Das Jahr 2020 ist bislang ungewöhnlich trocken, die Waldbrandgefahr ist hoch. Eine Karte zeigt das Risiko bundesweit - und berücksichtigt dabei auch Faktoren wie Windrichtung und aufziehende Regenwolken.

Folgen der Corona-Grenzschließungen: Beim Bundesamt für Migration und Flüchtlinge sind in den ersten Monaten dieses Jahres offenbar fast ein Drittel weniger Asylanträge gestellt worden als im Vorjahreszeitraum.

I had designated today as a museum day. My original plan was to do one walking tour and one museum on each of my two days in Warsaw but since all museums are closed on Tuesdays that plan was quickly scuppered. Both museums that I intended to visit were p

Các chuyên gia cảnh báo số lượng nhiễm trùng thực sự có thể cao hơn do tỷ lệ xét nghiệm thấp ở nhiều quốc gia.

As the UK looks to lift restrictions, how do other European countries plan to re-open after lockdown?

Tottenham are ahead of Manchester United in the race for Thomas Meunier, Real Madrid want Aubameyang decision, plus more.

12 November 2014 , Volume 90, Number 6

Antibodies are widely used as cancer therapeutics, but their current use is limited by the low number of antigens restricted to cancer cells. A receptor tyrosine kinase, receptor tyrosine kinase-like orphan receptor 2 (ROR2), is normally expressed only during embryogenesis and is tightly down-regulated in postnatal healthy tissues. However, it is up-regulated in a diverse set of hematologic and solid malignancies, thus ROR2 represents a candidate antigen for antibody-based cancer therapy. Here we describe the affinity maturation and humanization of a rabbit mAb that binds human and mouse ROR2 but not human ROR1 or other human cell-surface antigens. Co-crystallization of the parental rabbit mAb in complex with the human ROR2 kringle domain (hROR2-Kr) guided affinity maturation by heavy-chain complementarity-determining region 3 (HCDR3)-focused mutagenesis and selection. The affinity-matured rabbit mAb was then humanized by complementarity-determining region (CDR) grafting and framework fine tuning and again co-crystallized with hROR2-Kr. We show that the affinity-matured and humanized mAb retains strong affinity and specificity to ROR2 and, following conversion to a T cell–engaging bispecific antibody, has potent cytotoxicity toward ROR2-expressing cells. We anticipate that this humanized affinity-matured mAb will find application for antibody-based cancer therapy of ROR2-expressing neoplasms.

Actinobacillus pleuropneumoniae (App) is the etiological agent of acute porcine pneumonia and responsible for severe economic losses worldwide. The capsule polymer of App serotype 1 (App1) consists of [4)-GlcNAc-β(1,6)-Gal-α-1-(PO4-] repeating units that are O-acetylated at O-6 of the GlcNAc. It is a major virulence factor and was used in previous studies in the successful generation of an experimental glycoconjugate vaccine. However, the application of glycoconjugate vaccines in the animal health sector is limited, presumably because of the high costs associated with harvesting the polymer from pathogen culture. Consequently, here we exploited the capsule polymerase Cps1B of App1 as an in vitro synthesis tool and an alternative for capsule polymer provision. Cps1B consists of two catalytic domains, as well as a domain rich in tetratricopeptide repeats (TPRs). We compared the elongation mechanism of Cps1B with that of a ΔTPR truncation (Cps1B-ΔTPR). Interestingly, the product profiles displayed by Cps1B suggested processive elongation of the nascent polymer, whereas Cps1B-ΔTPR appeared to work in a more distributive manner. The dispersity of the synthesized products could be reduced by generating single-action transferases and immobilizing them on individual columns, separating the two catalytic activities. Furthermore, we identified the O-acetyltransferase Cps1D of App1 and used it to modify the polymers produced by Cps1B. Two-dimensional NMR analyses of the products revealed O-acetylation levels identical to those of polymer harvested from App1 culture supernatants. In conclusion, we have established a protocol for the pathogen-free in vitro synthesis of tailored, nature-identical App1 capsule polymers.

