BACKGROUND AND PURPOSE:

Hemangioblastoma is a rare vascular tumor that occurs within the central nervous system in children. Differentiating hemangioblastoma from other posterior fossa tumors can be challenging on imaging, and preoperative diagnosis can change the neurosurgical approach. We hypothesize that a "lightbulb sign" on the arterial spin-labeling (ASL) sequence (diffuse homogeneous intense hyperperfusion within the solid component of the tumor) will provide additional imaging finding to differentiate hemangioblastoma from other posterior fossa tumors.

BACKGROUND AND PURPOSE:

Gadolinium-based contrast agents are widely used for meningioma imaging; however, concerns exist regarding their side effects, cost, and environmental impact. At the standard gadolinium dose, most meningiomas show avid contrast enhancement, suggesting that administering a smaller dose may be feasible. The purpose of this study was to evaluate the impact of a lower gadolinium dose on the differentiation between meningiomas and adjacent intracranial tissues.

BACKGROUND AND PURPOSE:

Previous studies have reported metal accumulation and microstructure changes in deep gray nuclei (DGN) in Wilson disease (WD). However, there are limited studies that investigate whether there is metal accumulation and microstructure changes in DGN of patients with WD with normal-appearing routine MRI. This study aimed to evaluate multiparametric changes in DGN of WD and whether the findings correlate with clinical severity in patients with WD.

BACKGROUND AND PURPOSE:

Prediction of aneurysm instability is crucial to guide treatment decisions and to select appropriate patients with unruptured intracranial aneurysms (IAs) for preventive treatment. High-resolution 4D MR flow imaging and 3D quantification of aneurysm morphology could offer insights and new imaging markers for aneurysm instability. In this cross-sectional study, we aim to identify 4D MR flow imaging markers for aneurysm instability by relating hemodynamics in the aneurysm sac to 3D morphologic proxy parameters for aneurysm instability.

BACKGROUND AND PURPOSE:

Intracranial vessel wall imaging is technically challenging to implement, given the simultaneous requirements of high spatial resolution, excellent blood and CSF signal suppression, and clinically acceptable gradient times. Herein, we present our preliminary findings on the evaluation of a deep learning–optimized sequence using T1-weighted imaging.

SUMMARY:

The 2021 World Health Organization Classification of Tumors of the Central Nervous System (CNS5), introduced significant changes, impacting tumors ranging from glial to ependymal neoplasms. Ependymal tumors were previously classified and graded based on histopathology, which had limited clinical and prognostic utility. The updated CNS5 classification now divides ependymomas into 10 subgroups based on anatomic location (supratentorial, posterior fossa, and spinal compartment) and genomic markers. Supratentorial tumors are defined by zinc finger translocation associated (ZFTA) (formerly v-rel avian reticuloendotheliosis viral oncogene [RELA]), or yes-associated protein 1 (YAP1) fusion; posterior fossa tumors are classified into groups A (PFA) and B (PFB), spinal ependymomas are defined by MYCN amplification. Subependymomas are present across all these anatomic compartments. The new classification kept an open category of "not elsewhere classified" or "not otherwise specified" if no pathogenic gene fusion is identified or if the molecular diagnosis is not feasible. Although there is significant overlap in the imaging findings of these tumors, a neuroradiologist needs to be familiar with updated CNS5 classification to understand tumor behavior, for example, the higher tendency for tumor recurrence along the dural flap for ZFTA fusion-positive ependymomas. On imaging, supratentorial ZFTA-fused ependymomas are preferentially located in the cerebral cortex, carrying predominant cystic components. YAP1-MAMLD1-fused ependymomas are intra- or periventricular with prominent multinodular solid components and have significantly better prognosis than ZFTA-fused counterparts. PFA ependymomas are aggressive paramedian masses with frequent calcification, seen in young children, originating from the lateral part of the fourth ventricular roof. PFB ependymomas are usually midline, noncalcified solid-cystic masses seen in adolescents and young adults arising from the fourth ventricular floor. PFA has a poorer prognosis, higher recurrence, and higher metastatic rate than PFB. Myxopapillary spinal ependymomas are now considered grade II due to high recurrence rates. Spinal-MYCN ependymomas are aggressive tumors with frequent leptomeningeal spread, relapse, and poor prognosis. Subependymomas are noninvasive, intraventricular, slow-growing benign tumors with an excellent prognosis. Currently, the molecular classification does not enhance the clinicopathologic understanding of subependymoma and myxopapillary categories. However, given the molecular advancements, this will likely change in the future. This review provides an updated molecular classification of ependymoma, discusses the individual imaging characteristics, and briefly outlines the latest targeted molecular therapies.

