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Undiagnosed NIDDM: Clinical and Public Health Issues

Maureen I Harris
Apr 1, 1993; 16:642-652
Kelly West Lecture 1992




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Consensus Development Conference on the Diagnosis of Coronary Heart Disease in People With Diabetes: 10-11 February 1998, Miami, Florida

American Diabetes Association
Sep 1, 1998; 21:1551-1559
Consensus Development Conference Report




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Memo: Prior COVID-19 diagnosis 'permanently disqualifying' for U.S. military service

Military Entrance Processing Stations won't process individuals who have had COVID-19 for military service, even if they've fully recovered from the virus, the Pentagon confirmed this week.




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The Pros and Cons of Diagnosing Diabetes With A1C

Enzo Bonora
May 1, 2011; 34:S184-S190
Diabetes




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Guideline Approach to Therapy in Patients With Newly Diagnosed Type 2 Diabetes

Itamar Raz
Aug 1, 2013; 36:S139-S144
Diabetes Pathophysiology




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ADA free webinar exploring radiographs, diagnostic imaging

In a time when teledentistry is gaining more attention during the COVID-19 pandemic, the ADA will stream a free webinar in May that takes a close look at the different types of images needed for diagnosis, treatment planning and operative procedures.




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Suicide risk high in first year after brain cancer diagnosis

People with brain cancer are at increased risk for suicide compared to the general population, particularly within the first year following diagnosis, a new analysis has found.




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CDC: Nearly 5,000 workers at meat processing plants diagnosed with COVID-19

Nearly 5,000 workers in 115 meat processing workers across 19 states have been diagnosed with COVID-19, according to figures released Friday by the U.S. Centers for Disease Control and Prevention.




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Clinical and Public Health Implications of 2019 Endocrine Society Guidelines for Diagnosis of Diabetes in Older Adults

OBJECTIVE

Screening for diabetes is typically done using hemoglobin A1c (HbA1c) or fasting plasma glucose (FPG). The 2019 Endocrine Society guidelines recommend further testing using an oral glucose tolerance test (OGTT) in older adults with prediabetic HbA1c or FPG. We evaluated the impact of this recommendation on diabetes prevalence, eligibility for glucose-lowering treatment, and estimated cost of implementation in a nationally representative sample.

RESEARCH DESIGN AND METHODS

We included 2,236 adults aged ≥65 years without known diabetes from the 2005–2016 National Health and Nutrition Examination Survey. Diabetes was defined using: 1) the Endocrine Society approach (HbA1c ≥6.5%, FPG ≥126 mg/dL, or 2-h plasma glucose ≥200 mg/dL among those with HbA1c 5.7–6.4% or FPG 100–125 mg/dL); and 2) a standard approach (HbA1c ≥6.5% or FPG ≥126 mg/dL). Treatment eligibility was defined using HbA1c cut points (≥7 to ≥9%). OGTT screening costs were estimated using Medicare fee schedules.

RESULTS

Diabetes prevalence was 15.7% (~5.0 million) using the Endocrine Society’s approach and 7.3% (~2.3 million) using the standard approach. Treatment eligibility ranged from 5.4 to 0.06% and 11.8–1.3% for diabetes cases identified through the Endocrine Society or standard approach, respectively. By definition, diabetes identified exclusively through the Endocrine Society approach had HbA11c <6.5% and would not be recommended for glucose-lowering treatment. Screening all older adults with prediabetic HbA1c/FPG (~18.3 million) with OGTT could cost between $737 million and $1.7 billion.

CONCLUSIONS

Adopting the 2019 Endocrine Society guidelines would substantially increase the number of older adults classified as having diabetes, require significant financial resources, but likely offer limited benefits.




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Strict Preanalytical Oral Glucose Tolerance Test Blood Sample Handling Is Essential for Diagnosing Gestational Diabetes Mellitus

OBJECTIVE

Preanalytical processing of blood samples can affect plasma glucose measurement because on-going glycolysis by cells prior to centrifugation can lower its concentration. In June 2017, ACT Pathology changed the processing of oral glucose tolerance test (OGTT) blood samples for pregnant women from a delayed to an early centrifugation protocol. The effect of this change on the rate of gestational diabetes mellitus (GDM) diagnosis was determined.

RESEARCH DESIGN AND METHODS

All pregnant women in the Australian Capital Territory (ACT) are recommended for GDM testing with a 75-g OGTT using the World Health Organization diagnostic criteria. From January 2015 to May 2017, OGTT samples were collected into sodium fluoride (NaF) tubes and kept at room temperature until completion of the test (delayed centrifugation). From June 2017 to October 2018, OGTT samples in NaF tubes were centrifuged within 10 min (early centrifugation).

RESULTS

A total of 7,509 women were tested with the delayed centrifugation protocol and 4,808 with the early centrifugation protocol. The mean glucose concentrations for the fasting, 1-h and 2-h OGTT samples were, respectively, 0.24 mmol/L (5.4%), 0.34 mmol/L (4.9%), and 0.16 mmol/L (2.3%) higher using the early centrifugation protocol (P < 0.0001 for all), increasing the GDM diagnosis rate from 11.6% (n = 869/7,509) to 20.6% (n = 1,007/4,887).

