Extended Producer Responsibility (EPR) is increasingly recognised worldwide as an efficient waste management policy to help improve recycling and reduce landfilling of products and materials. This Forum took place on 17-19 June 2014, in Tokyo, Japan, to identify key challenges and opportunities for further developing EPR policies.

Tourism has boomed in Indonesia in recent years and is already one of the main sources of foreign-currency earnings.

Mexico is faced with difficult trade-offs as it pursues its economic, social and environmental goals. Like other emerging economies Mexico is balancing the need to protect its natural resources with the need to address high levels of income inequality and poverty.

This publication examines the role of institutional investors in promoting good corporate governance and reviews Australia, Chile and Germany in more detail.

This report provides the main findings and recommendations of a case study review of entrepreneurship education and business start-up support in Tunisian universities and universities of applied sciences as part of a series of reviews on Skills and Competences for Entrepreneurship carried out by the LEED Programme of the OECD.

Promoting quality employment for older workers is crucial to boosting growth and ensuring a financially sustainable pension system, according to a new OECD report on ageing and employment policies in France.

Korea has made significant progress towards decentralising the management of employment and training programmes, but can still do more to create stronger links with employers at the local level, according to a new OECD report.

Encouraging more people to work later in life would help Poland meet the challenges of a rapidly ageing population. The percentage of old to younger groups (defined as share of over 65s to people aged 20-64) is projected to nearly triple from 22% in 2012 to 63% in 2050, according to a new OECD report.

Apprenticeships provide opportunities to build up new skills and knowledge both on and off the job. When they are of high quality, apprenticeships promote a smoother transition from school to work for young people, giving them a good start to their working careers.

Encouraging more people to continue to work later in life would help Denmark meet the challenges of its rapidly ageing population. The ratio of the population aged 65 and over to the working-age population is projected to increase from 30% in 2012 to 43% in 2050, according to a new OECD report.

Indonesia has improved its macro-economic and structural policies over the last 15 years. Its economy, with strong and stable growth rates of 5–6.6%, is catching up with other countries in the region and allowing Indonesia to focus on its development agenda.

The OECD and the Scrutiny Committee on Law Implementation of the French Senate co-organised a conference on 5 December 2013 on “Law evaluation and better regulation: the role for parliaments” at the Luxembourg Palace in Paris.

This brochure looks at the corruption, labour, human rights and environmental risks associated with the organisation of large sporting events. It describes how OECD instruments and expertise in implementation of complex projects can help host governments, event organisers and their business partners ensure that the world of sport remains associated with the traditional values of excellence and fair play.

This report provides a map for strengthening the OECD’s work in combating corruption and promoting integrity. It will help to guide reflection on current and future work, with a view to ensuring that the Organisation's anti-corruption and integrity policies are more coherent, more globally relevant and impactful.

This report provides the main findings and recommendations of a case study review of entrepreneurship education and business start-up support in Tunisian universities and universities of applied sciences as part of a series of reviews on Skills and Competences for Entrepreneurship carried out by the LEED Programme of the OECD.

Korea has made significant progress towards decentralising the management of employment and training programmes, but can still do more to create stronger links with employers at the local level, according to a new OECD report.

This report provides the main findings and recommendations of a case study review of entrepreneurship education and business start-up support in Tunisian universities and universities of applied sciences as part of a series of reviews on Skills and Competences for Entrepreneurship carried out by the LEED Programme of the OECD.

Korea has made significant progress towards decentralising the management of employment and training programmes, but can still do more to create stronger links with employers at the local level, according to a new OECD report.

The wife of Justin Bieber highlighted her stunning physique while urging her 26.8 million fans to donate to a COVID-19 charity benefiting the World Health Organization.

The Football League will announce next week that there will be no further games in Leagues One and Two - but that the play-offs could still take place to determine who wins promotion.

In 2005, the Education department of Tripura decided to give a push to Kok-Borok as a medium of instruction at the Junior Basic level to help tribal students learn in their mother tongue. Ratna Bharali Talukdar reports on the challenges as well as the gains from a strong focus on education in recent years in the state.

If charitable giving in India is to rise to the next level, the social sector needs to take more serious note of donors' preference for active involvement in the use of donations, explains Shankar Jaganathan.

Unlike conventional universities in the state, students of Maharashtra University of Health Sciences (MUHS) will not be promoted to the next level without examinations.

The Coronavirus crisis has changed work spaces and dynamics for many around the world. The entertainment industry too is slowly adjusting to new realities, and figuring out innovative ways to shoot. One of India's most popular game shows, Kaun Banega Crorepati,

Punjab Government has decided to promote students of Class 10 board exams 2020. Candidates who have appeared for the PSEB Class 10 Matric Board exams will be promoted on the basis of their pre-board examination results. Chief Minister of Punjab, Captain

We want a level playing field for all sellers: RSS affiliate.

