16 January 2020

Triple-negative breast cancer (TNBC) is characterized by its aggressive biology, early metastatic spread, and poor survival outcomes. TNBC lacks expression of the targetable receptors found in other breast cancer subtypes, mandating use of cytotoxic chemotherapy. However, resistance to chemotherapy is a significant problem, encountered in about two-thirds of TNBC patients, and new strategies are needed to mitigate resistance. In this issue of the Journal of Biological Chemistry, Geck et al. report that TNBC cells are highly sensitive to inhibition of the de novo polyamine synthesis pathway and that inhibition of this pathway sensitizes cells to TNBC-relevant chemotherapy, uncovering new opportunities for addressing chemoresistance.

24 January 2020

UK general election has been called - polling day is on the 12th of December, and from now until then we’re going to be bringing you a weekly election-themed podcast. We want to help you make sense of the promises and pledges, claims and counter-claims, that are being made around healthcare and the NHS out on the campaign trail. This week we're...

In many countries (including the UK and Australia) it is still common practice for hospital doctors to write letters to patients’ general practitioners (GPs) following outpatient consultations, and for patients to receive copies of these letters. However, Hugh Rayner, consultant nephrologist, and Peter Rees, former Chair of the Academy of...

Invitation Only Research Event

HE Raffaele Trombetta, Italian Ambassador to the UK, Co-Host, COP 26
Archie Young, UK Lead Climate Negotiator, Cabinet Office 
Peter Betts, Associate Fellow, Energy, Environment and Resources Department, Chatham House
Chair: Professor Tim Benton, Research Director, Energy, Environment and Resources, Chatham House  

26 February 2020

Despite the ADA Council on Dental Benefits’ efforts, the practice of using automated electronic means for verifying eligibility and benefits, checking claim status or receiving and reconciling payment remains underutilized by many dental providers according to an index, said Dr. Randall Markarian, council chair.

Is Pluto a planet? The world's astronomers met in Prague last week to vote on this question, and in a sort of cosmic game of "Survivor," they voted Pluto off the solar system.

"I'm a capitalist. I believe in the system. I believe you can increase the size of the pie and you could divide it well," says Ray Dalio, founder of Bridgewater Associates. He offers wide-ranging insight and advice on how we might recover from the global economic fallout of the coronavirus crisis -- and use it as an opportunity to reform the systems that help grow our economy. (This virtual conversation is part of the TED Connects series, hosted by head of TED Chris Anderson and business curator Corey Hajim. Recorded April 8, 2020)

Districts that can screen, interview, and select candidates virtually will have less disruption to their hiring, despite how coronavirus is upending every aspect of school operations.

Some states, such as California, Kentucky and North Dakota plan to use the Every Student Succeeds Act to bolster the decision-making powers of their local school boards in the coming years.

Boys -- Psychology.

Edinburgh : printed for William Creech, 1787.

London : published by S.W. Fores, 1795.

Oxford : printed by W. Baxter, 1843.

Gianluca Finocchio, Johannes Schmidt-Hieber.

Source: Electronic Journal of Statistics, Volume 14, Number 1, 239--271.

Abstract:
Consider the Gaussian sequence model under the additional assumption that a fixed fraction of the means is known. We study the problem of variance estimation from a frequentist Bayesian perspective. The maximum likelihood estimator (MLE) for $sigma^{2}$ is biased and inconsistent. This raises the question whether the posterior is able to correct the MLE in this case. By developing a new proving strategy that uses refined properties of the posterior distribution, we find that the marginal posterior is inconsistent for any i.i.d. prior on the mean parameters. In particular, no assumption on the decay of the prior needs to be imposed. Surprisingly, we also find that consistency can be retained for a hierarchical prior based on Gaussian mixtures. In this case we also establish a limiting shape result and determine the limit distribution. In contrast to the classical Bernstein-von Mises theorem, the limit is non-Gaussian. We show that the Bayesian analysis leads to new statistical estimators outperforming the correctly calibrated MLE in a numerical simulation study.

Anja Janßen, Phyllis Wan.

Source: Electronic Journal of Statistics, Volume 14, Number 1, 1211--1233.

Abstract:
The $k$-means clustering algorithm and its variant, the spherical $k$-means clustering, are among the most important and popular methods in unsupervised learning and pattern detection. In this paper, we explore how the spherical $k$-means algorithm can be applied in the analysis of only the extremal observations from a data set. By making use of multivariate extreme value analysis we show how it can be adopted to find “prototypes” of extremal dependence and derive a consistency result for our suggested estimator. In the special case of max-linear models we show furthermore that our procedure provides an alternative way of statistical inference for this class of models. Finally, we provide data examples which show that our method is able to find relevant patterns in extremal observations and allows us to classify extremal events.

