OBJECTIVE

Plasma protein N-glycan profiling integrates information on enzymatic protein glycosylation, which is a highly controlled ubiquitous posttranslational modification. Here we investigate the ability of the plasma N-glycome to predict incidence of type 2 diabetes and cardiovascular diseases (CVDs; i.e., myocardial infarction and stroke).

About 14,000 more students in the state are enrolled in special education, after the state lifted what it called a "benchmark" enrollment figure of 8.5 percent.

U.S. Chief Justice John Roberts on Friday put a temporary hold on the disclosure to a Democratic-led House of Representatives committee of grand jury material redacted from former Special Counsel Robert Mueller's report on Russian interference in the 2016 election. The U.S. Court of Appeals for the District of Columbia Circuit ruled in March that the materials had to be disclosed to the House Judiciary Committee and refused to put that decision on hold. The appeals court said the materials had to be handed over by May 11 if the Supreme Court did not intervene.

The ongoing investigation of the fatal shooting in Brunswick, Georgia, will also look at a neighbor of suspects Gregory and Travis McMichael who recorded video of the incident, authorities said.

All remaining criminal charges of city and state officials stemming from the Flint Water Crisis have been dismissed.

A searing report and federal oversight over Title IX enforcement in Chicago raises the question: Is it an outlier, or just the first to get caught?

Penn State University Police and Public Safety  Deputy Chief Tom Sowerby was recently appointed as the commander of a new University-wide Criminal Investigation Unit, to better serve 22 Penn State campuses where University Police and Public Safety provides police services.

Deputy Attorney General Rebecca Anderson secured a guilty plea and prison sentence for a man wanted for a shooting in Seaford, arrested while police were investigating illegal drug activity in Bridgeville. Teron West, 33, of Seaford, was arrested in July 2019, when members of the Delaware State Police Sussex County Governor’s Task Force executed a […]

Following a starting gate incident related to the fifth race on June 14, 2018, the Delaware Department of Agriculture opened a full animal cruelty investigation into the treatment of the horse, “Accolade.” Based upon a thorough investigation at both the state and track levels, the assistant starter was cleared of any wrong doing.

Attorney General Kathy Jennings today announced that Delaware has joined a bipartisan, multistate investigation of JUUL Labs. The 39-state coalition is investigating JUUL’s marketing and sales practices, including targeting of youth. The investigation also concerns claims regarding nicotine content, statements regarding the risks and safety of e-cigarettes, and the effectiveness of e-cigarettes as smoking cessation […]

STANTON (March 2, 2020) – Delaware Division of Public Health (DPH) Director Dr. Karyl Rattay announced at a press conference today that DPH has two Patients Under Investigation (PUIs) for coronavirus disease in Kent County, who had traveled to a country under a travel alert. Three previous PUIs were tested and all came back negative. […]

Hydro Tasmania says it is accelerating detailed investigation of three key opportunities for pumped storage hydro development in the state as part of the Battery of the Nation initiative. Work has begun on a full feasibility assessment of pumped hydro development opportunities at Lake Cethana and Lake Rowallan in the northwest and near Tribute Power Station on the West Coast.

Hydro Tasmania says it is accelerating detailed investigation of three key opportunities for pumped storage hydro development in the state as part of the Battery of the Nation initiative. Work has begun on a full feasibility assessment of pumped hydro development opportunities at Lake Cethana and Lake Rowallan in the northwest and near Tribute Power Station on the West Coast.

Presentation by Jasbir Bath of Christopher Associates.

Chinese spies have targeted Belgian biological warfare experts, vaccine-maker GSK, and other high-tech firms in the country, Belgium's intelligence service suspects.

On 10 June 2019, the Competition and Markets Authority (CMA) gave notice that it had made its Final Order following its market investigation into the investment consulting (IC) and fiduciary management (F...

On 10 June 2019, the Competition and Markets Authority (CMA) gave notice that it had made its Final Order following its market investigation into the investment consulting (IC) and fiduciary management (F...

Afghan President Ashraf Ghani has ordered a probe into the drowning of several Afghan migrants last week after reports that Iranian border guards allegedly forced them into a river.

