VOLUME 279 (2004) PAGES 33438–33446For Fig. 1B, the second, third, and fifth panels were mistakenly duplicated during article preparation as no yeast colonies were observed in these conditions. The corrected images are presented in the revised Fig. 1B. This correction does not affect the results or conclusions of the work. The authors apologize for the error.jbc;295/50/17382/F1F1F1Figure 1B.

Economic Recovery and Anticorruption in South Africa: Assessing Progress on the Reform Agenda 4 December 2019 — 3:00PM TO 4:00PM Anonymous (not verified) 25 November 2019 Chatham House | 10 St James's Square | London | SW1Y 4LE

South Africa has significant economic potential based on its resource endowment, quality human capital and well-developed infrastructure compared to the region. However, the country’s economic growth rate has not topped 2 per cent since 2013, and in 2018, was below 1 per cent. This has put a strain on citizens and communities in a country that still suffers from structural inequality, poverty and high unemployment. Economic recovery and anti-corruption were the central pillars of President Cyril Ramaphosa’s 2019 electoral campaign and he has set an investment target of $100 billion. However, voters and investors alike are demanding faster and more visible progress from the country’s enigmatic leader who has a reputation for caution and calculation.

At this event, Professor Nick Binedell will discuss the progress of and opposition to the president’s economic reform agenda and the opportunities for international investment to support long term inclusive and sustainable growth in South Africa.

Attendance at this event is by invitation only.

Inclusion, agency and influence: The role of women in Zimbabwe’s economy 8 July 2021 — 3:00PM TO 4:30PM Anonymous (not verified) 2 July 2021 Online

Speakers discuss the changing role of women in Zimbabwe’s economic structures and the priorities for promoting greater economic inclusion, agency and influence of women.

Zimbabwe’s National Development Strategy of 2021-2025 highlights the importance of gender sensitivity in policymaking and of women’s economic participation in attaining the government’s Vision 2030.

However, women have been among the worst affected groups by the devastating effects that COVID-19 has had on Zimbabwe’s already floundering economy, which has exacerbated the challenges they face in economic life, such as access to credit, financial services and social security.

Leveraging existing structures such as women’s groups, micro-finance facilities, education and training, and national gender mechanisms, as well as supporting wider financial and digital inclusion in Zimbabwe, is central for the country’s sustained economic recovery.

This event also focuses on the differing impacts of COVID-19 on women’s economic activities across various sectors, as well as along rural-urban and formal-informal economy lines.

Read a meeting summary

This webinar is part of a series of events in partnership with the Konrad Adenauer Stiftung on Zimbabwe’s economic recovery and reform.

This event will also be broadcast live on the Africa Programme Facebook page.

Who gains from artificial intelligence? 27 February 2023 — 5:30PM TO 6:30PM Anonymous (not verified) 6 February 2023 Chatham House and Online

What implications will AI have on fundamental rights and how can societies benefit from this technology revolution?

In recent months, the latest developments in artificial intelligence (AI) have attracted much media attention. These technologies hold a wealth of potential for a wide range of applications, for example, the recent release of OpenAI’s ChatGPT, a text generation model, has shed light on the opportunities these applications hold including to advance scientific research and discovery, enhance search engines and improve key commercial applications.

Yet, instead of generating an evidence-based public debate, this increased interest has also led to discussions on AI technologies which are often alarmist in nature, and in a lot of cases, misleading. They carry the risk of shifting public and policymakers’ attention away from critical societal and legal risks as well as concrete solutions.

This discussion, held in partnership with Microsoft and Sidley Austin LLP, provides an expert-led overview of where the technology stands in 2023. Panellists also reflect on the implications of implementing AI on fundamental rights, the enforcement of current and upcoming legislation and multi-stakeholder pathways to address relevant issues in the AI space.

More specifically, the panel explores:

• What is the current state of the art in the AI field?
• What are the opportunities and challenges presented by generative AI and other innovations?
• What are some of the key, and potentially most disruptive, AI applications to monitor in the near- and mid-term? 
• Which applications would benefit from greater public policy/governance discussions?
• How can current and future policy frameworks ensure the protection of fundamental rights in this new era of AI?
• What is the role of multi-stakeholder collaboration?
• What are the pathways to achieving inclusive and responsible governance of AI?

