Royal Bermuda Regiment divers are to join forces with an environmental watchdog to help protect the Island’s reef system. And the Regiment and the Bermuda Reef Ecosystem Analysis and Monitoring Programme [BREAM] appealed for volunteer divers and snorkelers to join them in a major reef mapping programme at Elbow Beach in Paget on Sunday. The […]

Mapping Black London — which is led by Northeastern University and aims to “visualise the multi-racial foundations and histories of London and the UK” — has created an interactive map chronicling the life of Bermudian Mary Prince. The organization said, “This exhibit traces the life of Mary Prince through the locations she described in her […]

Show your love for Mother Earth this Earth Day! For the month of April, take 20% off our entire line of World maps. All proceeds from the sale will go to support the Society’s many worldly causes. Use code EARTHLOVE09.

Take 20% off All World Maps!
1. Visit natgeomaps.com/vip
2. Register with your email address and the code above in the "New Member Registration" area.
3. Enter the required information and create an account.
BUY NOW ›

National Geographic’s Maps Division and Center for Sustainable Destinations teamed up to produce the first NG-developed Online Geotourism MapGuide to support sustainable tourism across the Greater Yellowstone region of Wyoming, Montana, and Idaho.

The site, http://www.yellowstonegeotourism.org/, which launched on March 31st, is open to anyone to discover and share information about unique features, tours, and businesses that best represent and sustain the natural and cultural character of the region. Visitors can also request a free print MapGuide.

Geotourism is the kind of travel that sustains or enhances the geographical character of a place — its environment, culture, aesthetics, heritage, and the well-being of its residents. Online Geotourism MapGuides are web versions of the print maps that National Geographic has developed for a number of regions around the world, including Crown of the Continent, Baja California, and Vermont’s Northeast Kingdom to name a few.

In addition to producing print and/or web maps, these projects bring together diverse representatives from the local communities to collectively define what makes their region special and how best to communicate it to the rest of the world. NG Maps is excited to participate in these projects that help travelers and local communities discover and preserve special places around the world. Anyone interested in developing a Geotourism MapGuide for their region, or simply becoming a “Geotraveler” should visit http://www.nationalgeographic.com/travel/sustainable/.

As college campuses across the country close for summer recess, we know of a few students heading home that are perhaps a little happier because their maps earned awards. National Geographic sponsors several map awards
(see http://natgeomaps.com/mapawards) to reward student innovation—so far six students have won this year:

Ben Coakley, University of Wisconsin-Madison, Scheduled Service on Small Airlines in Canada, Summer 2008.
Daniel Huffman, University of Wisconsin-Madison,
Rising Skyline: The Tallest Buildings in Europe, 1875-2007.

Mathieu Noble, Centre of Geographic Sciences (COGS), Nova Scotia Community College (NSCC), King of Coal.




Wes Jones, Centre of Geographic Sciences (COGS), Nova Scotia Community College (NSCC), Annapolis Royal Historic Gardens.
Cindy Prostak, Centre of Geographic Sciences (COGS), Nova Scotia Community College (NSCC), St. John’s, Newfoundland and Labrador.

This is "one gift I will definitely keep," President Obama said when he was presented with a National Geographic Society map cabinet at the White House.

Visit the NATGEO NEWS WATCH Blog by News Editor David Braun for the full story: http://tinyurl.com/ncmdqy












Photos courtesy of The White House

Since our inception as a division of the National Geographic Society in 1915, National Geographic Maps (originally the Cartographic Division) has routinely published maps that illustrate the news of the world. Our first supplement map, which appeared in the May 1918 issue of NATIONAL GEOGRAPHIC, titled the Western Theatre of War, served as a useful reference for overseas military personnel and soldier's families alike. Similarly our February 1967 map of Vietnam, Cambodia, and Laos, and recently, our Iraq and the Heart of the Middle East titles filled similar roles.

Maps are an excellent tool for the newshound, providing an accurate sense of place to issues local and abroad. To assist those that are interested in further understanding global news stories through good maps - we're pleased to announce a new monthly feature here on Contours that will highlight maps pertinent to today's news stories.

:: December 2009, Maps of the News ::

Afghanistan and Pakistan. Revised in Fall of 2009, this political map of the region contains thousands of place names, ideal for following news stories and deployed family members. Like all National Geographic cartography, our new Afghanistan and Pakistan map was carefully researched and edited and contains thousands of place names.

Iraq, Iran and the Middle East. This region dominates daily news stories. Our Middle East wall map covers over 18 nations in the region including: Iran, Iraq, Afghanistan, Pakistan, Syria, Jordan, and more.

Philippines. Follow the recent eruption of the Mayon volcano in the Philippines, with our Asia classic and executive style wall maps for the continent.

Vancouver and the Winter Olympics. A detailed city guide, perfect for global travelers attending the 2010 Winter Olympics.

January has been a big month for global news. From the devastating earthquake in Haiti to the damaging storms throughout the US which brought mudslides to California and snow to Florida.

On a more positive side, the Winter Olympics in Vancouver start in just 16 days, with opening ceremonies taking place on February 12th.

To illustrate these stories and more - here are this month's suggested National Geographic Maps:

Haiti::
West Indies Two-Sided Wall Map:: Has a political map of the Caribbean, including Haiti. For a historical perspective on the region, NATIONAL GEOGRAPHIC published three different supplement maps in 1913, 1922, and 1947 which specifically detailed the Caribbean region. These maps are available via our NG Map Collection Website - simply search for "caribbean".

US Weather::
National Geographic has a wide variety of US wall maps. Our most popular two titles are our US Clasic and US Executive editions. Both maps come in a variety of sizes and formats including enlarged and laminated. Additionally we started publishing a new series of State specific wall maps last year, and have released 8 States so far, including California.

Winter Olympics::
For those lucky enough to be heading to Vancouver to attend the 2010 Winter Olympics, be sure to carry along our Destination Vancouver city travel map. Updated in 2009, the Vancouver city map contains a detailed and easy to read street map with the locations of points of interest, hotels, public transportation and more.

