Autodesk vice president Brian Mathews talks with the NASA science communicator about the search for life on other planets and why it’s important

John Hopfield and Geoffrey Hinton shared the award for their work on artificial neural networks and machine learning

Sleep studies in Drosophila melanogaster rely mostly on behavioral read-outs to support molecular or circuit-level investigations in this model. Electrophysiology can provide an additional level of understanding in these studies to, for example, investigate changes in brain activity associated with sleep manipulations. In this protocol, we describe a procedure for performing multichannel local field potential (LFP) recordings in the fruit fly, with a flexible system that can be adapted to different experimental paradigms and situations. The approach uses electrodes containing multiple recording sites (16), allowing the acquisition of large amounts of neuronal activity data from a transect through the brain while flies are still able to sleep. The approach starts by tethering the fly, followed by positioning it on an air-supported ball. A multichannel silicon probe is then inserted laterally into the fly brain via one eye, allowing for recording of electrical signals from the retina through to the central brain. These recordings can be acquired under spontaneous conditions or in the presence of visual stimuli, and the minimal surgery promotes long-term recordings (e.g., overnight). Sleep and wake can be tracked using infrared cameras, which allow for the measurement of locomotive activity as well as microbehaviors such as proboscis extensions during sleep. The protocol has been optimized to promote subject survivability, which is an important factor when performing long-term (~16-h) recordings. The approach described here uses specific recording probes, data acquisition devices, and analysis tools. Although it is expected that some of these items might need to be adapted to the equipment available in different laboratories, the overall aim is to provide an overview on how to record electrical activity across the brain of behaving (and sleeping) flies using this kind of approach and technology.

Sleep is likely a whole-brain phenomenon, with most of the brain probably benefiting from this state of decreased arousal. Recent advances in our understanding of some potential sleep functions, such as metabolite clearance and synaptic homeostasis, make it evident why the whole brain is likely impacted by sleep: All neurons have synapses, and all neurons produce waste metabolites. Sleep experiments in the fly Drosophila melanogaster suggest that diverse sleep functions appear to be conserved across all animals. Studies of brain activity during sleep in humans typically involve multidimensional data sets, such as those acquired by electroencephalograms (EEGs) or functional magnetic resonance imaging (fMRI), and these whole-brain read-outs often reveal important qualities of different sleep stages, such as changes in frequency dynamics or connectivity. Recently, various techniques have been developed that allow for the recording of neural activity simultaneously across multiple regions of the fly brain. These whole-brain-recording approaches will be important for better understanding sleep physiology and function, as they provide a more comprehensive view of neural dynamics during sleep and wake in a relevant model system. Here, we present a brief summary of some of the findings derived from sleep activity recording studies in sleeping Drosophila flies and discuss the value of electrophysiological versus calcium imaging techniques. Although these involve very different preparations, they both highlight the value of multidimensional data for studying sleep in this model system, like the use of both EEG and fMRI in humans.

Gustavo Nader, professor of kinesiology and physiology in the Penn State College of Health and Human Development, has been named the Dorothy Foehr Huck and J. Loyd Huck Chair in Molecular, Cellular and Integrative Physiology by the Huck Institutes of the Life Sciences. 

Lisa Gatzke-Kopp, professor of human development and family studies, recently was named president-elect of the Society for Psychophysiological Research. The presidential role spans three years, over which she will serve as president-elect, president and past-president, each for a one-year period.

An OM Ukraine sports team member helps young Ukrainian women gain a healthier understanding and appreciation of the bodies God gave them.

Penn State Shenango Physical Therapist Assistant students and faculty recently volunteered at the Medical Equipment Recycling Program in Farrell.

Many teachers are tapped to teach physics without prior training or experience. A new study explores a possible solution.

A physical therapy clinic — staffed by students supervised by licensed professionals and offering free services to volunteer community participants in need — is planned for fall 2025 at Pennsylvania College of Technology.

David Radice, associate professor of physics and of astronomy and astrophysics, has been selected to receive a Sustainment Award from NASA to advance an open-source code called AthenaK for computational astrophysicists. The grant will provide nearly $920,000 over three years.

Pamela Pologruto has received the F.A. Davis Award for Outstanding Physical Therapist Assistant Educator. The American Physical Therapy Association recognized her achievement with this national award, only given to one recipient annually, at their honors and awards reception ceremony in Kansas City, Missouri.

Engaging in everyday physical activity has immediate benefits for brain health. Middle-aged people who participated in everyday movement showed improvement in cognitive processing speed equivalent to being four years younger, regardless of the activity's intensity level, according to a new study by researchers in the Penn State College of Medicine.

