 Oct 2024 00:00:00 -0000 Full Article
gen Stephen Colbert Congratulates OK Go | Smithsonian American Ingenuity Awards By www.smithsonianmag.com Published On :: Thu, 31 Oct 2024 00:00:00 -0000 "OK Go made music videos relevant again." – Stephen Colbert OK Go, Damian Kulash Jr. and Trish Sie won the Smithsonian magazine American Ingenuity Award for Visual Arts for pushing the music-video envelope with their zero-gravity video for "Upside Down & Inside Out." Read more about their work and see the video here: http://smithmag.co/HZ8vzr The Smithsonian has been celebrating innovation in American culture for more than 150 years, and following in this tradition, Smithsonian magazine presents the American Ingenuity Awards, honoring revolutionary breakthroughs in the arts and sciences, education and social progress. http://smithmag.co/R7hyRO Full Article
gen How Many Beads Can You Glue to the Outside of a Volkswagen Beetle? By www.smithsonianmag.com Published On :: Thu, 31 Oct 2024 00:00:00 -0000 The Huichol people of west-central Mexico have designed the Vochol—a car turned work of art Full Article
gen What 'Bridgerton' Gets Right About the Regency Era By www.smithsonianmag.com Published On :: Thu, 31 Oct 2024 00:00:00 -0000 From gender roles to etiquette to fashion, step back in time to learn more about the real lives of the Regency women who inspired 'Bridgerton.' --- To read more about the Regency era - and 'Bridgerton' - check out these articles from Smithsonian Magazine: What 'Bridgerton' Gets Wrong About Corsets: https://www.smithsonianmag.com/history/what-bridgerton-gets-wrong-about-corsets-180976691/ The Real History Behind 'Queen Charlotte: A Bridgerton Story' https://www.smithsonianmag.com/smart-news/the-real-history-behind-queen-charlotte-a-bridgerton-story-180982130/ Digital Editorial Director: Brian Wolly Supervising Producer & Scriptwriter: Michelle Mehrtens Producer: Nicki Marko Video Editor: Sierra Theobald Full Article
gen The Story Behind Gene Kranz's Vest By www.smithsonianmag.com Published On :: Thu, 31 Oct 2024 00:00:00 -0000 Listen to a short lecture given by curator Margaret Weitekamp on Gene Kranz career with NASA and how his vest ended up at the Smithsonian Full Article
gen How Artificial Intelligence Is Making 2,000-Year-Old Scrolls Readable Again By www.smithsonianmag.com Published On :: Thu, 31 Oct 2024 00:00:00 -0000 When Mount Vesuvius erupted in 79 C.E., it covered the ancient cities of Pompeii and Herculaneum under tons of ash. Millennia later, in the mid-18th century, archeologists began to unearth the city, including its famed libraries, but the scrolls they found were too fragile to be unrolled and read; their contents were thought to be lost forever. Only now, thanks to the advent of artificial intelligence and machine learning, scholars of the ancient world have partnered with computer programmers to unlock the contents of these priceless documents. In this episode of “There’s More to That,” science journalist and Smithsonian contributor Jo Marchant tells us about the yearslong campaign to read these scrolls. And Youssef Nader—one of the three winners of last year’s “Vesuvius Challenge” to make these clumps of vulcanized ash readable—tells us how he and his teammates achieved their historic breakthrough. Read Smithsonian’s coverage of the Vesuvius Challenge and the Herculaneum scrolls here (https://www.smithsonianmag.com/smart-news/three-students-decipher-first-passages-2000-year-old-scroll-burned-vesuvius-eruption-180983738/) , here (https://www.smithsonianmag.com/history/buried-ash-vesuvius-scrolls-are-being-read-new-xray-technique-180969358/) , and here (https://www.smithsonianmag.com/history/archaeologoists-only-just-beginning-reveal-secrets-hidden-ancient-manuscripts-180967455/) . Find prior episodes of our show here (https://www.smithsonianmag.com/podcast/) . There’s More to That is a production of Smithsonian magazine and PRX Productions. From the magazine, our team is Chris Klimek, Debra Rosenberg and Brian Wolly. From PRX, our team is Jessica Miller, Adriana Rosas Rivera, Genevieve Sponsler, Rye Dorsey, and Edwin Ochoa. The Executive Producer of PRX Productions is Jocelyn Gonzales. Fact-checking by Stephanie Abramson. Episode artwork by Emily Lankiewicz. Music by APM Music. Full Article
gen Stephen Hawking Congratulates the LIGO Team | Smithsonian American Ingenuity Awards By www.smithsonianmag.com Published On :: Thu, 31 Oct 2024 00:00:00 -0000 "They have given mankind a completely new way of looking at the universe." – Stephen Hawking, congratulates Kip Thorne, Rainer Weiss, Barry Barish and Ronald Drever, the first scientists to detect gravitational waves. | Smithsonian magazine #IngenuityAwards The Smithsonian has been celebrating innovation in American culture for more than 150 years, and following in this tradition, Smithsonian magazine presents the American Ingenuity Awards, honoring revolutionary breakthroughs in the arts and sciences, education and social progress. Full Article