Check back in a few weeks for our February installment of "Maps of the News". Additionally, we love your questions and comments. If you have a place or news story that you're looking for a map of, feel free to post a comment below, or connect with us on twitter @NatGeoMaps.

For those actively following the World's news, here is our monthly quick reference to National Geographic maps which add perspective to today's news stories.

WORLD

The 8.8 Magnitude earthquake in Chile, has left substantial devastation to the port town on Concepcion and left thousands homeless in the Capital city of Santiago. Our recently updated South America Wall Map contains place names for most major and secondary cities, plus physical features, and major transportation networks.



When I first heard about the Tsunami threat for the Hawaiian Islands, Australia, Japan and the islands of the Pacific on Saturday, I turned to our World Pacific Centered wall map. Unlike the wall map you likely had hanging in your classroom, which was Atlantic Ocean centered, our Pacific Centered edition provides a seamless view of the entire Ocean. This different perspective made it easier to understand the path of the Tsunami waves and helped clarify why places such as the California, Oregon and Washington coasts were under the warning as well.

Beyond the Chilean earthquake, this winter seems especially harsh, and on Sunday, France and four other countries were battered by a deadly storm named "Xynthia". In its wake the storm left 51 dead, millions without power, and generated extensive property damage throughout the region. Winds in excess of 130MPH were recorded over the Pyrenees with 100 MPH gusts along the Atlantic coast. National Geographic has a collection of up-to-date reference maps for most of the countries in Europe including: France, Belgium & The Netherlands, Spain & Portugal, and Germany. Additionally we recently revised our Europe wall map, which is available in several styles.


US

Here on the home front, winter weather continued to make headlines last week with the Northeast receiving another record breaking snowfall. National Geographic publishes a wide variety of United States Wall Maps, varying in style, size, and format that will assist with following nearly any US based news story.

The Tsunami warning for the Hawaiian Islands last Saturday had me turning to one of our most beautiful wall maps, The Hawaiian Islands, which exposes the dramatic terrain of the ocean floor around the island chain.




SPORTS

Now that the Winter Olympics have concluded, it's time to turn our eyes south to Arizona and Florida as MLB Spring Training kicks off today. If you're heading to watch any of the games, we have two useful maps for your glovebox, the Florida State Guide Map and the Arizona State Guide Map. Both maps have up-to-date road networks for the State, plus detailed inset maps for the major cities, like the Spring Training hubs of Tampa, Ft. Myers, Scottsdale and Tucson. While I'm a big fan of GPS for turn-by-turn directions, sometimes its just a little faster to use a real map, and you certainly get a better perspective of what's ahead when on a road trip.



As always - we love to hear your comments, questions and ideas for future posts.

Five new National Geographic maps complete coverage of Washington Cascades

Published: Tuesday, September 07, 2010, 3:15 AM
Terry Richard, The Oregonian
Washington's Cacades are covered.

With the release of five new maps this summer by National Geographic, the rugged mountains of Washington are covered from the British Columbia border to Oregon.

The maps are sold under the Trails Illustrated brand.

New titles this year area Mount St. Helens/Mount Adams, Goat Rocks/Norse Peak/William O. Douglas Wilderness Areas, Alpine Lakes Wilderness, Glacier Peak Wilderness and Mount Baker/Boulder River Wilderness Areas.

They go along with several other titles already in print to complete the coverage: North Cascades National Park, Mount Rainier National Park and Columbia River Gorge National Scenic Area.

The full-color maps are printed on hefty water-proof, tear resistant paper. National Geographic is one of the best mapmakers in the business, so the maps meet the highest standards.

The maps are topographical, but they cover such a large area that the contour interval is 50 feet. This is a little too big for serious off-trail mountain navigation, but National Geographic also sells state map series on CD Roms under the Topo brand with 20-foot contour intervals.

The new printed maps maps are excellent for hiking and driving. They show most of the trails and most of the roadside amenities, in easy-to-read formats.

Your map files may already contain U.S. Forest Service maps of the areas, but these maps often go 15 years or more between updates. The new Nat Geo maps are the best new maps at this time for the areas they cover.

Look for them at stores that sell maps, though getting this many new titles in any particular store may be difficult.

One place that does have them all is the Nature of the Northwest in Portland, at 800 N.E. Oregon St., Suite 965. Phone number is 971-673-2331.

You can also order them from National Geographic. Cover price is $11.95. For more information visit Trails Illustrated Washington maps.

-- Terry Richard

National Geographic Maps & Satmap Systems

Announce Alliance to Deliver Digital Mapping for Handheld Sports GPS

For the first time, National Geographic’s suite of Trails Illustrated, TOPO! and Adventure maps are made available on a handheld GPS; Satmap Active 10 TREK Launches in the U.S. this week.

November 17, 2010 - London, England... National Geographic Maps and Satmap Systems today announced the integration of the best-selling National Geographic outdoor recreation maps into the award-winning Satmap Active 10 handheld GPS. This integration is the result of a new product development alliance between the two organizations, both of which will launch the Active 10 TREK for sale in the United States this week.

The content offered on Satmap devices will include the complete line of National Geographic outdoor recreation maps, including the TOPO! USGS topographic map series, the AdventureMap series of international adventure travel maps, and, for the first time on any GPS, National Geographic’s premier Trails Illustrated series of maps for national parks, national forests and many popular recreation areas. National Geographic maps will be available via SD-Cards, which will plug-and-play into the Active 10 TREK handheld GPS.

The alliance brings together the mapping excellence of National Geographic with the engineering expertise of Satmap Systems Ltd., and the result is a product that meets the needs of outdoor enthusiasts. The Active 10 TREK will suit users of all skill levels in all weather conditions throughout the year. It has gained wide acceptance in Europe with outdoor professionals and consumers engaged in various activities such as mountain rescue, hiking, mountain biking, hunting and geocaching.