DEPARTMENT OF EDUCATION: Professional Standards Board

DEPARTMENT OF EDUCATION: Professional Standards Board

Introduction

Multiphysics is an integral part of the concepts around digital twins. In this post, I want to discuss the mechanical aspects of multiphysics in system simulations, which are critical for 3D-IC, multi-die, and chiplet design.

The physical world in which we live is growing ever more electrified. Think of the transformation that the cell phone has brought into our lives, as has the present-day migration to electronic vehicles (EVs). These products are not only feats of electronic engineering but of mechanical as well, as the electronics find themselves in new and novel forms such as foldable phones and flying cars (eVOTLs). Here, engineering domains must co-exist and collaborate to bring about the best end products possible.

Start with the electronics—chips, chiplets, IC packaging, PCB, and modules. But now put these into a new form factor that can be dropped or submerged in water or accelerated along a highway. What about drop testing, aerodynamics, and aeroacoustics? These largely computational fluid dynamics (CFD) and/or mechanical multiphysics phenomena must also be accounted for. And then how does the drop testing impact the electrical performance? The world of electronics and its vast array of end products is pushing us beyond pure electrical engineering to be more broadly minded and develop not only heterogeneous products but heterogeneous engineering teams as well.

Cadence's Unique Expertise

It's at this crossroad of complexity and electronic proliferation that Cadence shines. Let's take, for example, the latest push for higher-performing high-bandwidth memory (HBM) devices and AI data center expansion. These technologies are growing from several layers to 12, and I can't emphasize enough the importance of teamwork and integrated solutions in tackling the challenges of advanced packaging technologies and how collaboration is shaping the future of semiconductor innovation and paving the way for cutting-edge developments in the industry.

These layered electronics are powered, and power creates heat. Heat needs to be understood, and thus, the thermal integrity issues uncovered along the way must be addressed. However, electronic thermal issues are just the first domino in a chain of interdependencies. What about the thermal stress and warpage that can be caused by the powering of these stacked devices? How does that then lend to mechanical stress and even material fatigue as the temperature cycles from high to low and back through the use of the electronic device? This is just one example in a long list of many...

Cadence Multiphysics Analysis Offerings

The confluence of electrical, mechanical, and CFD is exactly why Cadence expanded into multiphysics at a significant rate starting in 2019 with the announcement of the Clarity 3D Solver and Celsius Thermal Solver products for electromagnetic (EM) and thermal multiphysics system simulations. Recent acquisitions of Numeca, Pointwise, and Cascade (now branded within Cadence as the Fidelity CFD Platform) as well as Future Facilities (now the Cadence Reality Digital Twin product line) are all adding CFD expertise. The recent addition of Beta CAE brings mechanical multiphysics to the suite of solutions available from Cadence. The full breadth of these multiphysics system analyses, spanning EM, thermal, signal integrity/power integrity (SI/PI), CFD, and now mechanical, creates a platform for digital twinning across a wide array of applications. You can learn more by viewing Cadence's Reality Digital Twin platform launch on the keynote stage at NVIDIA's GTC in March, as well as this Designed with Cadence video: NV5, NVIDIA, and Cadence Collaboration Optimizes Data Centers.

Conclusion

Ever more sophisticated electronic designs are in demand to fulfill the needs of tomorrow's technologies, driving a convergence of electrical and mechanical aspects of multiphysics in system simulations. To successfully produce the exciting new products of the future, both domains must be able to collaborate effectively and efficiently. Cadence is fully committed to developing and providing our customers with the software products they need to enable this electrical/mechanical evolution. From EM, to thermal, to SI/PI, CFD, and mechanical, Cadence is enabling digital twinning across a wide array of applications that are forging pathways to the future.

For more information on Cadence's multiphysics system analysis offerings, visit our webpage and download our brochure.

Have you ever wanted to write a DRC rule deck to check for space or width constraints on polygons? Or have you wondered how the multiple lines of an LVS rule deck extract and conduct a comparison between the schematic and layout? Maybe you've been curious about the role of rule deck writers in creating high-quality designs ready for tape-out.

If any of these questions interest you, there is good news: the latest version (v23.1) of the Physical Verification Rules Writer (PVLRW) course is designed to teach you rule deck writing. This free 16-hour online course includes audio and labs designed to make your learning experience comfortable and flexible. Whether you are new to the concept or an experienced CAD/PDK engineer, the course is structured to enhance your rule deck writing skills.

