The National Academy of Engineering has elected 83 new members and 16 foreign members, announced NAE President C. D. (Dan) Mote, Jr., today.

Source: Streetwise Reports   04/24/2020

Mesoblast Ltd. (MESO:NASDAQ; MSB:ASX) today announced that it had achieved an "83% survival in ventilator-dependent COVID-19 patients (10/12) with moderate/severe acute respiratory distress syndrome (ARDS) treated during the period March-April 2020 with two intravenous infusions of Mesoblast's allogeneic mesenchymal stem cell product candidate remestemcel-L within the first five days." The company stated that of the 12 patients treated, 75% (9/12) successfully came off ventilator support after a median timeframe of 10 days. The firm advised that all of the patients were treated under an emergency Investigational New Drug (IDA) application or expanded access protocol at Mt. Sinai hospital in New York City and so far seven of the patients have been discharged from the hospital. The company noted that each of the patients had received a variety of experimental agents prior to being treated with remestemcel-L.

The firm explained that until now only about 9% (38/445) of ventilator-dependent COVID-19 patients at a major referral hospital network in New York City were able to come off ventilator support when treated with existing standard of care treatments during March and April 2020. The company reported that at a second major referral hospital network in New York City over the same period, there was 88% mortality with only 12% survival (38/320) among ventilator-dependent COVID-19 patients.

The company's CEO Dr. Silviu Itescu commented, "The remarkable clinical outcomes in these critically ill patients continue to underscore the potential benefits of remestemcel-L as an anti-inflammatory agent in cytokine release syndromes associated with high mortality, including acute graft versus host disease and COVID-19 ARDS. We intend to rapidly complete the randomized, placebo-controlled Phase 2/3 trial in COVID-19 ARDS patients to rigorously confirm that remestemcel-L improves survival in these critically ill patients."

Dr. Fred Grossman, Mesoblast's Chief Medical Officer, added, "There is a significant need to improve the dismal survival outcomes in COVID-19 patients who progress to ARDS and require ventilators. We have implemented robust statistical analyses in our Phase 2/3 trial as recommended by the US Food and Drug Administration (FDA) in order to maximize our ability to evaluate whether remestemcel-L provides a survival benefit in moderate/severe COVID-19 ARDS."

Mesoblast Ltd. is headquartered in Melbourne, Australia, and is a developer of industrial-scale, cryopreserved, off-the-shelf allogeneic cellular medicines. The company utilizes its proprietary mesenchymal lineage cell therapy technology platform in order to create a wide portfolio of commercial products and late-stage product candidates. The firm indicated that "the Biologics License Application to seek approval of its product candidate RYONCIL™ (remestemcel-L) for steroid-refractory acute graft versus host disease has been accepted for priority review by the U.S. Food and Drug Administration." The company has offices in Australia, the U.S. and Singapore.

Mesoblast began the day with a market capitalization of around $687.9 million with approximately 106.7 million shares outstanding. MESO shares opened nearly 142% higher today at $15.59 (+$9.14, +141.71%) over yesterday's $6.45 closing price and reached a new 52-week high price this morning of $20.57. The stock has traded today between $13.01 and $20.57 per share and is presently trading at $14.76 (+$8.30, +128.76%).

Disclosure:
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( Companies Mentioned: MESO:NASDAQ; MSB:ASX, )

Grey broke a routine, Myke dealt with a huge deadline, and they both watched 7 Days Out: Eleven Madison Park.

Colleges and high schools have gathered in Detroit to show off their super-efficient home-built hot rods. Meanwhile, Shell is building its own fuel miser.

It’s the end of the year and time for our annual mini-stories episodes. Mini-stories are fun, quick hit stories that came up in our research for another episode...or maybe it was some cool thing someone told us about that we found really interesting. They didn’t quite warrant a full episode and two months of hard reporting, but they’re great 99pi stories nonetheless. And my favorite part is we do them as unscripted interviews where I’m in the studio with the people who work on this show, who I like a lot. Sometimes I know a little about what they’re going to talk about, but sometimes I know nothing. It’s very fun. This week we have stories of mistaken identity, unreachable iconic tour destinations, haunted architecture, and of course, raccoons.

Mini-Stories: Volume 7

Make your mark. Go to radiotopia.fm to donate today.