Spinal CSF leak care has evolved during the past several years due to pivotal advances in its diagnosis and treatment. To the reader of the American Journal of Neuroradiology (AJNR), it has been impossible to miss the exponential increase in groundbreaking research on spinal CSF leaks and spontaneous intracranial hypotension (SIH). While many clinical specialties have contributed to these successes, the neuroradiologist has been instrumental in driving this transformation due to innovations in noninvasive imaging, novel myelographic techniques, and image-guided therapies. In this editorial, we will delve into the exciting advancements in spinal CSF leak diagnosis and treatment and celebrate the vital role of the neuroradiologist at the forefront of this revolution, with particular attention paid to CSF leak–related work published in the AJNR.

The potential for more than one distinct hematolymphoid neoplasm to arise from a common mutated stem or precursor cell has been proposed based on findings in primary human malignancies. Particularly, angioimmunoblastic T-cell lymphoma (AITL), which shares a somatic mutation profile in common with other hematopoietic malignancies, has been reported to occur alongside myeloid neoplasms or clonal B-cell proliferations, with identical mutations occurring in more than one cell lineage. Here we report such a case of an elderly woman who was diagnosed over a period of 8 years with diffuse large B-cell lymphoma, polycythemia vera, and AITL, each harboring identical somatic mutations in multiple genes. Overall, at least five identical nucleotide mutations were shared across multiple specimens, with two identical mutations co-occurring at variable variant allele frequencies in all three specimen types. These findings lend credence to the theory that a common mutated stem cell could give rise to multiple neoplasms through parallel hematopoietic differentiation pathways.

Affibody molecules are small, robust, and versatile affinity proteins currently being explored for therapeutic, diagnostic, and biotechnological applications. Surface-exposed residues on the affibody scaffold are randomized to create large affibody libraries from which novel binding specificities to virtually any protein target can be generated using combinatorial protein engineering. Affibody molecules have the potential to complement—or even surpass—current antibody-based technologies, exhibiting multiple desirable properties, such as high stability, affinity, and specificity, efficient tissue penetration, and straightforward modular extension of functional domains. It has been shown in both preclinical and clinical studies that affibody molecules are safe, efficacious, and valuable alternatives to antibodies for specific targeting in the context of in vivo diagnostics and therapy. Here, we provide a general background of affibody molecules, give examples of reported applications, and briefly summarize the methodology for affibody generation.

PURPOSE

HIV pre-exposure prophylaxis (PrEP) may increase rates of bacterial sexually transmitted infections (STIs) among gay, bisexual, and other men who have sex with men (GBM) through risk compensation (eg, an increase in condomless sex or number of partners); however, longitudinal studies exploring the time-dependent nature of PrEP uptake and bacterial STIs are limited. We used marginal structural models to estimate the effect of PrEP uptake on STI incidence.

PURPOSE

The impact of digital health on medically underserved patients is unclear. This study aimed to determine the early impact of a digital innovation to grow quality care through an interprofessional care team (DIG IT) on the blood pressure (BP) and 10-year atherosclerotic cardiovascular disease (ASCVD) risk score of medically underserved patients.

PURPOSE

Meeting scholarly activity requirements continues to be a challenge in many family medicine (FM) residency programs. Studies comprehensively describing FM resident scholarship have been limited. We sought to identify institutional factors associated with increased scholarly output and meeting requirements of the Accreditation Council for Graduate Medical Education (ACGME).

PURPOSE

We undertook a trial to test the efficacy of a technology-assisted health coaching intervention for weight management, called Goals for Eating and Moving (GEM), within primary care.

PURPOSE

Despite being key to better health outcomes for patients from racial and ethnic minority groups, the proportion of underrepresented in medicine (URiM) physicians remains low in the US health care system. This study linked a nationally representative sample of family physicians (FPs) with Medicaid claims data to explore the relative contributions to care of Medicaid populations by FP race and ethnicity.

PURPOSE

Currently, 40% of counties in the United States do not have an obstetrician or midwife, and in rural areas the likelihood of childbirth being attended to by a family medicine (FM) physician is increasing. We sought to characterize the effect of the FM presence on unit culture and a key perinatal quality metric in Iowa hospital intrapartum units.

BACKGROUND

For many patients with post–COVID-19 condition (long COVID), primary care is the first point of interaction with the health care system. In principle, primary care is well situated to manage long COVID. Beyond expressions of disempowerment, however, the patient’s perspective regarding the quality of long COVID care is lacking. Therefore, this study aimed to analyze the expectations and experiences of primary care patients seeking treatment for long COVID.