The PVLRW course covers six core modules: Layer Processing, DRC Rules, Layout Extraction, ERC and LVS Rules, Schematic Netlisting, and Coloring Rules. There are also three optional appendix sections. Each module explains relevant rules with syntax, concepts, graphics, examples, and case studies.

This course is based on tool versions PEGASUS231 and Virtuoso Studio IC231.

Pegasus Input and Output

Pegasus is a cloud-ready physical verification signoff solution that enables engineers to support faster delivery of advanced-node integrated circuits (ICs) to market.

Pegasus requires input data in the form of layout geometry, schematic netlists, and rules that direct the tool operation. The rules fall into two categories: those that describe the fabrication process and those that control the job-specific operation.

Pegasus provides log and report files, netlists, databases, and error databases as output.

Overview of Pegasus Rule File

The rule decks written in Physical Verification Language (PVL) work for the Cadence PV signoff tools Pegasus and PVS (Physical Verification System).   

The PVL rules are placed in a file that gets selected in a run from the GUI or the command line, as the user directs. PVL rules may be on separate lines within the file and can also be contained in named rule blocks.

Each line of code starts with a PVL rule that uses prefix type notation. It consists of a keyword followed by options, input layer or variable names, and output layer or variable names.

A rule block has the format of the keyword rule, followed by a rule name you wish to give it, followed by an opening curly brace. You enter the rules you wish to perform, followed by a closing curly brace on the last separate line.

  Sample Rule deck with individual lines of code and rule blocks.

DRC Rules

The first step in a typical Pegasus flow is a Design Rule Check (DRC), which verifies that layout geometries conform to the minimum width, spacing, and other fabrication process rules required by an IC foundry. Each foundry specifies its own process-dependent rules that must be met by the layout design.

There are three types of DRC rules: layer definition rules, layer derivation rules, and DRC design check rules. Layer definition rules identify the layers contained in the input layout database, and layer derivation rules derive additional layers from the original input layers, allowing the tool to test the design against specific foundry requirements using the design check rules.

A sample DRC Rule deck

A layout view displaying the DRC violations

LVS Rules

The Pegasus Layout Versus Schematic (LVS) tool compares the layout netlist with the schematic netlist to check for discrepancies.

There are two essential LVS rule sets: LVS extraction rules and comparison rules. LVS extraction rules help extract drawn devices and connectivity information from the input layout geometry data and outputs into a layout netlist. The LVS extraction rule set also includes the layer definition, derivation, extraction, connectivity, and net listing rules.

LVS comparison rules are associated with comparing the extracted layout netlist to a schematic netlist.

A sample LVS Rule deck. 

TCL, Macros, and Conditional commands

Tcl is supported and used in various Pegasus functionalities, such as Pegasus rule files and Pegasus configurator. Macros are functional templates that are defined once and can be used multiple times in a rule file. Conditional Commands are used to process or skip specific commands in the rule file.

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• On the Cadence Support portal, select Register Now and provide the requested information on the Registration page.
• You will need an email address and host ID to sign up.
• If you need help with registration, contact support@cadence.com.

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If you have questions about courses, schedules, online, public, or live onsite training, reach out to us at Cadence Training.

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Related Resources

About Knowledge Booster Training Bytes

Knowledge Booster Training Bytes is an online journal that relays information about Cadence Training videos, online courses, and upcoming webinars in the Learning section of the Cadence Learning and Support portal. This blog category brings you direct links to these videos, courses, and other related material on a regular basis. Subscribe to receive email notifications about our latest Custom IC Design blog posts.

Read this blog for an overview to the Circuit physical verification and parasitic extraction design stage in the Custom IC Design methodology and the key design steps which can help you achieve this.(read more)

Robots transporting heavy metal at a Toyota plant. Yaskawa’s robots working alongside human coworkers in factories. To advance efforts like these virtually, Rikei Corporation develops digital twin tooling to assist planning. And if that weren’t enough, diversified retail holdings company Seven & i Holdings is running digital twin simulations to enhance customer experiences. Physical AI Read Article

Strange solids called temporal metamaterials finally make it possible to investigate the controversial idea of quantum friction – and push special relativity to its limits

Alex Lupsasca plans to extend Earth's largest telescope network beyond the atmosphere with a space-based dish. It could spot part of a black hole we've never seen before – and perhaps discover new physics

Simple words like "force" and "particle" can mislead us as to what reality is actually like. Physicist Matt Strassler unpacks how to see things more clearly

Astronomer Jo Dunkley is planning to use the Simons Observatory to snare evidence for inflation, the theory that the universe expanded at incredible speed after its birth

