SoftwareOne Holding sales increased during its third quarter by 1.4%, the company said on Wednesday, adding that discussions about taking it private were progressing but were "challenging". Group revenues increased to 236.7 million Swiss francs ($268.06 million), while adjusted core operating…

Breaking up with someone is often one of the most difficult experiences we face. It can feel as though your entire world has shifted, leaving you disoriented and unsure of what comes next. But even amid the pain, a breakup can also be a profound opportunity for growth. This journey—one of rediscovering who you are, ... Read more

The post How to Get Over Someone: A Step-by-Step Guide to Moving On with Your Life appeared first on LifeHack.

The Leonid meteor shower peaks in North America overnight from Nov. 17 to 18, with fast-moving fireballs possible in US skies.

High-profile entities in India have become the target of malicious campaigns orchestrated by the Pakistan-based Transparent Tribe threat actor and a previously unknown China-nexus cyber espionage group dubbed IcePeony. The intrusions linked to Transparent Tribe involve the use of a malware called ElizaRAT and a new stealer payload dubbed ApoloStealer on specific victims of interest, Check Point

Donald Trump's rocket fuel is rage and resentment, with a new and very detailed agenda to match. His country, this nation and the world await the full meaning and consequence of his second presidency, writes Tony Leon.

Paleontologist Dave Hone rates the realism of the dinosaur attacks in the "Jurassic Park" and "Jurassic World" movies.

Health not independence is focus for Sturgeon successor Expert comment NCapeling 15 February 2023

Nicola Sturgeon’s star may have been fading, but Rishi Sunak and Keir Starmer will be relieved at the exit of one of the UK’s most influential politicians.

Nicola Sturgeon has left at the right time, maybe even a bit late. Although one of the most influential politicians the UK has seen in recent times, she was also one of the most divisive.

Her ability to fan Scotland’s sense of difference from England brought new hope to the independence movement, but this cause – by which she measured herself above all others – has been losing ground and for now, looks to be in abeyance.

Neat and disciplined, Sturgeon could not have presented a greater contrast to Boris Johnson in the first months of the pandemic. That was one of her finest moments.

She used the powers of the devolved government to make different lockdown decisions for Scotland – never all that different from those in England but often announced just a few hours earlier.

Although analysts surmise that these made little difference to the death rate – although poverty and other health support factors make comparisons hard – she used the platform, with the cameras on her, to ram home the point that Scotland could set its own rules.

Rallying young voters to independence

Her second greatest moment was in the aftermath of Brexit. Scots voted overwhelmingly to stay in the European Union (EU) and so, she argued, they should have the right to leave the UK to join that other union. Younger voters in particular responded, rallying to the independence cause.

But two recent setbacks showed her star was fading. She lost the Supreme Court battle to hold a second independence referendum in November, when she was told Scotland simply did not have the powers to hold one on its own if Westminster said no – and the UK government did just that. It was hard to see how her campaign for independence could move forwards.

And her planned reforms to the gender recognition process in Scotland have been blocked by the UK government – but unease about her reforms within Scotland meant this rebuff did not win her the support at home she hoped for. She was also accused of playing politics by pressing ahead with unpopular reforms simply because of their potential to discomfit the UK government.

Health, education, and public services need attention

Other challenges were also building up and, even if less eye-catching, her successor is likely to focus on health and education above the birth of a new nation. Sturgeon’s critics have long argued that under Scottish National Party rule, health, education, and other public services have declined.

In elections, these factors can be eclipsed by passions about independence but it is rare in political life for a leader to be insulated from public anger on this front. This is almost certainly where her successor will want to focus first.

Creon Butler appointed to lead Global Economy and Finance Programme News Release sysadmin 22 October 2019

Creon Butler has been appointed to lead the Global Economy and Finance programme at Chatham House, joining the institute at the beginning of December. He will also form part of the institute’s senior leadership team.

In this GPU age, CPUs are often considered second citizens because most of the performance comes from the GPU. In most systems, GPUs are separate PCIe devices used by the […]

The post Xeon 6 vs. Zen-5 HPC Benchmark Showdown appeared first on HPCwire.

Actor Leonardo DiCaprio turns 50 and actor Calista Flockhart turns 60, among the famous birthdays for Nov. 11.

It has incredible psychological and physiological power.

These little treats may be the secret to boosting someone’s mood.