Are you one of those people who have given their camera a name? If the answer is yes, .. this might be one of the most normal things in the world. Today i’d like to explore the emotional relationship between us and our photographic machines. Special guest: Monika Andrae. Photo by William Daigneault Links: Photo … Continue reading "883 The Man Machine Connection"

The post 883 The Man Machine Connection appeared first on PHOTOGRAPHY TIPS FROM THE TOP FLOOR.

The Hanover Street Bridge will be closed this weekend. Part of Greene Street in the downtown area will be closed on Saturday. There are new traffic patterns on I-83 Southbound in Timonium and on I-95 in Bel Air. Mid-day work continues on I-97 in Crownsville and on MD 295 in Westport. The Southbound Harbor Tunnel on I-895 remains closed for long term work.

The Hanover Street Bridge will be closed this weekend. Part of Greene Street in the downtown area will be closed on Saturday. There are new traffic patterns on I-83 Southbound in Timonium and on I-95 in Bel Air. Mid-day work continues on I-97 in Crownsville and on MD 295 in Westport. The Southbound Harbor Tunnel on I-895 remains closed for long term work.

The latest NHS figures show a small increase in recorded deaths

Connections between set theoretic Yang-Baxter and reflection equations and quantum integrable systems are investigated. We show that set theoretic $R$-matrices are expressed as twists of known solutions. We then focus on reflection and twisted algebras and we derive the associated defining algebra relations for $R$-matrices being Baxterized solutions of the $A$-type Hecke algebra ${cal H}_N(q=1)$. We show in the case of the reflection algebra that there exists a "boundary" finite sub-algebra for some special choice of "boundary" elements of the $B$-type Hecke algebra ${cal B}_N(q=1, Q)$. We also show the key proposition that the associated double row transfer matrix is essentially expressed in terms of the elements of the $B$-type Hecke algebra. This is one of the fundamental results of this investigation together with the proof of the duality between the boundary finite subalgebra and the $B$-type Hecke algebra. These are universal statements that largely generalize previous relevant findings, and also allow the investigation of the symmetries of the double row transfer matrix.

Let $hat G$ be the finite simply connected version of an exceptional Chevalley group, and let $V$ be a nontrivial irreducible module, of minimal dimension, for $hat G$ over its field of definition. We explore the overgroup structure of $hat G$ in $mathrm{GL}(V)$, and the submodule structure of the exterior square (and sometimes the third Lie power) of $V$. When $hat G$ is defined over a field of odd prime order $p$, this allows us to construct the smallest (with respect to certain properties) $p$-groups $P$ such that the group induced by $mathrm{Aut}(P)$ on $P/Phi(P)$ is either $hat G$ or its normaliser in $mathrm{GL}(V)$.

In cite{S 2017}, Suh gave a non-existence theorem for Hopf real hypersurfaces in the complex quadric with parallel normal Jacobi operator. Motivated by this result, in this paper, we introduce some generalized conditions named $mathcal C$-parallel or Reeb parallel normal Jacobi operators. By using such weaker parallelisms of normal Jacobi operator, first we can assert a non-existence theorem of Hopf real hypersurfaces with $mathcal C$-parallel normal Jacobi operator in the complex quadric $Q^{m}$, $m geq 3$. Next, we prove that a Hopf real hypersurface has Reeb parallel normal Jacobi operator if and only if it has an $mathfrak A$-isotropic singular normal vector field.

In this paper, we give new constructions of strongly regular Cayley graphs on abelian groups as generalizations of a series of known constructions: the construction of covering extended building sets in finite fields by Xia (1992), the product construction of Menon-Hadamard difference sets by Turyn (1984), and the construction of Paley type partial difference sets by Polhill (2010). Then, we obtain new large families of strongly regular Cayley graphs of Latin square type or negative Latin square type.

We give an efficient algorithm for robustly clustering of a mixture of two arbitrary Gaussians, a central open problem in the theory of computationally efficient robust estimation, assuming only that the the means of the component Gaussians are well-separated or their covariances are well-separated. Our algorithm and analysis extend naturally to robustly clustering mixtures of well-separated strongly logconcave distributions. The mean separation required is close to the smallest possible to guarantee that most of the measure of each component can be separated by some hyperplane (for covariances, it is the same condition in the second degree polynomial kernel). We also show that for Gaussian mixtures, separation in total variation distance suffices to achieve robust clustering. Our main tools are a new identifiability criterion based on isotropic position and the Fisher discriminant, and a corresponding Sum-of-Squares convex programming relaxation, of fixed degree.

