Archives, Room Use Only - HE7671.P63 1910

In the crystal structure of the isostructural title compounds, namely {2,6-bis­[(di-tert-butyl­phosphan­yl)­oxy]-4-hy­droxy­phen­yl}chlorido­palladium(II), [Pd(C22H39O3P2)Cl], 1, and {2,6-bis­[(di-tert-butyl­phosphan­yl)­oxy]-4-hy­droxy­phen­yl}chlorido­platinum(II), [Pt(C22H39O3P2)Cl], 2, the metal centres are coordinated in a distorted square-planar fashion by the POCOP pincer fragment and the chloride ligand. Both complexes form strong hydrogen-bonded chain structures through an inter­action of the OH group in the 4-position of the aromatic POCOP backbone with the halide ligand.

High-resolution single-crystal X-ray measurements of the monoclinic polymorph of bicalutamide and the aspherical atom databank approach have served as a basis for a reconstruction of the charge density distribution of the drug and its androgen receptor (AR) and albumin complexes. The contributions of various types of intermolecular interactions to the total crystal energy or ligand:AR energy were estimated. The cyan and amide groups secured the ligand placement in the albumin (Lys-137) and the AR binding pocket (Leu-704, Asn-705, Arg-752), and also determined the packing of the small-molecule crystals. The total electrostatic interaction energy on average was −230 kJ mol−1, comparable with the electrostatic lattice energy of the monoclinic bicalutamide polymorph. This is the result of similar distributions of electropositive and electronegative regions on the experimental and theoretical molecular electrostatic potential maps despite differences in molecular conformations. In general, bicalutamide interacted with the studied proteins with similar electrostatic interaction energies and adjusted its conformation and electrostatic potential to fit the binding pocket in such a way as to enhance the interactions, e.g. hydrogen bonds and π⋯π stacking.

There is little doubt that human activity is affecting planet Earth, but just how much? And is it all negative? Rick Potts is the director […]

The post Smithsonian anthropologist Rick Potts answers questions about the Anthropocene appeared first on Smithsonian Insider.

Archived feed of this symposium » The world is changing at a rapid pace. Scientists have documented significant changes during the past century in climate, […]

The post Smithsonian Symposium: The Anthropocene appeared first on Smithsonian Insider.

A new analysis of the fossil record by scientists at the Smithsonian’s National Museum of Natural History has revealed that the structure of plant and […]

The post Smithsonian Scientists Trace Anthropocene Roots to Early Human Activity appeared first on Smithsonian Insider.

Westley Heydeck, Brian A. Bayless, Alexander J. Stemm-Wolf, Eileen T. O'Toole, Amy S. Fabritius, Courtney Ozzello, Marina Nguyen, and Mark Winey

Basal bodies (BBs) are microtubule-based organelles that template and stabilize cilia at the cell surface. Centrins ubiquitously associate with BBs and function in BB assembly, maturation, and stability. Human POC5 (hPOC5) is a highly conserved centrin-binding protein that binds centrins through Sfi1p-like repeats and is required for building full-length, mature centrioles. Here, we use the BB-rich cytoskeleton of Tetrahymena thermophila to characterize Poc5 BB functions. Tetrahymena Poc5 (TtPoc5) uniquely incorporates into assembling BBs and is then removed from mature BBs prior to ciliogenesis. Complete genomic knockout of TtPOC5 leads to a significantly increased production of BBs yet a markedly reduced ciliary density, both of which are rescued by reintroduction of TtPoc5. A second Tetrahymena POC5-like gene, SFR1, is similarly implicated in modulating BB production. When TtPOC5 and SFR1 are co-deleted, cell viability is compromised, and levels of BB overproduction are exacerbated. Overproduced BBs display defective transition zone formation and a diminished capacity for ciliogenesis. This study uncovers a requirement for Poc5 in building mature BBs, providing a possible functional link between hPOC5 mutations and impaired cilia.