Competition Law E-Briefing: Fashion sector competition probe On Tuesday 24 March 2015, the UK’s competition regulator, the Competition and Markets Authority (the “CMA”), opened an investigation into suspected anti-competitive arrangements in the UK ...

The Hong Kong Court has recently confirmed the Securities and Futures Commission (“SFC”)’s powers to seize, search and compel access to digital devices rejecting challenges to such powers based on privacy grounds. Data privacy is a...

We have begun an independent investigationinto the contact the Metropolitan Police Service (MPS) had with a man before he suffered a life-changing injury in Haringey, north London on Monday 4 May 2020. The MPS made a mandatory referralto us following the incident when police on patrol approached a man, in his 20s, on Burgoyne Road, N4. Such a referralis usual practice when a person is seriously injured following direct or indirect police contact. We understand that the man ran off and police officers chased and then Tasered him as he jumped over a wall. The man fell and suffered serious injuries. He was arrested for drug related offences and was taken to hospital where he was assessed as...

Sports stars sign letter sent to U.S. Attorney General Bill Barr and FBI Director Christopher Wray

[Shabelle] The African Union and the UN have welcomed the decision by leaders from Somalia, Kenya, and Ethiopia to investigate Monday's plane crash in southwest Somalia which killed six people on board.

'Australia is “gum stuck to the bottom of China’s shoe”, huh? Ok, well, it’s time for Australia to rethink trade and other agreements with China if they don’t like criticism'

NFL greats Tom Brady and Anquan Boldin were among dozens of prominent players and coaches who called on Friday for a federal investigation into the death of Ahmaud Arbery, an unarmed black man who was shot while running in Georgia.

South Africa is a mineral-rich country with a diverse geology and a long history of mining. The rich history of mining activities includes the extraction of coal from the Ecca Group Sediments of the Karoo Supergroup (250 Ma), gold and uranium from the Witwatersrand Supergroup (2900 Ma), as well as platinum, uranium, tin and lead from the layered Bushveld Igneous Complex (BIC) (2150 Ma). The extraction of gold, copper, tin, lead and rare earth minerals also took place in the Archean rocks of Swazium age (3500–3000 Ma). The historical mining records have either not been accurately recorded or have been lost over time. This has resulted in significant geohazard risk during infrastructure development, especially in and around historical mining towns, such as Johannesburg and Ermelo. These geohazard risks require careful appraisal and quantification prior to any infrastructure design or construction.

This case study aims to set out the development aspects of the Multi-Faceted Geophysical Modelling Systems approach, which was used by the South African National Roads Agency SOC Ltd (SANRAL) during an investigation of undermined ground for the historical coal-mining town of Ermelo in South Africa. The N11/N2 ring road was planned to go around Ermelo to ensure mobility between major routes, whilst still maintaining town access.

The systems approach used a combination of airborne geophysics (Versatile Time Domain Electromagnetic System (VTEM^TM) and magnetics), generally used in mining exploration, land-based and borehole geophysics, borehole water testing, and ground-truthing. The approach was continuous and iterative, building on the data at hand and reducing unnecessary investigations while eliminating the possibility of anomalies being missed, as in the case of conventional discrete drilling. The investigation ensured that 100% of the route was comprehensively investigated with a high confidence in the geological and geophysical data, and concomitant mitigation of infrastructure risk.

The Multi-Faceted Geophysical Modelling Systems approach was successfully used to identify a previously unknown 1 x 1 m mining stope cavity at 90 m depth and a 3 x 5 m access tunnel at 24 m depth in a timely and cost-effective manner. Seven reverse-circulation percussion boreholes confirmed the structural integrity of these underground cavities, as well as the structural geology along the centreline. Based on the great success achieved in identifying shallow anomalies, this Multi-Faceted Geophysical Modelling Systems approach is now being considered for field trails on the dolomitic formations and the Wild Coast greenfields road project where there are large historical slumps and many fault lines.