Anru Zhang, Lawrence D. Brown, T. Tony Cai.

Source: The Annals of Statistics, Volume 47, Number 5, 2538--2566.

Abstract:
We propose a general semi-supervised inference framework focused on the estimation of the population mean. As usual in semi-supervised settings, there exists an unlabeled sample of covariate vectors and a labeled sample consisting of covariate vectors along with real-valued responses (“labels”). Otherwise, the formulation is “assumption-lean” in that no major conditions are imposed on the statistical or functional form of the data. We consider both the ideal semi-supervised setting where infinitely many unlabeled samples are available, as well as the ordinary semi-supervised setting in which only a finite number of unlabeled samples is available. Estimators are proposed along with corresponding confidence intervals for the population mean. Theoretical analysis on both the asymptotic distribution and $ell_{2}$-risk for the proposed procedures are given. Surprisingly, the proposed estimators, based on a simple form of the least squares method, outperform the ordinary sample mean. The simple, transparent form of the estimator lends confidence to the perception that its asymptotic improvement over the ordinary sample mean also nearly holds even for moderate size samples. The method is further extended to a nonparametric setting, in which the oracle rate can be achieved asymptotically. The proposed estimators are further illustrated by simulation studies and a real data example involving estimation of the homeless population.

O. Collier, L. Comminges, A.B. Tsybakov.

Source: Bernoulli, Volume 26, Number 3, 1989--2020.

Abstract:
We study the problem of estimation of $N_{gamma }( heta )=sum_{i=1}^{d}| heta _{i}|^{gamma }$ for $gamma >0$ and of the $ell _{gamma }$-norm of $ heta $ for $gamma ge 1$ based on the observations $y_{i}= heta _{i}+varepsilon xi _{i}$, $i=1,ldots,d$, where $ heta =( heta _{1},dots , heta _{d})$ are unknown parameters, $varepsilon >0$ is known, and $xi _{i}$ are i.i.d. standard normal random variables. We find the non-asymptotic minimax rate for estimation of these functionals on the class of $s$-sparse vectors $ heta $ and we propose estimators achieving this rate.

Giacomo Aletti, Irene Crimaldi, Andrea Ghiglietti.

Source: Bernoulli, Volume 26, Number 2, 1098--1138.

Abstract:
This work deals with a system of interacting reinforced stochastic processes , where each process $X^{j}=(X_{n,j})_{n}$ is located at a vertex $j$ of a finite weighted directed graph, and it can be interpreted as the sequence of “actions” adopted by an agent $j$ of the network. The interaction among the dynamics of these processes depends on the weighted adjacency matrix $W$ associated to the underlying graph: indeed, the probability that an agent $j$ chooses a certain action depends on its personal “inclination” $Z_{n,j}$ and on the inclinations $Z_{n,h}$, with $h eq j$, of the other agents according to the entries of $W$. The best known example of reinforced stochastic process is the Pólya urn. The present paper focuses on the weighted empirical means $N_{n,j}=sum_{k=1}^{n}q_{n,k}X_{k,j}$, since, for example, the current experience is more important than the past one in reinforced learning. Their almost sure synchronization and some central limit theorems in the sense of stable convergence are proven. The new approach with weighted means highlights the key points in proving some recent results for the personal inclinations $Z^{j}=(Z_{n,j})_{n}$ and for the empirical means $overline{X}^{j}=(sum_{k=1}^{n}X_{k,j}/n)_{n}$ given in recent papers (e.g. Aletti, Crimaldi and Ghiglietti (2019), Ann. Appl. Probab. 27 (2017) 3787–3844, Crimaldi et al. Stochastic Process. Appl. 129 (2019) 70–101). In fact, with a more sophisticated decomposition of the considered processes, we can understand how the different convergence rates of the involved stochastic processes combine. From an application point of view, we provide confidence intervals for the common limit inclination of the agents and a test statistics to make inference on the matrix $W$, based on the weighted empirical means. In particular, we answer a research question posed in Aletti, Crimaldi and Ghiglietti (2019).

What do cucumbers, mustard, almonds and alfalfa have in common? On the surface it appears to be very little. However, there is one thing they do share: They all owe their existence to the service of bees. There is more to the tiny striped helper than sweet honey and a painful sting. For millennia, it has carried out its service [...]

The U.S. Department of the Treasury will issue significantly more debt than the market had expected in the wake of...

The post What The 20-Year Bond Means for Interest Rate Markets appeared first on OpenMarkets.

