At seven of Penn State’s Commonwealth Campuses, campus gardens and farms help to connect students with nature. Programs aimed at sustainable food practices and mental well-being help to create an environment for growth and joy within the community. 

At seven of Penn State’s Commonwealth Campuses, campus gardens and farms help to connect students with nature. Programs aimed at sustainable food practices and mental well-being help to create an environment for growth and joy within the community. 

Bhool Bhulaiyaa 3 featuring Kartik Aaryan was released in the cinemas on November 1.

A wide-ranging group of community organizations serving Delawareans from all walks of life have been selected to receive year 2022 grants from the Financial Literacy Education Fund (FLEF). “Financial literacy levels the playing field across all communities in our state,” said Delaware State Bank Commissioner Robert Glen. “For this round of grants, our team reviewed […]

DOVER, Del. – Lt. Governor Bethany Hall-Long, Governor John Carney, and community leaders are encouraging Delawareans to check their eligibility for free or low-cost internet options as Delaware kicks off summer learning and enrichment activities. The awareness coincides with the Biden Administration’s Affordable Connectivity Program (ACP) Week of Action this June.  Starting this summer, libraries across Delaware will be hosting free enrollment events so […]

The challenge is geared towards children ages 4 through 10, but all ages are welcome to join. The Smokey Bear Reading Challenge aims to engage youth in reading about wildfire prevention, forests, and natural resource careers while they explore their local environment.

Dover, DE – The Delaware Department of Correction (DOC) today announced several recent leadership promotions within the Bureau of Prisons. “The Bureau of Prisons is fortunate to have an exceptional team of highly trained and highly experienced staff who are well positioned to serve in senior roles with increasing authority and responsibility,” Bureau of Prisons Chief Shane Troxler […]

Dover, DE – Delaware Department of Correction (DOC) Acting Commissioner Terra Taylor today announced that James T. Vaughn Correctional Center Warden Robert May has been promoted to Chief of the Bureau of Prisons.  May, a 31-year veteran of the DOC and the Department’s most experienced Warden, began his career as a Correctional Officer at Howard […]

Delaware Office of Highway Safety Promotes National Child Passenger Safety Week from September 20 – 26, 2020 FOR IMMEDIATE RELEASE Media Contacts: Cynthia Cavett, Marketing Specialist & Public Information Officer Delaware Office of Highway Safety Cynthia.Cavett@delaware.gov 302-744-2743 DOVER, Del. (September 21, 2020) – Child Passenger Safety Week is a nationwide campaign that spreads critical awareness and […]

Media Contact: Veronica Marshall Traffic Safety Outreach Coordinator Veronica.Marshall@Delaware.Gov Car crashes are a leading cause of death for children – let’s change that OHS Promotes National Child Passenger Safety Week September 19 – 25, 2021 [DOVER, Del.] September 15, 2021 — Car crashes are a leading cause of death for children, according to the latest National […]

Smyrna, DE – The Delaware Department of Correction (DOC) announced today that James T. Vaughn Correctional Center (JTVCC) Security Superintendent Major Jason Schaffer has been promoted to Deputy Warden of JTVCC. The promotion is effective immediately. Schaffer’s promotion fills the vacancy created when then-Deputy Warden Philip Parker was promoted in March to Warden of Howard […]

Wilmington, DE, May 31, 2024 – Habitat for Humanity of New Castle County (HFHNCC) and Delaware State Housing Authority (DSHA), in partnership with Governor John Carney’s office, are proud to announce a press conference to highlight their efforts in supporting homeownership and community development across Wilmington and the entire state of Delaware. The press conference, […]

Learn why integrating EHR data with pharmacy and claims data improves patient care.

