The future of one of outback Australia's tourist drawcards, the National Transport Hall of Fame, is in doubt after an independent audit found financial irregularities by management.

A fatal crash following a police pursuit near a community north-east of Alice Springs is being treated as a death in custody, with police declining to say what prompted them to chase the 42-year-old man.

Aboriginal leaders on South Australia's remote Anangu Pitjantjatjara Yankunytjatjara (APY) Lands should consider suspending their manager Richard King while an investigation is carried out into the use of Commonwealth funding, an independent report has found.

The Northern Territorys first known contract killer may have accidentally died in his prison cell after using drugs, investigators believe.

A young teenage girl is forcibly stripped and kept naked in a police cell for almost an hour after being briefly forced into one of the spit-hoods banned in youth prisons ahead of the Northern Territory royal commission.

The Territory Families Department finalised half the number of child-protection investigations it planned to last financial year, but child welfare advocates say the figure is a result of longer-term reforms.

Dozens of horse carcasses, car bodies and dangerous substances are being illegally dumped in a catchment area for Darwin's water supply, prompting concerns about potential contamination.

The ACCC has been asked to look into mortgage pricing and obstacles customers face in switching banks.

The ACCC has been asked to look into mortgage pricing and obstacles customers face in switching banks.

Rape victims are being made to wait for hours in the clothes they were assaulted in before being examined, or sometimes not examined at all, a damning auditor-general report reveals, highlighting the lack of qualified staff.

Florists say deceptive advertising is tricking customers into thinking they're buying local flowers when they're not. One businesswoman says the practice has cost her as much as $80,000.

Residents of a suburban Gold Coast development site say they are about to start digging for cash, days after a stash of old bank notes was found in their neighbourhood.

Researchers at Australia's first 'body farm' have observed that dead bodies move significantly when they decompose and believe it could be important in investigations.

(United States Eighth Circuit) - In an action by a company which provides security and consulting services to casino operators, seeking a declaratory judgment that an Indian tribal court lacked jurisdiction and an order compelling arbitration, summary judgment for defendant is affirmed in part where the tribal courts could exercise adjudicatory jurisdiction over the tribe's claims against plaintiff for trespass to land, trespass to chattels, and conversion of tribal trade secrets. However, the judgment is reversed in part where the tribal court did not have jurisdiction under the second Montana exception over the tribe's claim for conversion of tribal funds.

London's Metropolitan Police have finally dropped their investigations into working-class Brexit campaigner Darren Grimes and Vote Leave's Alan Halsall, in another defeat for the supposedly neutral Electoral Commission.

A Colorado legislator has filed an ethics complaint against U.S. Sen. Cory Gardner over a Palm Beach party he attended in February that was hosted by a champagne company.

Outrage is spreading over a shooting of a black man that led to murder charges more than two months later against a white father and son, but "all that matters is what the facts tell us,” Georgia Bureau of Investigation Director Vic Reynolds said Friday.

Officers from multiple jurisdictions were involved Wednesday morning in a fatal police shooting in Commerce City.

Many connected to the Brooklyn rapper are refusing to talk.

In lieu of an attendance fee, ID is encouraging donations to nonprofit organizations that we support at the channel, including: the National Center for Missing & Exploited Children, National Network to End Domestic Violence, and One Love.

A day after a father and son were charged in the February killing of unarmed jogger Ahmaud Arbery, a Georgia official promised a thorough probe into the case and said the man who filmed the horrific incident is also under investigation. In a news conference Friday morning, Georgia Bureau of Investigation Director Vic Reynolds said “every stone will be turned over" and if the facts lead agents to make another arrest “they will do that.”

Lawrence Cuneo, an eighth-grade social studies teacher in the coastal town of Toms River, is under investigation by school officials.

A day after a father and son were charged in the February killing of unarmed jogger Ahmaud Arbery, a Georgia official promised a thorough probe into the case and said the man who filmed the horrific incident is also under investigation. In a news conference Friday morning, Georgia Bureau of Investigation Director Vic Reynolds said “every stone will be turned over" and if the facts lead agents to make another arrest “they will do that.”

A suspect accused in the shooting of Ahmaud Arbery, an unarmed black jogger killed in a Georgia suburrb more than two months ago, was involved in a previous prosecution of the 26-year-old runner back when he worked for the local district attorney’s office.

Matt Doig is joining the Los Angeles Times as assistant managing editor, investigations.

MLB found the Red Sox illegally used technology to steal signs during the 2018 season, but only one Red Sox employee, an advance scout, was suspended.

