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The World cannot wait for 30 years to have fusion clean energy, so that PULSOTRON "B" plan is designed to reach ignition in less than 3 years that is by far the fastest way as it was demonstrated by certify ignition in 2013

Get a free set of LED micro race cars with the purchase of select RC cars or boats

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The Code has expanded the definition of “employer” as well as “employee”, resulting in a broad based applicability of the regulations and is now applicable to employees in both organised and unorganised sectors.

Margaret Parker, MD, MCCM, speaks with George P. Liao, MD and Charles S. Cox, MD

VERMILION CLIFFS, Ariz. – California Condors will be released to the wild in the Vermilion Cliffs National Monument in northern Arizona at 11 a.m. Saturday, Sept. 30. The public is welcome to observe the release from a viewing area where spotting scopes will be set up and project personnel will be available to answer questions. https://www.nps.gov/grca/learn/news/public-invited-to-release-of-california-condors.htm

On December 20, 2017 a private Colorado river trip participating in a day hike up the Monument Creek drainage, discovered human remains. Investigating Rangers located evidence at the scene indicating the remains are likely those of 72 year old Raafat "Ralph" Nasser-Eddin of Los Angeles, CA. https://www.nps.gov/grca/learn/news/body-recovery-monument-creek.htm

The public invited to the 23rd annual public condor release scheduled for Saturday, Sept. 28, 2019, and witness first-hand a spectacular release into the wild of several captive-bred young condors on National Public Lands Day. https://www.nps.gov/grca/learn/news/ca-condor-release-saturday-sept-28-at-vermilion-cliffs.htm

Kroger, which is the largest supermarket chain in the US by revenue, has now given their employees two different bonuses for their work during the pandemic.

The post Hourly Workers at Largest Grocery Chain in US Are All Getting ‘Hero Bonuses’ for Their Service Amid COVID-19 appeared first on Good News Network.

"This pay bonus is just one way we are saying thank you to our colleagues and recognising that they are on the front line, helping to feed the nation"

Investigate the simmering tensions between groups of Australians that led to racially motivated violence at Sydney’s Cronulla Beach in December 2005.

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The invention relates to a process for the preparation of oligonucleotides by the following steps: reaction of a nucleoside with a phosphine derivative, reaction of the nucleotide derivative thus obtained with a nucleoside bonded to a polymeric carrier, oxidation of the carrier-bound nucleoside-nucleotide thus obtained with formation of phosphotriester groups, blocking of free primary 5'--OH groups, elimination of a protective group from the terminal 5'--OH group, where appropriate single or multiple repetition of the abovementioned steps to introduce further nucleoside phosphate or oligonucleoside phosphate units, and cleavage of the nucleoside-carrier bond and, where appropriate, elimination of all protective groups present in the oligonucleoside phosphates. The phosphine derivative used is a compound of the general formula III ##STR1## in which X and L can react with OH groups of the sugar units in the oligonucleotides, and R3 is a protective group which can be liberated by β-elimination.

The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that demonstrates enhanced efficacy along with lower liver toxicity as a result of lower lipid levels in the liver. The present invention employs low molecular weight cationic lipids with one short lipid chain to enhance the efficiency and tolerability of in vivo delivery of siRNA.

Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for generating search results. In one aspect, a method includes obtaining a transcription of a voice query, and data that identifies an accent of the voice query, submitting the transcription and the data that identifies the accent of the voice query to a search engine to generate one or more accent-influenced results of the voice query, and providing the accent-influenced results to a client device for display.

An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in SEQ ID NO: 1 to 202.

This invention relates to a process for preparing an oligonucleotide 5'-triphosphate. The process comprises the steps of: (a) synthesizing an oligonucleotide having a 5' hydroxyl moiety; (b) reacting the 5' hydroxyl moiety with a reagent of formula I: to convert the 5' hydroxyl moiety to a 5'-H-phosphonate, wherein R1 and R2 are each independently selected from the group consisting of haloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, heterocycle, and substituted heterocycle, acyl, phosphoryl, substituted alkyl acyl, substituted heteroalkyl acyl, substituted aryl acyl or substituted heteroaryl acyl, substituted alkyl phosphoryl, substituted heteroalkyl acyl, substituted aryl phosphoryl, and substituted heteroaryl phosphoryl; (c) activating the H-phosphonate of step (b) by reacting the H-phosphonate with a silylating agent, a halogenated oxidizing agent, a nitrogen-containing heteroaryl, or a combination thereof, to form an activated H-phosphonate; and (d) treating the oligonucleotide having an activated H-phosphonate from step (c) with a poly(alkylammonium)pyrophosphate.