Thematic collection: This article is part of the Ground-related risk to transportation infrastructure collection available at https://www.lyellcollection.org/cc/Ground-related-risk-to-transportation-infrastructure

Klebsiella species are problematic pathogens in neonatal units and may cause outbreaks, for which the sources of transmission may be challenging to elucidate. We describe the use of whole-genome sequencing (WGS) to investigate environmental sources of transmission during an outbreak of extended-spectrum-β-lactamase (ESBL)-producing Klebsiella michiganensis colonizing neonates. Ceftriaxone-resistant Klebsiella spp. isolated from neonates (or their mothers) and the hospital environment were included. Short-read sequencing (Illumina) and long-read sequencing (MinION; Oxford Nanopore Technologies) were used to confirm species taxonomy, to identify antimicrobial resistance genes, and to determine phylogenetic relationships using single-nucleotide polymorphism profiling. A total of 21 organisms (10 patient-derived isolates and 11 environmental isolates) were sequenced. Standard laboratory methods identified the outbreak strain as an ESBL-producing Klebsiella oxytoca, but taxonomic assignment from WGS data suggested closer identity to Klebsiella michiganensis. Strains isolated from multiple detergent-dispensing bottles were either identical or closely related by single-nucleotide polymorphism comparison. Detergent bottles contaminated by K. michiganensis had been used for washing milk expression equipment. No new cases were identified once the detergent bottles were removed. Environmental reservoirs may be an important source in outbreaks of multidrug-resistant organisms. WGS, in conjunction with traditional epidemiological investigation, can be instrumental in revealing routes of transmission and guiding infection control responses.

The IR Biotyper is a new automated typing system based on Fourier-transform infrared (FT-IR) spectroscopy that gives results within 4 h. We aimed (i) to use the IR Biotyper to retrospectively analyze an outbreak of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae (ESBL-KP) in a neonatal intensive care unit and to compare results to BOX-PCR and whole-genome sequencing (WGS) results as the gold standard and (ii) to assess how the cutoff values used to define clusters affect the discriminatory power of the IR Biotyper. The sample consisted of 18 isolates from 14 patients. Specimens were analyzed in the IR Biotyper using the default analysis settings, and spectra were analyzed using OPUS 7.5 software. The software contains a feature that automatically proposes a cutoff value to define clusters; the cutoff value defines up to which distance the spectra are considered to be in the same cluster. Based on FT-IR, the outbreak represented 1 dominant clone, 1 secondary clone, and several unrelated clones. FT-IR results, using the cutoff value generated by the accompanying software after 4 replicates, were concordant with WGS for all but 1 isolate. BOX-PCR was underdiscriminatory compared to the other two methods. Using the cutoff value generated after 12 replicates, the results of FT-IR and WGS were completely concordant. The IR Biotyper can achieve the same typeability and discriminatory power as genome-based methods. However, to attain this high performance requires either previous, strain-dependent knowledge about the optimal technical parameters to be used or validation by a second method.

OBJECTIVE

Hispanics/Latinos are the largest ethnic/racial group in the U.S., have the highest prevalence of diabetes, and are at increased risk for neurodegenerative disorders. Currently, little is known about the relationship between diabetes and cognitive decline and disorders among diverse Hispanics/Latinos. The purpose of this study is to clarify these relationships in diverse middle-aged and older Hispanics/Latinos.

Animal models of bacterial infection have been widely used to explore the in vivo activity of antibacterial drugs. These data are often submitted to the U.S. Food and Drug Administration to support human use in an investigational new drug application (IND). To better understand the range and scientific use of animal models in regulatory submissions, a database was created surveying recent pneumonia models submitted as part of IND application packages. The IND studies were compared to animal models of bacterial pneumonia published in the scientific literature over the same period of time. In this review, we analyze the key experimental design elements, such as animal species, immune status, pathogens selected, and route of administration, and study endpoints.

U.S. Chief Justice John Roberts on Friday put a temporary hold on the disclosure to a Democratic-led House of Representatives committee of grand jury material redacted from former Special Counsel Robert Mueller's report on Russian interference in the 2016 election.

NFL greats Tom Brady and Anquan Boldin were among dozens of prominent players and coaches who called on Friday for a federal investigation into the death of Ahmaud Arbery, an unarmed black man who was shot while running in Georgia.

The shipment of Ebola and henipavirus samples to Wuhan has given rise to groundless conspiracy theories involving Xiangguo Qiu. But there is no evidence whatsoever tying her to COVID-19

The overhaul of campus sexual assault regulations will ramp up the paperwork schools must do to comply with Title IX.