CONCLUSIONS

The findings of this study highlight the critical importance of the preanalytical processing protocol of OGTT blood samples used for diagnosing GDM. Delay in centrifuging of blood collected into NaF tubes will result in substantially lower rates of diagnosis than if blood is centrifuged early.




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Mars' magnetic field emerged earlier and lasted longer than previously thought

Mars' ancient magnetic field emerged earlier and persisted for longer than scientists previously thought, according to a new study.




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The Color of Health Care: Diagnosing Bias in Doctors

Long before word recently broke that white referees in the National Basketball Association were calling fouls at a higher rate on black athletes than on white athletes, and long before studies found racial disparities in how black and white applicants get called for job interviews, researchers no...




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Rich pork and eggplant lasagne

This recipe features on Foodie Tuesday, a weekly segment on 774 Drive with Raf Epstein, 3.30PM, courtesy of Justine Schofield. Justine's latest book is "Dinner With Justine".




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Pumpkin lasagne

1.2kg butternut pumpkin, peeled, cut into 2cm pieces 2 tablespoons olive oil 1 tablespoon chopped fresh sage, plus 12 whole leaves to serve 1/4 teaspoon freshly grated nutmeg 350g ricotta 1 egg 1 cup grated parmesan, plus extra to serve 8 fresh lasagne sheets 100g unsalted butter 2 tablespoons chopped walnuts




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Visit-to-Visit HbA1c Variability Is Associated With Cardiovascular Disease and Microvascular Complications in Patients With Newly Diagnosed Type 2 Diabetes

OBJECTIVE

To investigate the association between visit-to-visit HbA1c variability and cardiovascular events and microvascular complications in patients with newly diagnosed type 2 diabetes.

RESEARCH DESIGN AND METHODS

This retrospective cohort study analyzed patients from Tayside and Fife in the Scottish Care Information–Diabetes Collaboration (SCI-DC) who were observable from the diagnosis of diabetes and had at least five HbA1c measurements before the outcomes were evaluated. We used the previously reported HbA1c variability score (HVS), calculated as the percentage of the number of changes in HbA1c >0.5% (5.5 mmol/mol) among all HbA1c measurements within an individual. The association between HVS and 10 outcomes was assessed using Cox proportional hazards models.

RESULTS

We included 13,111–19,883 patients in the analyses of each outcome. The patients with HVS >60% were associated with elevated risks of all outcomes compared with the lowest quintile (for example, HVS >80 to ≤100 vs. HVS ≥0 to ≤20, hazard ratio 2.38 [95% CI 1.61–3.53] for major adverse cardiovascular events, 2.4 [1.72–3.33] for all-cause mortality, 2.4 [1.13–5.11] for atherosclerotic cardiovascular death, 2.63 [1.81–3.84] for coronary artery disease, 2.04 [1.12–3.73] for ischemic stroke, 3.23 [1.76–5.93] for heart failure, 7.4 [3.84–14.27] for diabetic retinopathy, 3.07 [2.23–4.22] for diabetic peripheral neuropathy, 5.24 [2.61–10.49] for diabetic foot ulcer, and 3.49 [2.47–4.95] for new-onset chronic kidney disease). Four sensitivity analyses, including adjustment for time-weighted average HbA1c, confirmed the robustness of the results.

CONCLUSIONS

Our study shows that higher HbA1c variability is associated with increased risks of all-cause mortality, cardiovascular events, and microvascular complications of diabetes independently of high HbA1c.




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Perspectives in Gestational Diabetes Mellitus: A Review of Screening, Diagnosis, and Treatment

Jennifer M. Perkins
Apr 1, 2007; 25:57-62
Feature Articles




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How women are revolutionizing Rwanda | Agnes Binagwaho

In 1996, Agnes Binagwaho returned home to Rwanda in the aftermath of its genocide. She considered leaving amid the overwhelming devastation, but women in her community motivated her to stay and help rebuild -- and she's glad she did. In an inspiring talk, Binagwaho reflects on her work as Rwanda's former Minister of Health and discusses her new women's education initiative for the country, which strives to create one of the greatest levels of gender equality worldwide.




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R.I. Education Commissioner Diagnosed with Brain Tumor

From guest blogger Kimberly Shannon Rhode Island Education Commissioner Deborah Gist has been diagnosed with a brain tumor and will undergo surgery in September, according to the Associated Press. She is expected to have a full recovery, but will be working a limited schedule until her operation. Af




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Des variétés cliniques de la folie en France et en Allemagne / par J. Roubinovitch.

Paris : Doin, 1896.




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Diagnose und Therapie der Krankheiten des Menschen : mit Zugrundelegung der Lehren und Recepturen der ersten medicinisch-chirurgischen Autoritäten, und Anführung von 1500 Receptformeln im metrischen Gewichte, nebst einem Anhange über Balneo

Wien : M. Perles, 1878.




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The diagnosis and treatment of diseases of the kidney, amenable to direct surgical interference / by W. Bruce Clarke.

London : H.K. Lewis, 1886.




