The present invention relates to a hypoallergenic molecule consisting of Bet v Ia or an allergen having at least 40% identity to Bet v Ia comprising mutations of at least four amino acid residues in the region of amino acids 100 to 125 of Bet v Ia or its corresponding region of the allergen having at least 40% identity to Bet v 1a.

The present application relates to antigen-binding proteins that are capable of binding to mammalian IgG. The frame-work regions of the antigen-binding proteins of the application preferably correspond to those of antibodies naturally that are devoid of light chains as may e.g. be found in camelids. The application further relates to nucleic acids that encode such antigen-binding proteins, to immunoadsorbent materials that comprise such proteins, to the uses of such immunoadsorbent materials for the purification of mammalian IgG antibodies and for therapeutic apheresis.

Antigen binding proteins with T cell receptor-like paratopes, that is, with an antigen binding region specific for an human leukocyte antigen-A2 restricted peptide are disclosed. The antigen binding proteins encompass antibodies in a variety of forms, including full-length antibodies, substantially intact antibodies, Fab fragments, F(ab')2 fragments, and single chain Fv fragments. Fusion proteins, such as scFv fusions with immunoglobulin or T-cell receptor domains, incorporating the specificity of the antigen binding region for each peptide are also contemplated by the invention. Furthermore, immunoconjugates may include antibodies to which is linked a radioisotope, fluorescent or other detectable marker, cytotoxin, or other molecule are also encompassed by the invention. Among other things, immunoconjugates can be used for delivery of an agent to elicit a therapeutic effect or to facilitate an immune effector function.

Systems and methods for optimizing system performance of capacity and spectrum constrained, multiple-access communication systems by selectively discarding packets are provided. The systems and methods provided herein can drive changes in the communication system using control responses. One such control responses includes the optimal discard (also referred to herein as “intelligent discard”) of network packets under capacity constrained conditions. Some embodiments inspect a video stream to determine priorities for various elements of the video stream. The elements may be discarding using the priorities. In various embodiments, the elements include frames, slices, macroblocks, and data partitions.

Thumbnail images representative of recorded TV programs are generated and presented to aid a user in browsing the recorded TV programs. In one implementation, a temporary thumbnail image is generated when a TV program first starts recording. The temporary thumbnail is used to populate any user interface (UI) screens that reference the recoded TV program. Once the TV program has reached a threshold amount of recording (e.g., a prescribed duration of recording, or completion of the recording), a permanent thumbnail image is generated and associated with the TV program. The permanent thumbnail is then presented in any subsequent UI screens, replacing the temporary thumbnail. In another implementation, display of the thumbnail images in the UI screens may be further controlled by setting preferences, such as parental controls.

A video-on-demand (VOD) content delivery system has a VOD Application Server which manages a database of templates ordered in a hierarchy for presentation of video content elements of different selected types categorized in hierarchical order. The templates include those for higher-order displays which have one or more links to lower-order displays of specific content. The VOD Application Server, in response to viewer request, displays a high-order templatized display, and in response to viewer selection of a link, displays the lower-order display of specific content. The hierarchical templatized displays enable viewers to navigate to an end subject of interest while having a unique visual experience of moving through a series of displays to the end subject of interest.

A generic route for synthesis of asymmetric nanostructures. This approach utilizes submicron magnetic particles (Fe3O4—SiO2) as recyclable solid substrates for the assembly of asymmetric nanostructures and purification of the final product. Importantly, an additional SiO2 layer is employed as a mediation layer to allow for selective modification of target nanoparticles. The partially patched nanoparticles are used as building blocks for different kinds of complex asymmetric nanostructures that cannot be fabricated by conventional approaches. The potential applications such as ultra-sensitive substrates for surface enhanced Raman scattering (SERS) have been included.

Systems and methods for improving operation of a hybrid vehicle are presented. In one example, an electrical load may be automatically activated to consume electrical energy produced during driveline braking so that driveline braking may be extended. The electrical load may be a windscreen heater or other device.