The present disclosure provides reagents that can be used to label synthetic oligonucleotides with rhodamine dyes or dye networks that contain rhodamine dyes.

The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that demonstrates enhanced efficacy along with lower liver toxicity as a result of lower lipid levels in the liver. The present invention employs low molecular weight cationic lipids comprising at least one short lipid chain to enhance the efficiency and tolerability of in vivo delivery of siRNA.

Provided is an oligonucleotide containing an azobenzene derivative, represented by Formula (1) or (2) below: (in the formulae, A1 and A2 each independently represent a hydrogen atom, nucleotide or oligonucleotide, B1 and B2 each independently represent a hydroxyl group, nucleotide or oligonucleotide, R11 and R12 each independently represent a C1-20 alkyl group, R21 and R22 each independently represent a hydrogen atom or C1-20 alkyl group, and R13 to R18 and R23 to R28 each independently represent a hydrogen atom; a C1-20 alkyl group or alkoxy group optionally substituted with a halogen atom, hydroxyl group, amino group, nitro group or carboxyl group; a C2-20 alkenyl group or alkynyl group optionally substituted with a halogen atom, hydroxyl group, amino group, nitro group or carboxyl group; a hydroxyl group; a halogen atom; an amino group; a nitro group; or a carboxyl group).

A gaming device having a bonus game with an adjacent selection feature. In one embodiment of the present invention, the gaming device provides a plurality of adjacent player selectable selections. An award is associated with each player selectable selection. The award associated with each selectable selection is not initially displayed or revealed to the player. The player selectable selections are arranged or grouped into a plurality of associated or related selection sets. In one embodiment, each selection set has a different number of player selectable selections. In one embodiment, the related plurality of selection sets are arranged adjacent to each other to enable each player selectable selection in one set to be adjacent to at least one player selectable selection from another selection set. The player's pick in each selection set limits the available selections in the subsequent selection sets.

This invention provides recombinant DNA constructs and methods for manipulating expression of a target gene that is regulated by a small RNA, by interfering with the binding of the small RNA to its target gene. More specifically, this invention discloses recombinant DNA constructs encoding cleavage blockers, 5-modified cleavage blockers, and translational inhibitors useful for modulating expression of a target gene and methods for their use. Further disclosed are miRNA targets useful for designing recombinant DNA constructs including miRNA-unresponsive transgenes, miRNA decoys, cleavage blockers, 5-modified cleavage blockers, and translational inhibitors, as well as methods for their use, and transgenic eukaryotic cells and organisms containing such constructs.

The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions.

A system and a method of conducting games of chance with enhanced payouts based on a cash in or initial investment amount are described. In response to a player's initial investment or cash in amount, a payout schedule is selected. The larger the initial investment the better the selected payout schedule for the player. Live games of chance, games of chance facilitated by electronic gaming machines or devices and server-based games may utilize the method shown here. Players may also receive enhanced awards such as enhanced player points based on the amount of the initial investment, or based on other parameters and factors. Awards and bonuses may also be provided to players who exhaust an initial investment exceeding a threshold amount. Other different variations and combinations of the games and winnings are also explained in details.

A system and a method of conducting games of chance with enhanced payouts based on a cash in or initial investment amount are described. In response to a player's initial investment or cash in amount, a payout schedule is selected. The larger the initial investment the better the selected payout schedule for the player. Live games of chance, games of chance facilitated by electronic gaming machines or devices and server-based games may utilize the method shown here. Players may also receive enhanced awards such as enhanced player points based on the amount of the initial investment, or based on other parameters and factors. Awards and bonuses may also be provided to players who exhaust an initial investment exceeding a threshold amount. Other different variations and combinations of the games and winnings are also explained in details.