How did the supermassive black holes we’re now seeing in the early universe get so big so fast? Astrophysicist Sophie Koudmani is using sophisticated galaxy simulations to figure it out

Daniele Oriti’s pursuit of a theory of quantum gravity has led him to the startling conclusion that the laws of nature don’t exist independently of us – a perspective shift that could yield fresh breakthroughs

Could the universe's missing matter be hiding in a "dark" extra dimension? We now have simple ways to test this outlandish idea - and the existence of extra dimensions more generally

A new equation shows a surprisingly simple relationship between pressure and the temperature needed to melt any solid substance into a liquid

Claudia de Rham thinks that gravitons, hypothetical particles thought to carry gravity, have mass. If she’s right, we can expect to see “rainbows” in ripples in space-time

Nobel prizewinning theoretical physicist Peter Higgs has died aged 94. He proposed the particle that gives other particles mass – now named the Higgs boson and discovered by the Large Hadron Collider at CERN in 2012

Researchers have used quantum light to create a magnetic field with a strength that is measured in imaginary numbers

A contentious meeting of physicists highlighted concerns, failures and possible fixes for a crisis in condensed matter physics

When I heard Stephen Hawking extol the mysteries of black holes, I knew theoretical physics was what I wanted to do. There is still so much to learn about these strange regions, says Chanda Prescod-Weinstein

Strange solids called temporal metamaterials finally make it possible to investigate the controversial idea of quantum friction – and push special relativity to its limits

While time is relative, it still flows in one direction for every observer. We don’t yet understand why, but some physicists are looking for answers that invoke the evolution of entropy, says Chanda Prescod-Weinstein

An experiment with a robot and gelatine determined that 65-micrometre-thick paper is the most prone to slicing our skin – but it can also make for a handy recyclable knife

A jiggling robot has revealed the ideal vibrating speed to free jumbled fibres

A subatomic particle called the muon caused waves when its experimental behaviour didn't align with a prediction based on the standard model. A new calculation might resolve the discrepancy – but some particle physicists are sceptical

In the quantum realm, a particle’s properties can be separate from the particle itself, including its angular momentum – which could require a rethinking of fundamental laws

In 2022, physicists were excited by hints that something was wrong with our understanding of the universe - but new results have put that in doubt

A recent atomic physics workshop was outside my dark matter comfort zone, but learning about science beyond my usual boundaries was invigorating, says Chanda Prescod-Weinstein

Simple words like "force" and "particle" can mislead us as to what reality is actually like. Physicist Matt Strassler unpacks how to see things more clearly

Daniele Oriti’s pursuit of a theory of quantum gravity has led him to the startling conclusion that the laws of nature don’t exist independently of us – a perspective shift that could yield fresh breakthroughs

Could the universe's missing matter be hiding in a "dark" extra dimension? We now have simple ways to test this outlandish idea - and the existence of extra dimensions more generally

The symbols and mathematical operations used in the laws of physics follow a pattern that could reveal something fundamental about the universe

A sprawling research program aims to improve hurricane forecasts by collecting data at the chaotic interface of ocean and atmosphere

Title: Vaping May Trigger Lung Damage Like That Seen in Emphysema
Category: Health News
Created: 8/26/2019 12:00:00 AM
Last Editorial Review: 8/27/2019 12:00:00 AM

Title: For Back Pain, Earlier Is Better for Physical Therapy
Category: Health News
Created: 8/9/2022 12:00:00 AM
Last Editorial Review: 8/10/2022 12:00:00 AM

Two decades into the era of Electronic Health Records (EHRs), the promise of streamlining clinical care, reducing burden, and improving patient outcomes has yet to be realized. A cross-sectional family physician census conducted by the American Board of Family Medicine in 2022 and 2023 included self-reported physician EHR satisfaction. Of the nearly 10,000 responding family physicians, only one-in-four (26.2%) report being very satisfied and one-in-three (33.8%) were not satisfied. These low levels of satisfaction point to the need for greater transparency in the marketplace and pressure to increase user-centric EHR design.

Purpose:

Sexual misconduct by physicians is a consequential violation of patient trust. The purpose of this study was to determine the frequency and patterns of sexual misconduct by physicians certified by the American Board of Family Medicine (ABFM).

Background:

Nested within a growing body of evidence of a gender pay gap in medicine are more alarming recent findings from family medicine: a gender pay gap of 16% can be detected at a very early career stage. This article explores qualitative evidence of women’s experiences negotiating for their first job out of residency to ascertain women’s engagement with and approach to the negotiation process.