Disclosed are a method, a composition, a microarray, an antibody and a kit for diagnosis and prognosis of cancer, based on detection of deletion of the exon 3 region of G-CSF gene or levels of a mutated G-CSF protein having a deletion of an amino acid sequence corresponding to the exon 3 region, wherein the deletion of the exon 3 region of the G-CSF gene is used as a cancer biomarker.

The present invention is directed to the use of the peptide compound Ac-Arg-Phe-Met-Trp-Met-Arg-NH2 as a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung diseases, heart and vascular diseases and metabolic diseases. Moreover the present invention relates to pharmaceutical compositions preferably in form of a lyophilisate or liquid buffer solution or artificial mother milk formulation or mother milk substitute containing the peptide Ac-Arg-Phe-Met-Trp-Met-Arg-NH2 optionally together with at least one pharmaceutically acceptable carrier, cryoprotectant, lyoprotectant, excipient and/or diluent.

The present invention is directed to the use of the peptide compound Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 as a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung diseases, heart and vascular diseases and metabolic diseases. Moreover the present invention relates to pharmaceutical compositions preferably in form of a lyophilizate or liquid buffer solution or artificial mother milk formulation or mother milk substitute containing the peptide Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 optionally together with at least one pharmaceutically acceptable carrier, cryoprotectant, lyoprotectant, excipient and/or diluent.

A chimeric protein containing neutrophil inhibitory factor and hirugen, the chimeric protein having an amino acid sequence that includes FPRPGSGG (SEQ ID NO:21) Also provided is a pharmaceutical composition comprising the chimeric protein, which can be used for treating or preventing cerebral injury and cerebral edema, or for inhibiting platelet aggregation.

Peptides having a structure characterized by the presence of two loops constrained in cyclic structure by the presence of covalent bonds between amino acid side chains, the amino acid sequences of the first and the second loop being substantially homologues to that of loop 1 (residues 29-38) and of loop 4 (residues 92-97) of NGF, respectively, displaying nerve growth factor (NGF) agonist or partial agonist activity.

Mono-pegylated arginase conjugate and method producing thereof. The mono-pegylated arginase is homogeneous in molecular weight and shows therapeutic effect for treating cancers and viral infections. The method of producing such arginase conjugate has a main step of genetically modifying the gene encoding an arginase so that the PEG moiety can attach to the enzyme at a predetermined, specific intended site. This is achieved by removing the PEG attaching amino acid residues at undesirable sites while keeping (or adding, if necessary) the one at the desirable site of the enzyme. Two exemplary mono-pegylated arginase conjugates so produced are human arginase I (HAI) where a polyethylene glycol (PEG) moiety is site-specific covalently bonded to Cys45 of the enzyme and Bacillus caldovelox arginase (BCA) where a polyethylene glycol (PEG) moiety is site-specific covalently bonded to Cys161 of the enzyme.

An insect-resistant protein exhibiting a sufficient resistance to insects; an insect-resistance gene encoding the insect-resistant protein; a recombinant vector containing the insect-resistance gene; a host cell and a plant cell having the recombinant vector transfected thereinto; a transformant transformed by the insect-resistance gene and a method for producing the same; a protein recovered thereby; and an insect-resistant agent comprising them as active ingredients. In accordance with the present invention, the insect-resistant protein is derived from a plant.

Disclosed is a drug effective in the treatment of fibromyalgia. Basically, the disclosed therapeutic agent was created on the basis of experiments showing improvement in symptoms when etanercept was administered to patients suffering from fibromyalgia. Etanercept is known as a therapeutic agent for rheumatoid arthritis, and the JFIQ score of patients not suffering from fibromyalgia improved considerably in the preferred embodiment. In other words, a therapeutic agent for fibromyalgia is disclosed that contains etanercept as an active ingredient in an effective amount.

The present invention provides variable mass labeling reagents, a set of the variable mass labeling reagents, and a multiplexed set of variable mass labeling reagents.