The post Closing data gaps to promote integrated health care appeared first on The Data Roundtable.

ferrard Sun, 06/05/2022 - 13:07

Holding this year’s presidency of the Group of 20 (G20) large industrial and emerging economies is allowing Brazil to push forward the dream of creating a global biofuels market without the current trade barriers. Brazil is trying, at least since the beginning of this century, to free up global trade in ethanol, but so far […]

What started as a broad attempt to allow women to live a more dignified life, an indigenous women’s organization, Masehual Siuamej Mosenyolchicauani, now aims to solve environmental and climate problems that others have created.

This report examines the progress of trade facilitation in Asia and the Pacific, highlights recent trends in paperless trade, and evaluates the impact of trade facilitation initiatives on trade costs and overall trade.

The TA is proposed to develop Bhutan's overall power dispatch options and strategies for domestic electricity consumption and international power trade. It will look into strategic views to maximize power export from various potential energy sources of hydropower, solar power, and wind power while meeting growing domestic electricity consumption.

Title: Promoting Social Wellness in Your Community
Category: Health News
Created: 8/29/2017 12:00:00 AM
Last Editorial Review: 8/29/2017 12:00:00 AM

Long noncoding (lnc)RNAs emerge as regulators of genome stability. The nuclear-enriched abundant transcript 1 (NEAT1) is overexpressed in many tumors and is responsive to genotoxic stress. However, the mechanism that links NEAT1 to DNA damage response (DDR) is unclear. Here, we investigate the expression, modification, localization, and structure of NEAT1 in response to DNA double-strand breaks (DSBs). DNA damage increases the levels and N6-methyladenosine (m⁶A) marks on NEAT1, which promotes alterations in NEAT1 structure, accumulation of hypermethylated NEAT1 at promoter-associated DSBs, and DSB signaling. The depletion of NEAT1 impairs DSB focus formation and elevates DNA damage. The genome-protective role of NEAT1 is mediated by the RNA methyltransferase 3 (METTL3) and involves the release of the chromodomain helicase DNA binding protein 4 (CHD4) from NEAT1 to fine-tune histone acetylation at DSBs. Our data suggest a direct role for NEAT1 in DDR.

ABSTRACTDespite global consensus on the importance of male involvement in family planning, disparities persist in low- and middle-income countries, where women continue to bear the responsibility for these initiatives. The Philippines, with a high fertility rate and unmet family planning needs, exemplifies this challenge. We present the experiences and lessons learned from implementing the no-scalpel vasectomy (NSV) program in Davao City, showcasing its potential for increasing male engagement in family planning decisions. Launched in 2008, the program aimed to address gender disparity by promoting NSV as a safe and effective contraceptive alternative to female-centric methods. Through the use of culturally sensitive information campaigns and couple-focused counseling, the program challenged traditional notions of masculinity and encouraged shared decision-making. Strong local government commitment and public-private partnerships played key roles in driving the program’s success. Results showed an average annual increase of 80% in NSV clients over the past 3 years compared to before the COVID-19 pandemic, underscoring its effectiveness. The program presents a compelling intervention model for similar initiatives, highlighting how overcoming cultural barriers, infrastructure limitations, and budgetary constraints through policy advocacy, strategic partnerships, and tailored approaches can significantly boost male involvement in family planning and improve reproductive health outcomes within communities.

The concierge team at The Balmoral have helped raise awareness for a special event to raise money for charity in memory of Scotland legend Doddie Weir.

The Puerto Rican singer covers the latest issue of 'Out' magazine.

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Telegram has established itself as a unique messaging platform with a strong emphasis on privacy, encryption, and an intuitive API. What sets it apart is its ability to support large group chats, with a capacity of up to 200,000 participants, which is far greater than what competitors like WhatsApp and Signal offer. This feature makes […]

The post A Comprehensive Guide on How to Find Telegram Groups to Promote Your Brand appeared first on Chart Attack.

Many parents opt for more expensive baby milk, equating higher costs with better quality, the watchdog found.

Disclosure: I sit on the Planning Committee for the FDLI Ad-Promo conference. This is an unpaid, volunteer position. The contents of this post were not discussed with or influenced by any member of the FDLI staff.