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The diagnosis, prevention, & treatment of diseases of the heart, and of aneurism : with observations on rheumatism / by J.J. Furnivall.

London : J. Churchill, 1845.




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Diagnostic et traitement de la pelade et des teignes de l'enfant / par R. Sabouraud.

Paris : Rueff, 1895.




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Diagnostic et traitement des abcès du foie / par Victor Leblond.

Paris : J.-B. Baillière, 1893.




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Diagnostic et traitement des maladies du coeur / par Constantin Paul.

Paris : Asselin et Houzeau, 1887.




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Diagnostic et traitement des tumeurs de l'abdomen et du bassin / par J. Pean.

Paris : V. Adrien Delahaye, 1880-1899.




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The diagnostic signs of incompetence of the pulmonary valve / by G. A. Gibson.

Edinburgh : Young J. Pentland, 1894.




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Diagnostica dei batteri delle acque con una guida alle ricerche batteriologiche e microscopiche / del Alessandro Lustig.

Torino : Rosenberg & Sellier, 1890.




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Diagnostik der chirurgischen Krankheiten / von Dr E. Albert.

Wien : Holder, 1896.




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Diagnostik der Harnkrankheiten : zehn Vorlesungen zur Einführung in die Pathologie der Harnwege / von C. Posner.

Berlin : Hirschwald, 1902.




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Diagnostik der inneren Krankheiten auf Grund der heutigen Untersuchungs-methoden : ein Lehrbuch für Äerzte und Studirende / von Oswald Vierordt.

Leipzig : F.C.W. Vogel, 1888.




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Diagnostik der inneren Krankheiten auf Grund der heutigen Untersuchungs-methoden : ein Lehrbuch für Äerzte und Studirende / von Oswald Vierordt.

Leipzig : F.C.W. Vogel, 1894.




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Diagnostik der Krankheiten der Verdauungsorgane / von Hans Leo.

Berlin : A. Hirschwald, 1890.




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Diagnostik der Krankheiten des Nervensystems : eine Anleitung zur Untersuchung Nervenkranker / von A. Goldscheider.

Berlin : Fischer's Medicin. Buchhandlung, H. Kornfeld, 1897.




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Diagnostik der Rückenmarks-Krankheiten / von Dr. Schuster.

Berlin : T.C.F. Enslin, 1882.




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Diagnostik und allgemeine Symptomatologie der Lungenkrankheiten ... / von Albert Fraenkel.

Wien : Urban & Schwarzenberg, 1890.




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Diagnostische und pathogenetische Untersuchungen : in der Klinik des Herrn Geh. Raths Dr. Schönlein auf dessen Veranlassung angestellt und mit Benutzung anderweitiger Beobachtungen veröffentlicht / von R. Remak.

Berlin : A. Hirschwald, 1845.




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Diagnostisches Lexikon fur praktische Arzte / unter Mitwirkung der Herren A. Adamkiewicz [and others] ; herausgegeben von Anton Bum und M.T. Schnirer.

Wien : Urban & Schwarzenberg, 1893-1895.




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Die Anatomie des Auges bei den Griechen und Römern / von Hugo Magnus.

Leipzig : Veit, 1878.




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Die Blindheit, ihre Entstehung und ihre Verhütung / von Hugo Magnus.

Breslau : J.U. Kern, 1883.




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Die Diagnose der Blasen-und Nierenkrankheiten mittelst der Harnleiterpincette / von M. Tuchmann.

Berlin : Hirschwald, 1887.




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Die Diagnostik des Pulses in Bezug auf die localen Veränderungen desselben / von A. Mosso.

Leipzig : Veit, 1879.




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Die Diagnostik verdachtiger Flecke in Criminalfallen : ein physiologisch-chemischer Beitrag zur gerichtlichen Medicin / von Carl Schmidt.

Mitau : G.A. Reyher, 1848.




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Die diagnostische Bedeutung der einzelnen Symptome der hitzigen Hirnhöhlenwassersucht der Kinder / von Heinrich Wolff.

Bonn : A. Marcus, 1839.




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Die diagnostische Bedeutung des Katheterismus der Ureteren / von Leopold Casper.

Berlin : Coblentz, 1896.




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Die Entstehung der Gefahr im Krankheitsverlaufe : mit besonderer Berücksichtigung der Diagnose der Gefahr, ihrer Prophylaxe und Therapie / von L.M. Politzer.

Wien : W. Braumuller, 1878.




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Die Entwickelung des Farbensinnes / von Hugo Magnus.

Jena : H. Dufft, 1877.




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Die Frühdiagnose des Abdominaltyphus : eine klinische und literarische Studie / von A. Kuhn.

Jena : Fischer, 1904.




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Die Harncylinder : mit besonderer Berucksichtigung ihrer diagnostischen Bedeutung : gekronte Preisschrift / von A. Burkart.

Berlin : A. Hirschwald, 1874.




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Die Magensonde : die Geschichte ihrer Entwicklung und ihre Bedeutung in diagnostisch-therapeutischer Hinsicht / von W.O. Leube.

Erlangen : E. Besold, 1879.