Mechanisms and methods for clamping force generation are described. In one embodiment, a clamping force generator system includes a permanent magnet bearing coupled to a traction ring and to a torque coupling. The traction ring can be provided with an electromagnetic bearing rotor and the torque coupling can be provided with an electromagnetic bearing stator. In some embodiments, a mechanical load cam, a permanent magnet bearing, and an electromagnetic bearing cooperate to generate a clamping force between the traction rings, the power rollers, and the idler. In other embodiments, a series of permanent magnet bearings and a mechanical bearing are configured to produce a clamping force. In one embodiment an electromagnetic bearing is coupled to a control system and produces an optimal clamping force that is associated with a torque transmitted in the transmission during operation. In some embodiments, a mechanical load cam produces a clamping force proportional to torque, while a permanent magnet bearing provides a minimum clamping force.

A motor-generator system for a vehicle, in which power transmission between a crankshaft of an engine and a motor-generator is performed by a V-belt wound around pulleys thereof, includes a speed controller controlling the rotational speed of the V-belt within a predetermined range and provided on a crankshaft pulley mounted on the crankshaft. The motor-generator system, among others, can maintain the power transmission force of the V-belt at a high level.

A bearing support plate for use in a generator has a radially enlarged flange with a first cylindrical portion extending from the flange in one direction which will provide a bearing support for an outer race of a ball bearing, and a radially inner cylindrical portion extending in an opposed direction that will be away from the ball bearing relative to the flange. The flange is generally cylindrical but has a truncated portion over a circumferential extent. The first cylindrical portion is formed with radially enlarged portions with intermediate radially thinner portions. The flange includes bolt holes circumferentially aligned with the radially thinner portions.

Methods and apparatus for correlating event notifications between agents in a management network are provided. An agent constructs a network notification in response to receiving an event notification. If the received event notification is associated with a prior notification already received and stored by the agent, a correlation attribute is added to the constructed network notification. If the received notification matches a peer agent notification category that another agent in the management network is interested in receiving, the constructed network notification is sent to the other agent.

The disclosure generally describes computer-implemented methods, software, and systems for allowing provisioning of open data protocol (OData) services on top of a generic interaction layer (GenIL). One computer-implemented method includes receiving an OData-compliant request for data, determining a GenIL data provider to receive the OData-compliant request for data, determining the memory location of the data, requesting the data from the determined memory location, receiving the requested data from the determined memory location, converting, using at least one computer, the received data into an OData-compliant format, rendering an OData-compliant response, and transmitting the OData-compliant response.

After a cyclopentadiene compound and a vinyl aromatic compound are thermally polymerized, the obtained copolymer is subjected to a hydrogenation reaction to form a hydrogenated product. After most of the hydrogenation solvent is separated by a solvent evaporation tank from the hydrogenated product, an additive separately prepared by dissolving an antioxidant is added to the hydrogenated product to form a mixture. While the hydrogenation solvent is a naphthenic solvent, the additive is prepared by dissolving the antioxidant in an aromatic additive solvent having the same carbon atoms as those of the hydrogenation solvent. Then, the low-molecular-weight component as well as the remaining hydrogenation solution and the additive solvent are separated by a thin-film evaporator from the mixture. The obtained molten resin is pelletized to produce hydrogenated petroleum resin pellets. The time for uniformly blending the antioxidant can be shortened.

The present disclosure provides a system for recovering emissions generated from an olefin polymerization process, comprising: a devolatilizer for receiving a fresh sweep gas and emissions generated from the olefin polymerization process and outputting a first fluid and a polyolefin resin; a compression refrigeration unit including a compression device and a first heat exchange device, for receiving said first fluid and outputting a first gas-liquid mixture; a first gas-liquid separation device for separating the first gas-liquid mixture and outputting a first recovery product and a first gas phase composition; a first gas separation device for receiving the first gas phase composition, removing small molecular substances therefrom, and outputting a composition rich in small molecular gases and a second gas phase composition rich in hydrocarbons; and a second gas separation device having a second heat exchange device, a second gas-liquid separation device, and a first gas expansion device.