According to the weekly report of the Smithsonian’s Global Volcanism Program, gas-and-ash plumes rose nearly one mile above the crater of Mexico’s Popocatépetl volcano from […]

The post Mexico’s Popocatepetl volcano active again appeared first on Smithsonian Insider.

Moore, Amelia, 1981- author

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Newark Mayor Cory Booker performs social media magic like no other politician.

A Sitka spruce on Campbell Island may be the 'golden spike' that denotes the controversial beginning of the Anthropocene epoch.

500 square miles of Appalachian forest is gone forever due to illegal mountaintop mining, and the EPA doesn't seem to mind.

New film, based on the best-selling book by Dan Brown, warns of humanity's demise from unchecked population growth.

Modern-day dowsers are helping drought-stricken California wineries and farms find water for their crops.

Rutherford Seydel's Oxygen Project creates a sustainable Earth while creating financial sustainability for all. All it will take is a massive group action.

When is rhetoric over-the-top when you're talking about climate change?

Good looking pants that protect your valuables.

Two student teams from the 2013 Solar Decathlon, USC and Santa Clara University, need to sell their innovative, solar-powered homes to private buyers.

Bees often flit around with yellow saddlebags, called pollen baskets, hanging from their hind legs.

Australia's desert ants are thriving in the face of climate change.

Chair Pockets Can Be a Great Addition to Your Classroom Great references here. Get more here. Keywords: Dorm room organization, Dorm room organization, Seat sacks, How to decorate dorm room, Chair pocket, Stylish dorm rooms.

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This article describes the importance of cell phones in our everyday lives and the etiquettes one should follow in different occasions.

Book becomes #1 Best Seller in 4 categories on Amazon

Finally - a big screen laser cinema projector that ACTUALLY fits in your pocket. With standalone and Raspberry Pi compatible versions.

Ms. Pochini has been endorsed by Marquis Who's Who as a leader in the fields of communications, interior design and coaching

Reading the Constitution can help us to understand our rights as citizens, Norcross personal injury law firm says.

Olive Oil Organically Grown and Pure Enough to Carry the Name of the Father of Medicine

Could we see the yellow metal at $5,000 or even higher amid the coronavirus crisis? We invite you thus to read our today’s article and find out how high gold prices can go in this downturn.

Rakesh Khurana, Harvard Business School professor.

Access the 2020 Anders Tax Pocket Guide for this year’s corporate and individual tax rates, retirement plan contribution limits and more, including:

Estate tax and lifetime gift tax exemption increase to $11,580,000
AMT exemption increase
Standard deduction increase

View the… Read More

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Access the 2020 Anders Tax Pocket Guide for this year’s corporate and individual tax rates, retirement plan contribution limits and more, including: Estate tax and lifetime gift tax exemption increase to $11,580,000 AMT exemption increase Standard deduction increase View the 2020 Anders Tax Pocket Guide. Contact an Anders advisor to learn how these rates affect you...

The post 2020 Tax Pocket Guide appeared first on Anders CPA.

The Anthropocene is the current geological age, in which human activity has profoundly shaped the planet and its biodiversity. On The Anthropocene Reviewed, John Green rates different facets of the human-centered planet on a five-star scale. This week 99% Invisible is featuring two episodes of The Anthropocene Reviewed in which John Green dissects: pennies, the Piggly Wiggly grocery store chain, a 17,000-year-old cave painting, and the Taco Bell breakfast menu. Plus, Roman talks with John about the show, sports, and all the things we love now, but hated as teenagers.

The Anthropocene Reviewed

Subscribe to The Anthropocene Reviewed on Apple Podcasts or RadioPublic

There is a lot to be said for the therapeutic benefits of sewing. Life has certainly been challenging lately. Concern over elderly family members and family members with high risk medical conditions, together with working long hours, has left little energy or inclination to be creative. I knew I needed a colourful scrappy project to... 

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The post Patchwork Pocket Pouch appeared first on A Spoonful of Sugar.

