Constipated scorpions, nature and nurture and why we try to cool fevers.

The China file is back on the desk of Canada's foreign affairs minister, Francois-Philippe Champagne. Not that it ever wandered very far.

A well-crafted collection of songs that proves two heads can be better than one.

Marek Janowski guest conducts Mendelssohn, Bruch and Wagner.

Her husband is believed to be a suspect.

Mount Saint Agnes Academy [MSA] honored its 2024 graduates, with one-third receiving scholarships and most continuing their studies overseas. A spokesperson said, “MSA is celebrating the achievements of its 2024 graduating class, one-third of whom earned scholarships to attend tertiary institutions. “Of the 26 graduates, 18 will continue their education overseas. Fifteen will attend university […]

[Written by Anya Thompson] At Cedarbridge Academy, some students shine not just in academics but also in practical, hands-on fields. Terry Charlemagne, a dedicated student with a passion for mechanics, is one of them. From turbocharged car projects to mastering vehicle operation, Terry has cultivated a distinctive skill set that distinguishes him from his peers. […]

Kreml dokáže využít opravdu jakýkoli možný způsob, který může oslabit Evropu zevnitř. Každý problém, s nímž se Evropa zrovna potýká, vnímá Moskva jako svoji potenciální příležitost. A jelikož Rusko dobře ví, že k hlavním výzvám Evropy patří ilegální migrace, snaží se ještě přisypávat sůl do krvácející rány a problém ještě více prohloubit.

Abstract: The Lorentz force law is fundamental for electromagnetism. However, it is known long ago that the Lorentz forces between two current elements do not respect the Newton’s third law. This seemingly harmless flaw had never been corrected. In physical sciences a discrepancy often hides in it new understanding or unexpected breakthrough. For solving this...

Abstract: The walls of Tokamaks are heavily eroded by plasma which suggests that a mysterious force pushes the plasma to the wall. We have theoretically discovered this force and named it extra-force. This force appears only on single charges but not on current carrying wire, which is why the Lorentz force law does not contain...

Gnocchi (potato dumplings) served in an Italian style tomato sauce with sausage topped with a lasagna style cheese mixture! Lasagna is one of my all time favourite meals and this is a quick and easy gnocchi version that’s just packed with flavour! The original dish is made with layers of noodles, meat and tomato sauce...

Read On →

The post Quick and Easy Gnocchi Lasagna appeared first on Closet Cooking.

Experts suggest that the number of people with ADHD is actually going to remain steady.

Oliver Bearman replaces Kevin Magnussen for the entire Sao Paulo Grand Prix weekend after the Dane had to pull out through illness.

President Trump on Friday shared a pre-recorded video message on Twitter saying he is “doing very well” and thanked Americans for their overwhelming support following his early morning announcement of his COVID-19 diagnosis. pic.twitter.com/B4H105KVSs — Donald J. Trump (@realDonaldTrump) October 2, 2020 “I want to thank everybody for the tremendous support,” Trump said in the […]

The post Trump Tweets First Video Remarks Since Revealing COVID-19 Diagnosis appeared first on Hispolitica.

World leaders and officials sent their best wishes to President Trump and First Lady Melania Trump on Friday for a swift recovery after he announced early Friday morning that the First couple tested positive for COVID-19. Israeli Prime Minister Benjamin Netanyahu tweeted that he and his wife Sara, along with “millions of Israelis” are wishing […]

The post World Leaders React To Trump’s COVID-19 Diagnosis appeared first on Hispolitica.

President Trump tweeted a second video update from Walter Reed Medical Center on Sunday, stating his personal positive diagnosis have been a “very interesting journey,” and that he learned a lot about COVID-19. pic.twitter.com/0Bm9W2u1x7 — Donald J. Trump (@realDonaldTrump) October 4, 2020 “So it’s been a very interesting journey. I learned a lot about COVID. […]

The post Trump In Second Video Update Says He ‘Learned A Lot’ About Covid Since Being Diagnosed appeared first on Hispolitica.