A magnetic particle-polymer hybrid material can include: a substance having a structure of Formula 1 or derivative or salt thereof:Z(Y-Triazole-CH2—X—CH2—(FP)n)m (Formula 1), wherein Z is a magnetic particle smaller than 1 mm; n and m are independently integers; Y includes a first linker having an alkyl and/or aryl linked to the magnetic particle; X is CH2 or a heteroatom; FP is a functionalized polymer having: a first structure derived from a first norbornene compound linked to the magnetic particle through the Y-Triazole-CH2—X—CH2 linker; and one or more monomeric units each including a second structure derived from a second norbornene compound, where one of the monomeric units is linked to the first structure through a saturated or unsaturated alkyl, each monomeric unit includes a functional group capable of binding with another substance.

An ion conducting membrane for fuel cells involves coupling a compound having a sulfonic acid group with a polymeric backbone. Each of the compounds having a sulfonic acid group and the polymeric backbone are first functionalized with a halogen.

The present invention provides polymerization processes utilizing an ansa-metallocene catalyst system for the production of olefin polymers. Polymers produced from the polymerization processes have properties that vary based upon the presence or the absence of hydrogen and/or comonomer in the polymerization process.

A method for preparing a catalyst system for heterogenous catalysis of an isobutylene polymerization reaction includes the steps of forming an alumina support in which the alumina support has pores formed therein, and reacting BF3/methanol catalyst complex with the alumina support. The ratio of methanol to BF3 in the catalyst complex ranges from 0.5 moles to 2 moles of methanol per mole of BF3. The alumina support is formed so as to have pores each having a diameter of greater than twenty nanometers. The alumina support can be in the form of beads or extrudates having a length significantly greater than a diameter. The extrudate can also have a tri-lobe configuration.

A method for repairing an aged or damaged asphalt pavement is provided. The method involves preparing a surface of the aged or damaged asphalt pavement by filling in deviations from a uniform surface plane with dry aggregate and compacting the dry aggregate; applying a reactive asphalt emulsion to the prepared surface; and passing an emitter over the prepared pavement, wherein the emitter generates electromagnetic radiation having a wavelength of from 2-5 mm that penetrates into the pavement to a depth of at least 2 inches. The asphalt pavement is repaired by disturbing voids and interstices in the damaged pavement without dehydrogenation of the asphalt, such that oligomers present in the aged asphalt are linked together into longer polymer chains to improve ductility of the aged asphalt.

A heated cosmetic applicator that has a plurality of small, individual heating elements placed within and/or on at least some of the lash grooming elements. A heat-generating applicator head for a heated cosmetic applicator that has a plurality of small, individual heating elements placed within and/or on at least some of the lash grooming elements.

A container adapted to contain and dispense a product and method for its use. The container comprises a hollow body, a filling opening, a dispensing opening, a valve and a resiliently deformable means for said valve. The valve may form a leak-tight engagement with the dispensing opening, and is openable by an external force acting on said valve whereby the leak-tight engagement is disengaged, allowing the product to be spread onto a fabric by the valve. The container may be used in a method for pretreating and subsequently laundering pretreated fabrics in an automatic washing machine.

Methods and apparatus for performing radio resource management (RRM) measurements in a heterogeneous network (HetNet) are provided in an effort to prevent failure of RRM measurement procedures in a dominant interference scenario. Several alternatives are provided for determining particular resources (e.g., subframes) to use for performing the RRM measurements, wherein the particular resources are based on cooperative resource partitioning between cells of the HetNet, wherein the cells may be of different types (e.g., macro, pico, or femto cells). These alternatives include, for example: (1) intra-frequency or intra-RAT (radio access technology) alternatives, which may involve transmitting resource partitioning information (RPI) in or deriving non-serving cell RPI based on the serving cell's RPI, as well as (2) inter-frequency or inter-RAT alternatives, where the RRM measurements may be performed during a measurement gap.

A method for user detachment when a handover or change occurs in a heterogeneous network is provided. The method includes: a user equipment (UE) is handed over or switched from a source network to a target network; a network element on a network side determines whether to detach the UE from the source network, and if yes, the network element on the network side detaches the UE from the source network. A system and a device for user detachment when a handover or change occurs in a heterogeneous network, and another method for user detachment when a handover or change occurs in a heterogeneous network are also provided.

