Cardiac pacing methods for an implantable single chamber pacing system, establish an offset rate for pacing at a predetermined decrement from either a baseline rate (i.e. dictated by a rate response sensor), or an intrinsic rate. Pacing maintains the offset rate until x of y successive events are paced events, at which time the offset rate is switched to the baseline rate for pacing over a predetermined period of time. Following the period, if an intrinsic event is not immediately detected, within the interval of the offset rate, the rate is switched back to baseline for pacing over an increased period of time. Some methods establish a preference rate, between the offset and baseline rates, wherein an additional criterion, for switching from the offset rate to the baseline rate, is established with respect to the preference rate.

The present invention relates to muscle repair promoters for local application that contain a colony-stimulating factor (CSF) as an active ingredient. The muscle repair promoters of the present invention exhibit their effect at low doses, particularly when they are administered intramuscularly.

A promotional form is provided which includes a detachable element received within the surrounding margin of a base sheet, the base sheet being folded and sealed around one side of the detachable element to initially conceal a message, question or other indicia hidden until the detachable element is at least partially removed. The promotional form may include a plurality of detachable elements having correlated indicia printed on an exposed side and either on the concealed side of the element or in a portion of the opposing form section in registry with the detachable element. A game or educational piece may be inexpensively provided by correlating different indicia messages corresponding to respective detachable elements, so that in response to an initial query or instruction, a plurality of possible results may be revealed, leading in turn to an outcome revealed by removal of a further detachable element. Tampering with the form is revealed when multiple detachable elements corresponding to alternate results are removed, or the adhesive bonding the facing form sections is disturbed.

According to one embodiment, a first gene encodes a reporter protein. The first gene is disposed at the downstream of the gene promoter. A second gene is disposed at the downstream of the gene promoter and encodes a replication origin-binding protein. An internal ribosome entry site is disposed between the first gene and the second gene. The transcription termination signal sequence encodes a signal for terminating the transcription of the first gene and the second gene. A replication origin sequence is recognized by the replication origin-binding protein.

The invention relates to genes coding for TCP family transcription factors and having a biological role in the development of axillary buds and branch growth. Furthermore, the invention relates to the promoters of the transcription of said genes, to the genetic constructs containing same and to the uses thereof, including the use of agents that modulate the expression of these genes in order to modify plant architecture.

A composition to decommission firearms is presented. The composition comprises a monomer, a quantity of calcium chloride; and sulfur-containing compound. The sulfur containing compound includes sodium persulfate and/or sodium thiosulfate.

Vaporizable material is supported within a vessel to promote contact of an introduced gas with the vaporizable material, and produce a product gas including vaporized material. A heating element supplies heat to a wall of the vessel to heat vaporizable material disposed therein. The vessel may comprise an ampoule having a removable top. Multiple containers defining multiple material support surfaces may be stacked disposed within a vessel in thermal communication with the vessel. A tube may be disposed within the vessel and coupled to a gas inlet. Filters, flow meters, and level sensors may be further provided. Product gas resulting from contact of introduced gas with vaporized material may be delivered to atomic layer deposition (ALD) or similar process equipment. At least a portion of source material including a solid may be dissolved in a solvent, followed by removal of solvent to yield source material (e.g., a metal complex) disposed within the vaporizer.

Bandcamp is waiving their fees, so we're going to spotlight and promote you, our community members.

The post Operation: Help DJTT Artists – submit your Bandcamp project and we’ll promote you. appeared first on DJ TechTools.

The 16th annual African-American Male Wellness Walk takes place Saturday morning in Columbus, beginning at 7 at Livingston Park.

After Rs 11,360 crore PNB scam , another ace businessman - Vikram Kothari from Kanpur -has been accused of defaulting on repayment of more than Rs 800 crore loans from five government banks

The Group has launched a marketing campaign including digital, outdoor, television and cinema to promote the brand, the company said in a statement.

Hanung Toys and Textile Ltd owes Rs 2,300 crore from a consortium of 15 lenders led by state-owned PNB, which alone has exposure of Rs 599 crore.

