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Biden to host Indonesian President Subianto at White House meeting

President Joe Biden will hold a White House meeting with President Prabowo Subianto of Indonesia on Tuesday to celebrate 75 years of U.S.-Indonesian relations and discuss ways to strengthen their countries' cooperation.




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Biden, Israeli President Herzog meet to discuss Gaza, Middle East

President Joe Biden and Israeli President Isaac Herzog met at the White House on Tuesday afternoon to discuss the war against Hamas and Hezbollah and other Middle East concerns.




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Bid to halt in-person classes denied; prison cases protested




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Key role for Black policy leaders on Biden's transition team




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Schools Could See U-Turn on Civil Rights Under Biden

Activists expect to see renewed guidance, more active enforcement, and better data collection coming from the Education Department’s civil rights office.




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What Educators Need to Hear From Biden on COVID-19

Consistent, science-based messaging is crucial, but the new administration still faces political headwinds and a skeptical public.




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Joe Biden Backs Two Proposals to Increase Education Funding in 2020 Swing State

Biden's campaign announced March 31 that the 2020 Democratic presidential candidate backs two local attempts to raise more tax revenue for schools.




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South Carolina a unanimous No. 1 in women's AP Top 25 after 2 wins to open repeat bid; Stanford, Oregon crack rankings

South Carolina a unanimous No. in women's AP Top 25 after 2 wins to open repeat bid; Stanford, Oregon crack rankings.




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Biden Issues a 'Long Overdue' Formal Apology for Native American Boarding Schools

The president atoned for the federal government's role in forcing Native American children into boarding schools, where many were abused and more than 900 died




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Jill Biden Unveils a Reimagined White House Tour, Which Invites Visitors to 'Touch, Hear and See' History

The public tours of the historic residence hadn't been overhauled in decades. For two years, the first lady's office has been working to make them more interactive and educational




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Ex-Penguins goalie Marc-André Fleury bids farewell to Pittsburgh fans on retirement tour

Marc-André Fleury stopped 26 shots in what will likely be his final game in Pittsburgh as the Minnesota Wild beat the Penguins 5-3 on Tuesday night. He spent 13 seasons with Pittsburgh and won Stanley Cups in 2009, 2016 and 2017.



  • Sports/Hockey/NHL

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How Biden Could Steer Education Spending Without Waiting on Congress

Congress controls how much gets spent on education. But a presidential administration can influence how it's spent. Here's a few areas to watch.




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Biden's Segregation Comments Resurrect His Anti-Busing History

Former Vice President Joe Biden’s recent remarks on his willingness to work with segregationists resurrected his long-ago efforts to oppose school busing. Will it hurt his campaign?




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Biden hosts Israel's president at the White House amid peace push

President Joe Biden hosted Israeli President Isaac Herzog at the White House on Tuesday as the outgoing administration seeks cease-fire progress in Gaza and Lebanon.




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WATCH: Biden, Harris lay wreath at Tomb of the Unknown Soldier on Veterans Day

This is the first time Biden and Harris appeared together since Election Day. 




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News24 Business | Halt to Amazon HQ: WCape MEC launches legal bid to restart construction

Western Cape MEC for local government, environmental affairs and development Anton Bredell has filed an application for leave to appeal a high court order suspending construction of a R4.5 billion project that will house Amazon’s Africa headquarters.




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News24 Business | 'Food inflation has all but disappeared': Bidcorp flags record trading, 'excellent' SA result

Shares of Bidcorp, the food services giant founded by Brian Joffe, jumped almost 5% on Tuesday after it reported a record revenue performance for the four months to end October, including an "excellent" result from SA.




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Joe Biden Picks Kamala Harris for VP After Intense School Desegregation Clash

Although Harris clashed with Biden over his record on school desegregation, some of her education proposals might dovetail well with his.




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Trump Plans Immigration Crackdown, Aims To End Biden's Entry Programs

President-elect Donald Trump is expected to take a slew of executive actions on his first day in the White House to ramp up immigration enforcement and roll back President Joe Biden's flagship legal entry programs.