Charlie Regan, general manager and vice president, National Geographic Maps, said: “National Geographic prides itself on publishing the best maps, whether for outdoor recreation, education, travel or reference. We are pleased to announce this alliance with Satmap and are eager to see outdoor enthusiasts and professionals begin using the Active 10 TREK to guide them on their adventures. Satmap’s sterling reputation and the critical acclaim that their Active 10 has garnered in Europe made the decision to partner, as they expand into the U.S. market, an easy one.”

Richard Calthrop-Owen, managing director of Satmap Systems, commented: “We are really excited about launching into the U.S., especially with such a globally respected brand as National Geographic. This alliance is good news for everyone who spends time in the great outdoors, and this is a major product first. The Active 10 TREK, combined with the superb National Geographic map data, gives users the freedom to focus on the enjoyment of their sport rather than worrying about location. Accurate navigation is an essential part of enjoying the outdoors, and this quality of map detail will help users to keep on track and stay safe.”

Fourteen TOPO! USGS-based SD Map Cards will be available at launch, covering many popular outdoor recreation states including Arizona, California, Colorado, Idaho, the Mid-Atlantic region, Montana, Nevada, New England, New Mexico, North and South Carolina, Oregon, Utah, Washington and Wyoming. SD Map Cards for the remaining states and regions will be released in the first quarter of 2011. Three additional Trails Illustrated SD Map Cards also will be part of the initial offering, covering California’s Sierra Nevada, the Southern Appalachians and America’s “Greatest National Parks.” New Trails Illustrated Map Cards featuring some of the most important recreational areas in the country will be available in the coming months.

In addition to recreation users, Satmap Systems Ltd. supplies GPS handsets to search and rescue teams, police, military and other professionals in Europe, giving the company a unique insight into and understanding of the needs of outdoor users. Central to this is the need to see the best quality mapping possible on a large screen in a handheld device that is rugged and user friendly.

The Active 10 TREK

The Active 10 TREK comes pre-loaded with World and USA Base Maps. Customers can then buy the National Geographic SD Map Cards that slot into the GPS, making map reading fast and easy. The map is displayed on a large 3.5” screen in full color suitable for day and night use, including a red backlight option to help protect night vision.

The Active 10 TREK is priced at $369.99, and the National Geographic SD Map Cards cost $99.99 each. Customers also can purchase topographical mapping for most countries in Western Europe, making the GPS useful for home and when travelling abroad. There is a range of high-quality accessories such as Bike Mount, Vehicle Mount and a Deluxe Carry Case, which retail from $14.99.

The Active 10 TREK and National Geographic SD Map Cards will be sold online at www.shopng.com, www.satmap.com, www.topo.com, and www.amazon.com and will be available at premier outdoor retailers nationwide in the upcoming months.

Frank Biasi, Director, Conservation and Special Projects
National Geographic Maps

We all know (or should know!) that geography is the study of the Earth and its lands, features, inhabitants, and phenomena. This breadth of fascinating subjects is what led me to become a geographer 25 years ago. The sub-discipline of cartography allowed me to combine my earlier interest in visual art with my newfound passion for geography. I was lucky to come of age early in the growth of computer mapping technologies, including Geographic Information Systems (GIS). Seeing the potential of GIS to make a difference in the world and to build a career, I quickly jumped on that bandwagon.

I first used GIS to do maps and analysis for geography courses, and to inventory property parcels around my campus as part of an internship. After graduation, I worked for a regional planning agency to help design transportation corridors that maximize business opportunities and minimize environmental impacts. I went on to work for a state environmental agency where I helped to map all of the wetlands in Massachusetts to aid in the permitting of development and construction projects.

I further developed my geographic thinking and skills working for The Nature Conservancy, where I used GIS to help conservation planners and preserve managers map biodiversity and design and execute ways to save it. I realized that conservation, as with many other fields, deals with a wide variety of systems operating across the landscape, including biological, geological, hydrological, climatological, political, transportation, and economic systems. GIS provides a powerful platform to create and combine data layers representing each of these systems in order to make maps and answer questions about the world. Seeing these maps and answering these questions helps organizations across all sectors make informed decisions about what to do and where to do it.

Recently, we as individuals have begun using simple GIS tools on our PCs and mobile phones to make maps and answer spatial questions to help us decide where to eat, shop, travel, and invest. The growing phenomena of geo-browsing and geo-searching are enabled by interactive mapping services by Google, Microsoft, Yahoo, MapQuest, and others. These services are becoming increasingly personalized through GPS-enabled mobile phones and apps that tell us who and what is near us, wherever we are. The initial applications of these services have been for commercial and social uses. However, they can also help us discover and decide how we can make a positive difference in the world.

Many people are unaware of the fact that there are hundreds of thousands of dedicated nonprofit organizations working around the world to reduce human suffering, protect wildlife and ecosystems, preserve cultures, and advance scientific knowledge. These heroic people and organizations are stepping in to fill critical gaps that governments and businesses are unable or unwilling to fill. Most of the organizations have very limited financial and human resources to accomplish their objectives, yet they still manage to make an enormous difference in the lives of people, animals, and society at large.

At National Geographic, we have begun an initiative called the Global Action Atlas to highlight the work of these heroic nonprofits, and to give our audience tangible opportunities to discover and get involved in this work by donating, volunteering, advocating, visiting, and sharing with their social networks. Although it is still a beta site, ActionAtlas.org has over 400 on-the-ground projects by more than 100 reputable nonprofits around the world. Users can browse projects on an interactive global map or by themes including Conservation, Humanitarian, Cultures, Exploration, Climate Change, and Energy. They can also enter keywords to get a list of relevant projects in the U.S and around the world.
Every project has an interactive profile where the organization summarizes the issues the project is working to address, their goals, and the progress being made. They also include photos, videos, documents, blogs, maps, links to more information, and lists of similar and nearby projects. Once a user has found a project that interests them, they can become a fan or comment on the project, as well as donate, volunteer, visit, or share the project with their Facebook friends. Users can build up a portfolio of their favorite projects to follow and interact with over time, thus establishing their own “Geography of Action.” We plan to add thematic layers to the map viewer such as infant mortality, biodiversity, and cultural hotspots to help people decide where they should invest their time and resources in making a difference.