N. Leigh Anderson
Nov 1, 2002; 1:845-867
Reviews/Perspectives

Visual Abstract

Weixian Deng
Dec 22, 2020; 0:RA120.002411v1-mcp.RA120.002411
Research

Deep proteome coverage in bottom-up proteomics requires peptide-level fractionation to simplify the complex peptide mixture before analysis by tandem mass spectrometry. By decreasing the number of co-eluting precursor peptide ions, fractionation effectively reduces the complexity of the sample leading to higher sample coverage and reduced bias towards high abundance precursors that are preferentially identified in data-dependent acquisition strategies. To achieve this goal, we report a bead-based off-line peptide fractionation method termed CIF or Carboxylate modified magnetic bead-based isopropanol gradient peptide fractionation. CIF is an extension of the SP3 (single-pot solid-phase-enhanced sample preparation) strategy and provides an effective but complementary approach to other commonly used fractionation methods including strong cation exchange (SCX) and reversed phase (RP)-based chromatography. We demonstrate that CIF is an effective offline separation strategy capable of increasing the depth of peptide analyte coverage both when used alone or as a second dimension of peptide fractionation in conjunction with high pH RP. These features make it ideally suited for a wide range of proteomic applications including the affinity purification of low abundance bait proteins.

Diagnosing social behavioural dynamics of corruption Other resource dora.popova 8 December 2021

This interactive toolkit identifies the types of social expectations which sustain selected corrupt practices and provides behaviourally-informed recommendations for changing them.

When tackling a problem as complex as corruption, it is important to understand why and how people behave in different situations where corruption occurs. In contexts where it is easier to engage in corruption than avoid it, identifying the social expectations and informal rules which sustain corrupt practices can advance corruption prevention and deepen collective action.  

Behavioural approaches to corruption offer a better understanding of diverse social settings, group dynamics, power distribution, social motivations, and expectations that contribute to a more tolerant environment for certain forms of the phenomenon. They are also highly complementary to traditional corruption measures, which tend to focus on the enforcement of legal sanctions and deterrents. Behavioural approaches, especially those inspired by social norms theory, highlight complex social characteristics and informal rules of specific corrupt practices, and effectively support implementation of more dynamic context-specific anti-corruption interventions.

Since 2016, the Chatham House Africa programme’s Social Norms and Accountable Governance (SNAG) project has adopted a behavioural approach based on social norms methodology to investigate the social beliefs which motivate different forms of corruption. Drawing on the project’s extensive evidence-gathering and analysis, this toolkit offers users navigable behavioural mapping of contextual factors, beliefs, and expectations surrounding common corrupt practices. 

It aims to support anti-corruption actors in diagnosing informal rules and social expectations which sustain corruption in some societies. It also proposes behavioural-informed guidance for developing or adapting anti-corruption interventions and activities, so they account for informal rules of behaviour such as social norms. 
 
The toolkit supports users to:

• Identify whether and how widespread corrupt practices are motivated by social beliefs and expectations.

• Understand how society influences the types of corrupt activity individuals engage in, or avoid, and the factors informing these choices

• Integrate empirical evidence and behavioural insights into anti-corruption strategies from diagnostics to design, and eventual implementation and evaluation

The toolkit presents evidence from SNAG’s research into three key corrupt practices – bribery, embezzlement, and electoral fraud. Each was examined in the context of typical situations in which they occur, such as law enforcement, healthcare, the power sector, voting, and education while critical factors such as religion, gender, and ethnicity were considered. 

The toolkit presents an overview of specific contexts and behavioural features of the practices and provides behavioural-informed recommendations. It also contains pop-up features with definitions and explanations of key concepts. The toolkit is designed to be expandable, allowing further content and behavioural dynamics to be added.   