In a wireless base station, a specific information receiver receives specific information delivered from a higher-level device to a wireless terminal. A specific information deliverer delivers the specific information to the wireless terminal via multiple physical channels activated in a wireless base station. Where a common channel via which information is periodically broadcast to multiple wireless terminals and a shared channel of which available radio resources are allocated to wireless terminals to transmit voice data and the like to the terminals are activated in the wireless base station, for example, the specific information deliverer can deliver the specific information using the common channel if the wireless terminal is in a standby state, and can deliver the specific information using the shared channel if the wireless terminal is in a communicating state.

The invention relates to an optical device for imparting an asymmetrical light beam. The optical device comprises a lens (10) having an exit diopter (12) having an exit surface consisting of a convex surface (16) defining a curved rear portion (18) having a first curvature and a curved front portion (19) having a second curvature different from the first curvature. Furthermore the lens (10) comprises an entry diopter (11) including at least one concave lodging (13) for lodging at least one light source, the surface of the concave lodging (13) facing at least partly the curved rear portion (18).

A lighting module comprising at least one first lighting device and one second lighting device; the first lighting device comprises a support common to at least one first light emitter generating a first light strip and at least one second light emitter generating a second light strip. The first light emitter is arranged relative to second light emitter so as to generate a zone that is unlit by the first lighting device between the first light strip and the second light strip. The at least one second lighting device generates at least one third light strip that extends in the zone that is unlit.

Disclosed herein are a private key generation apparatus and method, and storage media storing programs for executing the methods on a computer. The private key generation apparatus includes a root private key generation unit and a sub-private key generation unit. The root private key generation unit sets a root master key and predetermined parameters capable of generating private keys, and generates a first sub-master key set capable of generating a number of private keys equal to or smaller than a preset limited number. The sub-private key generation unit generates private keys with the root private key generation unit by receiving the first sub-master key set from the root private key generation unit, to generate a private key corresponding to a user ID using the first sub-master key set, and issues the private key to a user.

A content data reproducing method includes: decrypting encrypted data to generate plain-text data; dividing the plain-text data into decrypted content data and reproduction management information; sending the reproduction management information to a user space; storing the decrypted content data in a secret buffer; obtaining the decrypted content data as reproduction target data from the secret buffer and transmitting the reproduction target data to a decoder; and decoding the reproduction target data by the decoder.

In one or more embodiments, an integrated circuit includes a programmable memory, a key generation module and a module. The programmable memory is to maintain a first key portion. The key generation module is to generate a key using the first key portion from the programmable memory and a second key portion received via a memory interface. The module is to encrypt or decrypt data using the key.

A secret key generation apparatus and method are provided. The secret key generation apparatus includes at least one antenna, amplification/phase controllers, a transceiver, and a random signal controller. The antenna receives a wireless signal from a counterpart terminal that performs wireless communication. The amplification/phase controllers control the amplification gain and phase of the wireless signal that is received via at least one antenna. The transceiver measures the status of a wireless channel using the wireless signal having the controlled amplification gain and phase, determines parameters based on results of the measurement, and generates a secret key based on results of the determination. The random signal controller controls the amplification/phase controllers so that the amplification gain and phase are adjusted whenever the transceiver generates a secret key.

An improved polymerization and process method allows the production of special nitrile rubbers which are characterized by a specific anion content and an excellent storage stability and allow a particularly good vulcanization rate and moreover result in vulcanized materials that have advantageous properties, especially with regard to the contact with metal components of molded parts based on said vulcanized materials.

Systems and methods are provided for generating a composite video based on a plurality of asynchronously recorded input video streams. A plurality of segments of the input video streams are identified. A number of the input video streams that were recording during the particular segment are determined. A video display configuration for the particular segment is determined based on the number of video streams that were recording, where the video display configuration includes a display sub-region for each of the number of video streams that was recording. A composite video is generated, where the composite video includes a portion of video associated with each of the segments, where the composite video portion associated with the particular segment is formatted according to the video display configuration and displays the video streams that were recording during the particular segment in the display sub-regions of the video display configuration.