We hope that the Global Action Atlas provides the public a useful and trusted service that advances National Geographic’s mission of “inspiring people to care about the planet,” by enabling them to turn inspiration into action. Over the past century National Geographic’s writers, photographers, and filmmakers have richly documented places and cultures and the challenges facing communities and the planet. Our Mission Programs have funded thousands of field-based projects to understand and conserve wildlife and cultures and advance the frontiers of science. The Global Action Atlas is the beginning of a new effort to deeply engage our audience in this wonderful, but challenged world, and to help them become active participants in making it more wonderful.

As a result of the devastating earthquake in Japan early this morning, National Geographic has received requests for maps that show the impacted region. Below is a complete list of titles that are currently available:

1. Japan and Korea Wall Map

2. World Ocean Floor Wall Map

3. Hawaii State Wall Map

4. Alaska State Wall Map

4. World Classic Pacific Centered

5. Oregon State Wall Map

6. California State Wall Map

7. Washington State Wall Map

As this event further unfolds, we shall update the map resources list accordingly.

Cold Fusion 9 Mappings I have been trying to tackle this problem for some time now and have had little to no success with mapping directories directly in the Application.cfc. Trying to extend the Application.cfc seems to be an answer at this time, but not sure just yet. A particular post brought about the ideal […]

Our Blogging Delay Update First off, if anyone who is a subscriber has been wondering why the news letter has been the same for about two months now, it has been because of being extremely busy. There has been an extensive amount of work being completed elsewhere for another company over the last few months. […]

Free Sitemap Creation Considering all the available resources for creating sitemaps, this one is the best around as far as I am concerned. I personally have tinkered around with several sitemap programs and multiple sitemap generators online. Some charge for these services but there are plenty of free resources available online. The option is yours. […]

Well, let me start off by saying thing’s have been busy since the last post back in early November. Most of my time and focus has been spent updating websites to HTML5 code. So my apologize for the long delay of writing. There is still plenty of updating to complete so it could be a […]

You've certainly heard of the Tacoma Narrows Bridge, but have you heard of the Nutty Narrows Bridge? Futility Closet introduces us to this bridge that was built in 1963 in Longview, Washington.

Workers in an office building near the R. A. Long Park noticed a number of squirrels that were killed crossing the street from the park to an area with abundant nut trees. They proposed that the city build a bridge for them. Two local architects and an engineer designed the bridge, and it was built by contractor Amos Peters. He built the bridge with recycled aluminum piping and a recycled fire hose, for a total cost of a thousand dollars. The bridge is 60 feet long and 22 feet high over the street. A city councilwoman named it the Nutty Narrows Bridge. The bridge has since been removed and repaired several times, and the location has been changed slightly a couple of times. The squirrels love it and use it regularly. The tourist attraction is known as "the world's narrowest bridge," and inspired the city to launch their annual Squirrel Fest in 2011. The bridge was placed on the National Register of Historic Places in 2014. -via Nag on the Lake  

(Image credit: SounderBruce)

Research by Princeton scholars at the Atacama Cosmology Telescope collaboration has culminated in a significant breakthrough in understanding the evolution of the universe.

Two projects — one that maps the function of the brain’s neuronal network in unprecedented detail and another that combines robotics and light-based computer circuits to create safe self-driving vehicles — have been awarded funding through Princeton’s Eric and Wendy Schmidt Transformative Technology Fund.

An international team of researchers and gamers, led by Princeton’s Mala Murthy and Sebastian Seung, mapped every neuron and every synaptic connection in an adult fruit fly's brain, building a comprehensive “connectome” that represents a massive step toward understanding the human brain.

This workshop will introduce participants to the primary features of ArcGIS StoryMaps and the necessary preparation to publish an effective StoryMaps project. As a member of the Princeton community, you have access to ArcGIS Online and its many apps like StoryMaps. Skills taught or addressed include: pairing maps, multimedia, and text; geolocation; embedding content; digital map making; using ArcGIS templates and layouts; digital storytelling strategies. Please bring a laptop. If you have not already activated your Princeton ArcGIS Online account, you are encouraged to do so beforehand.

An anonymous reader quotes a report from 404 Media: Flock is one of the largest vendors of automated license plate readers (ALPRs) in the country. The company markets itself as having the goal to fully "eliminate crime" with the use of ALPRs and other connected surveillance cameras, a target experts say is impossible. [...] Flock and automated license plate reader cameras owned by other companies are now in thousands of neighborhoods around the country. Many of these systems talk to each other and plug into other surveillance systems, making it possible to track people all over the country. "It went from me seeing 10 license plate readers to probably seeing 50 or 60 in a few days of driving around," [said Alabama resident and developer Will Freeman]. "I wanted to make a record of these things. I thought, 'Can I make a database of these license plate readers?'" And so he made a map, and called it DeFlock. DeFlock runs on Open Street Map, an open source, editable mapping software. He began posting signs for DeFlock (PDF) to the posts holding up Huntsville's ALPR cameras, and made a post about the project to the Huntsville subreddit, which got good attention from people who lived there. People have been plotting not just Flock ALPRs, but all sorts of ALPRs, all over the world. [...] When I first talked to Freeman, DeFlock had a few dozen cameras mapped in Huntsville and a handful mapped in Southern California and in the Seattle suburbs. A week later, as I write this, DeFlock has crowdsourced the locations of thousands of cameras in dozens of cities across the United States and the world. He said so far more than 1,700 cameras have been reported in the United States and more than 5,600 have been reported around the world. He has also begun scraping parts of Flock's website to give people a better idea of where to look to map them. For example, Flock says that Colton, California, a city with just over 50,000 people outside of San Bernardino, has 677 cameras. People who submit cameras to DeFlock have the ability to note the direction that they are pointing in, which can help people understand how these cameras are being positioned and the strategies that companies and police departments are using when deploying them. For example, all of the cameras in downtown Huntsville are pointing away from the downtown core, meaning they are primarily focused on detecting cars that are entering downtown Huntsville from other areas.