• How can countries around the world work together to develop frameworks for responsible AI that upholds democratic values and advance AI collaboration across borders?

As with all member events, questions from the audience drive the conversation.

Read the transcript.

Understanding which patients with human epidermal growth factor receptor 2 (HER2)–negative or –low metastatic breast cancer (MBC) benefit from HER2-targeted strategies is urgently needed. We assessed the whole-body heterogeneity of HER2 expression on ⁸⁹Zr-trastuzumab PET (HER2 PET) and the diagnostic performance of HER2 PET in a large series of patients, including HER2-negative and -low MBC. Methods: In the IMPACT-MBC study, patients with newly diagnosed and nonrapidly progressive MBC of all subtypes were included. Metastasis HER2 status was determined by immunohistochemistry and in situ hybridization.⁸⁹Zr-trastuzumab uptake was quantified as SUV_max and SUV_mean. HER2 immunohistochemistry was related to the quantitative ⁸⁹Zr-trastuzumab uptake of all metastases and corresponding biopsied metastasis, uptake heterogeneity, and qualitative scan evaluation. A prediction algorithm for HER2 immunohistochemistry positivity based on uptake was developed. Results: In 200 patients, ⁸⁹Zr-trastuzumab uptake was quantified in 5,163 metastases, including 186 biopsied metastases. With increasing HER2 immunohistochemistry status, uptake was higher (geometric mean SUV_max of 7.0, 7.6, 7.3, and 17.4 for a HER2 immunohistochemistry score of 0, 1, 2, or 3+, respectively; P < 0.001). High uptake exceeding 14.6 (90th percentile) was observed in one third of patients with a HER2-negative or -low metastasis biopsy. The algorithm performed best when lesion site and size were incorporated (area under the curve, 0.86; 95% CI, 0.79–0.93). Conclusion: HER2 PET had good diagnostic performance in MBC, showing considerable whole-body HER2 heterogeneity and uptake above background in HER2-negative and -low MBC. This provides novel insights into HER2-negative and -low MBC compared with standard HER2 immunohistochemistry on a single biopsy.

Premier League reference David Coote is suspended indefinitely after videos surfaced that appeared to show him criticizing former Liverpool coach Jurgen Klopp, officials announced Monday.

SANTA CLARA, Calif., Aug. 13, 2024 — Pure Storage today announced that it joined Ultra Ethernet Consortium (UEC), a Linux Foundation initiative dedicated to building a complete, open, and accessible Ethernet-based […]

The post Pure Storage Embraces Next-Gen Networking for AI with Ultra Ethernet Consortium Membership appeared first on HPCwire.

In this webinar, Martijn de Vries, CTO at Bright Computing and Robert Stober, Director of Product Management at Bright Computing, discuss the convergence of HPC and AI in the context […]

The post The Convergence of HPC and AI appeared first on HPCwire.

Oct. 29, 2024 — ORCA Computing today announced the unveiling of the PT-2, the latest advancement in its PT Series of photonic quantum systems. Building on the success of the […]

The post ORCA Computing Unveils PT-2 to Integrate Quantum Computing with Generative AI and HPC appeared first on HPCwire.

U.S. fighter jets escorted a small plane flown by a U.S. Army soldier out of restricted air space over New York City during the United Nations General Assembly.

COLLEGE PARK, Md., Nov. 8, 2024 — IonQ, a leader in the quantum computing industry, has announced a partnership with NKT Photonics, a subsidiary of Hamamatsu Photonics, to procure next-generation laser […]

The post IonQ and NKT Photonics Collaborate on Next-Gen Laser Tech for Quantum Data Centers appeared first on HPCwire.

SAN JOSE, Calif., Nov. 12, 2024 — VDURA, a leader in data infrastructure for AI and HPC, today has announced a groundbreaking release of its VDURA Data Platform software, designed to […]

The post VDURA Unveils Next-Gen Data Platform with Enhanced AI and HPC Performance appeared first on HPCwire.

Nutritional supplements that contain curcumin -- a natural anti-inflammatory compound -- may protect the eyes from the development and progression of age-related macular degeneration, a new study suggests.