It matters not if we are from 200 countries; we are one in Christ and shall be for eternity. OMNI-team member Greg Kernaghan about ‘globalisation’.

"In order to fulfil our mandate, there are several needs we must invest in," says Stephan Bauer.

Next week, Nicola Sturgeon is promising to outline her proposals for lifting the lockdown. Good luck with that. She is unlikely to open the schools because she can't rely on parents to send their children.

Your cheat sheet to the ESEA rewrite's teacher provisions.

Primary care providers (PCPs) identify patients with undescended testis (UDT) and refer them to surgical specialists. Referral beyond the recommended times for orchiopexy has been reported, and PCPs' accuracy in identifying and distinguishing UDTs from retractile testes has been questioned.

We describe 3 observations that are strongly correlated with UDT, that is, birth history of UDT, prematurity, and visible scrotal asymmetry. UDT diagnoses are best made by 8 months of age, to reduce confusion with testicular retraction and to facilitate timely orchiopexy. (Read the full article)

An executive order signed this week is meant to address concerns of anti-Semitism on college and university campuses. But the legal underpinnings of that order apply to elementary and secondary schools, too.

Property experts weigh in on the Monetary Policy Committee of the SA Reserve Bank's decision to lower interest rates.

After considering the evidences and conclusions in previous trials, the Court could not establish that the Trial Courts or the High Court were wrong in holding the case against the appellant. Implied consent for the trainer to fly an aircraft do not apply here, as there were telephonic signals sent to the aircraft, to bring it back. Wrongful gain can be mere unlawful acquisition of a property, creating ‘temporary’ loss to the Government. The circumstances conclude both the essential ingredients of theft – absence of consent and unlawfulness of means. From the factual analysis, the Court concludes that the wrongful gain and loss were intentional. However, considering that the appellant has already undergone imprisonment, his sentence was modified to the period already undergone. The appeal was dismissed while maintaining the conviction.

The news that Ronaldo '"Jacare" Souza, plus his two cornermen, tested positive for coronavirus couldn't have come at a worse time for the UFC, who had done everything they could to mitigate risk ahead of UFC 249.
Read Full Article at RT.com

Hi Team, I am from Delhi. The issue is as subjected. My brothers got the NOC signed just after the death of my father (in 1981) and, claimed to transfer property to Mother’s name. Now, when our Mother died recently (Feb’2020), I got to know that they have transferred the property in their names (2 person) already. But, they have not informed me. Please suggest if I can claim my share.

From redesigning logo to driving digital campaigns, brands are adapting to the situation by driving sensitive and timely campaigns

Let’s review a key characteristic feature of Cadence Liberate AMS Mixed-Signal Characterization that offers to you ease of use along with many other benefits like automation of standard Liberty model creation and improvement of up to 20X throughput.(read more)

Cine-UK Limited v Union Square Developments Ltd [2019] CSOH 3 A landlord and tenant couldn’t agree revised rent due in terms of a rent review. An expert surveyor was appointed to determine the issue in accordance with the provisions of the lea...

On 12 August this year, the Insurance Act 2015 will introduce the most significant changes to insurance law in 110 years – how will it affect the shipping industry? The Act applies to all insurance policies taken out by businesses which are subject ...

The European Data Protection Board (EDPB) has published a set of guidelines (in draft) for public consultation. These will be absolutely key to providers of online services, such as social media, e-commerce, internet search engines, communication an...

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(MENAFN - Jordan News Agency) Amman, May 9 (Petra)- Minister of Planning and International Cooperation, Dr. Wissam Rabadi, discussed with the British ... ......

His New York City hospital has been all pandemic, all the time. ......

Is the Leaving Cert cancelled or postponed?

The current coronavirus pandemic can offer insight into how to shake-up traditional methods of data collection, and might provide an opportunity to do it in more innovative ways, in turn enhancing progress towards gender equality. “Necessity is the mother of invention, and when you look at society’s crisis – whether that’s a health crisis or […]

The post Q&A: COVID-19 Means we Must Innovate Data Collection, Especially on Gender appeared first on Inter Press Service.

The Asia and Pacific region is aging rapidly, and that is affecting the region’s workforce, but increased longevity is adding an unexpected element to the picture

The dust has settled on the elections drama and the BJP is now firmly in the driver’s seat. By and large, this is being seen as the best possible news for the Indian real estate sector – and rightly so. Narendra Modi has the business mind-set, background and also determination which are called for to bring India’s entire economy back on track. What the real estate sector now awaits is his policy approach to the issue of housing in India. Now, as the country stands poised on the verge of a major change in economic climate, it is a good time to reflect on why boosting the housing sector is […]