Multidrug resistance (MDR) in cancer arises from cross-resistance to structurally- and functionally-divergent chemotherapeutic drugs. In particular, MDR is characterized by increased expression and activity of ATP-binding cassette (ABC) superfamily transporters. Sphingolipids are substrates of ABC proteins in cell signaling, membrane biosynthesis, and inflammation, for example, and their products can favor cancer progression. Glucosylceramide (GlcCer) is a ubiquitous glycosphingolipid (GSL) generated by glucosylceramide synthase, a key regulatory enzyme encoded by the UDP-glucose ceramide glucosyltransferase (UGCG) gene. Stressed cells increase de novo biosynthesis of ceramides, which return to sub-toxic levels after UGCG mediates incorporation into GlcCer. Given that cancer cells seem to mobilize UGCG and have increased GSL content for ceramide clearance, which ultimately contributes to chemotherapy failure, here we investigated how inhibition of GSL biosynthesis affects the MDR phenotype of chronic myeloid leukemias. We found that MDR is associated with higher UGCG expression and with a complex GSL profile. UGCG inhibition with the ceramide analog d-threo-1-(3,4,-ethylenedioxy)phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol (EtDO-P4) greatly reduced GSL and monosialotetrahexosylganglioside levels, and co-treatment with standard chemotherapeutics sensitized cells to mitochondrial membrane potential loss and apoptosis. ABC subfamily B member 1 (ABCB1) expression was reduced, and ABCC-mediated efflux activity was modulated by competition with nonglycosylated ceramides. Consistently, inhibition of ABCC-mediated transport reduced the efflux of exogenous C6-ceramide. Overall, UGCG inhibition impaired the malignant glycophenotype of MDR leukemias, which typically overcomes drug resistance through distinct mechanisms. This work sheds light on the involvement of GSL in chemotherapy failure, and its findings suggest that targeted GSL modulation could help manage MDR leukemias.

Civil society provides a crucial link between governments and the communities they represent—infusing policy processes with grassroots knowledge to which governments may not otherwise have access. Looking at the European Union’s efforts to engage with civil society in its “neighborhood,” this report examines the benefits, challenges, and mechanisms to building dialogue and cooperation on migration and development.

Showcasing joint research by MPI and the European University Institute and funded by the European Commission, this event featured discussion on some of the most promising reform proposals on both sides of the Atlantic. Speakers discuss the project’s comparative research, which draws on MPI’s longstanding experience advising European and North American governments on immigration.

European dominance in U.S. immigration flows has decreased significantly since World War II, a result of economic, demographic, and policy trends on both sides of the Atlantic. Today, migration from European Union Member States to the United States, while small, is characterized by a substantial numbers of European scientists, professionals, and businesspeople.

This final report summarizes and reflects upon the key findings of the Improving EU and U.S. Immigration Systems: Learning from Experience comparative research project undertaken by MPI and the European University Institute through a grant from the European Commission.

Ce manuel pratique et simple d’utilisation à l’usage des décideurs et des praticiens fait le point des mesures les plus récentes prises par les pouvoirs publics en direction des diasporas. La question qui se pose aux responsables politiques n’est pas tant de savoir si les diasporas peuvent être utiles à leur pays d’origine, mais comment elles le sont et quels types de politiques et de programmes publics sont à même de favoriser ces relations.

The discovery of an inhibitory memory circuit could lead to novel treatments for conditions such as PTSD

In order to remember, we must forget. Recent research shows that when your brain retrieves newly encoded information, it suppresses older related information so that it does not interfere with the process of recall. Now a team of European researchers has identified a neural pathway that induces forgetting by actively erasing memories. The findings could eventually lead to novel treatments for conditions such as post-traumatic stress disorder (PTSD).

We’ve known since the early 1950s that a brain structure called the hippocampus is critical for memory formation and retrieval, and subsequent work using modern techniques has revealed a great deal of information about the underlying cellular mechanisms. The hippocampus contains neural circuits that loop through three of its sub-regions – the dentate gyrus and the CA3 and CA1 areas – and it’s widely believed that memories form by the strengthening and weakening of synaptic connections within these circuits.

Related: Light switches memories on and off | Mo Costandi

Related: The Homer Simpson effect: forgetting to remember

New research shows that a genetic mutation associated with schizophrenia alters the process of cellular differentiation, disturbing the balance of neurons and glia in the brain

Stem cells obtained from patients with schizophrenia carry a genetic mutation that alters the ratio of the different type of nerve cells they produce, according to a new study by researchers in Japan. The findings, published today in the journal Translational Psychiatry, suggest that abnormal neural differentiation may contribute to the disease, such that fewer neurons and more non-neuronal cells are generated during the earliest stages of brain development.

Schizophrenia is a debilitating mental illness that affects about 1 in 100 people. It is known to be highly heritable, but is genetically complex: so far, researchers have identified over 100 rare genetic variations and dozens of mutations associated with increased risk of developing the disease.

