The Lost Dungeon Of Knight is a first-person adventure game with puzzle elements. The game takes place in a mysterious dungeon in which you have to explore the mysterious catacombs and be smart to uncover all the secrets of this mysterious place.

Nickelodeon used its Kids' Choice Awards show broadcast to premiere the first footage of its trademark green slime floating on board the International Space Station.

By Amanda Mannen  Published: May 06th, 2020 

How many books of Ringo Starr songs does Billie own? That’s the second one!

It is dark when I wake . It is Day 48 of the lockdown . The sun has not risen and the birds have not woken. It is Thursday . Sage are meeting today with our government . Sage used to be that herb that you stuffed up a chicken together with onion . Now it i

Most buyers, understandably, would want to know if a violent death occurred in the houses they are considering.

When Clippers coach Doc Rivers watches Kawhi Leonard, he sees hallmarks of other prolific scorers he has coached.

Lakers star LeBron James heads a list of 44 players nominated to represent the U.S. at the upcoming Summer Olympics. Others include Kawhi Leonard and Damian Lillard.

LeBron James, Anthony Davis and Kawhi Leonard were all wearing the same uniform, Frank Vogel coaching on the sidelines and thought of what might have been.

Clippers star Kawhi Leonard was one of several NBA stars who developed a close relationship with Lakers legend Kobe Bryant, who took pride in helping players.

Fans attending the Clippers game Friday will each receive a backpack with a note from Leonard to use the bag as an agent of change for a good cause.

His former teachers remember Clippers star Kawhi Leonard just as he is now: quiet, focused and successful.

Kawhi Leonard was having one of the best statistical seasons in Clippers history, a feat done only 15 times by five players, before the season stopped.

The secret car lairs of L.A. are under the radar and plentiful. Check out one of the latest: a state-of-the-art garage near LAX that is part Pantheon, part Batcave. Cigars? They have that too.

Vice President Mike Pence says the cornavirus task force could end in early June. Why?

Painter Antoine-Jean Gros made the French general into a military hero, turning troublesome truth into feel-good fiction.

Cynthia Erivo, Jamie Foxx, Louis Gossett Jr., Lena Waithe and HBO's 'The Wire' cast were honored at the 2020 American Black Film Festival Honors on Sunday.

ANDREW NEIL mocked Nicola Sturgeon after she admitted NHS England did not take PPE from Scotland.

A CONSERVATIVE MP has lashed out at Nicola Sturgeon's bizarre coronavirus plan. David Mundell, the Conservative MP for Dumfriesshire, Clydesdale & Tweeddale, was enraged by reports Ms Sturgeon is planning to shut Scotland's border to England.

Frank Warren says there is no chance Tyson Fury vs Deontay Wilder 3 will happen behind closed doors.

Here's the question. With coronavirus raising its ugly head in this green and pleasant land, and with a pressing desire not to catch the horrible bug or pass it on to nearest and dearest - not to mention vulnerable strangers - at which point do we pitch in and speak out?

Leonard has made 284 tackles, 12 sacks and seven interceptions in his first two years, but says he only met 3 or 4 of his 15 goals last year.

The punching bag in The Last Dance documentary about the final season of the champion Bulls is GM Jerry Krause, who got his start from Slick Leonard.

The punching bag in The Last Dance documentary about the final season of the champion Bulls is GM Jerry Krause, who got his start from Slick Leonard.

Leonard has made 284 tackles, 12 sacks and seven interceptions in his first two years, but says he only met 3 or 4 of his 15 goals last year.

Jerome Adams took his inhaler out while discussing the impact of Covid-19 on black people.

A chronology of key events

Key facts, figures and dates

Joe d'Eon, Airline Pilot and host of "Fly With Me"

The Amateur Traveler talks to Chris Guillebeau from the Art of Non-Conformity about his years volunteering in West Africa with the NGO (non-governmental organization) Mercy Ships. Chris and his wife volunteered with this organization in Sierra Leone and Liberia which gave them a very different view of West Africa. For those not familiar with Mercy Ships, they provide medical services in under-served areas of the world from their floating hospital ships. Chris was in Sierra Leone shortly after the end of its costly civil war. This episode is not about travel to lie on the beach and work on your tan (although Chris does recommend bringing your sunscreen) but about life changing travel. And no, Chris is not a doctor.

When I started this blog more than 10 years ago, I had one goal: to entertain as many people as possible with my travel stories. I got away from that goal in recent years, focusing on guides for travelers instead, realizing that it’s hard to earn a living when you tell stories like these. But …

I’m Telling Stories I’ve Never Told Before — on Patreon! Read More »

The post I’m Telling Stories I’ve Never Told Before — on Patreon! appeared first on Adventurous Kate.

Creon Butler has been appointed to lead the Global Economy and Finance programme at Chatham House, joining the institute at the beginning of December. He will also form part of the institute’s senior leadership team.

In 2014, Oliver Johnson was a 28 year old British doctor, working on health policy in Sierre Leone after finishing medical school. Also working in Freetown was Sinead Walsh, then the Irish Ambassador to the country. Then the biggest outbreak of Ebola on record happened in West Africa, starting in Guinea and quickly spreading to Liberia, Sierre...

Permanent neonatal diabetes mellitus (PNDM) is caused by reduced β-cell number or impaired β-cell function. Understanding of the genetic basis of this disorder highlights fundamental β-cell mechanisms. We performed trio genome sequencing for 44 patients with PNDM and their unaffected parents to identify causative de novo variants. Replication studies were performed in 188 patients diagnosed with diabetes before 2 years of age without a genetic diagnosis. EIF2B1 (encoding the eIF2B complex α subunit) was the only gene with novel de novo variants (all missense) in at least three patients. Replication studies identified two further patients with de novo EIF2B1 variants. In addition to having diabetes, four of five patients had hepatitis-like episodes in childhood. The EIF2B1 de novo mutations were found to map to the same protein surface. We propose that these variants render the eIF2B complex insensitive to eIF2 phosphorylation, which occurs under stress conditions and triggers expression of stress response genes. Failure of eIF2B to sense eIF2 phosphorylation likely leads to unregulated unfolded protein response and cell death. Our results establish de novo EIF2B1 mutations as a novel cause of permanent diabetes and liver dysfunction. These findings confirm the importance of cell stress regulation for β-cells and highlight EIF2B1’s fundamental role within this pathway.