The Pacers final game before the NBA went on hiatus was vs. the Celtics, whose player Marcus Smart has tested positive for the coronavirus

The Pacers dealt the No. 2 pick in the 1984 draft for one season of Tom Owens

I’ve been asked to explain how online ads are delivered many times and every time I’m surprised by the complexity of covering even the most basic elements of how ads appear on Web pages. Since Wikipedia’s article on ad serving … Continue reading →

The Pacers dealt the No. 2 pick in the 1984 draft for one season of Tom Owens

Simon Bogg says it took him 10 days to make the sculpture in tribute to the "absolute legend".

With uncertainty around the next transfer window, what shape are Premier League squads in? We take a look at the clubs in the bottom half.

Peyton Manning, Tom Brady, Tiger Woods and Phil Mickelson are playing for COVID-19 relief on May 24.

F1 driver Lando Norris calls McLaren fan Captain Tom Moore after the 99-year-old raised more than £27m for the NHS by completing 100 laps of his garden.

A chronology of key events

Key facts, figures and dates

The actor is well known for his daring stunts, but this takes things to another level.

A newly opened Delaware seafood restaurant has a unique item on its menu: robot servers. The machines are the latest example of intelligent machines working in the restaurant industry.

The Patriots quarterback has been sensational for years, but with everything on the line for your fantasy season in Week 16, he's a liability.

The reality TV star wrote that she and her husband, real estate developer Michael Darby, are "savoring every moment."

The Fox Nation host got plenty of criticism for her tweet about the Democratic presidential candidate — including from fellow Fox-ers.

America only benefits from U.S.-trained scientists.

The world lost an incredible talent with the death of Tomie dePaola. 

The world lost an incredible talent with the death of Tomie dePaola. 

oscon: Only 48 hours left to get discounted tickets to #OSCON. Early registration prices end tomorrow at midnight http://t.co/E0JKpcj1Rp

According to Ascend2, 71% of businesses use marketing automation. The benefits of marketing automation are significant across all industries, including real estate. Even better, marketing isn’t the only process that real estate agents can automate in their business.  Managing a real estate business can be time-consuming. Numerous, repetitive tasks can prevent agents from maximizing their […]

The post The Challenges and Opportunities for Automation in the Real Estate Industry appeared first on ReadWrite.

Assuredly, IoT (Internet of Things) has the potential to improve customer experience. The rapid expansion of technology has impacted businesses in many ways. Besides, IoT enables data sharing, inventory management, security, and increased efficiency and productivity. But, what is IoT? Well, in simple words, IoT is the network of interconnected devices that embedded with sensors, software, […]

The post Why You Need to Consider IoT in Improving Customer Experience appeared first on ReadWrite.

Did you know that, on average, 51% of companies are currently using marketing automation, and more than half of B2B companies (58%) plan to adopt the technology? The statistic may be mind-boggling, but it is very much justified. Companies and marketers are always in search of ways that make things easy and convenient for them. Automating […]

The post Marketing Automation and Customer Service: How are they Connected? appeared first on ReadWrite.

Paper is an essential commodity for office operations. Most conventional offices rely on paper for completing the simplest tasks. Even after digitization, the dream of a completely paperless office is far from reality. Humans are used to a standard form of note-taking and documentation. Here is how to achieve paperless operations and document automation with […]

The post Achieving Paperless Operations and Document Automation with AI and ML appeared first on ReadWrite.

We live in an increasingly connected world. It’s estimated that there will be about 260 million internet-connected devices in the U.S. by 2020, and the next wave of these devices will push our data demand even further. New Bluetooth advancements, for instance, enable devices to perform within a range that’s four times greater, twice the speed, and eight times the […]

The post The Automation Boom is Coming. Will the Internet Be Ready? appeared first on ReadWrite.

This one-pan chicken dinner is made with potatoes, onions, garlic, cherry tomatoes, and an easy paprika sauce. Dairy-free, gluten-free. 1 hour start to finish.

Continue reading "One-Pan Paprika Chicken with Potatoes and Tomatoes" »

Selling your services and wares online can be challenging, as today’s digital shoppers are smart and demanding. You need a customer-focused approach right from the start. The customer is the most significant pillar of modern businesses, so you need to build a genuine relationship with them if you want your online store to survive. Read […]

Miles from Tomorrowland Synopsis Miles from Tomorrowland is an animated television series produced by the Disney Channel that premiered in February of 2015. Miles from Tomorrowland is an American animated TV series about the adventures of an inquisitive, if somewhat reckless boy named Miles who travels the universe with his family. Miles from Tomorrowland is […]

With a bright, 8.2-inch HD display and the flexibility to work in almost any vehicle, the Lanmodo Automotive Vast Night Vision System is a near-perfect alternative to factory-installed systems.

The post Brighten Up Your After-Dark Road-Tripping with Lanmodo’s Vast Automotive Night Vision System appeared first on Vagabondish.

The Ontario government gave garden centres and nurseries the green light to open their doors to the public on Friday.