This post provides some of the highlights from FDLI's ad-promo conference. An on-demand version of the conference presentations is available on-demand at: https://www.fdli.org/2023/11/advertising-promotion-for-medical-products-conference-on-demand/

The Food and Drug Law Institute's (FDLI) Advertising & Promotion for Medical Products conference wrapped up last week. I attended the conference and also moderated a panel on data privacy and concerns about the use of health data for the targeting of advertising.

The first day kicked off with a fireside chat with Arun Rao from the Department of Justice (DOJ), Lauren Roth from the Food & Drug Administration (FDA), and Serena Viswanathan from the Federal Trade Commission (FTC), led by Christine Simmon of FDLI.

FDA and FTC both noted their recent guidance updates. For FDA, that means the new Communications From Firms to Health Care Providers Regarding Scientific Information on Unapproved Uses of Approved/Cleared Medical Products Questions and Answers Guidance for Industry (SIUU) and the newly finalized Presenting Quantitative Efficacy and Risk Information in Direct-to-Consumer (DTC) Promotional Labeling and Advertisements. 

FTC has also been busy, providing updated guidance on endorsements, reviews and testimonials, and a distinct Health Products Compliance Guidance.

DOJ, FDA, and FTC also mentioned the extent to which they are still very much digging out from the backlog created by the pandemic. More than three years after COVID-19 first came to our shores, its effects are very much still being felt.

Rao also mentioned a new policy from DOJ to create a safe harbor for self-reported disclosures made in connection with a merger or acquisition. Under this new policy, companies that learn of wrongdoing at a company they have acquired can be protected from later liability if they report the wrongdoing to DOJ within six months of closing the merger or acquisition. This is as Rao described it a "very big juicy carrot" to encourage self-reporting of wrongdoing, and it also ramps up the need for effective due diligence during the M&A to ensure that all wrongdoing is uncovered and can be reported.

One final point mentioned by Roth is the importance to FDA of combatting misinformation about medical products. Commissioner Califf has repeatedly warned about the need to combat misinformation, and it is not a stretch to see FDA's SIUU guidance as one small step in that direction. By providing further guidance about exactly how sponsors can share truthful, not misleading information about unapproved uses, FDA is enabling efforts to get good information from the people who should be seen as the most reliable source of that information, the product's sponsors.

The next session of the day included an update from OPDP, APLB, CDRH, and CVM related to advertising and promotion.

Katie Gray from OPDP gave a detailed presentation on the Recorlev enforcement action from earlier this year and an overview of the SIUU guidance. Lisa Stockbridge from APLB provided a reminder on reminder advertising, indicating that this well-established category of communication continues to cause firms difficulties. Debra Wolf of CDRH emphasized that although there has not been a significant amount of publicly available enforcement actions from CDRH, the Agency continues to have many private communications with firms about their marketing efforts.

The next plenary session covered scientific exchange and pre-approval communications. Elisabethann Wright of Cooley provided particular insight into the EU's approach, which of course varies widely by country, and has been especially active on platforms such as LinkedIn. Of note is the extremely active role played by the industry's own associations in not merely promulgating guidance and establishing codes of conduct but in regularly enforcing violations of those codes against member companies.

After lunch, the first set of breakout sessions occurred including the panel I moderated on data privacy. I found the discussion very lively and enjoyed hearing from Elisa Jillson from the FTC, Lyra Correa from HHS's Office of Civil Rights, and Nancy Perkins from Arnold & Porter. I have previously opined that the 2020s will be most known for its focus on privacy, and while the cookie-less future we keep hearing about gets pushed back once again, there's growing awareness and concern about how much deeply personal information has been given up and on how companies are using (or misusing) that data.

Simultaneous sessions looked at the recently finalized guidance from the FDA on Presenting Quantitative Efficacy and Risk Information in Direct-to-Consumer (DTC) Promotional Labeling and Advertisements while another session looked more into the promotion of veterinary products. Because I was leading another session, I couldn't attend either, but I'm looking forward to using that link provided earlier to view the recordings. 