Agriculture Minister holds meeting on preparedness ahead of kharif season

To understand the effects of road salting on ants, Michael Kaspari of the Smithsonian Tropical Research Institute and the University of Oklahoma led a team that looked at how ant colonies are affected by these conditions; their research is published in a recent issue of the journal Ecological Entomology.

The post Study reveals road salt may promote health and well-being of roadside ant colonies appeared first on Smithsonian Insider.

Before iPhones and laptops there were human computers, some of whom worked at the Harvard College Observatory. Women like Henrietta Swan Leavitt, Williamina Fleming, and […]

The post Volunteers needed to preserve astronomical history and promote discovery appeared first on Smithsonian Insider.

Laura O'Regan, Giancarlo Barone, Rozita Adib, Chang Gok Woo, Hui Jeong Jeong, Emily L. Richardson, Mark W. Richards, Patricia A.J. Muller, Spencer J. Collis, Dean A. Fennell, Jene Choi, Richard Bayliss, and Andrew M. Fry

EML4-ALK is an oncogenic fusion present in ~5% non-small cell lung cancers. However, alternative breakpoints in the EML4 gene lead to distinct variants with different patient outcomes. Here, we show in cell models that EML4-ALK variant 3 (V3), which is linked to accelerated metastatic spread, causes microtubule stabilization, formation of extended cytoplasmic protrusions and increased cell migration. It also recruits the NEK9 and NEK7 kinase to microtubules via the N-terminal EML4 microtubule-binding region. Overexpression of wild-type EML4 as well as constitutive activation of NEK9 also perturb cell morphology and accelerate migration in a microtubule-dependent manner that requires the downstream kinase NEK7 but not ALK activity. Strikingly, elevated NEK9 expression is associated with reduced progression-free survival in EML4-ALK patients. Hence, we propose that EML4-ALK V3 promotes microtubule stabilization through NEK9 and NEK7 leading to increased cell migration. This represents a novel actionable pathway that could drive metastatic disease progression in EML4-ALK lung cancer.

Olivia R. Grafinger, Genya Gorshtein, Tyler Stirling, Megan I. Brasher, and Marc G. Coppolino

Malignant cancer cells can invade extracellular matrix (ECM) through the formation of F-actin-rich subcellular structures termed invadopodia. ECM degradation at invadopodia is mediated by matrix metalloproteinases (MMPs), and recent findings indicate that membrane-anchored membrane type 1-matrix metalloproteinase (MT1-MMP) has a primary role in this process. Maintenance of an invasive phenotype is dependent on internalization of MT1-MMP from the plasma membrane and its recycling to sites of ECM remodeling. Internalization of MT1-MMP is dependent on its phosphorylation, and here we examine the role of β1 integrin-mediated signaling in this process. Activation of β1 integrin using the antibody P4G11 induced phosphorylation and internalization of MT1-MMP and resulted in increased cellular invasiveness and invadopodium formation in vitro. We also observed phosphorylation of Src and epidermal growth factor receptor (EGFR) and an increase in their association in response to β1 integrin activation, and determined that Src and EGFR promote phosphorylation of MT1-MMP on Thr⁵⁶⁷. These results suggest that MT1-MMP phosphorylation is regulated by a β1 integrin-Src-EGFR signaling pathway that promotes recycling of MT1-MMP to sites of invadopodia formation during cancer cell invasion.

Victor J. F. Kitano, Yoko Ohyama, Chiyomi Hayashida, Junta Ito, Mari Okayasu, Takuya Sato, Toru Ogasawara, Maki Tsujita, Akemi Kakino, Jun Shimada, Tatsuya Sawamura, and Yoshiyuki Hakeda

Osteoporosis is associated with vessel diseases attributed to hyperlipidemia, and bone resorption by multinucleated osteoclasts is related to lipid metabolism. In this study, we generated low-density lipoprotein receptor (LDLR)/lectin-like oxidized LDL receptor-1 (LOX-1) double knockout (dKO) mice. We found that, like LDLR single KO (sKO), LDLR/LOX-1 dKO impaired cell-cell fusion of osteoclast-like cells (OCLs). LDLR/LOX-1 dKO and LDLR sKO preosteoclasts exhibited decreased uptake of LDL. The cell surface cholesterol levels of both LDLR/LOX-1 dKO and LDLR sKO osteoclasts were lower than the levels of wild-type OCLs. Additionally, the amount of phosphatidylethanolamine (PE) on the cell surface was attenuated in LDLR/LOX-1 dKO and LDLR sKO pre-OCLs, while the PE distribution in wild-type OCLs was concentrated on the filopodia in contact with neighboring cells. Abrogation of the ATP binding cassette G1 (ABCG1) transporter, which transfers PE to the cell surface, caused decreased PE translocation to the cell surface and subsequent cell-cell fusion. The findings of this study indicate the involvement of a novel cascade (LDLR~ABCG1~PE translocation to cell surface~cell-cell fusion) in multinucleation of OCLs.