Research Event

Event participants

Yezid Sayigh, Senior Fellow, Carnegie Middle East Center
David Butter, Associate Fellow, Middle East and North Africa Programme, Chatham House
Chair: Lina Khatib, Head, Middle East and North Africa Programme, Chatham House

Timothy J. Griffin
Apr 1, 2002; 1:323-333
Research

Sean R. Collins
Mar 1, 2007; 6:439-450
Research

Linn Fagerberg
Feb 1, 2014; 13:397-406
Research

M el-Saadani
Apr 1, 1989; 30:627-630
Articles

The respiratory epithelium comprises polarized cells at the interface between the environment and airway tissues. Polarized apical and basolateral protein secretions are a feature of airway epithelium homeostasis. Human respiratory syncytial virus (hRSV) is a major human pathogen that primarily targets the respiratory epithelium. However, the consequences of hRSV infection on epithelium secretome polarity and content remain poorly understood. To investigate the hRSV-associated apical and basolateral secretomes, a proteomics approach was combined with an ex vivo pediatric human airway epithelial (HAE) model of hRSV infection (data are available via ProteomeXchange and can be accessed at https://www.ebi.ac.uk/pride/ with identifier PXD013661). Following infection, a skewing of apical/basolateral abundance ratios was identified for several individual proteins. Novel modulators of neutrophil and lymphocyte activation (CXCL6, CSF3, SECTM1 or CXCL16), and antiviral proteins (BST2 or CEACAM1) were detected in infected, but not in uninfected cultures. Importantly, CXCL6, CXCL16, CSF3 were also detected in nasopharyngeal aspirates (NPA) from hRSV-infected infants but not healthy controls. Furthermore, the antiviral activity of CEACAM1 against RSV was confirmed in vitro using BEAS-2B cells. hRSV infection disrupted the polarity of the pediatric respiratory epithelial secretome and was associated with immune modulating proteins (CXCL6, CXCL16, CSF3) never linked with this virus before. In addition, the antiviral activity of CEACAM1 against hRSV had also never been previously characterized. This study, therefore, provides novel insights into RSV pathogenesis and endogenous antiviral responses in pediatric airway epithelium.

In bacteria, the restart of stalled DNA replication forks requires the DNA helicase PriA. PriA can recognize and remodel abandoned DNA replication forks, unwind DNA in the 3'-to-5' direction, and facilitate the loading of the helicase DnaB onto the DNA to restart replication. Single-stranded DNA–binding protein (SSB) is typically present at the abandoned forks, but it is unclear how SSB and PriA interact, although it has been shown that the two proteins interact both physically and functionally. Here, we used atomic force microscopy to visualize the interaction of PriA with DNA substrates with or without SSB. These experiments were done in the absence of ATP to delineate the substrate recognition pattern of PriA before its ATP-catalyzed DNA-unwinding reaction. These analyses revealed that in the absence of SSB, PriA binds preferentially to a fork substrate with a gap in the leading strand. Such a preference has not been observed for 5'- and 3'-tailed duplexes, suggesting that it is the fork structure that plays an essential role in PriA's selection of DNA substrates. Furthermore, we found that in the absence of SSB, PriA binds exclusively to the fork regions of the DNA substrates. In contrast, fork-bound SSB loads PriA onto the duplex DNA arms of forks, suggesting a remodeling of PriA by SSB. We also demonstrate that the remodeling of PriA requires a functional C-terminal domain of SSB. In summary, our atomic force microscopy analyses reveal key details in the interactions between PriA and stalled DNA replication forks with or without SSB.

O que é Candidíase? Candidíase, é uma infecção sistêmica causada pelo fungos da Candida albicans. A Candida albicans é um tipo de fungo (levedura) que vive em harmonia no organismo,…

The post Candidíase – Conheça as causas, sintomas e tratamentos appeared first on Saúde Próspera.

It may be hard to accept but it.s likely that we.d all be much safer in autonomous vehicles driven by computers, not humans. Annually more than 30,000 Americans die in car crashes, almost all due to human error. Autonomous vehicles will communicate position and speed to each other and avoid potential collisions-without the possibility of dozing off or road rage. There are still many legal (and insurance) issues to resolve, but researchers who are revving up the development of autonomous vehicles are relying on geometry for recognizing and tracking objects, probability to assess risk, and logic to prove that systems will perform as required. The advent of autonomous vehicles will bring in new systems to manage traffic as well, for example, at automated intersections. Cars will communicate to intersection-managing computers and secure reservations to pass through. In a matter of milliseconds, the computers will use trigonometry and differential equations to simulate vehicles. paths through the intersection and grant entry as long as there is no conflict with other vehicles. paths. Waiting won.t be completely eliminated but will be substantially reduced, as will the fuel--and patience--currently wasted. Although the intersection at the left might look wild, experiments indicate that because vehicles would follow precise paths, such intersections will be much safer and more efficient than the ones we drive through now.

In bacteria, the restart of stalled DNA replication forks requires the DNA helicase PriA. PriA can recognize and remodel abandoned DNA replication forks, unwind DNA in the 3'-to-5' direction, and facilitate the loading of the helicase DnaB onto the DNA to restart replication. Single-stranded DNA–binding protein (SSB) is typically present at the abandoned forks, but it is unclear how SSB and PriA interact, although it has been shown that the two proteins interact both physically and functionally. Here, we used atomic force microscopy to visualize the interaction of PriA with DNA substrates with or without SSB. These experiments were done in the absence of ATP to delineate the substrate recognition pattern of PriA before its ATP-catalyzed DNA-unwinding reaction. These analyses revealed that in the absence of SSB, PriA binds preferentially to a fork substrate with a gap in the leading strand. Such a preference has not been observed for 5'- and 3'-tailed duplexes, suggesting that it is the fork structure that plays an essential role in PriA's selection of DNA substrates. Furthermore, we found that in the absence of SSB, PriA binds exclusively to the fork regions of the DNA substrates. In contrast, fork-bound SSB loads PriA onto the duplex DNA arms of forks, suggesting a remodeling of PriA by SSB. We also demonstrate that the remodeling of PriA requires a functional C-terminal domain of SSB. In summary, our atomic force microscopy analyses reveal key details in the interactions between PriA and stalled DNA replication forks with or without SSB.