Life Science Centre in Newcastle hosts challenging debate and here's how to join its online audience for free

A method is disclosed for preparing a soft tissue site, and augmenting the soft tissue site, such as the breast(s), scar, depression, or other defect, of a subject through use of devices that exert a distractive force on the breast(s) and grafting of autologous fat tissue such as domes with sealing rims for surrounding each of the soft tissue site and a regulated pump. The method for preparing the soft tissue site, and enhancing fat graft results, entails application of the distracting force to the targeted soft tissue site at least intermittently for some period of time and preferably several weeks prior to the graft procedure. A related aspect of the invention includes following the preparation steps by transfer of fat from other areas of the subject to the subject's soft tissue site, and then reapplication of the distractive force to the soft tissue site that received the autologous fat graft. Alternatively, fat from genetically related sources may be used, and the fat may be further processed prior to injection. Substantial soft tissue augmentation, high rates of graft survival and negligible graft necrosis (data demonstrating 80% survival and only 20% necrosis is presented) or calcification result from the practice of these methods.

Stake pocket formations are secured to a cargo bed frame of a land vehicle such as trailers and flatbed trucks for removably supporting sidewall supporting members. The formations include sidewalls secured to and projecting from the frame and an end wall extending between the sidewalls. An opening extends through the end wall and is adapted to receive the terminal end of a J-hook therethrough. The J-hook is secured to the formation by inserting the terminal end thereof into the pocket placing an upper edge of the end wall into the J-hook gap and rolling/rotating the J-hook thereby inserting the terminal end into the opening. The J-hook cannot be removed from the pocket unless it is rolled/rotated in the opposite direction. While within the stake pocket and without strap tension, the J-hook abuts the trailer frame and formation end wall and is, thereby, maintained within the pocket.

A binding cover having a transparent overlay cover disposed over and around the spine of the binding is configured to provide a label pocket on the spine portion of the binding cover wherein a label may be inserted easily without tools or rigid label material. In several embodiments the label pocket provides a fixed label space. In another embodiment the label pocket opens along the spine when the binding cover is opened, and returns to a closed position when closed, thereby retaining a label inserted therein. In another embodiment a method for forming the label pocket is provided.

A multi-pocketed decorative fabric organizer that resembles a folding file and serves as a workspace when opened and then folds up in seconds keeping all the items and materials stored in it intact, and provides a portable and compact organizer for various purposes. The organizer consists of a hard surface that folds out to a writing or working space consisting of conveniently located plastic storage pockets and an exterior of decorative fabrics.

The invention relates to a bag of variable volume able to contain fluids and designed to be introduced into a container through the container's neck, said bag consisting of a pouch with one closed end and one open end, the open end being dimensionally stable over temperature ranges of from −30 to 55° C., to a device incorporating said bag and to a process for filling it.

A system and a device for anti-thief protection, especially for open pockets of trousers, bags and the like, includes a mobile protection strip element (1) to be applied on the pockets hooks (12). The aim is attained by superposing the strip (1) on the pocket (T) and blocking the strip (1) using a plurality of hooks (12) in the form of clips located in the lower part (5) of the strip (1), the strip (1) supported by support elements (G), located in the upper part (2) thereof, which insert or hook in the zone overlying the pocket (T) to be protected.

A one-piece ice chest cover for changing the appearance of an ice chest includes a flexible main pocket portion having a front side, two lateral sides, and a back side forming a main pocket opening for receiving a main body of the ice chest. It also includes a flexible lid pocket portion formed of an inner portion configured to face an inner-facing surface of a lid of the ice chest and an outer portion for covering an outer-facing surface of the lid. The lid pocket portion may include a lid pocket opening sized smaller than a size of the main pocket opening. The lid pocket opening may be sized to receive a portion of the lid of the ice chest. The outer portion of the lid pocket portion may be connected to the back side of the main pocket portion so that the ice chest cover flexes when the lid is pivoted to open and close the ice chest.