gen Erin Brockovich Congratulates Marc Edwards & LeeAnne Walters | Smithsonian American Ingenuity Awards By www.smithsonianmag.com Published On :: Thu, 31 Oct 2024 00:00:00 -0000 “Superman isn’t coming. It is a moment in our time when we must look to ourselves, and not take for granted or wait for something from the top to come down, but rather…pick up the torch, carry the torch, to find information and the truth…” – Erin Brockovich applauds Marc Edwards and LeeAnne Walters for their work exposing the Flint water crisis | Smithsonian Magazine American #IngenuityAwards Read more about Edwards and Walters’ work: http://smithmag.co/D4dIHy The Smithsonian has been celebrating innovation in American culture for more than 150 years, and following in this tradition, Smithsonian magazine presents the American Ingenuity Awards, honoring revolutionary breakthroughs in the arts and sciences, education and social progress. http://smithmag.co/R7hyRO Full Article
gen In Case Humans Go Extinct, This Memory Crystal Will Store Our Genome for Billions of Years By www.smithsonianmag.com Published On :: Fri, 20 Sep 2024 17:47:45 +0000 Scientists have created "a form of information immortality" meant to instruct future species on how to recreate humans. But who, or what, will find it? Full Article
gen Rare and Elusive Australian Bird, Once Thought Extinct for 100 Years, Discovered by Indigenous Rangers and Scientists By www.smithsonianmag.com Published On :: Thu, 26 Sep 2024 16:30:09 +0000 Using sound recordings, the team identified the largest known population of the night parrot, a secretive species known as the "Holy Grail of birdwatching" Full Article
gen American Scientists Win Nobel Prize in Medicine for 'Groundbreaking' Gene Discovery Made by Studying Worms By www.smithsonianmag.com Published On :: Mon, 07 Oct 2024 20:50:44 +0000 Victor Ambros and Gary Ruvkun discovered microRNA, tiny molecules that play a crucial role in how cells develop, paving the way for new treatments for diseases Full Article
gen Scientists Who Developed the Building Blocks of Artificial Intelligence Win Nobel Prize in Physics By www.smithsonianmag.com Published On :: Tue, 08 Oct 2024 19:38:22 +0000 John Hopfield and Geoffrey Hinton shared the award for their work on artificial neural networks and machine learning Full Article
gen A New Marine Sanctuary Off California Will Be Co-Managed by Indigenous Peoples By www.smithsonianmag.com Published On :: Mon, 21 Oct 2024 20:39:16 +0000 NOAA designated the Chumash Heritage National Marine Sanctuary this month, following a decade of advocacy by supporters. The protected site will be finalized after a 45-day review period Full Article
gen A 110-Year-Old Pickled Thylacine Head Helped Build the Most Complete Ancient Genome to Date, Says 'De-Extinction' Company By www.smithsonianmag.com Published On :: Mon, 28 Oct 2024 16:01:37 +0000 Colossal Biosciences reports it extracted DNA and RNA from the Tasmanian tiger specimen, a key step forward in its effort to create a modern proxy of the extinct species. Other scientists are calling for data to back up the claim Full Article
gen Land & Sea: The legacy of Nellie Winters, a much-loved Inuit crafts legend By www.cbc.ca Published On :: Sun, 10 Nov 2024 04:30:00 EST Nellie Winters is 87. From the time she was a child, her hands and mind have been busy pursuing her love of Inuit art and craft. Full Article News/Canada/Nfld. & Labrador
gen Indigenous children in foster care should stay in home communities, says head of roundtable By www.cbc.ca Published On :: Mon, 11 Nov 2024 04:30:00 EST A Labrador foster parent and head of a group working to better the Labrador foster care system is stressing the importance of keeping Indigenous children with Indigenous parents in their Indigenous communities. Full Article News/Canada/Nfld. & Labrador
gen School in Sipekne'katik First Nation commemorates Indigenous Veterans Day By www.cbc.ca Published On :: Sun, 10 Nov 2024 04:00:00 EST The L'nu Sipuk Kina'muokuom school observed Indigenous Veterans Day with an event on Friday. Students, faculty and staff got together to honour Mi’kmaw military veterans and RCMP members. Full Article
gen Video game shines light on Indigenous history and voices By www.cbc.ca Published On :: Tue, 12 Nov 2024 04:00:00 EST Two Falls (Nishu Takuatshina) was developed in Montreal by a local studio that collaborated closely with Indigenous designers and consultants. Full Article