Chief Justice John G. Roberts on Friday declined to order a judicial misconduct investigation into a federal judge's retirement and whether Senate Majority Leader Mitch McConnell had anything to do with it.

D.C. Circuit Court of Appeals Judge Sri Srinavasan had previously asked the chief justice to assign a court ...

Key items of protective equipment were not included in the government's pandemic stockpile when coronavirus hit the UK, an investigation has found.

Global health experts are investigating reports of a rare but serious illness affecting children and its links to coronavirus after UK medics raised the alarm.

A distressing video of an unidentified woman boxing her German Shepherd dog has sparked outrage on social media and prompted an investigation into alleged animal cruelty.

Police have dropped an investigation into two prominent Brexit campaigners accused of breaching spending rules during the referendum campaign. In 2018 the Electoral commission said that Alan Halsall, of Vote Leave, and Darren Grimes, founder of pro-Brexit youth group BeLeave, failed to declare a payment related to the campaign. The watchdog said that BeLeave "spent more than £675,000 with (Canadian data firm) Aggregate IQ under a common plan with Vote Leave". This spending took Vote Leave over its £7 million legal spending limit by almost £500,000. Vote Leave paid a £61,000 fine, but denied wrongdoing, while Mr Grimes won an appeal against his £20,000 fine in July. The Commission also referred the pair to the Metropolitan Police but on Friday it was revealed that the investigations had now been dropped. A spokesman for the Leave campaigners said: "The Metropolitan Police has written to Vote Leave board member Alan Halsall and BeLeave founder Darren Grimes to confirm that it will not be acting on allegations made against them by the Electoral Commission and various Remain campaigners. "This marks the end of a two-year ordeal for both individuals." Mr Grimes, 26, said the development called into question whether the Electoral Commission was "fit for purpose". He had insisted since the allegations were first made that he was "completely innocent" of making false declarations in relation to the £680,000 donation. In a statement, Mr Grimes, a former fashion student originally from County Durham, said: "The Metropolitan Police has found, after investigation and consultation with the Crown Prosecution Service, that there is no case to be answered. "Once again the Electoral Commission has been found to be part of the mob, a quango out of control that isn't policing elections so much as punishing Leavers who have the temerity to win them. "My ordeal at the hands of the kangaroo court that is the Electoral Commission is now over, but questions must now be asked of whether that body is fit for purpose." Mr Halsall, the responsible person for Vote Leave, said he was "delighted to have been exonerated" and thanked the police for their "professional" investigation. "I was very disappointed that my colleagues at Vote Leave and myself were never given the opportunity of making our case in person to the Electoral Commission before being fined and reported to the police," he added. "It seems a rather unusual way of conducting an inquiry into such matters that only the so-called whistleblowers who made these allegations are interviewed by the regulator." A spokesman for the Met said an investigation into the Electoral Commission's allegations against Vote Leave and BeLeave, submitted on July 17 2018, was handed over in October to the Crown Prosecution Service (CPS). "On Tuesday, March 3 preliminary advice was received from the CPS," said the force spokesman. "This advice has now been duly considered and no further action will be taken."

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Priti Patel has reportedly been cleared of bullying members of staff after an official investigation.

Trad says she will cooperate with investigation into allegation she interfered in appointment of school principal

Queensland’s deputy premier and treasurer, Jackie Trad, has stood down from ministerial duties over an investigation into the appointment of a Brisbane principal.

The Crime and Corruption Commission (CCC) is investigating the recruitment and selection process for the principal of the Inner City South Secondary College.

Owner Tahnoon Nimer and former chairman Matt Southall intend to co-operate with the investigation

EXCLUSIVE

Former Schalke player Hiannick Kamba has reportedly been found alive and well in Germany, four years after his death.

Bruno Fernandes' move to Manchester United is part of a Fifa investigation after Sampdoria lodged a complaint against Sporting Lisbon for unpaid sell-on fees.

A new union-released report accuses Qantas of downplaying the risks of coronavirus before an outbreak at Adelaide Airport — but the airline has denied any wrongdoing.

Getting to the bottom of what caused the crash of a Canadian air force maritime helicopter could take a "year or more," Defence Minister Harjit Sajjan said Thursday as the government made plans to recover the wreckage from the bottom of the Ionian Sea.