Cricketer Yuvraj Singh promoted investment fund YouWeCan Ventures has invested in Mumbai-based brand licensing start-up Black White Orange Brands for an undisclosed amount.

Project management for podcasters is now available! Podcaster's Toolbox combines podcasting tools for show notes, interviews, social-media promotion, scheduling, automation, and more!

Looking to raise funds for a cause during COVID-19? Have a new album to promote? If so, your friends at All About Jazz can help. All About Jazz is currently broadcasting select livestream programs as we pivot our platform to present music performances, album release concerts, master classes, interviews, and more...

One of the hottest debates in the coronavirus pandemic is whether the malaria drugs promoted as possible treatments by President Donald Trump really work. But Americans don’t seem overly eager to help answer the question. Enrollment in several clinical trials of chloroquine and hydroxychloroquine — including two by the University of Washington — has been […]

One of the hottest debates in the coronavirus pandemic is whether the malaria drugs promoted as possible treatments by President Donald Trump really work. But Americans don’t seem overly eager to help answer the question. Enrollment in several clinical trials of chloroquine and hydroxychloroquine — including two by the University of Washington — has been […]

One of the hottest debates in the coronavirus pandemic is whether the malaria drugs promoted as possible treatments by President Donald Trump really work. But Americans don’t seem overly eager to help answer the question. Enrollment in several clinical trials of chloroquine and hydroxychloroquine — including two by the University of Washington — has been […]

One of the hottest debates in the coronavirus pandemic is whether the malaria drugs promoted as possible treatments by President Donald Trump really work. But Americans don’t seem overly eager to help answer the question. Enrollment in several clinical trials of chloroquine and hydroxychloroquine — including two by the University of Washington — has been […]

The UN Security Council plans to call for a 90-day 'humanitarian pause' in conflicts worldwide as part of the ongoing struggle against the COVID-19 pandemic. It's hoped that in some of the world's worst conflict zones, this could lay the groundwork for longer term peace agreements.

With hundreds of free activities and workshops, this curated project is a chance to learn new skills, battle boredom, and connect with like-minded people.

Spraying graffiti on heritage listed buildings is something that is usually frowned upon. But when it is done in an environmentally sound way, does no actual damage and delivers an important message about sustainability, the results are surprisingly well received.

High school students from across Australia took part in a program called Fresh Faced Friday to promote positive body image amongst teenagers.

The Duke and Duchess of Sussex throw their celebrity power behind a campaign to help children and families struggling during the COVID-19 pandemic.

According to medical experts, a condition that requires coloured glasses does not exist, yet WA and NSW teachers have attended training sessions on it.

A Newcastle pub has apologised for promoting a Wolf of Wall Street-style "midget-tossing" game during a casino-themed night later this month, saying they only planned to throw a doll, not a real person.

A pharmaceutical giant owned by the Sackler family in the United States is using flaws in regulation to push its latest product deep into regional Australia.

Government marketers are spending an increasing amount of money on bringing so-called influencers to Australia, but is it money well spent?

The Horn v Zerafa bout promoter brings in male "fight progress managers" to replace female ring card carriers, much to the Bendigo crowd's displeasure, as local councillors call the use of "ring girls" outdated and misogynist.

The national anthem has been rewritten and performed for the first time in Alice Springs by a group that says it should be more inclusive of all Australians.

The Stroke Foundation says patients with brain clots and haemorrhages are being left for hours untreated in rural hospitals which do not have the equipment or expertise to support them.

A SCREAMING 419 scammer. Maybe he is frustrated because nobody believes in the $700,000 prize money.

Actress and left-wing activist Alyssa Milano has promoted a deceptively edited video about Vice President Mike Pence that was created by late-night talk show host Jimmy Kimmel -- even though the video has been debunked and Kimmel has publicly apologized for it.

Turner And Boateng Will Oversee The Atlantic A&R Team, Joint Projects, As Well As Maintaining Their Own Artist Rosters

Clouzine Discovers And Promotes Indie Talents Part Of Discoveries (#16) Tremendous (UK), Jennifer Mlott (USA), And King Fally (Nigeria).