The afternoon plenary sessions resumed with a look at FTC's role in enforcement of healthcare advertising and closed out with a session on that perennial chestnut of social media usage.

Day two of the conference kicked off with an enlightening discussion of so-called CFL (Consistent with FDA-Labeling) claims. Torrey Cope of Sidley Austin provided an insightful look not just at FDA's enforcement post-guidance for claims that failed to meet the CFL standard, but also for taking the time to examine the nature and wording around the acceptance by FDA of so-called Real-World Evidence (RWE) in the context of product approvals. RWE is not the sole source of CFL claims, but Cope was able to provide some valuable lessons.

The afternoon's breakout sessions included one on artificial intelligence (which I attended), promotional challenges in rare disease treatments, and navigating accelerated approval promotion.

The closing session focused on other avenues for enforcement, including of course, the Better Business Bureau National Advertising Division's (NAD), as well as general counsel to general counsel complaint letters, filing complaints with the FDA, and perhaps even bringing a Lanham Act case.

The NAD's finding against Novartis earlier this year was of course a hot topic. But it is worth noting that in a more recent case, Viiv simply declined to participate in the NAD process. NAD referred the matter to FDA and FTC noting that decision, but as of the writing of this post, no further action by the government has been seen.

Alan Minsk of Arnall Golden Gregory noted the importance of determining your goal when looking at the appropriate path. If your goal is get a competitor in trouble then you really need to rely on the government or the courts, but if your goal is primarily to just get the company to stop the use of misleading promotion, then NAD or a direct complaint letter might be a far more cost-effective solution.

Overall, the conference was a huge success, though my opinion should be viewed as biased because I sit on the conference planning committee. FDA is definitely digging itself out from the pandemic backlog. I fully expect we'll see more from the Agency, as a very active 2023 has already demonstrated.

On December 3, a federal appeals court ruled against one of the FDA’s untouchable restrictions on industry—thou shalt not promote the off-label use of pharmaceutical products. An industry that is little interested in constitutional law suddenly finds itself talking about the First Amendment and whether, and on what grounds, the case will be appealed. Meantime, the court’s decision left FDA Matters torn between cheering and booing. Patients are poorly served if their doctor is prescribing drugs without being able to tap into all sources of relevant knowledge. However, permitting off-label promotion undercuts the incentive for companies to thoroughly investigate the safety and efficacy of a drug for a second or third use.

[Fair Warning: I have generally tried to keep this blog separate from my corporate existence, but am making an exception for two quick posts about the upcoming DIA 2013 Annual Meeting.]

Improving Enrollment in Pediatric Clinical Trials

Logistically, ethically, and emotionally, involving children in medical research is greatly different from the same research in adults. Some of the toughest clinical trials I've worked on, across a number of therapeutic areas, have been pediatric ones. They challenge you to come up with different approaches to introducing and explaining clinical research – approaches that have to work for doctors, kids, and parents simultaneously.

On Thursday June 27, Don Sickler, one of my team members, will be chairing a session titled “Parents as Partners: Engaging Caregivers for Pediatric Trials”. It should be a good session.

Joining Don are 2 people I've had the pleasure of working with in the past. Both of them combine strong knowledge of clinical research with a massive amount of positive energy and enthusiasm (no doubt a big part of what makes them successful).

However, they also differ in one key aspect: what they work on. One of them – Tristen Moors from Hyperion Therapeutics - works on an ultra-rare condition, Urea Cycle Disorder, a disease affecting only a few hundred children every year. On the other hand, Dr. Ann Edmunds is an ENT working in a thriving private practice. I met her because she was consistently the top enroller in a number of trials relating to tympanostomy tube insertion. Surgery to place “t-tubes” is one of the most common and routine outpatients surgeries there is, with an estimated half million kids getting tubes each year.

