A review by krisko6 (740). After 13 years, Half-Life has returned

A review by piltdown_man (179399). A good story, well told

A review by piltdown_man (179399). A short but enjoyable bit of perversion

A review by SomeRandomHEFan (46). An excellent showcase of Humongous Entertainment's sense of humour. And I guess there's an acceptable edutainment game in there somewhere, too.

A review by raiden_is_dj (2). Real fun in this game

Systemic sclerosis (SSc) is an autoimmune fibrotic disease whose pathogenesis is poorly understood and lacks effective therapies. We undertook quantitative analyses of T cell infiltrates in the skin of 35 untreated patients with early diffuse SSc and here show that CD4+ cytotoxic T cells and CD8+ T cells contribute prominently to these infiltrates. We also observed an accumulation of apoptotic cells in SSc tissues, suggesting that recurring cell death may contribute to tissue damage and remodeling in this fibrotic disease. HLA-DR–expressing endothelial cells were frequent targets of apoptosis in SSc, consistent with the prominent vasculopathy seen in patients with this disease. A circulating effector population of cytotoxic CD4+ T cells, which exhibited signatures of enhanced metabolic activity, was clonally expanded in patients with systemic sclerosis. These data suggest that cytotoxic T cells may induce the apoptotic death of endothelial and other cells in systemic sclerosis. Cell loss driven by immune cells may be followed by overly exuberant tissue repair processes that lead to fibrosis and tissue dysfunction.

The internet was seen as a major catalyst for the furry fandom finding one another during the times before we held conventions. During that earlier period in the 1990s, conventions and meets were rare, and finding one another was done mostly through the chat rooms and message boards of the past. There was no bandwidth for video or sharing major animation projects, therefore most of our intimate conversations were textual.

For many younger furries, it was a time that was lost in the annals of a distant history. Instead they found themselves joining in amongst a wave of growing conventions being held in various places around the world on any given weekend. Ones where those in custom fursuits march out in the streets openly rather than feeling a stifling isolation of being cooped up in hotel spaces, with a handful of home made creations, being wary of a hostile media looking for a freak show.

Coming out of 2019, it seemed that the time where furry was just an internet thing was fully behind it. However a series of unfortunate events were in line for 2020, a year that has led humanity to be forced into their rooms by an irate Mother Nature as an easily spread virus has forced governments around the globe to take drastic measures to slow its spread and put strict limits on social gatherings. A situation which has forced both the furry fandom, and the internet that brought it together, back to their roots.

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Leaders of political revolutions never quit before the official battle begins, and say that they will vote for and support their enemies. When the moment arrived of walking all that endless talk of Bernie Sanders about fighting his political revolution, he caved out of self interest Continue reading →

Undone by Blood #3 is now due out June 10.

The post EXCLUSIVE: More meta revenge in UNDONE BY BLOOD #3 appeared first on The Beat.

What if you mount a mirror at a 45 degree angle just outside your bedroom window?

Papel San Francisco garantiza la continuidad de operaciones aprovechando Servicios de IBM

Alrededor de 60 mentes creativas del emprendimiento y el desarrollo se dieron cita en el DeveloperConnect@Night, en un evento hecho por desarrolladores y para desarrolladores por parte de IBM México en el Plaza Condesa.

IBM (NYSE: IBM) anunció hoy que está trabajando con más de 300 universidades y más de 400 instituciones educativas en toda Latinoamérica para respaldar la inminente necesidad de desarrollar habilidades asociadas a los requerimientos de la transformación digital, ya que el 60% de los ejecutivos se esfuerza hoy por mantener las habilidades de la fuerza laboral actualizadas y relevantes frente al rápido avance tecnológico.

IBM y Red Hat, líder mundial de software de nube de código abierto, anunciaron un acuerdo en el que IBM adquirirá todas las acciones comunes emitidas y en circulación de Red Hat por USD$190.00 por acción en efectivo, lo que representa un valor total para la empresa de aproximadamente USD$34 mil millones.

MineHub Technologies e IBM anunciaron hoy una colaboración para utilizar la tecnología blockchain con el objetivo de mejorar la eficiencia operativa, logística, financiamiento y reducir los costos en la cadena de suministro de concentrados minerales de alto valor, desde la mina hasta el comprador final.