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Commissioner Navarro Signs Health Policy Letter to President-Elect Biden

Joins ten Insurance Commissioners in providing short- and long-term recommendations to the incoming administration A group of the nation’s state insurance commissioners joined together in a pledge to work with President-elect Joe Biden by providing health policy recommendations to the incoming administration. The commissioners share President-elect Biden’s vision that no American should have to go […]




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Joe Biden Hosts Diwali Celebration At White House

US President Joe Biden on Monday hosted a Diwali celebration at the White House that was attended by more than 600 eminent Indian Americans, including Congressmen, officials, and corporate executives, from across the country.




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DPH Cautions Public to Watch for Rabid Animals During Active Season

DOVER, DEL. (June 26, 2024) – With the weather warming up, the Delaware Division of Public Health (DPH) urges the public to take precautions to avoid exposure to rabies and to be on the lookout for rabid animals during this active season. Rabies is endemic in Delaware, meaning it occurs regularly within the state’s wildlife populations. […]



  • Delaware Health and Social Services
  • Division of Public Health
  • DE Division of Public Health
  • Delaware Department of Health and Social Services
  • Delaware Division of Public Health
  • Delaware rabies
  • DPH Rabies Program
  • rabies

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Cape Town Secures Historic Bid to Host WorldPride 2028

[allAfrica] We are excited to share the momentous news that Cape Town Pride has officially won the bid to host WorldPride 2028. This significant event is a global celebration of LGBTQ+ pride and rights, marking a pivotal milestone not only for the LGBTQ+ community in the city but also for the entire African continent. This victory positions Cape Town as a leading symbol of inclusivity and diversity, showcasing its commitment to advancing a welcoming environment for all.




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Biden Administration Faces Daunting Task of Rebuilding US Economic Diplomacy

Biden Administration Faces Daunting Task of Rebuilding US Economic Diplomacy Biden Administration Faces Daunting Task of Rebuilding US Economic Diplomacy
ferrard Wed, 12/09/2020 - 14:49

East-West Wire

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News, Commentary, and Analysis
East-West Wire

The East-West Wire is a news, commentary, and analysis service provided by the East-West Center in Honolulu. Any part or all of the Wire content may be used by media with attribution to the East-West Center or the person quoted. To receive East-West Center Wire media releases via email, subscribe here.

For links to all East-West Center media programs, fellowships and services, see www.eastwestcenter.org/journalists.

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East-West Wire

Tagline
News, Commentary, and Analysis
East-West Wire

The East-West Wire is a news, commentary, and analysis service provided by the East-West Center in Honolulu. Any part or all of the Wire content may be used by media with attribution to the East-West Center or the person quoted. To receive East-West Center Wire media releases via email, subscribe here.

For links to all East-West Center media programs, fellowships and services, see www.eastwestcenter.org/journalists.

Explore




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Merryweather and his alleged attacker both fail in SCA costs bid




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Court turns down amnesty bid in COSAS 4 murders




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Indonesia’s Prabowo meets Biden after signing maritime deal with Beijing

President Joe Biden and Indonesian President Prabowo Subianto met Tuesday at the White House to strengthen U.S.–Indonesia ties. The meeting came days after Jakarta signed a maritime agreement with Beijing that critics say could lend credibility to China’s “nine-dash line” that reflects its expansive claims in the South China Sea. White House Bureau Chief Patsy Widakuswara has this report




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Biden, Israeli president stress need to end conflicts

U.S. President Joe Biden on Tuesday hosted Israel's president while President-elect Donald Trump has separately held multiple phone calls recently with Israel's head of government, Prime Minister Benjamin Netanyahu. These parallel talks have focused on the conflicts in Gaza and Lebanon and hopes for the release of hostages held by Hamas. VOA White House correspondent Anita Powell reports from Washington.




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Diplomacy is in full swing as Biden meets with Israeli president, and Trump speaks to Israeli prime minister.