The present invention provides an inbred corn line designated HID3483, methods for producing a corn plant by crossing plants of the inbred line HID3483 with plants of another corn plant. The invention further encompasses all parts of inbred corn line HID3483, including culturable cells. Additionally provided herein are methods for introducing transgenes into inbred corn line HID3483, and plants produced according to these methods.

Live from Bed Stuy’s Restoration Plaza, we bring you a very special event with Buddha Monk and Mickey Hess, authors of a new biography of the Wu’s Ol’ Dirty Bastard. Occurring only blocks from Dirty’s childhood home, this conversation features not only the authors, but also special appearances from the Wu member’s family and friends. Buddha Monk was Dirty’s close friend since they were children, and had a front row seat to the artist’s rise and fall. His book, co-written with Rider professor Mickey Hess, is The Dirty Version: On Stage, In the Studio, and In the Streets With Ol’ Dirty Bastard, published by Harper Collins. You can buy it here.

If you like this episode, be sure to check out our recent article on the Wu for Radio.com

See http://theciphershow.com/episode/83/ for full show notes and comments.

Salaam is a producer who is behind some of the most popular hip-hop, r&b, pop, and dancehall songs of the past several decades. His work with icons like Nas, Amy Winehouse, and The Fugees has been on the airwaves and on the charts consistently since the 1990s.

Salaam is the son of a musician, and got his start early, working on songs with the likes of Kurtis Blow as a teenager in the mid-1980s. By the early 90s, he was already producing hip-hop and dancehall. He did some remixes for an under-appreciated rap group called The Fugees whose first album was on the verge of flopping, and that quickly led to him producing the song “Fu-gee-la” on their monster hit follow up album The Score.

But it was in the early 2000s that Salaam really hit his commercial stride, as he began working closely with Nas on, including many others, the iconic single “Made You Look.” And Remi began working closely with a young singer from London named Amy Winehouse on her 2003 debut Frank, and also produced five songs on her smash hit follow up Back to Black. Miraculously, that’s only the beginning of Salaam’s track record as a producer, musician, composer, and executive.

See http://theciphershow.com/episode/183/ for full show notes and comments.

Nick Turturro, from The Longest Yard, Blue Bloods and many more tv shows and movies calls in.

This podcast is brought to you by Onnit.com. Use Promo code CHURCH at checkout for a discount.

This podcast is also brought to you by Hulu Plus. Go to Huluplus.com/joey for an extended free trial.

Streamed live on 05/27/2013

John Moffitt, NFL Offensive Lineman, joins Joey Diaz and Lee Syatt live in studio.

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Theo Von, Comedian who special "No Offense" is available on Netflix, joins Joey Diaz and Lee Syatt live in studio!

This podcast is brought to you by:

Tom Segura, a stand up comedian with multiple specials available on Netflix and a podcast called "Your Mom's House," joins Joey Diaz and Lee Syatt LIVE in studio.

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Steve Avillo, a childhood friend of Joey's, and Joey have a Zoom call to trade childhood stories. Steve gives his point of view of some of Joey's craziest stories and even reminds Joey of some stories that he forgot. 

Joey's going to be doing this type of podcast more often, to introduce you to the people who made Joey who he is today. 

Follow Steve's band, The Past Masters at http://tpmrocks.com/

The deal would value the company at close to Rs 4,300 crore, a premium of about 15% to its previous round of funding which valued the company at over Rs 3,700 crore, according to filings from ministry of corporate affairs sources by TOI.

Dieter Bohn joins the show to talk about the iPad Magic Keyboard, the new iPhone SE, and the state of Android flagship phones.

Coronavirus canceled their mountain climbing trips and adventure runs, so these Seattleites found creative ways to stay fit, stay sane and conquer their lofty goals — all while maintaining social distancing.

Coronavirus canceled their mountain climbing trips and adventure runs, so these Seattleites found creative ways to stay fit, stay sane and conquer their lofty goals — all while maintaining social distancing.

Coronavirus canceled their mountain climbing trips and adventure runs, so these Seattleites found creative ways to stay fit, stay sane and conquer their lofty goals — all while maintaining social distancing.

Doctors are shocked by how quickly this season's flu is striking down the young and healthy. Last year, Amanda Nix was doing Tough Mudder, but a few weeks ago she was struck down with the infection, blacking out in an emergency ward as it took hold.

Responses

Bye, Amazon