The industry veteran is looking to help grow the next generation of not only promoters and managers, but also entertainment lawyers, accountants, publicists and, naturally, artists.

The industry veteran is looking to help grow the next generation of not only promoters and managers, but also entertainment lawyers, accountants, publicists and, naturally, artists.

The United Way chairwoman supports BET's relief effort.

More airport operations/management academic programs at both the high school and community college levels would help the airport industry. With baby boomers currently reaching retirement age at the rate of 10,000 each day, and later generations much smaller in size, new employees are not entering the workforce swiftly enough to replace those leaving because of retirement, illness, and other complicating factors. As a result, the aviation industry, like others, is experiencing a significant labor shortage...

The TRB' Airport Cooperative Research Program's ACRP LRD 37: Legal Issues Relating to Airports Promoting Competition explores permissible means and methods of encouraging and accommodating competition at U.S. airports. It discusses the history of how competition has been addressed by government and airports and provides the context of the concentration of air carriers and fixed-base operators (FBOs), the accommodation of air carriers with differing business models, and avoiding the grant of exclusive rig...

Fibroblasts are key effector cells in tissue remodeling. They remain persistently activated in fibrotic diseases, resulting in progressive deposition of extracellular matrix. Although fibroblast activation may be initiated by external factors, prolonged activation can induce an “autonomous,” self-maintaining profibrotic phenotype in fibroblasts. Accumulating evidence suggests that epigenetic alterations play a central role in establishing this persistently activated pathologic phenotype of fibroblasts. We demonstrated that in fibrotic skin of patients with systemic sclerosis (SSc), a prototypical idiopathic fibrotic disease, TGF-β induced the expression of DNA methyltransferase 3A (DNMT3A) and DNMT1 in fibroblasts in a SMAD-dependent manner to silence the expression of suppressor of cytokine signaling 3 (SOCS3) by promoter hypermethylation. Downregulation of SOCS3 facilitated activation of STAT3 to promote fibroblast-to-myofibroblast transition, collagen release, and fibrosis in vitro and in vivo. Reestablishment of the epigenetic control of STAT3 signaling by genetic or pharmacological inactivation of DNMT3A reversed the activated phenotype of SSc fibroblasts in tissue culture, inhibited TGF-β–dependent fibroblast activation, and ameliorated experimental fibrosis in murine models. These findings identify a pathway of epigenetic imprinting of fibroblasts in fibrotic disease with translational implications for the development of targeted therapies in fibrotic diseases.

Increased microvascular permeability to plasma proteins and neutrophil emigration are hallmarks of innate immunity and key features of numerous inflammatory disorders. Although neutrophils can promote microvascular leakage, the impact of vascular permeability on neutrophil trafficking is unknown. Here, through the application of confocal intravital microscopy, we report that vascular permeability–enhancing stimuli caused a significant frequency of neutrophil reverse transendothelial cell migration (rTEM). Furthermore, mice with a selective defect in microvascular permeability enhancement (VEC-Y685F-ki) showed reduced incidence of neutrophil rTEM. Mechanistically, elevated vascular leakage promoted movement of interstitial chemokines into the bloodstream, a response that supported abluminal-to-luminal neutrophil TEM. Through development of an in vivo cell labeling method we provide direct evidence for the systemic dissemination of rTEM neutrophils, and showed them to exhibit an activated phenotype and be capable of trafficking to the lungs where their presence was aligned with regions of vascular injury. Collectively, we demonstrate that increased microvascular leakage reverses the localization of directional cues across venular walls, thus causing neutrophils engaged in diapedesis to reenter the systemic circulation. This cascade of events offers a mechanism to explain how local tissue inflammation and vascular permeability can induce downstream pathological effects in remote organs, most notably in the lungs.

Criminal Minds aired the ninth episode of season twelve last night at 9:00pm ET/PT. “Profiling 202” pulled in 7.25 million viewers and...