The present invention relates to a pocketbook system that allows to easily mix and match how many pocketbooks, other carriers, and/or straps will suffice for that day or evenings' use while this pocketbook system is easy to use and inexpensive to manufacture. More particularly, the pocketbook system has a primary pocketbook for carrying contents, one or more removably attached secondary carrier for carrying contents, a device(s) for removably attaching the secondary carrier(s) to the inside or outside of the primary pocketbook, or for attaching the primary pocketbook and secondary carrier together, and preferably has at least one removable flexible strap(s) and a device(s) for removably attaching the strap(s) to the primary pocketbook and/or secondary carrier. The user makes use of the pocketbook system by attaching, detaching, re-attaching, exchanging, and switching different parts and/or elements to form a suitable pocketbook structure for a particular use at a particular time.

A pocket knife including a first body portion including a first engaging member, and a second body portion including a second engaging member arranged to engage the first body portion with the second body portion. The first body portion and the second body portion are separated from each other when not engaged. A tool element is arranged to be housed in the first body portion when in a closed state and displaced outward when in an opened state. A first locking member is arranged to be actuated by the tool element, and cooperates with a second locking member provided on the second body portion, and wherein when the first engaging member is engaged with the second engaging member, and when the first locking member and the second locking member are prevented from moving, the first body portion and the second body portion are prevented from being separated.

Provided is activewear with hidden pockets. More particularly, athletic garments such as pants comprising one or more waistband pocket, preferably concealable, are included. In embodiments, athletic garments with an interior concealed pocket in the fold-over portion of a fold down waistband are provided. The waistband pocket enables the wearer to store items such as car keys, hotel room keys and/or smart phones relatively inconspicuously and securely in the waistband of the garment. A purpose of the concealment includes minimizing attention from the items stored within the pocket and allowing the wearer to participate in a variety of athletic sports or events while carrying personal items in a secure manner. Preferred embodiments include athletic pants comprising (i) a fold down waistband, (ii) an annular storage pocket capable of retaining items without any additional material added to the pant, and (iii) one or more slits for the opening for the pocket.

Compositions and methods useful for point of care testing for hemophilia by measuring coagulation factor levels are provided.

A data security pocket and garment is disclosed for better positioning and protecting data and information contained in a card or device for housing such information from its theft or misappropriation when it is placed in the pocket portion of the invention. The pocket portion of the invention is specially positioned on and secured to a portion of the garment or clothing surface near or adjacent to the arm-pit area with which it is used in combination, with its own design, to provide a more protective pocket environment for placement and transportation of a card, chip or other data/information carrying or storing device or means. The pocket and the garment in combination make up four layers from which the pocket is constructed, secured and positioned. These layers include the top pocket layer (12); the top security layer (14) and the bottom security layer (16), each fabricated from security anti-RFID material; and the garment, clothing or base layer (18). These layers are connected one to the other so that the pocket portion has a first accessible opening (40) and a second accessible opening (42) when secured in proper position on the garment (18). Further provided is the trim security flap cover (22), also fabricated from security anti-RFID material, and the upper cover enclosure (20), each of which is secured above the pocket portion on the garment layer (18), and which pivot and close over the top pocket layer (12). Coupling is provided for both the upper cover enclosure (20) and the top pocket layer (12); and the trim security flap cover (22) and the top pocket layer (12). In another aspect of the invention an auxiliary security area (39) is provided on the top pocket layer (12) adjacent or near the coupling for the trim security flap (22).

An article having a panel secured between two layers of a trim piece and having a pocket affixed to a zipper, where a first zipper tape is affixed to the panel, and a second zipper tape is secured between the two layers of the trim piece such that the pocket is in communication with an incised opening in the panel is provided. The panel may be secured between the two layers of the trim piece at a first edge, and the incised opening may be formed proximate to the first edge such that the article comprises a pocket presented proximate to the trim piece. The present invention further comprises a method of manufacturing the article including a pocket presented proximate to the trim piece.

Perhaps Squire would have been a more fitting title?

King doesn't quite reach the new heights listeners have come to expect from a new Fleshgod Apocalypse release.