Read more of this story at Slashdot.

In some parts of the capital, protesters negotiated with police. In other parts there was no talking.

Mozambique is on a knife's edge as young people continue to protest against the outcome of the October elections that extended 49 years of Frelimo rule.

Amid calls for ongoing protests after violent clashes on Thursday, South Africa's High Commissioner to Mozambique Siphiwe Nyanda has declared "Maputo is almost under siege".

The “Reading Peaceniks” The authors of this article are a group of researchers and practitioners who are looking to end the divisiveness of the “reading wars” — and help children learn to read and write with competence and pleasure. See the list of contributing editors as well as the 25 nationally recognized colleagues who support this effort.

President Cyril Ramaphosa's lawyers say former spy boss Arthur Fraser's claims about the Phala Phala break-in are like something from a movie - but are founded on nothing more than baseless speculation.

The human cardiovascular system has adapted to function optimally in Earth's 1G gravity, and microgravity conditions cause myocardial abnormalities, including atrophy and dysfunction. However, the underlying mechanisms linking microgravity and cardiac anomalies are incompletely understood. In this study, we investigated whether and how calpain activation promotes myocardial abnormalities under simulated microgravity conditions. Simulated microgravity was induced by tail suspension in mice with cardiomyocyte-specific deletion of Capns1, which disrupts activity and stability of calpain-1 and calpain-2, and their WT littermates. Tail suspension time-dependently reduced cardiomyocyte size, heart weight, and myocardial function in WT mice, and these changes were accompanied by calpain activation, NADPH oxidase activation, and oxidative stress in heart tissues. The effects of tail suspension were attenuated by deletion of Capns1. Notably, the protective effects of Capns1 deletion were associated with the prevention of phosphorylation of Ser-345 on p47phox and attenuation of ERK1/2 and p38 activation in hearts of tail-suspended mice. Using a rotary cell culture system, we simulated microgravity in cultured neonatal mouse cardiomyocytes and observed decreased total protein/DNA ratio and induced calpain activation, phosphorylation of Ser-345 on p47phox, and activation of ERK1/2 and p38, all of which were prevented by calpain inhibitor-III. Furthermore, inhibition of ERK1/2 or p38 attenuated phosphorylation of Ser-345 on p47phox in cardiomyocytes under simulated microgravity. This study demonstrates for the first time that calpain promotes NADPH oxidase activation and myocardial abnormalities under microgravity by facilitating p47phox phosphorylation via ERK1/2 and p38 pathways. Thus, calpain inhibition may be an effective therapeutic approach to reduce microgravity-induced myocardial abnormalities.

Defining discontinuous antigenic epitopes remains a substantial challenge, as exemplified by the case of lipid transfer polyproteins, which are common pollen allergens. Hydrogen/deuterium exchange monitored by NMR can be used to map epitopes onto folded protein surfaces, but only if the complex rapidly dissociates. Modifying the standard NMR-exchange measurement to detect substoichiometric complexes overcomes this time scale limitation and provides new insights into recognition of lipid transfer polyprotein by antibodies. In the future, this new and exciting development should see broad application to a range of tight macromolecular interactions.

From local to global: A roadmap for US climate action 14 April 2021 — 6:30PM TO 8:00PM Anonymous (not verified) 28 March 2021 Online

Ahead of Biden’s Earth Day Summit, panellists discuss a range of climate issues, from city-level climate management to the international security implications of climate deals.

On their first day in office, the Biden-Harris administration sent a strong message to Americans and allies by rejoining the Paris Agreement. Experienced climate and environmental leaders were appointed to senior leadership roles as part of a ‘whole of government approach’ to climate action.

Although decisive action is welcomed by many Americans and international partners, the divided domestic perspectives on climate and a changed international landscape pose significant challenges.

Ahead of the Earth Day Summit on April 22, an event hosted by Joe Biden to mark America’s formal return to global climate talks, panellists discuss a range of climate issues, from city-level climate management to the international security implications of climate deals.

• How will post-COVID domestic priorities and policy influence the international approach of the US to climate action?
• How will US policy, both foreign and domestic, need to respond to the security and geopolitical elements posed by climate change?
• What actions are needed during the upcoming Earth Day Summit for the US to establish credibility as a climate leader?
• What shape are key debates taking on US-China climate relations ahead of COP 26, and how might climate issues be approached in relation to wider geopolitical tensions?

Christoforos Neofytidis
Trans. Amer. Math. Soc. 377 (), 5289-5321.
Abstract, references and article information

Rubén Medina and Andrés Quilis
Proc. Amer. Math. Soc. 152 (), 5137-5148.
Abstract, references and article information

Intrinsically disordered protein domains often have multiple binding partners. It is plausible that the strength of pairing with specific partners evolves from an initial low affinity to a higher affinity. However, little is known about the molecular changes in the binding mechanism that would facilitate such a transition. We previously showed that the interaction between two intrinsically disordered domains, NCBD and CID, likely emerged in an ancestral deuterostome organism as a low-affinity interaction that subsequently evolved into a higher-affinity interaction before the radiation of modern vertebrate groups. Here we map native contacts in the transition states of the low-affinity ancestral and high-affinity human NCBD/CID interactions. We show that the coupled binding and folding mechanism is overall similar but with a higher degree of native hydrophobic contact formation in the transition state of the ancestral complex and more heterogeneous transient interactions, including electrostatic pairings, and an increased disorder for the human complex. Adaptation to new binding partners may be facilitated by this ability to exploit multiple alternative transient interactions while retaining the overall binding and folding pathway.