A day after a father and son were charged in the February killing of unarmed jogger Ahmaud Arbery, a Georgia official promised a thorough probe into the case and said the man who filmed the horrific incident is also under investigation. In a news conference Friday morning, Georgia Bureau of Investigation Director Vic Reynolds said “every stone will be turned over" and if the facts lead agents to make another arrest “they will do that.”

A suspect accused in the shooting of Ahmaud Arbery, an unarmed black jogger killed in a Georgia suburrb more than two months ago, was involved in a previous prosecution of the 26-year-old runner back when he worked for the local district attorney’s office.

Accusations of sexual impropriety by powerful men should be taken seriously.

PLEASE NOTE: This event has been cancelled due to the rapid spread of coronavirus.

Indianapolis Mayor Joe Hogsett is asking for federal law enforcement to "actively monitor" his police department's investigations into two fatal police shootings.

Former South Bend, Indiana, mayor and former Democratic hopeful for president Pete Buttigieg responded to the shooting of Dreasjon Reed.

Former South Bend, Indiana, mayor and former Democratic hopeful for president Pete Buttigieg responded to the shooting of Dreasjon Reed.

Indianapolis Mayor Joe Hogsett is asking for federal law enforcement to "actively monitor" his police department's investigations into two fatal police shootings.

A heavy police presence outside a Kitchener apartment building late Friday afternoon has been linked to a homicide investigation by Windsor Police.

The following article, BREAKING: New Docs Prove Obama Knew Details Of Flynn Wiretapping…Newly Surfaced Video Shows Obama Explaining How He Stays Out Of FBI Investigations, was first published on 100PercentFedUp.com.

Barack Obama knew. Documents released yesterday that were used to exonerate President Trump’s new NSA General Flynn, prove that President Barack Obama was aware of the details of Michael Flynn’s intercepted phone calls on December 16 with then-Russian Ambassador Sergey Kislyak. On January 5, 2017, then-Deputy Attorney General, Sally Yates attended an Oval Office meeting […]

Continue reading: BREAKING: New Docs Prove Obama Knew Details Of Flynn Wiretapping…Newly Surfaced Video Shows Obama Explaining How He Stays Out Of FBI Investigations ...

Samvel K Gularyan
Apr 6, 2020; 0:RA120.001986v1-mcp.RA120.001986
Research

Glioblastoma (GBM) is one of the most aggressive human cancers with a median survival of less than two years. A distinguishing pathological feature of GBM is a high degree of inter- and intratumoral heterogeneity. Intertumoral heterogeneity of GBM has been extensively investigated on genomic, methylomic, transcriptomic, proteomic and metabolomics levels, however only a few studies describe intratumoral heterogeneity due to the lack of methods allowing to analyze GBM samples with high spatial resolution. Here, we applied TOF-SIMS (Time-of-flight secondary ion mass spectrometry) for the analysis of single cells and clinical samples such as paraffin and frozen tumor sections obtained from 57 patients. We developed a technique that allows us to simultaneously detect the distribution of proteins and metabolites in glioma tissue with 800 nm spatial resolution. Our results demonstrate that according to TOF-SIMS data glioma samples can be subdivided into clinically relevant groups and distinguished from the normal brain tissue. In addition, TOF-SIMS was able to elucidate differences between morphologically distinct regions of GBM within the same tumor. By staining GBM sections with gold-conjugated antibodies against Caveolin-1 we could visualize border between zones of necrotic and cellular tumor and subdivide glioma samples into groups characterized by different survival of the patients. Finally, we demonstrated that GBM contains cells that are characterized by high levels of Caveolin-1 protein and cholesterol. This population may partly represent a glioma stem cells. Collectively, our results show that the technique described here allows to analyze glioma tissues with a spatial resolution beyond reach of most of other omics approaches and the obtained data may be used to predict clinical behavior of the tumor.

Investigations continue into the murder of two men, who were shot in Swallowfield, St. Andrew yesterday evening. The incident occurred at about 6:00 p.m. Our news team understands that a Nissan AD wagon, carrying men armed with...

Trial MVA85A - monkey trials for a booster vaccine for BCG, developed by researchers at Oxford University, is the subject of an investigation published on bmj.com. Experts warn that today’s investigation is just one example of “a systematic failure” afflicting preclinical research and call for urgent action “to make animal research more fit for...

Joachim Spranger
Mar 1, 2003; 52:812-817
Pathophysiology

David C. Klonoff
Aug 1, 2018; 41:1681-1688
Emerging Technologies: Data Systems and Devices