Comprehensive maps of neuronal connectivity provide a foundation for understanding the structure of neural circuits. In a circuit, neurons are diverse in morphology, electrophysiology, gene expression, activity, and other neuronal properties. Thus, constructing a comprehensive connectivity map requires associating various properties of neurons, including their connectivity, at cellular resolution. A commonly used approach is to use the gene expression profiles as an anchor to which all other neuronal properties are associated. Recent advances in genomics and anatomical techniques dramatically improved the ability to determine and associate the long-range projections of neurons with their gene expression profiles. These studies revealed unprecedented details of the gene–projection relationship, but also highlighted conceptual challenges in understanding this relationship. In this article, I delve into the findings and the challenges revealed by recent studies using state-of-the-art neuroanatomical and transcriptomic techniques. Building upon these insights, I propose an approach that focuses on understanding the gene–projection relationship through basic features in gene expression profiles and projections, respectively, that associate with underlying cellular processes. I then discuss how the developmental trajectories of projections and gene expression profiles create additional challenges and necessitate interrogating the gene–projection relationship across time. Finally, I explore complementary strategies that, together, can provide a comprehensive view of the gene–projection relationship.

The broad application of noninvasive imaging has transformed preclinical cancer research, providing a powerful means to measure dynamic processes in living animals. While imaging technologies are routinely used to monitor tumor growth in model systems, their greatest potential lies in their ability to answer fundamental biological questions. Here we present the broad range of potential imaging applications according to the needs of a cancer biologist with a focus on some of the common biological processes that can be used to visualize and measure. Topics include imaging metastasis; biophysical properties such as perfusion, diffusion, oxygenation, and stiffness; imaging the immune system and tumor microenvironment; and imaging tumor metabolism. We also discuss the general ability of each approach and the level of training needed to both acquire and analyze images. The overall goal is to provide a practical guide for cancer biologists interested in answering biological questions with preclinical imaging technologies.

For many severe lung diseases, non-invasive biomarkers from imaging could improve early detection of lung injury or disease onset, establish a diagnosis, or help follow-up disease progression and treatment strategies. Imaging of the thorax and lung is challenging due to its size, respiration movement, transferred cardiac pulsation, vast density range and gravitation sensitivity. However, there is extensive ongoing research in this fast-evolving field. Recent improvements in spatial imaging have allowed us to study the three-dimensional structure of the lung, providing both spatial architecture and transcriptomic information at single-cell resolution. This fast progression, however, comes with several challenges, including significant image file storage and network capacity issues, increased costs, data processing and analysis, the role of artificial intelligence and machine learning, and mechanisms to combine several modalities. In this review, we provide an overview of advances and current issues in the field of spatial lung imaging.

Imaging methods are fundamental tools to detect and diagnose lung diseases, monitor their treatment and detect possible complications. Each modality, starting from classical chest radiographs and computed tomography, as well as the ever more popular and easily available thoracic ultrasound, magnetic resonance imaging and nuclear medicine methods, and new techniques such as photon counting computed tomography, radiomics and application of artificial intelligence, has its strong and weak points, which we should be familiar with to properly choose between the methods and interpret their results. In this review, we present the indications, strengths and main limitations of methods for chest imaging.

A fire engine on its way to a callout has been involved in a collision with two cars on a road junction in Edinburgh.

Chris is not an automated phone system. Josh has been delayed until 2023. And Kelley gets cases for her Star Wars cases.

The post RPG Cast – Episode 642: “We Are Not Bringing Up Your Cat Fountain” appeared first on RPGamer.

Congested Kelley goes HONK! Chris runs over old people in GTA while distracting Anna Marie with Octopath. RPGamer tip of the week: If your game has more than 12 currencies, it's main stream.

The post RPG Cast – Episode 643: “Kinky Chemical Engineer” appeared first on RPGamer.

Richard Branson’s Virgin Group has swapped out its envoy on Virgin Australia’s board, putting in Warwick Negus.

Part of the fun of Dragon Age's fantasy is that it's inconsistent - or at least, inconsistent by the standards of fantasy RPGs, which often break down into a million neatly organised and interlocking codex entries. It all rides on who you speak to. The humans believe one thing about the origins and workings of Thedas, the elves another, the qunari something else entirely. These differences are the basis for many factional disagreements and thus, many core series plot developments. According to former lead writer David Gaider, however, there's an "uber-plot" behind it all that may one day be resolved and bring the series to a close, assuming BioWare continue to refer to his original (and closely guarded) narrative documents.