A system and a method of conducting games of chance with enhanced payouts based on a cash in or initial investment amount are described. In response to a player's initial investment or cash in amount, a payout schedule is selected. The larger the initial investment the better the selected payout schedule for the player. Live games of chance, games of chance facilitated by electronic gaming machines or devices and server-based games may utilize the method shown here. Players may also receive enhanced awards such as enhanced player points based on the amount of the initial investment, or based on other parameters and factors. Awards and bonuses may also be provided to players who exhaust an initial investment exceeding a threshold amount. Other different variations and combinations of the games and winnings are also explained in details.

A system and a method of conducting games of chance with enhanced payouts based on a cash in or initial investment amount are described. In response to a player's initial investment or cash in amount, a payout schedule is selected. The larger the initial investment the better the selected payout schedule for the player. Live games of chance, games of chance facilitated by electronic gaming machines or devices and server-based games may utilize the method shown here. Players may also receive enhanced awards such as enhanced player points based on the amount of the initial investment, or based on other parameters and factors. Awards and bonuses may also be provided to players who exhaust an initial investment exceeding a threshold amount. Other different variations and combinations of the games and winnings are also explained in details.

The invention relates to design of short oligonucleotides and analogs thereof (such as, di-, and trinucleotide compounds) useful for various therapeutic applications. It is believed that the compounds of the invention can be used as antiviral agents, anticancer agents and so on. In certain embodiments, the compounds of the invention can modulate immune-stimulatory pathways and non-TLR pathways. The invention also relates to design modified oligonucleotides for therapeutic applications, by excluding nucleotide segments having off-target effects from the modified oligonucleotides. In another aspect, the invention provides pharmaceutical compositions including one or more compounds of the invention. It is believed that the compounds and compositions as described herein have therapeutic utility against a variety of diseases, including viral diseases, autoimmune diseases (such as, allergy, asthma, and inflammatory disorders) and cancer.

In one aspect, the invention relates to a method of loading exosomes with oligonucleotide cargo, by incubating an oligonucleotide comprising one or more hydrophobic modifications with a population of exosomes for a period of time sufficient to allow loading of the exosomes with the oligonucleotide. Exosomes loaded with hydrophobic ally modified oligonucleotide cargo, and uses thereof, are also provided.

An employee at a Dunkin' (formerly Dunkin' Donuts) restaurant in Concord has inspired the company's brand-new DIY Dunkin' Donut Kits.

Norma Valkenaar asked the restaurant's franchisee, Matt Cobo, whether she could bring home some donuts, frosting, and sprinkles so that her young nephews could experiment with customizing their own treats.…

PALACE House on the outskirts of Bishop's Waltham enjoys stunning gardens and an intriguing medieval history.

Rafeef Ziadah is a Palestinian poet and human rights activist living in London. Her poem, “We Teach Life, Sir,” is powerful and poignant reminder of the human condition in conflict. On this bonus episode of Stories with a Heartbeat, host Will McInerney reflects on some of the stories from our past episodes covering the Chapel Hill Shooting in season 1. Rafeef's beautiful and moving poetry is emblematic of the legacy and the lasting message of life that Deah Barakat , Yusor Abu Salha , and Razan Abu Salha left behind. Listen to Rafeef's poem with the link below. Download the Bonus Episode Now Season 1 of the Stories with a Heartbeat podcast is over, but you can still download all the episodes today! Stories with a Heartbeat is a new podcast produced by North Carolina Public Radio and hosted by poet Will McInerney that uses poetry and storytelling to help us understand conflict. You can subscribe to this podcast on iTunes , Google Play , or your podcast platform of choice. Check out

Amin Drew Law is a Palestinian-American poet and educator based in Washington D.C. In his poem, "The Secret Weapon of Chubby Boys," Amin taps into a classic schoolyard conflict and provides a hilarious and heartwarming solution. On this bonus episode of Stories with a Heartbeat, we reflect on some of the classroom conflicts we covered in season 1 of the podcast. From the first days of elementary to college graduation, we explored the spectrum of friction at school. This week we hear from poet Amin Drew Law with a new, potent, and poetic reminder of school conflict. Download the Bonus Episode Now Season 1 of the Stories with a Heartbeat podcast is over, but you can still download all the episodes today! Stories with a Heartbeat is a new podcast produced by North Carolina Public Radio and hosted by poet Will McInerney that uses poetry and storytelling to help us understand conflict. You can subscribe to this podcast on iTunes , Google Play , or your podcast platform of choice. Follow