IBM Security anunció los resultados de un estudio global que explora los factores y desafíos de ser una organización ciberresiliente. El estudio encontró que el 77% de los encuestados admiten no tener un plan formal de respuesta a incidentes de seguridad cibernética (CSIRP) aplicado sistemáticamente en toda su organización. Casi la mitad de los encuestados informaron que su plan de respuesta a incidentes es informal o completamente inexistente.

IBM (NYSE: IBM) reveló hoy una serie de nuevos servidores diseñados para potenciar las cargas de trabajo cognitivas y elevar la eficiencia en el centro de cómputo. Con un nuevo chip, la línea basada en Linux incorpora innovaciones de la comunidad OpenPOWER que ofrecen mayores niveles de desempeño y mayor eficiencia de cómputo que los disponibles en cualquier servidor basado sobre x86.

IBM et Holcim France Benelux annoncent la migration vers Windows 7 des postes de travail de 2500 utilisateurs sur 286 sites en seulement trois mois grâce au savoir-faire d’IBM Global Technology Services.

What if, after Harry faces Voldemort in the Forest, he doesn't go to his mental construct of King's Cross Station? Rather he finds himself on the shore of the Black Lake in a host of Guardian Angels (one a little odd, another disturbingly familiar looking), and a tall, hooded black-robed figure. On a white horse. Named Binky...

One of the people that I'm subscribed to on YouTube a while back did a tribute video to this song by My Darkest Days to the new Robin Hood movie starring Russell Crowe. I thought this song would be a perfect match to the Mad Max trilogy

Falling down is the tale of Bill Foster (played by Michael Douglas) a.k.a D-FENS which is his license plate. A guy who isn’t having a very good time. He lost his wife, his home, his daughter, and his job at a defence plant.............

1. Should You Get A Nintendo Switch Lite If You Can’t Find Switch Availability? It Depends  Forbes
2. Nintendo Switch Lite is in stock at Amazon and Best Buy: Latest inventory update  CNET
3. Best Switch Games So Far In 2020  Trusted Reviews
4. Nintendo Switch Capture Cards: How to Record Video of Your Gameplay  Screen Rant
5. View Full coverage on Google News

Volunteers clad as Superman and Spider-Man sprayed disinfectant against the coronavirus on Indonesia's island of Java, flanking a colleague wearing the winged helmet of local superhero Gatotkaca who shouted, "Wear masks, wash hands and stay alert."

On 11 March, Stuart Muirhead from Iriss hosted a group discussion on the Duty of Candour with representatives from the Scottish Social Services Council (SSSC), the Coalition of Care and Support Providers (CCPS), the Care Inspectorate and Care Concern Group.

We hear more about the Duty of Candour provisions which set out what needs to happen when unexpected or unintended harm has occurred to a person, and the views of organisations that represent the health and social care workforce in Scotland.

In partnership, the SSSC has produced an e-learning module on the Duty of Candour to support implementation.

Transcript of episode

Music Credit: Make your dream a reality by Scott Holmes

CONDOMS I'd Rather use it than stare at it all night

PotterCast is back with a super exciting episode taped live with the Orlando Harry Potter Club talking all about the PotterCast Trio's day at the Wizarding World of Harry Potter at Universal Islands of Adventure in Orlando, Florida! Melissa John and Frankie were there for the soft open of the new Harry Potter land at the theme park and had an incredible time!

Episode 221 — Live at Wizarding World Orlando!

Find the latest episode and explore PotterCast interviews, discussions and more at PotterCast.com

Visit the-leaky-cauldron.org for the latest and greatest from Harry Potter's Wizard World.

By Leo Babauta This month, I’m issuing a challenge to all of you procrastinators … and no, you can’t make the joke that you’ll do it later! The challenge is called Undone: The Unprocrastination Challenge, and it’s a part of my Sea Change Program. The challenge is to set aside an “unprocrastination session” every day […]

https://www.bestbuy.com/site/promo/nintendo-labo-offer

Includes Variety Kit, Robot Kit, Vehicle Kit, and VR Starter Kit.