Diana Samodova
Dec 1, 2020; 19:2139-2156
Technological Innovation and Resources

Gerhard Liebisch
Dec 1, 2020; 61:1539-1555
Special Report

A comprehensive and standardized system to report lipid structures analyzed by MS is essential for the communication and storage of lipidomics data. Herein, an update on both the LIPID MAPS classification system and shorthand notation of lipid structures is presented for lipid categories Fatty Acyls (FA), Glycerolipids (GL), Glycerophospholipids (GP), Sphingolipids (SP), and Sterols (ST). With its major changes, i.e., annotation of ring double bond equivalents and number of oxygens, the updated shorthand notation facilitates reporting of newly delineated oxygenated lipid species as well. For standardized reporting in lipidomics, the hierarchical architecture of shorthand notation reflects the diverse structural resolution powers provided by mass spectrometric assays. Moreover, shorthand notation is expanded beyond mammalian phyla to lipids from plant and yeast phyla. Finally, annotation of atoms is included for the use of stable isotope-labeled compounds in metabolic labeling experiments or as internal standards. This update on lipid classification, nomenclature, and shorthand annotation for lipid mass spectra is considered a standard for lipid data presentation.

Kir2.1, a strong inward rectifier potassium channel encoded by the KCNJ2 gene, is a key regulator of the resting membrane potential of the cardiomyocyte and plays an important role in controlling ventricular excitation and action potential duration in the human heart. Mutations in KCNJ2 result in inheritable cardiac diseases in humans, e.g. the type-1 Andersen-Tawil syndrome (ATS1). Understanding the molecular mechanisms that govern the regulation of inward rectifier potassium currents by Kir2.1 in both normal and disease contexts should help uncover novel targets for therapeutic intervention in ATS1 and other Kir2.1-associated channelopathies. The information available to date on protein-protein interactions involving Kir2.1 channels remains limited. Additional efforts are necessary to provide a comprehensive map of the Kir2.1 interactome. Here we describe the generation of a comprehensive map of the Kir2.1 interactome using the proximity-labeling approach BioID. Most of the 218 high-confidence Kir2.1 channel interactions we identified are novel and encompass various molecular mechanisms of Kir2.1 function, ranging from intracellular trafficking to cross-talk with the insulin-like growth factor receptor signaling pathway, as well as lysosomal degradation. Our map also explores the variations in the interactome profiles of Kir2.1^WT versus Kir2.1^314-315, a trafficking deficient ATS1 mutant, thus uncovering molecular mechanisms whose malfunctions may underlie ATS1 disease. Finally, using patch-clamp analysis, we validate the functional relevance of PKP4, one of our top BioID interactors, to the modulation of Kir2.1-controlled inward rectifier potassium currents. Our results validate the power of our BioID approach in identifying functionally relevant Kir2.1 interactors and underline the value of our Kir2.1 interactome as a repository for numerous novel biological hypotheses on Kir2.1 and Kir2.1-associated diseases.

Trypsin is the protease of choice in bottom-up proteomics. However, its application can be limited by the amino acid composition of target proteins and the pH of the digestion solution. In this study we characterize ProAlanase, a protease from the fungus Aspergillus niger that cleaves primarily on the C-terminal side of proline and alanine residues. ProAlanase achieves high proteolytic activity and specificity when digestion is carried out at acidic pH (1.5) for relatively short (2 h) time periods. To elucidate the potential of ProAlanase in proteomics applications, we conducted a series of investigations comprising comparative multi-enzymatic profiling of a human cell line proteome, histone PTM analysis, ancient bone protein identification, phosphosite mapping and de novo sequencing of a proline-rich protein and disulfide bond mapping in mAb. The results demonstrate that ProAlanase is highly suitable for proteomics analysis of the arginine- and lysine-rich histones, enabling high sequence coverage of multiple histone family members. It also facilitates an efficient digestion of bone collagen thanks to the cleavage at the C terminus of hydroxyproline which is highly prevalent in collagen. This allows to identify complementary proteins in ProAlanase- and trypsin-digested ancient bone samples, as well as to increase sequence coverage of noncollagenous proteins. Moreover, digestion with ProAlanase improves protein sequence coverage and phosphosite localization for the proline-rich protein Notch3 intracellular domain (N3ICD). Furthermore, we achieve a nearly complete coverage of N3ICD protein by de novo sequencing using the combination of ProAlanase and tryptic peptides. Finally, we demonstrate that ProAlanase is efficient in disulfide bond mapping, showing high coverage of disulfide-containing regions in a nonreduced mAb.

Antibodies play essential roles in both diagnostics and therapeutics. Epitope mapping is essential to understand how an antibody works and to protect intellectual property. Given the millions of antibodies for which epitope information is lacking, there is a need for high-throughput epitope mapping. To address this, we developed a strategy, Antibody binding epitope Mapping (AbMap), by combining a phage displayed peptide library with next generation sequencing. Using AbMap, profiles of the peptides bound by 202 antibodies were determined in a single test, and linear epitopes were identified for >50% of the antibodies. Using spike protein (S1 and S2)-enriched antibodies from the convalescent serum of one COVID-19 patient as the input, both linear and conformational epitopes of spike protein specific antibodies were identified. We defined peptide-binding profile of an antibody as the Binding Capacity (BiC). Conceptually, the BiC could serve as a systematic and functional descriptor of any antibody. Requiring at least one order of magnitude less time and money to map linear epitopes than traditional technologies, AbMap allows for high-throughput epitope mapping and creates many possibilities.

Subsidies and Sustainable Agriculture: Mapping the Policy Landscape Research paper sysadmin 10 December 2019

Agricultural subsidies shape production and consumption patterns, with potentially significant effects on poverty, nutrition and other sustainability concerns. This paper maps the different types of support provided by governments to the agricultural sector, and highlights some of the complex political economy dynamics that underpin the relevant policies.