North Carolina is one of only two states in the US where 16 and 17 years old kids are routinely charged as adults for even the most minor offenses. This policy has serious consequences for the youth involved. In this bonus podcast episode, poet Kane Smego shares a gripping poem called, “Oh Carolina” about justice and conflict in North Carolina. Download the Bonus Episode Now Season 1 of the Stories with a Heartbeat podcast is over, but you can still download all the episodes today! Stories with a Heartbeat is a new podcast produced by North Carolina Public Radio and hosted by poet Will McInerney that uses poetry and storytelling to help us understand conflict. You can subscribe to this podcast on iTunes , Google Play , or your podcast platform of choice. Check out Kane's website to learn more about his poetry. Thanks to Torian Ugworji, Robalu Gibsun, and the VCU Ram Slam for the audio from Kane’s poem. Subscribe To This Podcast

'Top voice stars' of the 'Trolls' sequel were reportedly not told beforehand that the animated movie would be skipping theaters and premiering straight on VOD.

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This week, we talk to MF Grimm, along with his producer and group-mate Drasar Monumental. Grimm is a rapper, producer, and now an award-winning comic book writer, who is just now making some of the greatest music of his long and storied career.

After growing up in the New York City of the 70s and 80s - and making a short stint as a child actor on Sesame Street - Grimm began his hip-hop career on the city’s battle scene. He quickly gained attention, started ghostwriting for more successful acts, and was on the verge of solo stardom when he was shot and paralyzed in 1993, in an incident that also killed his brother.

Grimm recovered, and even executive produced his friend MF Doom’s 1999 solo debut Operation: Doomsday, which was recorded in the basement of Grimm’s Rockland County house. Starting in 2001, he began releasing a string of powerful solo albums that molded the ups and downs of his life into powerful artistic statements. He also moved into another medium, writing the autobiographical graphic novel Sentences: The Life of MF Grimm.

Since 2012, he has been working on the Good Morning Vietnam trilogy of albums with our second guest, producer Drasar Monumental.

See http://theciphershow.com/episode/123/ for full show notes and comments.

Richard Lutz reports on life in lockdown.

Sonuscore has announced the release of a free version of its Kontakt library Ethnic Flute Phrases, a scoring tool made to breathe life into every composition. The free Ethnic Flute Phrases library includes over 100 live recorded ethnic flute phrases, providing an expressiveness which is unachievable in traditional sampling. This freebie offers an insight into […]

The post Sonuscore offers free Ethnic Flute Phrases scoring tool for Kontakt appeared first on rekkerd.org.

Sub51 has launched a new Kontakt instrument that blends the origins of electro with 21st century drum sounds. Mechanic is designed to produce rhythmic loops that combine stunning clarity with a contemporary feel, all controlled via an intuitive, user-friendly interface. Formatted for use with NI Kontakt 6.2.2, Mechanic comes with 100 tempo sync’d loops which […]

The post Sub51 releases Mechanic for Kontakt, Komplete Kontrol and REX + Bonus Kontakt Instrument appeared first on rekkerd.org.

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The post Get ERA 4 Voice Leveler by Accusonus FREE with any purchase at Plugin Boutique appeared first on rekkerd.org.

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Myths of the Civil War and slavery are being kept alive at Confederate monuments, where visitors hear stories of “benevolent slave owners” and enslaved people “contented with their lot.”  We team up with The Investigative Fund and discover how public money is supporting this false version of history.

Plus, an artist finds herself in the middle of the creation of New Mexico’s most controversial historical monument.

Don’t miss out on the next big story. Get the Weekly Reveal newsletter today.

Myths of the Civil War and slavery are being kept alive at Confederate monuments, where visitors hear stories of “benevolent slave owners” and enslaved people “contented with their lot.”  Plus, an artist finds herself in the middle of the creation of New Mexico’s most controversial historical monument.

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*Don’t miss out on the next big story. Get the Weekly Reveal newsletter today.

News Corp. Executive Chairman Rupert Murdoch has voluntarily forgone his entire cash bonus for fiscal 2020 following the impact of the COVID-19 pandemic on the media company's financial results. Thursday, News Corp. reported a net loss of $1 billion for the third quarter, reflecting a write-down in the value of its Australian Pay-TV operator Foxtel.