Diplomacy is in full swing as U.S. President Joe Biden meets with Israel's president, and President-elect Donald Trump speaks with Israel's prime minister. Fast-rising methane emissions could undermine efforts to limit global warming by mid-century, prompting scientists and policymakers to urge aggressive action to curb the output of the potent greenhouse gas. An election in Somaliland, and the fight against Boko Haram in Chad. Plus, Trump’s foreign policy.




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AFCON qualifier: Super Eagles stars arrive Abidjan ahead of Benin clash 

A number of Super Eagles players, including Moses Simon, Samuel Chukwueze, Amas Obasogie, Raphael Onyedika and Frank Onyeka, have arrived Ivory Coast on Monday ahead of preparation for their 2025 Africa Cup of Nations qualifier against Benin Republic. Also in camp in Abidjan are Bruno Onyemaechi, Gabriel Osho and Fisayo Dele-Bashiru. The Super Eagles Media […]

The post AFCON qualifier: Super Eagles stars arrive Abidjan ahead of Benin clash  first appeared on Business Hallmark.



  • Sports
  • AFCON qualifier: Super Eagles stars arrive Abidjan ahead of Benin clash
  • Super Eagles

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Over 1,000 firms bid for 2017 railway projects

Over 1000 companies expressed interest in 17 categories of projects for the 2017 capital projects of the Nigerian Railway Corporation (NRC). The Managing Director of the NRC, Engr. Fidet Okhiria disclosed this on Tuesday while declaring open the process for the opening of bids for the projects. The formal opening of bids held at the […]

Over 1,000 firms bid for 2017 railway projects




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Biden vows peaceful White House handover, Trump eyes Putin talks

Joe Biden pledged a peaceful transfer of power Thursday after Donald Trump's decisive US election win, while the Republican showed his intent to ditch the outgoing president's policies by suggesting he would talk to Vladimir Putin.




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Sabiduría divina para la familia A

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.




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Sabiduría divina para la familia B

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.




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Buscando sabiduría divina A

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.




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Buscando sabiduría divina B

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.




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The Benefits of Abiding in Christ, Part 1




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The Benefits of Abiding in Christ, Part 2




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The Benefits of Abiding in Christ, Part 3




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Russia bans 'child-free propaganda' in bid to boost birth rate

Russia's lower house of parliament voted unanimously on Tuesday to ban what authorities cast as pernicious propaganda for a child-free way of life, hoping to boost a faltering birth rate. - REUTERS




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2940-PRC: Hubei Huangshi Urban Pollution Control and Environmental Management Project[LR-C01-1 Ci lake dredging part 1 Bid No.: 0703-1520CIC1J602]




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Loan No. 42486-IND: Madhya Pradesh Urban Services Improvement Program [MPUSIP 6D REBIDDING]




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L3211-PRC: JILIN URBAN DEVELOPMENT PROJECT[NCB Bid No.: 0722-162FE672FZO; EBC6]




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Biden to Sign Bill That Helps Veterans Exposed to Toxic Burn Pits

Title: Biden to Sign Bill That Helps Veterans Exposed to Toxic Burn Pits
Category: Health News
Created: 8/10/2022 12:00:00 AM
Last Editorial Review: 8/11/2022 12:00:00 AM




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Scientists Shock Spuds in Bid to Boost Antioxidants

Title: Scientists Shock Spuds in Bid to Boost Antioxidants
Category: Health News
Created: 8/23/2010 2:10:00 PM
Last Editorial Review: 8/24/2010 12:00:00 AM




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First Lady Jill Biden Leaves Isolation After Testing Negative for COVID Twice

Title: First Lady Jill Biden Leaves Isolation After Testing Negative for COVID Twice
Category: Health News
Created: 8/22/2022 12:00:00 AM
Last Editorial Review: 8/22/2022 12:00:00 AM




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First Lady Jill Biden Tests Positive for COVID Again

Title: First Lady Jill Biden Tests Positive for COVID Again
Category: Health News
Created: 8/24/2022 12:00:00 AM
Last Editorial Review: 8/25/2022 12:00:00 AM