The present invention provides a content data recording/reproducing device, comprising a communication unit that engages in communication with an external device, a storage unit that stores content data and additional data related to the content data, a content data extraction unit that selectively extracts the content data from the storage unit based upon condition data received at the communication unit from the external device and the additional data stored in the storage unit and a contents list generation unit that generates a contents list based upon the condition data and additional data corresponding to the content data extracted by the content data extraction unit.

A fluidic structure has a first chamber having a connection to a fluid reservoir and a connection to an array of apertures, the chamber forming a flow path between the fluid reservoir and the array of apertures, a second chamber having a connection to at least one vent connected to an atmosphere external to the fluidic structure, and at least one path between the first chamber and the second chamber.

An output converter includes a DCDC conversion section, a secondary side voltage/current monitoring section detecting a power from the DCDC conversion section, a maximum operation point control section determining what voltage is to be set by the DCDC conversion section so that the power detected by the secondary side voltage/current monitoring section is maximum, a DCDC short-circuit switch via which a current from a module bypasses the DCDC conversion section to outside, a primary side voltage/current monitoring section measuring the current from the module, a module short-circuit switch switching between a state where a secondary side cathode and a secondary side anode are short-circuited and a state where they are not short-circuited, the maximum operation point control section causing the DCDC short-circuit switch and the module short-circuit switch to switch.

According to one embodiment, there is provided a power-fluctuation reducing apparatus in a power generation system to control a converter connected to the power generation system and connected to secondary batteries. The power-fluctuation reducing apparatus includes adjusting direct current voltages output from the secondary batteries, respectively, detecting the directing current voltages output from the secondary batteries, respectively, controlling to adjust the direct current voltages output from the secondary batteries to make the direct current voltages uniform, based on the detected direct current voltages, and controlling the converter to reduce power fluctuations in the power generation system.

A power distribution system for distributing electric power generated by a wind farm between an AC power transmission link and a DC power transmission link is provided. Both power transmission links connect the wind farm to a substation of a power grid. The power distribution system includes a central wind farm controller and a distribution device. In response to a control signal from the central wind farm controller, the distribution device distributes the generated electrical power between the two power transmission links. It is further described a power transmission system with the above described power distribution system and a method for distributing electric power between an AC power transmission link and a DC power transmission link.

A power generation and control system is easily installed in a consumer household, a business, or an end-user establishment for generating power and preventing power from flowing to a power grid from a consumer circuit during a power outage. A communications transceiver is adapted to transmit a permission signal for allowing power generation only after the control system has been installed. The control system can be adapted to replace an existing circuit breaker in a household circuit breaker box and prevents power from traveling from consumer power generators to the grid during a power outage. In the same manner that end-users can add appliances to existing circuits, end-users can easily add additional power generation devices without hiring a professional electrician and without worrying about causing harm to utility workman during power outages.

An electric driving type utility vehicle having a regenerative brake force distribution control function, and a regenerative brake force distribution control method thereof are provided. The utility vehicle includes: a controller for controlling an output and a recovery of a motor; recovery sensing means for sensing a recovery braking state when the motor is driven; a power measurement unit for measuring the amount of recovery power generated in the recovery braking state; and a power switching unit for automatically switching a drive mode from a two-wheel drive mode to a four-wheel drive mode or vice versa according to the load condition. The present invention can switch the present mode to the four-wheel drive mode by operating the power switching unit according to the control of the controller when sensing the recovery brake through the recovery sensing means in the driving state.

Systems and methods disclosed herein may be useful emergency braking systems for use in, for example, an aircraft. A system is disclosed that allows emergency braking without the need for a manually operated emergency brake. For example, a system is provided comprising a potentiometer in mechanical communication with a brake pedal, a first electronic switch in electrical communication with the potentiometer, a second electronic switch indicating a displacement of the brake pedal, wherein a brake control valve opens in response to the first electronic switch, and wherein a shutoff valve opens in response to the second electronic switch.