Nintendo $50 USD eShop Cards US for $42.5

Coupon: NK8

Product Info: Developer: Arcade Distillery Publisher: Arcade Distillery Website: Mecho Wars: Desert Ashes Twitter: @ArcadeDistiller

Product Info: Developer: Sebastian Nigro, Christ Anselmo Publisher: HItcents Website: Duke Of Defense Twitter: @tophtacular / @Seabass_N / @Hitcents

At this time, the world continues to be significantly impacted by COVID-19 and we no longer believe it is possible to host and conduct the NFPA Conference and Expo in June. NFPA is a safety organization and we would not hold an event where the well-being

This week for Case Mod Friday we have what might be the ultimate bench build! It is from KillR_MODZ and he calls it the IndominAORUS Bench featuring all new Z490 hardware and some awesome watercooling!

The post Case Mod Friday: IndominAORUS Bench appeared first on ThinkComputers.org.

Well things are not looking good for Computex as many companies are simply pulling out of the show all together, even though it has been rescheduled.

The post Multiple Motherboard and VGA Vendors Pulling out of Computex appeared first on ThinkComputers.org.

Vem dar risada com a gente neste quadro “Experimentando Doces Gringos”! ???? Desta vez provamos doces de Dubai e Tailândia! Entre eles está um dos meus doces industrializados favoritos! Assista e veja se você também fica com água na boca!

O post Experimentando Doces: Dubai e Tailândia apareceu primeiro em Cozinha do Bom Gosto.

The 2020 Coronavirus/COVID-19 pandemic has created a new normal for much of the population — a daily routine that now means moving from the bedroom to the living room instead of battling a commute and logging hours in an office building. With the kids tackling remote learning and you working from home, the carbon dioxide to oxygen ratio under your roof is likely different than it was just a few months ago. After all, there’s no doubt that an increase in the number of people at home affects the overall indoor air quality (IAQ) within the space. With that in[...]

In the Indonesian city of Semarang, international architecture firm SHAU has completed Microlibrary Warak Kayu, an inspiring new public space that raises the bar for community design and sustainable architecture. Prefabricated with only FSC-certified timber, the new neighborhood icon is the fifth built project in the Microlibrary series, an initiative to encourage reading in low-income areas by creating "socially performative multifunctional community spaces with environmentally conscious designs and materials." In addition to the exclusive use of sustainably grown and logged timbers, the project is the first library in Indonesia made entirely of FSC-certified wood. The Microlibrary Warak Kayu is also[...]

A constant connection to nature pervades the Home by the Park, a newly completed single-family residence that faces a park in the South Indian city of Hubballi. Bangalore-based practice 4site architects designed the house to engage views of the adjacent park from multiple floors and vantage points, while bringing the lush greenery indoors with the creation of a rain courtyard and landscaped terraces. The abundant plantings not only give the house a sense of tranquility but also create a cooling microclimate to counteract the region’s tropical climate.[...]

In an industry notorious for food waste, award-winning chef Douglas McMaster has achieved the seemingly unattainable — Silo, the world’s first zero-waste restaurant. For Silo’s second outpost in London, local interior design studio Nina+Co teamed up with McMaster to craft an interior that reinforces the restaurant’s sustainable ethos with locally sourced natural materials and innovative design aimed at minimizing environmental impact.[...]

There’s nothing stopping Jimmy Donaldson aka Mr. Beast from giving away money, this time doing it via video calls. Watch as he and his friends pretend to be a news reporter, school professor, and many others as they interview people, and then surprise them by giving them thousands of dollars. Some recognize him and his team, however.

“A lot of people are going through a ruff time right now so I tried my best to do some good,” he said in the video description. He also posted this on his birthday, and said that liking or subscribing would be “a dope present.”

Very wholesome.

(Video Credit: MrBeast/ YouTube)

The series, a prequel to Rogue One, will star Diego Luna and Alan Tudyk reprising their film roles

Windows can't fix all the bugs on each release. I'll look at some of the reasons Windows might not fix something you consider important.

Why Didn’t Windows Fix My Pet Peeve? from Ask Leo!.
Get the newsletter: https://newsletter.askleo.com

Princeton this week endorsed new guidelines aimed at accelerating the transition of the University's COVID-19 discoveries into solutions to protect health care workers and prevent, diagnose, treat and contain the pandemic.

Click here for a much better video version.