Laurence Haren, Dorian Farache, Laurent Emorine, and Andreas Merdes

-tubulin is a major protein involved in the nucleation of microtubules in all eukaryotes. It forms two different complexes with proteins of the GCP family (gamma-tubulin complex proteins): -tubulin small complexes (TuSCs), containing -tubulin and GCPs 2 and 3, and -tubulin ring complexes (TuRCs), containing multiple TuSCs, in addition to GCPs 4, 5, and 6. Whereas the structure and assembly properties of TuSCs have been intensively studied, little is known about the assembly of TuRCs, and about the specific roles of GCPs 4, 5, and 6. Here, we demonstrate that two copies of GCP4 and one copy each of GCP5 and GCP6 form a salt-resistant sub-complex within the TuRC that assembles independently of the presence of TuSCs. Incubation of this sub-complex with cytoplasmic extracts containing TuSCs leads to the reconstitution of TuRCs that are competent to nucleate microtubules. In addition, we investigate sequence extensions and insertions that are specifically found at the amino-terminus of GCP6, and between the GCP6 grip1 and grip2 motifs, and we demonstrate that these are involved in the assembly or stabilization of the TuRC.

Ganlu Deng, Yihong Chen, Cao Guo, Ling Yin, Ying Han, Yiyi Li, Yaojie Fu, Changjing Cai, Hong Shen, and Shan Zeng

Epithelial-mesenchymal transition (EMT) is a crucial process for cancer cells to acquire metastatic potential, which primarily causes death in gastric cancer (GC) patients. Bone morphogenetic protein 4 (BMP4) is a member of the TGF-β family that plays an indispensable role in human cancers. However, little is known about its roles in GC metastasis. In this study, BMP4 was found to be frequently overexpressed in GC tissues and was correlated with patient's poor prognosis. BMP4 was upregulated in GC cell lines and promoted EMT and metastasis of GC cells both in vitro and in vivo, while knockdown of BMP4 significantly inhibited EMT and metastasis of GC cells. Meanwhile, the inhibitor of DNA binding 1 (Id1) was identified as a downstream target of BMP4 by PCR arrays and upregulated via Smad1/5/8 phosphorylation. Id1 knockdown attenuated BMP4-induced EMT and invasion in GC cells. Moreover, Id1 overexpression in BMP4 knockdown cells restored the promotion of EMT and cell invasion. In summary, BMP4 induced EMT to promote GC metastasis by upregulating Id1 expression. Antagonizing BMP4 may be a potential therapeutic strategy in GC metastasis.

Georgi Dimchev
Apr 9, 2020; 133:jcs239020-jcs239020
Articles

Norbert Volkmar
Apr 24, 2020; 133:jcs243519-jcs243519
REVIEW

A new report from the Institute of Medicine (IOM) recommends that eight preventive health services for women be added to the services that health plans will cover at no cost to patients under the Patient Protection and Affordable Care Act of 2010 (ACA).

In response to alarming evidence of high rates of depression and suicide among U.S. health care workers, the National Academy of Medicine is launching a wide-ranging “action collaborative” of multiple organizations to promote clinician well-being and resilience.

Despite their potential, many English learners (ELs) -- who account for more than 9 percent of K-12 enrollment in the U.S. -- lag behind their English-speaking monolingual peers in educational achievement, in part because schools do not provide adequate instruction and social-emotional support to acquire English proficiency or access to academic subjects at the appropriate grade level, says a new report from the National Academies of Sciences, Engineering, and Medicine.

A systemwide change to the culture and climate in higher education is needed to prevent and effectively respond to sexual harassment, says a new report from the National Academies of Sciences, Engineering, and Medicine.

On May 10, the National Academies of Sciences, Engineering, and Medicine hosted a roundtable with senior representatives of academia, industry, and the federal government to exchange ideas about how to maximize the benefits of international science and technology collaboration while strengthening U.S. economic and national security.

The changes in brain structure and connectivity that occur between the ages of 10 and 25 present adolescents with unique opportunities for positive, life-shaping development, and for recovering from past adversity, says a new report from the National Academies of Sciences, Engineering, and Medicine.