To date, the imaging and diagnosis of hepatocellular carcinoma (HCC) rely on CT/MRI, which have well-known limitations. Glypican-3 (GPC3) is a cell surface receptor highly expressed by HCC but not by normal or cirrhotic liver tissue. Here we report initial clinical results of GPC3-targeted PET imaging with [⁶⁸Ga]Ga-DOTA-RYZ-GPC3 (RAYZ-8009), a peptide-based GPC3 ligand in patients with known or suspected HCC. Methods: [⁶⁸Ga]Ga-RAYZ-8009 was obtained after labeling the peptide precursor with ⁶⁸Ga from a ⁶⁸Ge/⁶⁸Ga generator and heating at 90°C for 10 min followed by sterile filtration. After administration of [⁶⁸Ga]Ga-RAYZ-8009, a dynamic or static PET/CT scan was acquired between 45 min and 4 h after administration. Radiotracer uptake was measured by SUVs for the following tissues: suspected or actual HCC or hepatoblastoma lesions, non–tumor-bearing liver, renal cortex, blood pool in the left ventricle, and gastric fundus. Additionally, tumor–to–healthy-liver ratios (TLRs) were calculated. Results: Twenty-four patients (5 patients in the dynamic protocol; 19 patients in the static protocol) were scanned. No adverse events occurred. Two patients had no lesion detected and did not have HCC during follow-up. In total, 50 lesions were detected and analyzed. The mean SUV_max of these lesions was 19.6 (range, 2.7–95.3), and the mean SUV_mean was 10.1 (range, 1.0–49.2) at approximately 60 min after administration. Uptake in non–tumor-bearing liver and blood pool rapidly decreased over time and became negligible 45 min after administration (mean SUV_mean, <1.6), with a continuous decline to 4 h after administration (mean SUV_mean, 1.0). The opposite was observed for HCC lesions, for which SUVs and TLRs continuously increased for up to 4 h after administration. In individual lesion analysis, TLR was the highest between 60 and 120 min after administration. Uptake in the gastric fundus gradually increased for up to 45 min (to an SUV_max of 31.3) and decreased gradually afterward. Conclusion: [⁶⁸Ga]Ga-RAYZ-8009 is safe and allows for high-contrast imaging of GPC3-positive HCC, with rapid clearance from most normal organs. Thereby, [⁶⁸Ga]Ga-RAYZ-8009 is promising for HCC diagnosis and staging. Further research is warranted.

This study evaluates the diagnostic utility of PET/MRI for primary, locoregional, and nodal head and neck squamous cell carcinoma (HNSCC) through systematic review and metaanalysis. Methods: A systematic search was conducted using PubMed and Scopus to identify studies on the diagnostic accuracy of PET/MRI for HNSCC. The search included specific terms and excluded nonhybrid PET/MRI studies, and those with a sample size of fewer than 10 patients were excluded. Results: In total, 15 studies encompassing 638 patients were found addressing the diagnostic test accuracy for PET/MRI within the chosen subject domain. Squamous cell carcinoma of the nasopharynx was the most observed HNSCC subtype (n = 198). The metaanalysis included 12 studies, with pooled sensitivity and specificity values of 93% and 95% per patient for primary disease evaluation, 93% and 96% for locoregional evaluation, and 89% and 98% per lesion for nodal disease detection, respectively. An examination of a subset of studies comparing PET/MRI against PET/CT or MRI alone for evaluating nodal and locoregional HNSCC found that PET/MRI may offer slightly higher accuracy than other modalities. However, this difference was not statistically significant. Conclusion: PET/MRI has excellent potential for identifying primary, locoregional, and nodal HNSCC.