Related: Brain’s immune cells hyperactive in schizophrenia

Related: Turning urine into brain cells | Mo Costandi

The global economic crisis and changing migration patterns in Europe bring up questions about how well immigrants are able to find employment and progress into better jobs over time. This overview report caps a series of six country case studies evaluating the employment outcomes for foreign-born workers during their first decade in the Czech Republic, France, Germany, Spain, Sweden, and the United Kingdom.

This day-long conference in Brussels, co-sponsored by the International Labour Office and the European Commision’s Directorate-General for Employment, Social Affairs, and Inclusion, focuses on the dynamics by which migrants get stuck in low-skilled work, and the role of training and employment services in helping them progress in their occupations.

This report is the final one in an MPI-International Labour Office series that examines the employment prospects of migrants in the EU (focusing on the case-study countries of the Czech Republic, France, Germany, Spain, Sweden, and the United Kingdom), as well as the effectiveness of integration and workforce development policies in helping these workers overcome barriers and ascend out of low-skilled work.

A day-long conference in Brussels, co-sponsored by the International Labour Office and the European Commision’s Directorate-General for Employment, Social Affairs, and Inclusion, where panelists discuss the dynamics by which migrants get stuck in low-skilled work, and the role of training and employment services in helping them progress in their occupations. The conference concludes a project and series of reports prepared on the Labor Market Integration of New Arrivals in Europe. 

One sister was formally trained in France. The other learned how to bake off the internet and shows how you don't need to go abroad to know about bread.

Work of OM Romania among the Roma population

OM Lifehope coordinates the Transit Challenge, sending out teams all over Europe to love, serve and proclaim Christ.

OM's Riverboat will bring the gospel to six ports in three European countries over the course of three months, starting in December 2017.

THE Treasury has bombarded us all week with facts, figures and forecasts making the case for the UK to remain in the European Union. Its big report, on Monday, warned Brexit would tip the country into a year-long recession, resulting in up to 820,000 job losses within two years.

It didn't take long for the list of warnings about Brexit to start coming true.

European youth more than ever need good relationships with adults, says OM Europe’s Empowering Kids&Youth team, who focus on positively impacting Europe’s next generation.

Bus4Life begins its sixth year serving churches and OM teams across Central and Eastern Europe.

After years of dreaming and praying, OM Finland purchases a new vehicle to replace the old Bus4Life, opening more opportunities to reach Eastern Europe.

THERE was a popular fad in the 1990s for presenting music in its rawest form. Rather than the traditional bombast of turning everything up to 11, MTV Unplugged stripped it back to the basics. Often it was simply one singer, one guitar and a stool. And it was hugely popular.

OM field leader Martin believes Belgium has a strategic part to play, with OM, in helping grow a church planting movement in Europe.

CY20e volumes cut by 6% due to Covid-19; limited upside from current levels; ‘Neutral’ maintained.

Existing contracts will need careful analysis and strategies for renegotiation if needed.

The near-term outlook is challenging amid economic stress across sectors due to the lockdown, which has added pain to the already weak demand environment and anomalies due to the BS VI transition.

Women entrepreneurs will soon be able to market their products globally using an accessible online platform to be created by the Women and Child Development Ministry in collaboration with ebay.

Sugarcane arrears in Maharashtra have now mounted to Rs 5,000 crore and industry sources claim the position is likely to worsen.

A look back at our recent coverage, as net neutrality vanishes — temporarily we hope — into the dustbin of history

The 27-nation EU economy is predicted to contract by 7.5 per cent this year, before growing by about 6 per cent in 2021.

1. Human urine could help make concrete on moon, says European Space Agency  Times Now
2. Human urine could be used to make concrete on moon in the future  Economic Times
3. Ever thought of urine for lunar concrete?  NEWS9 live
4. You Can Now Buy a Piece of the Moon for $2.5 Million  Beebom
5. European Space Agency: Human urine could help make concrete on Moon  The New Indian Express
6. View Full coverage on Google News

1 Ugandan Shilling = 0.0012 Romanian Leu

1 Ugandan Shilling = 0.0047 Moldovan Leu

1 Ugandan Shilling = 0.0002 Euro

1 Salvadoran Colon = 0.5089 Romanian Leu

1 Salvadoran Colon = 2.0375 Moldovan Leu

1 Salvadoran Colon = 0.1042 Euro