Summary

• Agricultural subsidies, a mainstay of government policy, have a large part in shaping production and consumption patterns, with potentially significant effects as regards poverty, food security, nutrition, and other sustainability concerns such as climate change, land use practices and biodiversity.
• There are multiple types of direct and indirect support provided by governments to various actors in the agricultural sector; and in terms of political economy, there are complex dynamics underpinning the policies that sustain these subsidies.
• Overall, subsidies targeting producers have the most significant effect on production, and the greater trade-distorting effect. These subsidies promote domestic production and discourage imports, leading to overproduction that is largely disposed of on the international market, with the help of export subsidies. This can tend to intensify negative environmental agricultural practices, such as cultivating marginal land, unsustainable types of intensification, or incentivizing excessive pesticide and fertilizer use.
• On the other hand, producer subsidies that are not tied to output of a specific commodity (i.e. delinked) have far fewer distorting impacts and could help to deliver sustainable outcomes. For example, this type of subsidies can require crop diversification or be linked to conservation of permanent grassland.
• Subsidies that enable transfers to consumers, for example through food stamp programmes, also serve to delink production from consumption, can foster healthier diets, can play an important role in delivering food accessibility and security among low-income groups, and can represent one of the less trade-distorting subsidies.
• If subsidies are to be reformed to help promote healthier diets and encourage more sustainable production, it is essential to understand not only the type and amount of support that key countries provide, but also the domestic dynamics that can shape such policies.
• While price support, input subsidies or investment aids remain the central pillars of programmes in large developing countries such as Brazil, China or India, other economies – notably including the EU and Japan – focus on direct payments, support for general services and set-aside schemes, as well as significant border protection. The US, for its part, has tended to focus on subsidized insurance schemes and food programmes for poorer consumers.
• If subsidies are to deliver policy objectives, their design and implementation should delink production from consumption. For example, consumer subsidies designed to deliver nutrition and food security, or payments for environmental services to enable more environmentally friendly production systems, could prove to be the most effective, least trade-distorting means of achieving more sustainable and equitable agricultural production.
• The political economy of food means that the removal of subsidies is often highly sensitive, and tends to be met with significant resistance. However, reform that delinks support from production through a gradual transition process could ultimately prove successful in delivering effective subsidy schemes.
• Effective subsidy schemes must by design be truly result- and performance-based, supported by robust and objective indicators. At the same time, engaging multiple actors along key commodity value chains – including leading importing and exporting countries, traders and transporters – could lead to the development of international, commodity-specific arrangements that are able to deliver effective nutrition and sustainability goals.

Ramaphosa Has Won the Battle. But Can He Win the War? Expert comment sysadmin 21 December 2017

Cyril Ramaphosa is taking charge of South Africa’s ruling party, the ANC, at its weakest point in post-apartheid history. Expectations couldn’t be higher.

Ramaphosa ran for the leadership of the ANC on a platform of party renewal, economic recovery, and building the capacity of the state. But Jacob Zuma remains the President of South Africa and, under the constitution, can stay in office until elections in 2019. Therefore, meeting expectations on economic recovery will depend on Ramaphosa taking the presidency – and he has a number of political battles to face before that becomes reality.

To begin with, Ramaphosa and his supporters did not win a total victory at the elective conference. The presidency was only one position in the senior cadre – the co-called ‘top six’ – that was elected. This body is now split evenly between Ramaphosa and his allies, and those that supported his opponent Dr Nkosazana Dlamini-Zuma - Jacob Zuma’s preferred successor. This creates two centres of power in the ANC, limiting what Ramaphosa will be able to achieve from within the party.

Although there is significant pressure from the electorate to remove Zuma from national office, actually doing so will be difficult. Zuma’s predecessor Thabo Mbeki was removed from the national presidency before his term was up when the National Executive Committee (NEC) of the party recalled him from office following Zuma’s assumption of party leadership. But this option may not be available to Ramaphosa. The split within the ‘top six’ and new NEC will make it difficult to present an ultimatum to Zuma. His loyalists will not want a witch hunt within the party.

Corruption and elitism within the party

Much of the tension centres on questions of corruption, the dominant political issue in South Africa at the moment. In the build up to the elective conference Gwede Mantashe - now national chairperson - admitted that “The biggest challenge from where we’re sitting is the image and the reputation of the ANC. The ANC is seen as equal to corruption and looting.” Ramaphosa made anti-corruption initiatives a centrepiece of his campaign, including the establishment of a judicial commission and rapid action to investigate and prosecute the guilty.

But the split within the party may undermine the credibility of these promises. Ramaphosa’s problem is that some of the new ‘top six’ - including Deputy President David Mabuza, and Secretary General Ace Magashule – would be high on the list of those the electorate want to see investigated. Party resistance may restrict the extent to which Ramaphosa can demonstrate a comprehensive break from the past.

Corruption within the party goes far deeper than the headline cases of ‘state capture’ and expropriation. At a branch level, access to political power has become the primary means of access to economic resource. It is a process of selective patronage that differentiates between those who are ‘in’ from those who aren’t. At its broadest, this type of corruption has created a mistrust of the ANC and the new economic elite that the party has created around it – including Ramaphosa himself.

Having lost out to Mbeki in the fight to succeed Mandela despite being the favourite for the job, Ramaphosa spearheaded the ANC’s deployment of cadres in business. He has become one of the country’s richest men, and a highly sought after board member by South Africa’s largest companies across mining, telecoms, and logistics.

One of his biggest challenges will be to remove the perception of elitism as his senior position within the party and economy has given rise to mistrust from a grass roots level. The political tussle at the conference was also largely driven by a small number of the party elite being able to control large groups of delegate votes. The nature of political competition within the party is symptomatic of the ANCs electoral dominance in the early days of the nation’s democracy. But this support is now far less certain, and the party cannot afford to become complacent.

Resetting the relationship with business

Ramaphosa’s business dealings may mean he has to walk a fine line in censuring his colleagues for making money from politics. But it may also be a significant opportunity for the party to reset its relationship with the private sector. Under Mbeki, relations between the ANC and business were distant, but characterized by recognition of mutual dependence.

Under Zuma this relationship deteriorated, and the President demonstrated he was willing to make decisions to boost his political power irrespective of economic consequences. Ramaphosa could, for the first time, truly align the interests of business and government, without abandoning his transformative policy agenda.

At an ANC regional economic colloquium in Johannesburg in November Ramaphosa outlined his ten-point economic plan. It would deliver the party’s adopted mantra of ‘radical economic transformation’, but through broadly neo-liberal policies on private business development and state-owned enterprise reform to allow private capital to co-invest.