SAN ANTONIO, Nov. 1, 2024 — Rackspace Technology, a leading hybrid, multicloud, and AI technology services company, announced that it has signed a Strategic Collaboration Agreement (SCA) with Amazon Web […]

The post Rackspace and AWS Expand Partnership to Accelerate Generative AI and Cloud Solutions appeared first on HPCwire.

The rapid advancement of digital technologies has led to the proliferation of electronic devices and systems, resulting in an alarming increase in electronic waste (e-waste).  GenAI, in particular, requires substantial […]

The post The Growing E-Waste Footprint of GenAI appeared first on HPCwire.

PITTSBURGH, June 19, 2024 — Ansys today announced that it is adopting NVIDIA Omniverse application programming interfaces (APIs) to offer 3D-IC designers valuable insights from Ansys’ physics solver results through […]

The post Ansys Enables 3D Multiphysics Visualization of Next-Gen 3D-IC Designs with NVIDIA Omniverse appeared first on HPCwire.

Nov. 11, 2024 — A team of researchers used the Frontier supercomputer at the Department of Energy’s Oak Ridge National Laboratory and a new methodology for conducting a genome-wide association […]

The post ORNL’s Frontier Powers KAUST-Led Genome Study for Gordon Bell Prize Nomination appeared first on HPCwire.

TROY, Mich., Nov. 12, 2024 — Altair, a global leader in computational intelligence, has entered into collaboration agreement with the European Space Agency (ESA) through the ESA Partnership Initiative for […]

The post Altair Partners with European Space Agency to Advance AI-Driven Aerospace Innovation appeared first on HPCwire.

The U.S. Department of Veterans Affairs announced plans Monday to eliminate copayments for all VA telehealth services, while expanding online emergency care access for rural veterans.

Harriet Tubman was posthumously awarded the rank of brigadier general of the Maryland National Guard on Monday in recognition of her service.

President-elect Donald Trump announced his choice Tuesday for CIA Director, tapping his former intelligence chief John Ratcliffe, who he called a "warrior of truth."

Two things which make you look more intelligent that you can do right now.

Your intelligence could influence how much alcohol you consume.

Over his decades of farming and ranching, Gabe Brown has noticed a troubling trend: the conventional farming techniques he used were degrading the soil and harming nature. He shares how his family farm turned things around by adopting regenerative agricultural practices — and shows how the wider food system can use these same methods to improve food quality and revitalize the land.

Female teachers, principals, and superintendents in Pennsylvania earn significantly less money than their male counterparts, a new study shows.

The rapid shift to tech-driven, remote learning this spring has infused more technology into K-12 education, but AI tools still remain on the fringe.

The two states are the first in 20 years to add such a requirement.

A federal appeals court rejected a multi-pronged challenge to a school district plan allowing transgender students to use restrooms and other facilities that match their gender identity.

AdvancED, the national accreditation company, has for the last two years operated Wyoming's entire accreditation process but the state will now do the work on its own.

Kentucky Attorney General Daniel Cameron has joined a private school in a lawsuit against Gov. Andy Beshear, arguing that a school closure order not only violated state law but also the First Amendment.

A former high school athletic standout and homecoming king, Pedro Garcia III “could connect with anybody,” no matter the language, said a teaching colleague in Cozad, Neb.

Kentucky Attorney General Daniel Cameron has joined a private school in a lawsuit against Gov. Andy Beshear, arguing that a school closure order not only violated state law but also the First Amendment.

The U.S. Department of Education's office for civil rights says that Connecticut's interscholastic sports governing body violates Title IX with its transgender participation policy.

The Trump administration argues that the U.S. Supreme Court's decision that federal law protects transgender employees does not apply to transgender athletes in school.

In a case involving a transgender track athlete, the Trump administration says female transgender athletes are seeking "special treatment" to compete in girls' or women's sports.

The judge said the law likely discriminates on the basis of transgender status in violation of the equal-protection clause of the U.S. Constitution.

The Maple Leafs called up leading Marlies scorer Alex Steeves but aren't expected to play him. He deserves a good look while other bottom-six players struggle, says Adam Proteau.

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