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Like a plague doctor delicately administering another handful of leeches, Ice Pick Lodge have shared a bit more about the recently announced Pathologic 3, explaining how their plans for the cult epidemic-battling series have progressed since the release of Pathologic 2.

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I didn’t get much further in the extremely popular beta for the haute-couture-asaurus action of Monster Hunter Wilds than perfecting the exact orange-to-white ratio of my cat. Not because I wasn’t having fun, but because I immediately started looking up GPU prices after playing for ten minutes. As such, I didn’t spend enough time with the combat to get a proper feel for it. Cultural osmosis has once again allowed me to form an uneducated take, however, and I’m getting the sense there’s been some mixed reactions re: bonk quality. According to a clip shared on X by user Blue Stigma, there's a good reason for those misgivings. It's all about frames, you see.

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The mystery surrounding Deadlock, Valve’s work-in-progress MOBA shooter, has largely evaporated. Its freely extendable invite system is about as effective at controlling player headcount as a disinterested football steward, meaning pretty much anyone with a clued-in Steam friend can get in and start poking around its secrets. And yet, being a lane-pushing wizard fighter in the Dota 2 vein, it’s already a vast tangle of interplaying abilities, items, strats, and often unspoken rules, of the kind that even experienced gankists will take hundreds of hours to learn. It’s been too much for poor Brendy, at any rate.

Still, Brendy is but one man. What if we had but four men, working in tandem to crush lanes and flatten Patrons just as Gabe intended? To find out if Deadlock is indeed more comprehensible as a team sport, Graham, Ed, Ollie, and James joined forces, promptly getting fucked up yet emerging from the warlock hospital with a deeper understanding of its workings. Or, at least, if anyone would keep playing.

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Amplitude Studios, developers of many a game with "Endless" in the name, have split with publisher Sega to become independent again, with ownership of the studio reverting to its original founders and "other members of the team". The developers say everyone is parting "on good terms" and that the last eight years of getting published under Sega has been "amazing". But there are other businessy reasons, of course. Namely, Sega have been trying to trim down their European studios for the past year, and Amplitude is just the latest bunch of devs affected by that.

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Greg Eghigian's After the Flying Saucers Came and Luis Elizondo's Imminent both show how our fascination with UFOs goes beyond simple curiosity

How did the supermassive black holes we’re now seeing in the early universe get so big so fast? Astrophysicist Sophie Koudmani is using sophisticated galaxy simulations to figure it out

Google, Microsoft and others have taken big steps towards error-free devices, hinting that quantum computers that solve real problems aren’t far away

Machines are fighting machines on the Ukrainian battlefield, as a technological arms race has given birth to a new way to wage war

Local officials are beginning to certify the results of this year's presidential election in a process that, so far, has been playing out quietly, in stark contrast to the tumultuous certification period four years ago that followed then-President Donald Trump's loss.

President-elect Donald Trump has chosen lawyer Willian McGinley to serve as his White House counsel.

Apple Music gives a whole new meaning to the phrase the hits just keep on coming.  It’s not the opposing candidates, it’s public AI systems that are spreading election disinformation, and LockBit, the cybercriminal gang may be back from the dead and saying so long to the ChatGPT plugins, which went from innovation to legacy […]

Human cognitive performance can be significantly influenced by the presence of audience members.

The post Study: Chimps Perform Better on Challenging Computer Tasks When They Have Audience appeared first on Sci.News: Breaking Science News.

Wastewater is a major reservoir for antibiotic resistance genes, but modified bacteria can chop up this DNA before the dangerous microbes reach people

Our immune cells change a lot as the decades progress, which could explain why we become more susceptible to certain conditions

The Biden administration will support a United Nations treaty this week that will create a new cybercrime convention, including China and Russia, which has not sat well with some lawmakers and critics.

William McGinley is returning to the Trump White House to serve as his White House Counsel, President-elect Trump announced.

The future of engineering is bright, and it’s being shaped by the young minds at the TryEngineering Summer Institute (TESI), a program administered by IEEE Educational Activities. This year more than 300 students attended TESI to fuel their passion for engineering and prepare for higher education and careers. Sessions were held from 30 June through 2 August on the campuses of Rice University, the University of Pennsylvania, and the University of San Diego.

The program is an immersive experience designed for students ages 13 to 17. It offers hands-on projects, interactive workshops, field trips, and insights into the profession from practicing engineers. Participants get to stay on a college campus, providing them with a preview of university life.

Student turned instructor

One future innovator is Natalie Ghannad, who participated in the program as a student in 2022 and was a member of this year’s instructional team in Houston at Rice University. Ghannad is in her second year as an electrical engineering student at the University of San Francisco. University students join forces with science and engineering teachers at each TESI location to serve as instructors.