Each presents a special challenge: for rare conditions, how do you even find enough patients? For routine procedures, how do you convince parents to complicate their (and their children’s) lives by signing up for a multi-visit, multi-procedure trial?

Ann and Tristen have spent a lot of time tackling these issues, and should have some great advice to give.

For more information on the session, here’s Don’s posting on our news blog.

Are we looking at our enrollment data in the right way?

Session Details:

June 25, 1:45PM - 3:15PM

• Session Number: 241
• Room Number: 205B

1. Enrollment Analytics: Moving Beyond the Funnel
Paul Ivsin
VP, Consulting Director
CAHG Clinical Trials

2. Use of Analytics for Operational Planning
Diana Chung, MSc
Associate Director, Clinical Operations
Gilead
3. Using Enrollment Data to Communicate Effectively with Sites
Gretchen Goller, MA
Senior Director, Patient Access and Retention Services
PRA

�El Vato� :30 sec video promo

Conoce a la familia Méndez, pionera en la transformación extrema de camiones. Texas Trocas, nueva serie de Discovery en Español. Estreno 15 de septiembre a las 10PM E/P.

MundoFox estrenará “¿Quién Mató a Patricia Soler?” el lunes 9 de febrero a las 9PM/8c.

Qantas Wallabies player Nick Cummins promotes the #pass4prostate challenge and USA vs. Australia match coming up on Sept. 5 in Chicago. #pass4prostate and the match are presented by Astellas Pharma

Meta Heart 2 Heart Featuring Michael and Gene Strahan

The Journey Home :60 TV PSA

The FBI is investigating a spate of racist text messages targeting Black Americans in the wake of Donald Trump’s election victory last week. The texts were reported in states including Alabama, North Carolina, Pennsylvania and Virginia, addressing recipients as young as 13 by name and telling them they were “selected to pick cotton at the nearest plantation” and other messages referencing slavery. For more, we speak with Robert Greene II, a history professor at Claflin University, South Carolina’s first and oldest historically Black university in Orangeburg, where many students were targeted. “Initially when I heard about the texts, I thought it was a bit of a hoax, but … it quickly became clear that this wasn’t just a Claflin problem, it was a national issue, as well,” says Greene. We also speak with Wisdom Cole, senior national director of advocacy for the NAACP, who says “this is only the beginning,” with a second Trump administration expected to attack civil rights and embolden hate groups.

Yoshiki Nakajima, M.A.O, Yoshino Nanjō, more join cast

Prime Minister Narendra Modi continues to advocate for Yoga as a vital part of daily life. On Thursday, he shared a video on X (formerly Twitter) demonstrating

Various studies on school-based dental health programs have shown how effective they can be in reducing tooth decay in elementary-aged children. Now,

The visit for water professionals from South Asia laid the groundwork for furthering dialogue on transboundary river management for water security.

The post IWMI and GWP promote water cooperation through a study tour to Central Asia first appeared on International Water Management Institute (IWMI).

The visit for water professionals from South Asia laid the groundwork for furthering dialogue on transboundary river management for water security.

The post IWMI and GWP promote water cooperation through a study tour to Central Asia first appeared on International Water Management Institute (IWMI).

Union Health Minister Mansukh Mandaviya announced that the Indian government has implemented several initiatives to boost medlinkorgan donations/medlink in the country.

bHighlights:/bul class="group-list punch-points" liChildren and parents unite for organ donation awareness/li liInspiring stories of transplant

SAMHSA and Child Development Experts Promote the Importance of Mental Health Starting at Birth

PHOTO ADVISORY -- SAMHSA and Child Development Experts Promote the Importance of Mental Health Starting at Birth - Natio

During the television show 'The View', Kim Kardashian, who has 255 million followers on Instagram, touted the benefit of migraine drug Nurtec ODT. She

Industrial residues is misplaced local resources, the best way of handling is to turn them into renewable resources. For example, the industrial residues can be used for the preparing cement raw material and can be used as concrete...