He took the ethos and principles of the Freedom Charter – the 1955 statement of core ANC principles – and applied them to a modernising economy. Talk of a ‘new deal’, productive partnerships in the mining sector, and an emphasis on job creation in manufacturing will woo investors. The rand surged upon his election.

But Ramaphosa will not be able to deliver on the economic demands of the country until he is in the office of the presidency - and Zuma still holds many of the cards. Ramaphosa can promise his followers potential power and government positions in future, but Zuma can still offer them now.

Removing Zuma will require skilful internal party politicking, and Ramaphosa will need to limit the fallout – he cannot afford to further damage the credibility of the party before it faces the electorate in 2019. He has won the battle, but the outcome of the war is far from certain.

Ramaphosa Must Act Fast With New Mandate in South Africa Expert comment sysadmin 23 May 2019

In the wake of South Africa’s election, political constraints will ebb momentarily. The president should seize the opportunity to deliver meaningful change.

On 25 May, Cyril Ramaphosa will be inaugurated as president of South Africa, having dragged the African National Congress (ANC) over the line in the 8 May election. The ANC gained a 57 per cent majority, its lowest vote since 1994, its status as national liberator deeply eroded by successive corruption scandals. Only Ramaphosa’s personal popularity stopped it haemorrhaging more support.

His sustained action against corrupt public servants and promises of job-creating economic growth has attracted support from beyond the ANC’s base, including a significant minority of white voters, and generated significant international goodwill. Ramaphosa now has a short window of opportunity to reset social democracy in South Africa before the political cycle of municipal, party and national elections from 2021 to 2024 forces his attention back to party politics.

Defining ‘Ramaphosa-ism’

But personal popularity is fickle, and goodwill alone will not turn around the ailing economy. To attract investment and keep the electorate on side, Ramaphosa’s government needs to move beyond pragmatic crisis responses and articulate a clear, shared vision for how market intervention can allow the economy to grow while simultaneously delivering social transformation.

Growth will be hard to achieve in the short term. The economy is expected to grow 1.2% in 2019 and 1.5% in 2020, according to the IMF. Consumer confidence remains subdued, and a decade of declining GDP per capita and increasing inequality has put a strain on households. A ‘fiscal stimulus’ in 2018 delivered very little new government spending, and over the past 10 years, the government wage bill has increased three times higher than the rate of inflation.

Eskom, the state electricity provider, has debts equating to the GDP of Latvia and is not the only state-owned enterprise (SOE) that has required bailing out by the government. There are plans to break up Eskom into three separate entities but calls for deeper reform – or even privatization – are growing.

The president’s responses to these challenges will go a long way to defining ‘Ramaphosa-ism’ and the role of government in pursuing equitable economy growth.

Economic expectations under Ramaphosa

Ramaphosa was a champion of the introduction of a minimum wage and a proponent of the National Development Plan, which relies on growth to drive job creation. His support for land reform is an individual conviction as much as it is a party line, although his views are softer than many in the party, with state-owned land being the initial target.

Investor uncertainty on land tenure and regulations in mining will need to be addressed through passing key pieces of legislation on land reform and the revised Mining and Petroleum Resources Development Act.

Where Ramaphosa differs from his predecessors is his links with business. Thabo Mbeki enjoyed a relationship of mutual respect with business; this disintegrated under Jacob Zuma. Ramaphosa, however, is part of South Africa’s business community, having founded the Shanduka Group, with investments in multiple sectors including retail, telecoms and extractives, and served as chairman of MTN and Bidvest. As president, he has surrounded himself with close economic advisers from business and banking.

In the short term, anti-corruption measures and competent appointments will ease investor woes. In the long term, there is a need to improve the ease of doing business, including labour market reforms, and to make South Africa a more competitive business environment by reducing the hold of large conglomerates on the economy. Ramaphosa may also make greater use of public-private partnerships for large projects.

Political constraints

Ramaphosa faces few immediate political challenges. The ANC is still deeply divided, but although Ramaphosa does not enjoy the ideological support of the entire party, his opponents are leaderless post-Zuma, and have been unable to offer a coherent alternative. ANC Secretary General Ace Magashule has fallen into the role of interim figurehead of this faction, and allegations of corruption would make it difficult for him to aspire to national leadership.

The need to avoid splits before the election meant Ramaphosa had to make concessions, and his first cabinet in February 2018 included opponents and those accused of corruption or incompetence, such as Malusi Gigaba and Bathabile Dlamini. Such concessions to political opponents are unlikely to continue after the election.

Meanwhile, opposition parties made some advances in the election, but where Zuma was an easy target, they are still grappling with how to confront Ramaphosa. The party with the biggest gains was the Economic Freedom Fighters, whose increase of just over 4 points from the last election gave it 11 per cent of the vote this time. They will likely continue to be an effective disruptor. Ramaphosa may also be challenged by trade unions on his reforms, notably over any break-up of SOEs.

But the biggest and most immediate external political challenge for Ramaphosa will be rebuilding trust between government and society, in a context where social protest has become an alternative form of political participation. A turnout of 65 per cent may be considered normal in Western democracies but is a notable drop for a country as politicized as South Africa, driven by frustration and a sense of exclusion as much as apathy. Turnout by young people was even lower.

Achieving the vision

South Africa has all the platforms it needs to project its renewal and attract vital external investment – it is a non-permanent member of the UN Security Council, it will take over as chair of the African Union in 2020, it is a member of BRICS and it is the only African member of the G20. But in the recent past, it has struggled to tell a coherent story about its vision for the future and offer to the world.

In the immediate wake of the election, internal and external political constraints will ebb. Ramaphosa must act fast to deliver results before the election cycle starts again. To attract much needed investment stimulus, he will not only need to articulate and market his vision for South Africa, but also outline how he plans to achieve it.

Last week the University of Colorado (Boulder), the CUbit Quantum Initiative, and the Elevate Quantum consortium released workforce roadmap for educating and building a quantum workforce. “This roadmap provides a […]

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