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Degradation of Obidoxime Chloride Solution for Injection upon Long-Term Storage under Field Conditions of Mediterranean Climate vs the Controlled Environment

Obidoxime chloride is an antidote for nerve gas intoxication. As an emergency medicine, it is being stored by the Israel Defense Forces (IDF) scattered throughout Israel in depots without a controlled environment (field conditions), thus being exposed to high and fluctuating temperatures. These conditions do not meet the manufacturer’s requirements. In addition, due to possible supply shortages, the utilization of expired batches was suggested. The current work investigated these matters. Long-term (15 years) storage under different conditions was initiated. Chemical stability and toxicity in rats were assessed. No difference was found between field conditions vs the controlled environment. The obidoxime assay remained >95% for 5 years and >90% for 7 years. The pH remained above the lower specification limit for 7–8 years. The major degradation product, 4-pyridinealdoxime, surpassed the allowed limit at 5 years. The content of total unknown impurities reached its maximum allowed by the IDF limit at 4–5 years. Threefold higher than clinically utilized doses of valid-to-date Toxogonin batches administered to rats did not cause any abnormality. However, expired batches produced significant toxic effects. Although no difference was found between storage of obidoxime ampoules when adhering to manufacturer’s recommendations vs field conditions, accumulation of degradants over the limit allowed by the IDF at 4–5 years of storage and the toxicity of the expired batches observed in rats led the IDF to a decision to shorten the shelf-life of this product from 5 to 4 years when stored in an uncontrolled environment of the Mediterranean climate.




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KLS-13019, a Novel Structural Analogue of Cannabidiol and GPR55 Receptor Antagonist, Prevents and Reverses Chemotherapy-Induced Peripheral Neuropathy in Rats [Special Section: Cannabinoid Signaling in Human Health and Disease]

Neuropathic pain is a form of chronic pain that develops because of damage to the nervous system. Treatment of neuropathic pain is often incompletely effective, and most available therapeutics have only moderate efficacy and present side effects that limit their use. Opioids are commonly prescribed for the management of neuropathic pain despite equivocal results in clinical studies and significant abuse potential. Thus, neuropathic pain represents an area of critical unmet medical need, and novel classes of therapeutics with improved efficacy and safety profiles are urgently needed. The cannabidiol structural analog and novel antagonist of GPR55, KLS-13019, was screened in rat models of neuropathic pain. Tactile sensitivity associated with chemotherapy exposure was induced in rats with once-daily 1-mg/kg paclitaxel injections for 4 days or 5 mg/kg oxaliplatin every third day for 1 week. Rats were then administered KLS-13019 or comparator drugs on day 7 in an acute dosing paradigm or days 7–10 in a chronic dosing paradigm, and mechanical or cold allodynia was assessed. Allodynia was reversed in a dose-dependent manner in the rats treated with KLS-13019, with the highest dose reverting the response to prepaclitaxel injection baseline levels with both intraperitoneal and oral administration after acute dosing. In the chronic dosing paradigm, four consecutive doses of KLS-13019 completely reversed allodynia for the duration of the phenotype in control animals. Additionally, coadministration of KLS-13019 with paclitaxel prevented the allodynic phenotype from developing. Together, these data suggest that KLS-13019 represents a potential new drug for the treatment of neuropathic pain.

SIGNIFICANCE STATEMENT

Chemotherapy-induced peripheral neuropathy (CIPN) is a common, debilitating side effect of cancer treatment with no known cure. The GPR55 antagonist KLS-13019 represents a novel class of drug for this condition that is a potent, durable inhibitor of allodynia associated with CIPN in rats in both prevention and reversal-dosing paradigms. This novel therapeutic approach addresses a critical area of unmet medical need.




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SNP MSP welcomes contest with Flynn as she declares bid to restand for seat

"I look forward to any contest, where of course it will be for branch members to select those they wish to represent them in Holyrood in the 2026 Scottish Parliament elections.”