Neuronal cytotoxic edema is implicated in neuronal injury and death, yet mitigating brain edema with osmotic and surgical interventions yields poor clinical outcomes. Importantly, neuronal swelling and its downstream consequences during early brain development remain poorly investigated, and new treatment approaches are needed. We explored Ca²⁺-dependent downstream effects after neuronal cytotoxic edema caused by diverse injuries in mice of both sexes using multiphoton Ca²⁺ imaging in vivo [Postnatal Day (P)12–17] and in acute brain slices (P8–12). After different excitotoxic insults, cytosolic GCaMP6s translocated into the nucleus after a few minutes in a subpopulation of neurons, persisting for hours. We used an automated morphology-detection algorithm to detect neuronal soma and quantified the nuclear translocation of GCaMP6s as the nuclear to cytosolic intensity (N/C ratio). Elevated neuronal N/C ratios occurred concurrently with persistent elevation in Ca²⁺ loads and could also occur independently from neuronal swelling. Electron microscopy revealed that the nuclear translocation was associated with the increased nuclear pore size. The nuclear accumulation of GCaMP6s in neurons led to neocortical circuit dysfunction, mitochondrial pathology, and increased cell death. Inhibiting calpains, a family of Ca²⁺-activated proteases, prevented elevated N/C ratios and neuronal swelling. In summary, in the developing brain, we identified a calpain-dependent alteration of nuclear transport in a subpopulation of neurons after disease-relevant insults leading to long-term circuit dysfunction and cell death. The nuclear translocation of GCaMP6 and other cytosolic proteins after acute excitotoxicity can be an early biomarker of brain injury in the developing brain.

Hyperbilirubinemia (HB) is a key risk factor for hearing loss in neonates, particularly premature infants. Here, we report that bilirubin (BIL)-dependent cell death in the auditory brainstem of neonatal mice of both sexes is significantly attenuated by ZD7288, a blocker for hyperpolarization-activated cyclic nucleotide-gated (HCN) channel-mediated current (I_h), or by genetic deletion of HCN1. GABAergic inhibitory interneurons predominantly express HCN1, on which BIL selectively acts to increase their intrinsic excitability and mortality by enhancing HCN1 activity and Ca²⁺-dependent membrane targeting. Chronic BIL elevation in neonatal mice in vivo increases the fraction of spontaneously active interneurons and their firing frequency, I_h, and death, compromising audition at the young adult stage in HCN1^+/+, but not in HCN1^–/– genotype. We conclude that HB preferentially targets HCN1 to injure inhibitory interneurons, fueling a feedforward loop in which lessening inhibition cascades hyperexcitability, Ca²⁺ overload, neuronal death, and auditory impairments. These findings rationalize HCN1 as a potential target for managing HB encephalopathy.

Anthony Atala | Smithsonian Magazine’s 2016 American Ingenuity Award Winner for Life Sciences The director of the Wake Forest Institute for Regenerative Medicine, Atala is a surgeon and leading expert in creating living human tissues and organs to replace those that are defective or damaged. He has spent the past decade attempting to construct living organs using 3-D printing technology. Atala implanted the world’s first laboratory-grown organ into a human in 1999 and, this year, he and his colleagues “printed” cartilage, bone and muscle tissue before successfully implanting them into a lab animal. That’s a crucial first step toward Atala’s long-term goal of overcoming the dire shortage of donated organs with custom-made body parts. Read more about Atala's work: http://smithmag.co/SiiV2J | #IngenuityAwards And more about the American Ingenuity Awards: http://smithmag.co/77xPqy

Read more at http://www.smithsonianmag.com/arts-culture/Herman-Leonards-Eye-for-Jazz.html With just a camera as his ticket, Herman Leonard captured jazz icons performing on and off stage.

When the blaze in Moscow subsided on September 18, 1812, the French—who had traveled hundreds of miles into Russia—were left without vital resources as a brutal winter approached

The annual award ceremony featured costumes, songs and paper airplanes as scientists recognized comedic research across ten disciplines

The vertical sign stretched across three stories of the Manhattan hotel, which once welcomed the likes of Bob Dylan, Patti Smith, Andy Warhol and Janis Joplin

The Galeón Andalucía, which is now making its way to London, was designed to resemble the armed merchant vessels manufactured by Spain and Portugal between the 16th and 18th centuries

The metropolis is an important center for paleontological research, but until now, fossils of plants and fish were the only remains of dinosaur-era life found there

The 1951 artwork, "La Grande Dame (The Cat Woman)," stands over six feet tall and features paintings of "hybrid creatures and lush dreamscapes"

Government debt in France is mounting amid large budget deficits, leading to higher borrowing costs.