Tumor hypoxia, an integral biomarker to guide radiotherapy, can be imaged with ¹⁸F-fluoromisonidazole (¹⁸F-FMISO) hypoxia PET. One major obstacle to its broader application is the lack of standardized interpretation criteria. We sought to develop and validate practical interpretation criteria and a dedicated training protocol for nuclear medicine physicians to interpret ¹⁸F-FMISO hypoxia PET. Methods: We randomly selected 123 patients with human papillomavirus–positive oropharyngeal cancer enrolled in a phase II trial who underwent 123 ¹⁸F-FDG PET/CT and 134 ¹⁸F-FMISO PET/CT scans. Four independent nuclear medicine physicians with no ¹⁸F-FMISO experience read the scans. Interpretation by a fifth nuclear medicine physician with over 2 decades of ¹⁸F-FMISO experience was the reference standard. Performance was evaluated after initial instruction and subsequent dedicated training. Scans were considered positive for hypoxia by visual assessment if ¹⁸F-FMISO uptake was greater than floor-of-mouth uptake. Additionally, SUV_max was determined to evaluate whether quantitative assessment using tumor-to-background ratios could be helpful to define hypoxia positivity. Results: Visual assessment produced a mean sensitivity and specificity of 77.3% and 80.9%, with fair interreader agreement ( = 0.34), after initial instruction. After dedicated training, mean sensitivity and specificity improved to 97.6% and 86.9%, with almost perfect agreement ( = 0.86). Quantitative assessment with an estimated best SUV_max ratio threshold of more than 1.2 to define hypoxia positivity produced a mean sensitivity and specificity of 56.8% and 95.9%, respectively, with substantial interreader agreement ( = 0.66), after initial instruction. After dedicated training, mean sensitivity improved to 89.6% whereas mean specificity remained high at 95.3%, with near-perfect interreader agreement ( = 0.86). Conclusion: Nuclear medicine physicians without ¹⁸F-FMISO hypoxia PET reading experience demonstrate much improved interreader agreement with dedicated training using specific interpretation criteria.

What can be achieved using applications such as AI/ML, Deep Learning, and Big Data Analytics has been revolutionized by Magnum IO GPUDirect Storage’s capabilities. Agencies have invested in these solutions […]

The post Accelerating GPU Based Applications with NVIDIA Validated Magnum IO GPUDirect Storage and Pavilion appeared first on HPCwire.

Two additional cases of a new strain of mpox have been detected in Britain, national health officials said Monday, less than a week after the first case was announced to the public.

From guest blogger Kimberly Shannon Rhode Island Education Commissioner Deborah Gist has been diagnosed with a brain tumor and will undergo surgery in September, according to the Associated Press. She is expected to have a full recovery, but will be working a limited schedule until her operation. Af

To soar over Stratford-upon-Avon in Warwickshire is to be transported back in time to the age of William Shakespeare, a man born in humble circumstances who would go on to become the most celebrated writer of all time.

Home to the worlds largest shell collection, the Smithsonian catalogues and studies shells both large and small, spiky and smooth (Brendan McCabe).

Experts added a carbon fiber pole to help anchor the "Apollo Belvedere," which had developed cracks along the legs and knees. Now, the looming Roman sculpture is finally back on display

Medical industry manufacturer reducing R&D costs, time to market, and scrap by up to 50 percent

Penn State’s Center for Socially Responsible Artificial Intelligence (CSRAI) will host “Diagnose-a-thon,” a competition that aims to uncover the power and potential dangers of using generative AI for medical inquiries. The virtual event will take place Nov. 11-17 with top prizes of $1,000.  

A new analysis of Voyager 2’s flyby of Uranus in 1986 reveals a unique magnetic anomaly caused by a rare solar wind event. Scientists from NASA's Jet Propulsion Laboratory and Caltech found that the solar wind’s impact on Uranus’s magnetosphere was a unique occurrence, influencing measurements of the planet’s magnetic field. The study also suggests that the planet’s outer moons lie within its magnetosphere, potentially aiding future probes in identifying subsurface oceans on these moons.

1. Magnus Carlsen interview: I probably will have the most fun playing Gukesh  Hindustan Times
2. "It's Chaotic": Chess World No. 1 Magnus Carlsen Reveals Why He Does Not Play In India  NDTV Sports
3. Tata Steel Chess set for a Carlsen-Pragg opening  Hindustan Times
4. Magnus Carlsen returns to Kolkata after almost five years at Tata Steel India Rapid and Blitz 2024  ChessBase India
5. King Carlsen hails growth of Indian chess, praises Praggnanandhaa's fighting spirit  Telegraph India

I have a small board that is not readable even though the document is 11' x 17'. Is there a way I could expand/magnify the board along with the components on them to make them legible? 
I have created a new film and is displaying the bottom and top side of the board but the board is too small and the components are not legible. Perhaps there is a way to upscale it or expand it?
Please note I have other stuff in the document that I am not showing , notes and other things, and I am trying to make just the boards look bigger in some way.
I do have a PDF image of the same file where the board appears to be MUCH bigger and is fully legible and I am trying to match that.