For many years, Ghannad wanted to follow in her mother’s footsteps and become a pediatric neurosurgeon. As a high school junior in Houston in 2022, however, she had a change of heart and decided to pursue engineering after participating in the TESI at Rice. She received a full scholarship from the IEEE Foundation TESI Scholarship Fund, supported by IEEE societies and councils.

“I really liked that it was hands-on,” Ghannad says. “From the get-go, we were introduced to 3D printers and laser cutters.”

The benefit of participating in the program, she says, was “having the opportunity to not just do the academic side of STEM but also to really get to play around, get your hands dirty, and figure out what you’re doing.”

“Looking back,” she adds, “there are so many parallels between what I’ve actually had to do as a college student, and having that knowledge from the Summer Institute has really been great.”

She was inspired to volunteer as a teaching assistant because, she says, “I know I definitely want to teach, have the opportunity to interact with kids, and also be part of the future of STEM.”

More than 90 students attended the program at Rice. They visited Space Center Houston, where former astronauts talked to them about the history of space exploration.

Participants also were treated to presentations by guest speakers including IEEE Senior Member Phil Bautista, the founder of Bull Creek Data, a consulting company that provides technical solutions; IEEE Senior Member Christopher Sanderson, chair of the IEEE Region 5 Houston Section; and James Burroughs, a standards manager for Siemens in Atlanta. Burroughs, who spoke at all three TESI events this year, provided insight on overcoming barriers to do the important work of an engineer.

Learning about transit systems and careers

The University of Pennsylvania, in Philadelphia, hosted the East Coast TESI event this year. Students were treated to a field trip to the Southeastern Pennsylvania Transportation Association (SEPTA), one of the largest transit systems in the country. Engineers from AECOM, a global infrastructure consulting firm with offices in Philadelphia that worked closely with SEPTA on its most recent station renovation, collaborated with IEEE to host the trip.

The benefit of participating in the program was “having the opportunity to not just do the academic side of STEM but also to really get to play around, get your hands dirty, and figure out what you’re doing.” — Natalie Ghannad

Participants also heard from guest speakers including Api Appulingam, chief development officer of the Philadelphia International Airport, who told the students the inspiring story of her career.

Guest speakers from Google and Meta

Students who attended the TESI camp at the University of San Diego visited Qualcomm. Hosted by the IEEE Region 6 director, Senior Member Kathy Herring Hayashi, they learned about cutting-edge technology and toured the Qualcomm Museum.

Students also heard from guest speakers including IEEE Member Andrew Saad, an engineer at Google; Gautam Deryanni, a silicon validation engineer at Meta; Kathleen Kramer, 2025 IEEE president and a professor of electrical engineering at the University of San Diego; as well as Burroughs.

“I enjoyed the opportunity to meet new, like-minded people and enjoy fun activities in the city, as well as get a sense of the dorm and college life,” one participant said.

Hands-on projects

In addition to field trips and guest speakers, participants at each location worked on several hands-on projects highlighting the engineering design process. In the toxic popcorn challenge, the students designed a process to safely remove harmful kernels. Students tackling the bridge challenge designed and built a span out of balsa wood and glue, then tested its strength by gradually adding weight until it failed. The glider challenge gave participants the tools and knowledge to build and test their aircraft designs.

One participant applauded the hands-on activities, saying, “All of them gave me a lot of experience and helped me have a better idea of what engineering field I want to go in. I love that we got to participate in challenges and not just listen to lectures—which can be boring.”

The students also worked on a weeklong sparking solutions challenge. Small teams identified a societal problem, such as a lack of clean water or limited mobility for senior citizens, then designed a solution to address it. On the last day of camp, they pitched their prototypes to a team of IEEE members that judged the projects based on their originality and feasibility. Each student on the winning teams at each location were awarded the programmable Mech-5 robot.

Twenty-nine scholarships were awarded with funding from the IEEE Foundation. IEEE societies that donated to the cause were the IEEE Computational Intelligence Society, the IEEE Computer Society, the IEEE Electronics Packaging Society, the IEEE Industry Applications Society, the IEEE Oceanic Engineering Society, the IEEE Power & Energy Society, the IEEE Power Electronics Society, the IEEE Signal Processing Society, and the IEEE Solid-State Circuits Society.

An ecologist’s long walks and detailed observations allowed him to chronicle the shifts in an iconic habitat and grow a once-overlooked branch of science

From the busy cities to ocean waters, our need to illuminate the world has had some strange and tragic consequences

The fight between environmental campaigners and fossil fuel moved to the Scottish courts today.