Thank you all.

Havana — A 6.8 magnitude earthquake shook eastern Cuba on Sunday, after weeks of hurricanes and blackouts that have left many on the island reeling.  The epicenter of the quake was located approximately 40 km south of Bartolomé Masó, Cuba, according to a report by the United States Geological Survey.  The rumbling was felt across the eastern stretch of Cuba, including in bigger cities like Santiago de Cuba. There were no immediate reports of damage or injuries.  Residents in Santiago, Cuba's second largest city, were left shaken on Sunday. Yolanda Tabío, 76, said people in the city flocked to the streets and were still nervously sitting in their doorways. She said she felt at least two aftershocks following the quake, but that among friends and family she hadn't heard of any damages.  "You had to see how everything was moving, the walls, everything," she told The Associated Press.  The earthquake comes during another tough stretch for Cuba.  On Wednesday, Category 3 Hurricane Rafael ripped through western Cuba, with strong winds knocking out power island-wide, destroying hundreds of homes and forcing evacuations of hundreds of thousands of people. Days after, much of the island was still struggling without power.  Weeks before in October, the island was also hit by a one-two punch. First, it was hit by island-wide blackouts stretching on for days, a product of the island's energy crisis. Shortly after, it was slapped by a powerful hurricane that struck the eastern part of the island and killed at least six people.  The blackouts and wider discontent among many struggling to get by has stoked small protests across the island. 

More than a decade’s worth of stagnant health packages lead to the build-up of PhilHealth’s idle funds, according to the government corporation’s chief. 

Franz Wagner pumped in 32 points on Tuesday as the Orlando Magic cruised past the visiting Charlotte Hornets, 114-89, in NBA Cup action. Moritz Wagner scored 18 points off the bench and Jalen Suggs tallied all 17 of his points in the first half for Orlando, which has its first three-game winning streak of the season. Franz Wagner made 14 of 25 shots from the field as the Magic shot 46.2 percent overall. He also led Orlando with eight rebounds and five assists. READ: NBA Cup set to begin with eight group-play games LaMelo Ball’s 35 points and Grant Williams’ […]...

Keep on reading: NBA Cup: Franz Wagner scoring surge as Magic rout Hornets

It’s no coincidence that extreme heat is engulfing huge swaths of Asia, Europe and North America all at the same time.

Tremors were felt in various cities of Khyber Pakhtunkhwa as well as Islamabad on Wednesday after a quake jolted Afghanistan’s Badakhshan region.

According to the United States Geological Survey (USGS), the earthquake had a magnitude of 5.1, while the Pakistan Meteorological Department (PMD) reported it as having a 5.3 magnitude.

The USGS said the quake’s centre was located 37 kilometres west-southwest of Afghanistan’s Ishkashim town and had a 220.7km depth.

The earthquake struck at 10:13am (Pakistan time), both the USGS and PMD confirmed.

No casualties have been reported so far.

DawnNewsTV reported that the tremors were felt in Peshawar and its adjoining areas, as well as Islamabad.

Speaking to DawnNewsTV, two correspondents based in the cities said the quake caused people to evacuate buildings.

More to follow

This study outlines actions Cambodia can take to diversify its economy and shows how cutting business costs, tackling human capital deficits, and reducing vulnerability to external shocks can help drive sustainable, inclusive growth.

Eurasian reed warblers don’t just get a sense of direction from Earth’s magnetic field – they can also calculate their coordinates on a mental map

Cases of prostate cancer are surging alarmingly around the world. Thankfully, we are developing more accurate tests that can catch the condition early

We can’t stir ordinary solids, but one research team now claims to have stirred an extraordinary quantum “supersolid”, generating tiny vortices

Researchers have used quantum light to create a magnetic field with a strength that is measured in imaginary numbers